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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Nutri-Sains: Jurnal Gizi, Pangan dan Aplikasinya Molecular and Cellular Biomedical Sciences (MCBS) Journal of Health Sciences JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan Al-Isyraq: Jurnal Bimbingan, Penyuluhan, dan Konseling Islam MEDIC MEdical Dedication Proceedings Series on Health & Medical Sciences Nursing Information Journal Jurnal Penyuuhan dan Pemberdayaan Masyarakat (JPPM) Conferences of Medical Sciences Dies Natalis Journal of Artificial Intelligence and Digital Business Journal of Medical Studies Prosiding Seminar Hukum Aktual Fakultas Hukum Universitas Islam Indonesia Jurnal Intelek Dan Cendikiawan Nusantara Jurnal Imiah Pengabdian Pada Masyarakat (JIPM) Indonesian Journal of Biomedicine and Clinical Sciences Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Jurnal Hukum dan Pendidikan Kewarganegaraan
Citra Maharani
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Althea Medical Journal

 1 
Profile of Apoptotic Marker Genes and Histopathology of the Placenta in Pregnancies with Pre-Eclampsia Herlambang, Herlambang; Enis, Rina Nofri; Tarawifa, Susan; Harahap, Huntari; Puspasari, Anggelia; Maharani, Citra; Kusdiyah, Erny
Althea Medical Journal Vol 10, No 2 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n2.3088

Abstract

Background: Pre-eclampsia (PE) is a hypertensive disorder in pregnancy and a significant cause of maternal and perinatal mortality and morbidity. Failure of spiral artery remodeling due to abnormal apoptosis, triggers disturbances in the mother and the baby’s growth. This study aimed to identify the profile of apoptotic marker genes and histopathological features of the placenta in pregnancies with pre-eclampsia.Methods: This study had used case-control method. Samples were taken from normal pregnancies (n=25) and pregnant women with pre-eclampsia (n=25) using a purposive sampling method from several hospitals in Jambi. qRT-PCR was used to examine apoptotic gene expression from placental tissue and hematoxyline eosin staining to view the placenta’s microscopic appearance. The targeted genes were BCL2-associated X (BAX) and B-cell lymphoma 2 (BCL-2). Histopathological changes of the placenta observed were syncytial node, cytotrophoblast, villous edema, hypervascularization, fibrosis stroma, atherosis, infarction, and thrombosis.Results: Relative BAX genes expression were increased once in placenta pre-eclampsia compared to controls, but not statistically significant (p-value>0.05). There was no difference between the decline of BCL-2 gene expression in pre-eclampsia placenta compared to the control (p-value >0.05). Histopathological changes in the placenta were syncytial node and cytotrophoblast (25 of 25), villous edema (19 of 25), hypervascularization (24 of 25), fibrosis stroma (22 of 25), atherosis (12 of 25), infarction (17 of 25), and thrombosis (24 of 25).Conclusion: The expression of BAX genes in pre-eclampsia tends to increase compared to normal pregnancy, and the expression of BCL-2 decreases.  The histopathological features of pre-eclampsia pregnancy placenta are mostly syncytial nodes, cytotrophoblasts, stromal fibrosis, and thrombosis.
Protein Insufficiency Among First-Trimester Pregnant Women in Jambi, Indonesia Herlambang, Herlambang; Puspasari, Anggelia; Maharani, Citra; Enis, Rina Nofri; Fitri, Amelia Dwi; Kusdiyah, Erny; Ibnu, Ismi Nurwaqiah
Althea Medical Journal Vol 12, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n2.4044

Abstract

Background: Insufficient protein intake or specific patterns of plasma amino acid levels during pregnancy has been associated with adverse maternal and neonatal outcomes. Studies in non-pregnant women have reported an association between protein intake and amino acid levels, however, data in pregnant women remain limited. Jambi, a region rich in freshwater fish, has a traditional dishes based on fish, which may affect maternal protein adequacy. This study aimed to assess protein sufficiency intake, plasma essential amino acid levels, and the relationship between fish consumption and protein intake among first-trimester pregnant women. Methods: A cross-sectional study was conducted in 2022 involving pregnant women at 9-16 weeks of gestation in Jambi, Indonesia, selected through purposive sampling. Protein intake and fish consumption data were collected using Food Frequency Questionnaires. Plasma essential amino acid levels were measured using Liquid Chromatography-Mass Spectrometry. Bivariate analyses were performed using Mann-Whitney and Chi-square tests.Results: Among 30 participants, 23.3% had insufficient protein intake and had lower plasma essential amino acid levels. Lysine levels showed a statistically significant difference between groups (p=0.010). Women with adequate protein intake reported significant higher fish consumption, particularly of freshwater fish (p=0.033).Conclusion: Adequate protein intake during early pregnancy is related to higher plasma essential amino acid levels. Consumption of local freshwater fish contributes to maintaining sufficient protein intake. These findings emphasize the importance of integrating healthy dietary patterns and locally sourced nutrient-rich foods into prenatal care to support maternal wellness and long-term health outcomes.
Co-Authors Agus Anggiana Ahmad Hamim Sadewa Ahmad Syauqy Ahmad Syauqy Alamri, Fahrial Alhadi, Annisa Alya Dwiva Juhari Amatullah, Afifah Ameli Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri, Amelia Dwi Amri, Fahrial Al An Aldia Asrial Andrea Zulius Anarta Anggelia Puspasari Annissa Delfira Arif, Cut Wulan Arinda Triagita Armaidi Darmawan Aryanti, Nindya Asro Hayani Harahap Azzahra Sarah Fatimah Ramadhanti Bachrudin Syaroni Bagya Agung Prabowo, Bagya Agung Bernhard Arianto Purba Betty Marlina Budi Justitia Budi Justitia Bulqis, Ratu Defriani Dwiyanti, Defriani Devy Afriyanti Dhea Assyifa Dhea Olivia Putri Effendi, Ian Ekaputri, Tia Wida Elfiani Elfiani Elfiani Elga Lauza Evelyna Ellysa Shalsabella Erny Kusdiyah Esa Indah Ayu, Esa Indah Eva Yuniritha, Eva Fanny Annisa Fazarrosy Fitriyanti Gian Mariana Hadi, Desta Asmara Hana Nurul Qur’ani Hanina Hasibuan, Fitra Husni Mubarak Hasmita, Debby Hasneli, Hasneli Helfira Citra Herlambang Herlambang Herlambang Herlambang HERLAMBANG HERLAMBANG Herlambang Herlambang Herman, Sriyana Huntari Harahap Ika Setyawati Ilham Rizqi Ariyandi Irfannuddin Irfannuddin Irlianissa, Mutiara Iskandar, Mirna Marhami Ismi Nurwaqiah Ibnu Jamilatul Rizqiyah Khairunnisa, Dhia Fairuz Kusumawati, Diana Lipinwati ., Lipinwati Maharani, Amrina Maulana Haikal An Nur Miftahurrahmah Miftahurrahmah, Miftahurrahmah Muhamad Reza Muhammad Basir Muhammad Iqbal Fasa Mus, Rosdiana Mustamin Mustamin Nalanwal, Khayla Nurul Izza Nyimas Natasha Ayu Shafira Pramudji Hastuti Prasetyawan, Riyan Dwi Prio Wibowo Rahma, Syawalya Rara indah Oktaviani Renaldi Rizki Nugraha Retno Wulansari Rina Nofri Enis Rita Halim Rita Halim Rusli Shandra Khaerunissa Sri Darningsih Suhaimi, Novadian Supartono Suprapti Suprapti Susan Tarawifa Syamsuriyati, Syamsuriyati Syarif Syifa Energi Maulana Syukur, Astian Nathaniel Tarawifa, Susan Tengku Arief Buana Perkasa Tia Wida Ekaputri Virginsia, Sonya Vivekanantharasa, Raveenthiran Vivi Fadhilah Safitri Wahyu Indah Dewi Aurora Wilma Wilma, Wilma Winiesti Melani Putri Zita Andini Sabillah Zulkhair Ali