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All Journal e-GIGI Dentika Dental Journal Jurnal Kesehatan Andalas Majalah Kedokteran Gigi Indonesia Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Buletin Ilmiah Nagari Membangun Bioscientia Medicina : Journal of Biomedicine and Translational Research Padjadjaran Journal of Dental Researchers and Students Interdental Jurnal Kedokteran Gigi (IJKG) Indian Journal of Forensic Medicine & Toxicology Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Kesehatan Saintika Meditory Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Andalas Dental Journal Cakradonya Dental Journal Journal of Pharmaceutical and Sciences. Jurnal of Syiah Kuala Dentistry Society
Nila Kasuma
Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Selective Suppression of Prevotella and Modulation of Oral Dysbiosis in Stunted Children: The Role of Systemic Zinc as a Biological Adjuvant to Mechanical Therapy Nila Kasuma; Dewa Made Wedagama; Thifla Rafifa Wirza; Dedi Sumantri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i2.1514

Abstract

Background: Gingivitis in stunted children represents a unique pathological entity driven by a compromised mucosal barrier and systemic zinc deficiency. These children exhibit a phenotype of acquired immunodeficiency, where standard mechanical debridement often fails to resolve inflammation, leading to a phenomenon known as dysbiotic rebound. This study investigated the biomolecular efficacy of systemic Zinc supplementation combined with scaling and root planing (SRP) in modulating the oral microbiome of nutritionally vulnerable children. Methods: A randomized, single-blind, pre-post test controlled clinical trial was conducted in Padang, Indonesia, involving 30 stunted children (Height-for-age Z-score < -2 SD) diagnosed with generalized gingivitis. Participants were randomized into a Control group (SRP + Placebo, n=15) and an Intervention group (SRP + 20mg Zinc Sulfate Monohydrate daily, n=15) for a duration of 14 days. Microbial profiling was performed on unstimulated saliva utilizing high-throughput 16S rRNA gene sequencing (V3–V4 region). Bioinformatics processing utilized the DADA2 pipeline to generate Amplicon Sequence Variants (ASVs). Results: Results indicated that SRP alone resulted in a pathogenic recolonization dominated by Firmicutes (+49.6%). Conversely, Zinc supplementation induced a significant Gram-negative crash, reducing Proteobacteria by 50.6%. Most notably, the key periodontal pathogen Prevotella was suppressed to undetectable levels in the Zinc group (p<0.05). Conclusion: Systemic zinc acts as a potent biological scaffold in the enterosalivary cycle, likely repairing the epithelial barrier and starving hemin-dependent pathogens. It is strongly recommended as a therapeutic adjuvant to prevent the ecological recurrence of gingivitis in nutritionally vulnerable pediatric populations.
The Relationship Between Alkaline Phosphatase Enzyme Levels and the Incidence of Enamel Defects in Permanent Teeth in Children Wulandari , Reno Wiska; Kasuma, Nila; Dasman , Hardisman; Ali , Hirowati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1304

Abstract

Enamel gigi merupakan jaringan yang paling keras yang ada di dalam tubuh manusia yang dibentuk oleh interaksi antara protein matriks dan enzim, terkhusus kadar enzim alkaline phosphatase (ALP). Gangguan dalam regulasi atau aktivitas ALP dapat menyebabkan mineralisasi enamel yang tidak tepat dan meningkatkan risiko terjadinya Developmental Defects of Enamel (DDE) pada gigi permanen. Tujuan penelitian adalah menganalisis hubungan kadar enzim ALP dengan kejadian DDE pada anak. A comparative cross-sectional study was conducted on 60 children divided into two groups: normal enamel and DDE. Pemeriksaan enamel gigi menggunakan modified DDE index. Saliva dianalsis dengan metode Kolorimetrik secara duplo. Analisa statistic menggunakan Mann-Whitney test dengan hasil signifikan ketika p < 0,05. Hasil penelitian menunjukan kadar ALP rata-rata pada kelompok enamel normal  lebih rendah [5,90 (1,38 – 27,82) mg/mL] dibandingkan dengan kelompok DDE [7,76 (0,13-11,89) mg/mL] dengan perbedaan yang tidak signifikan (p > 0,05).  Berdasarkan temuan ini, kadar ALP dalam saliva tidak memiliki hubungan langsung yang kuat dengan DDE, sehingga potensinya sebagai biomarker tunggal untuk deteksi dini DDE terbatas.
Selective Suppression of Prevotella and Modulation of Oral Dysbiosis in Stunted Children: The Role of Systemic Zinc as a Biological Adjuvant to Mechanical Therapy Nila Kasuma; Dewa Made Wedagama; Thifla Rafifa Wirza; Dedi Sumantri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i2.1514

Abstract

Background: Gingivitis in stunted children represents a unique pathological entity driven by a compromised mucosal barrier and systemic zinc deficiency. These children exhibit a phenotype of acquired immunodeficiency, where standard mechanical debridement often fails to resolve inflammation, leading to a phenomenon known as dysbiotic rebound. This study investigated the biomolecular efficacy of systemic Zinc supplementation combined with scaling and root planing (SRP) in modulating the oral microbiome of nutritionally vulnerable children. Methods: A randomized, single-blind, pre-post test controlled clinical trial was conducted in Padang, Indonesia, involving 30 stunted children (Height-for-age Z-score < -2 SD) diagnosed with generalized gingivitis. Participants were randomized into a Control group (SRP + Placebo, n=15) and an Intervention group (SRP + 20mg Zinc Sulfate Monohydrate daily, n=15) for a duration of 14 days. Microbial profiling was performed on unstimulated saliva utilizing high-throughput 16S rRNA gene sequencing (V3–V4 region). Bioinformatics processing utilized the DADA2 pipeline to generate Amplicon Sequence Variants (ASVs). Results: Results indicated that SRP alone resulted in a pathogenic recolonization dominated by Firmicutes (+49.6%). Conversely, Zinc supplementation induced a significant Gram-negative crash, reducing Proteobacteria by 50.6%. Most notably, the key periodontal pathogen Prevotella was suppressed to undetectable levels in the Zinc group (p<0.05). Conclusion: Systemic zinc acts as a potent biological scaffold in the enterosalivary cycle, likely repairing the epithelial barrier and starving hemin-dependent pathogens. It is strongly recommended as a therapeutic adjuvant to prevent the ecological recurrence of gingivitis in nutritionally vulnerable pediatric populations.
Praktik Ibu dalam Kesehatan Gigi Anak dan Early Childhood Caries: Scoping Review Zia, Hanim Khalida; Syah, Nur Afrainin; Machmud, Rizanda; Kasuma, Nila; Dasman, Hardisman; Mona, Deli; Purna, Rozi Sastra; Bachtiar, Adang
Padjadjaran Journal of Dental Researchers and Students Vol 9, No 3 (2025): Oktober 2025
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v9i3.67067

Abstract

Pendahuluan: World Health Organization (WHO) tahun 2022 menyatakan penyakit gigi dan mulut memengaruhi 3,5 miliar orang di seluruh dunia. Dua miliar orang dewasa dan 514 juta anak menderita karies gigi. Karies gigi pada usia dini disebut Early Childhood Caries (ECC). Metode: Penelitian ini menggunakan metode scoping review untuk menganalisis praktik kesehatan gigi anak oleh ibu yang berpengaruh terhadap kejadian ECC. Proses seleksi artikel melalui tahap pertama dilakukan pencarian artikel menggunakan kata kunci Knowledge, Attitude, Practice, Mother, Early Childhood Caries pada database PubMed didapatkan 53 artikel dan Science Direct didapatkan 499 artikel, total 552 artikel. Tahap kedua dilakukan penyaringan berdasarkan kriteria inklusi dan eksklusi terdapat 31 artikel. Tahap ketiga dilakukan penyaringan berdasarkan judul, abstrak, dan isi yang sesuai topik didapatkan 21 artikel untuk di review. Hasil: Penelitian ini menunjukkan praktik kesehatan gigi anak oleh ibu yang berpengaruh terhadap kejadian ECC, yaitu pemeliharaan kesehatan gigi dan mulut, meliputi mencari informasi kesehatan gigi dan mulut anak, membawa anak ke dokter gigi, mendampingi anak menyikat gigi, memberi anak pasta gigi ber flouride, mengganti sikat gigi anak, menyikat lidah anak, menggunakan benang gigi untuk anak, dan membiasakan anak berkumur setelah makan. Pemberian makanan, meliputi sering memberi anak makanan manis, sering memberi anak minuman manis, sering memberi ASI anak malam hari, memberi anak susu formula, dan memberi anak botol susu. Pencegahan transmisi bakteri, meliputi menjaga kesehatan gigi ketika hamil dan menggunyahkan makanan anak. Simpulan: Penelitian ini menyimpulkan bahwa praktik kesehatan gigi oleh ibu berpengaruh terhadap kejadian ECC.
Association of Palatal Rugae Patterns In The Maternal Lineage Between Biological Mothers And Daughters of The Minangkabau Ethnic Group In Padang City Arman, Andi Aisyah Farra; Nila Kasuma; Wulandari, Reno Wiska; Wedagama, Dewa Made
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 3 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i3.11804

Abstract

Introduction: Palatal rugae are unique, anatomically stable ridges in the oral cavity that serve as reliable markers for forensic identification and genetic research. The Minangkabau ethnic group, known for its matrilineal kinship system, to provides a unique context to for exploring the hereditary transmission of such traits. This study aimed to examine the morphological similarities and differences in palatal rugae patterns between biological mothers and their daughters within the Minangkabau ethnic group in Padang City, Indonesia. Material and Methods: An analytical cross-sectional design was employed involving 53 mother-daughter pairs of confirmed Minangkabau descent. Intraoral digital scans were used to record rugae patterns which were categorized by shape and size based on established classifications. Statistical analysis was conducted using the Mann-Whitney U test to assess intergenerational associations. Results and Discussion: Primary and secondary rugae patterns showed strong morphological similarities between mothers and daughters, indicating heritability. Notably, the wave-shaped rugae pattern was significantly more prevalent in daughters (p < 0.05). Conclusion: Palatal rugae patterns, particularly primary and secondary types, demonstrate maternal inheritance and have potential forensic relevance. The presence of unique ethnic-specific traits underscores the need for broader population-based classifications in forensic odontology and antropology
Co-Authors Adang Bachtiar Adriansyah Adriansyah Aida Fitriana Ali , Hirowati Andani Eka Putra Arman, Andi Aisyah Farra Aulia, Rahmi Khairani Danu Prianto Dasman , Hardisman Dasman, Hardisman Dedi Sumantri Denas Symond Dewa Made Wedagama Dewa Made Wedagama Dewi Muarofah Didin Kustantiningtyastuti Dika, Echa Febtri Endah Mardiati Endah Mardiati Eni Rahmi Eti Yerizel Fadil Oenzil Fajriah Fajriah fajrin, fildzah Fildzah Nurul Fajrin, Fildzah Nurul Filzdah Nurul FAJRIN Firahmi Elga Fitri, Citra Fitri, Haria Friska Meininda Putri Fuccy Utami Syafitri Fuccy Utamy Syafitri Giant ERNESTO Gita Dwi Jiwanda Sovira Gita Dwi JS Harfindo Nismal Haria Fitri Haria Ftri Hestia Warti Hidayati Hidayati Hilda Lestari Ida Ayu Putu Sri Widnyani Indrawati Lipoeto Khairani Aulia , Rahmi M. Dzaky Sayyid Effendi Maemunah Maemunah Meiyestri Dwi Riani Mona, Deli Murni Wati Murniwati Murniwati Murniwati Murniwati Nadhifah Salsabila Nerawati, Meiza Netti Suharti Nur Afrainin Syah Nurul Ikhsan Oryce Zahara Ovy Prima Damara Puji Kurnia Putri Mulya Sari Rahmi Khairani Ramadani, Mery Randy Fernandes Reno Wiska Wulandari Rheta Elkhaira Risa Widia Rizanda Machmud Rozi Sastra Purna Suci Rahma Sari Suci Rahma Sari Susi Susi susi susi Susi Susi Syafitri, Fuccy Utamy Thifla Rafifa Wirza Tiara Adzakiyah Tiara Adzakiyah Tiara Adzakiyah tomisha, sisi Vivi Triana Widya Puspita Sari Wita Wita Wulandani Liza Putri Wulandari , Reno Wiska Wulandari, Reno Wiska Yandi, Satria Yufri Aldi Yunike Genisya Putri Yustini Alioes Zahara, Oryce Zia, Hanim Khalida Zulkarnain Agus