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All Journal e-GIGI Dentika Dental Journal Jurnal Kesehatan Andalas Majalah Kedokteran Gigi Indonesia Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Buletin Ilmiah Nagari Membangun Padjadjaran Journal of Dental Researchers and Students Interdental Jurnal Kedokteran Gigi (IJKG) Indian Journal of Forensic Medicine & Toxicology Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Kesehatan Saintika Meditory Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Andalas Dental Journal Cakradonya Dental Journal Journal of Pharmaceutical and Sciences. Jurnal of Syiah Kuala Dentistry Society
Nila Kasuma
Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Hubungan Kadar Matrix Metalloproteinase-8 (MMP-8) pada Pasien Gingivitis Setelah Tindakan Scaling dan Root Planing Berdasarkan Gingival Index (GI) Thifla Rafifa Wirza; Nita Afriani; Nila Kasuma
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1419

Abstract

This study aims to analyze the relationship between the Gingival Index (GI) and the levels of Matrix Metalloproteinase-8 (MMP-8) in the saliva of gingivitis patients after Scaling and Root Planing (SRP). A total of 36 gingivitis patients aged 15-24 years who underwent SRP in Padang City were included in the study. GI was assessed using the WHO probe, and saliva samples were collected on day 7 after SRP using the unstimulated saliva method. MMP-8 levels in the saliva were analyzed using an ELISA kit. The results showed higher average MMP-8 levels in the moderate and severe gingivitis groups compared to the mild group, but with considerable individual variation. The Kruskal-Wallis test revealed that the difference in MMP-8 levels among GI categories was not statistically significant (p = 0.584). Although there was a trend of increasing levels, these results suggest that MMP-8 cannot be used as a sole determinant of gingivitis severity and is better utilized as a supportive biomarker when combined with other clinical parameters.
Efek Terapi Adjuvan Gel Kolagen terhadap Kadar Matriks Metaloproteinase-8 Saliva pada Gingivitis Pasca Scaling Root Planing Haria Fitri; Nila Kasuma; Hardisman Hardisman; Hirowati Ali
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1500

Abstract

Gingivitis is a reversible inflammatory condition of the gingival tissue without attachment loss, primarily caused by plaque accumulation, which can trigger an immune response. Matrix metalloproteinase-8 (MMP-8) is an enzyme that contributes to collagen degradation. Scaling and root planing (SRP) is the standard therapy; however, it may induce a transient inflammatory response and result in suboptimal tissue regeneration, thereby necessitating adjunctive therapy. This study aimed to evaluate the effect of adjunctive collagen gel therapy on salivary matrix metalloproteinase-8 levels in gingivitis. This experimental study employed a pre- and post-test control group design involving 50 subjects divided into five groups: healthy control, gingivitis treated with SRP, and gingivitis treated with SRP combined with 1%, 2%, and 4% collagen gel. Salivary MMP-8 levels were measured to assess the inflammatory response. Statistical analysis revealed that collagen gel at concentrations of 1% and 2% had a significant effect on MMP-8 levels. In conclusion, Collagen gel at 1% and 2% concentrations significantly modulated salivary MMP-8 levels, suggesting a potential role in the tissue remodeling phase following SRP.
EDUKASI MANFAAT NUTRISI BAGI TUMBUH KEMBANG GIGI DAN MULUT ANAK USIA PRA SEKOLAH PADA MURID TK ADZKIA III DI KOTA PADANG Gita Dwi Jiwanda Sovira; Wulandani Liza Putri; Nila Kasuma
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 7 No. 1 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i1.515

Abstract

Children's dental health is very important to ensure the child's nutritional status, speaking ability and attractive appearance. Nutrition, diet and dental health in children are closely related, especially in children who are in the growth and development phase. Good quality and proper nutrition is very important to support dental health. Likewise, dental health is also important for adequate nutritional intake. If the teeth and mouth are healthy, then nutritional intake will be optimal, and if nutrition is optimal then the growth and development of the teeth and mouth will also be optimal. As many as 89% of children in Indonesia suffer from dental disease. A number of surveys show that more than a third of the toddler population has experienced toothache and one sixth of them have had at least one tooth extracted. The growth and development of teeth is influenced by nutrition. Healthy dentition will occur if all nutritional elements are available in sufficient quantities. The aim of the activity: to provide education to young children about the importance of nutrition for the growth and development of teeth and mouth. The activity method used is the tell-show-do method with presentations using power point media, posters, models of teeth and toothbrushes, as well as examination of children's teeth and mouths. This method is one of the most appropriate methods for providing education to early childhood. Results of the activity: increased knowledge of children and the emergence of a sense of courage when having a dental examination by a dentist. Conclusion: This activity has a positive impact on young children because children understand better that there is a connection between nutrition and oral health.
Selective Suppression of Prevotella and Modulation of Oral Dysbiosis in Stunted Children: The Role of Systemic Zinc as a Biological Adjuvant to Mechanical Therapy Nila Kasuma; Dewa Made Wedagama; Thifla Rafifa Wirza; Dedi Sumantri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 2 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i2.1514

Abstract

Background: Gingivitis in stunted children represents a unique pathological entity driven by a compromised mucosal barrier and systemic zinc deficiency. These children exhibit a phenotype of acquired immunodeficiency, where standard mechanical debridement often fails to resolve inflammation, leading to a phenomenon known as dysbiotic rebound. This study investigated the biomolecular efficacy of systemic Zinc supplementation combined with scaling and root planing (SRP) in modulating the oral microbiome of nutritionally vulnerable children. Methods: A randomized, single-blind, pre-post test controlled clinical trial was conducted in Padang, Indonesia, involving 30 stunted children (Height-for-age Z-score < -2 SD) diagnosed with generalized gingivitis. Participants were randomized into a Control group (SRP + Placebo, n=15) and an Intervention group (SRP + 20mg Zinc Sulfate Monohydrate daily, n=15) for a duration of 14 days. Microbial profiling was performed on unstimulated saliva utilizing high-throughput 16S rRNA gene sequencing (V3–V4 region). Bioinformatics processing utilized the DADA2 pipeline to generate Amplicon Sequence Variants (ASVs). Results: Results indicated that SRP alone resulted in a pathogenic recolonization dominated by Firmicutes (+49.6%). Conversely, Zinc supplementation induced a significant Gram-negative crash, reducing Proteobacteria by 50.6%. Most notably, the key periodontal pathogen Prevotella was suppressed to undetectable levels in the Zinc group (p<0.05). Conclusion: Systemic zinc acts as a potent biological scaffold in the enterosalivary cycle, likely repairing the epithelial barrier and starving hemin-dependent pathogens. It is strongly recommended as a therapeutic adjuvant to prevent the ecological recurrence of gingivitis in nutritionally vulnerable pediatric populations.
Association of Palatal Rugae Patterns In The Maternal Lineage Between Biological Mothers And Daughters of The Minangkabau Ethnic Group In Padang City Andi Aisyah Farra Arman; Nila Kasuma; Reno Wiska Wulandari; Dewa Made Wedagama
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 3 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i3.11804

Abstract

Introduction: Palatal rugae are unique, anatomically stable ridges in the oral cavity that serve as reliable markers for forensic identification and genetic research. The Minangkabau ethnic group, known for its matrilineal kinship system, to provides a unique context to for exploring the hereditary transmission of such traits. This study aimed to examine the morphological similarities and differences in palatal rugae patterns between biological mothers and their daughters within the Minangkabau ethnic group in Padang City, Indonesia. Material and Methods: An analytical cross-sectional design was employed involving 53 mother-daughter pairs of confirmed Minangkabau descent. Intraoral digital scans were used to record rugae patterns which were categorized by shape and size based on established classifications. Statistical analysis was conducted using the Mann-Whitney U test to assess intergenerational associations. Results and Discussion: Primary and secondary rugae patterns showed strong morphological similarities between mothers and daughters, indicating heritability. Notably, the wave-shaped rugae pattern was significantly more prevalent in daughters (p < 0.05). Conclusion: Palatal rugae patterns, particularly primary and secondary types, demonstrate maternal inheritance and have potential forensic relevance. The presence of unique ethnic-specific traits underscores the need for broader population-based classifications in forensic odontology and antropology
Profil Oral Hygiene Index–Simplified (OHI‑S) dan Kadar Interleukin‑1β Saliva sebagai Biomarker Inflamasi pada Pasien dengan Gingivitis Bobby Bobby; Netti Suharti; Nila Kasuma
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1420

Abstract

Introduction: Gingivitis represents the initial stage of periodontal disease, primarily induced by dental plaque accumulation and characterized by gingival inflammation. Salivary interleukin-1β (IL-1β) has emerged as a key inflammatory biomarker in periodontal pathology. However, studies specifically examining the association between oral hygiene status and salivary IL-1β levels in adolescents with gingivitis remain limited in the Indonesian population. Objective: This study aimed to describe the Oral Hygiene Index–Simplified (OHI‑S) profile and salivary IL‑1β levels, and to analyze their correlation in adolescent patients with gingivitis. Methods: A cross‑sectional study was conducted involving 36 gingivitis patients aged 15–18 years in Padang City, selected through purposive sampling. Oral hygiene status was assessed using OHI‑S, while unstimulated whole saliva was collected to measure IL‑1β levels via enzyme-linked immunosorbent assay (ELISA). Data were analyzed using univariate and bivariate approaches; Pearson correlation test was applied to evaluate the relationship between OHI‑S and IL‑1β with a significance level set at p<0.05. Results: The mean age of respondents was 15.97±1.03 years, with the majority categorized as middle adolescence (15 years). Only 8.3% of subjects demonstrated good OHI‑S, whereas 66.7% were classified as fair and 25% as poor, indicating substantial plaque and calculus accumulation. A moderate, positive, and statistically significant correlation was observed between OHI‑S scores and salivary IL‑1β levels (r=0.536; p=0.001), suggesting that poorer oral hygiene corresponds to elevated gingival inflammatory activity reflected by increased IL‑1β. Conclusion: Predominantly fair‑to‑poor oral hygiene among adolescents with gingivitis is significantly associated with elevated salivary IL‑1β levels. Salivary IL‑1β demonstrates potential as a non‑invasive inflammatory biomarker that can be integrated with OHI‑S for comprehensive assessment of gingival inflammatory status and for developing targeted preventive strategies against periodontal disease progression in adolescent populations.
Pengaruh Penggantian Sikat Gigi Segera Setelah Scaling and Root Planing terhadap Kadar Streptococcus sanguinis Saliva pada Pasien Gingivitis Muhammad Dzaky Sayyid Effendi; Lino Sefa; Nila Kasuma
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1732

Abstract

Gingivitis is an inflammatory condition associated with microbial biofilm accumulation. Scaling and root planing (SRP) is an effective therapy for reducing microbial load; however, bacterial recolonization may occur after treatment. This study aimed to evaluate the effect of toothbrush replacement as an adjunctive home-care intervention after SRP on salivary Streptococcus sanguinis levels in patients with gingivitis. This experimental study used a pretest–posttest intervention design involving 36 gingivitis patients divided into control and intervention groups (18 subjects each). All participants received SRP, while the intervention group received a new toothbrush after SRP. Clinical parameters, including Gingival Index (GI) and Oral Hygiene Index-Simplified (OHI-S), and salivary S. sanguinis levels were evaluated before and after intervention. Saliva samples were analyzed using quantitative real-time polymerase chain reaction (qPCR). Both groups showed significant improvements in GI and OHI-S after SRP (p < 0.001). The mean salivary S. sanguinis level in the control group decreased from 4.94 ± 0.13 to 4.93 ± 0.12 (Δ -0.01; p = 0.863), while the intervention group decreased from 4.83 ± 0.23 to 4.76 ± 0.14 (Δ -0.07; p = 0.367). Post-intervention analysis demonstrated a significantly lower S. sanguinis level in the toothbrush replacement group compared with the control group (4.76 ± 0.14 vs. 4.93 ± 0.12; mean difference = 0.16; 95% CI: 0.07–0.26; p = 0.001). Toothbrush replacement following SRP may provide additional benefits in controlling microbial colonization and supporting periodontal health maintenance in patients with gingivitis.
The Relationship Between Alkaline Phosphatase Enzyme Levels and the Incidence of Enamel Defects in Permanent Teeth in Children Reno Wiska Wulandari; Nila Kasuma; Hardisman Dasman; Hirowati Ali
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1304

Abstract

Enamel gigi merupakan jaringan yang paling keras yang ada di dalam tubuh manusia yang dibentuk oleh interaksi antara protein matriks dan enzim, terkhusus kadar enzim alkaline phosphatase (ALP). Gangguan dalam regulasi atau aktivitas ALP dapat menyebabkan mineralisasi enamel yang tidak tepat dan meningkatkan risiko terjadinya Developmental Defects of Enamel (DDE) pada gigi permanen. Tujuan penelitian adalah menganalisis hubungan kadar enzim ALP dengan kejadian DDE pada anak. A comparative cross-sectional study was conducted on 60 children divided into two groups: normal enamel and DDE. Pemeriksaan enamel gigi menggunakan modified DDE index. Saliva dianalsis dengan metode Kolorimetrik secara duplo. Analisa statistic menggunakan Mann-Whitney test dengan hasil signifikan ketika p < 0,05. Hasil penelitian menunjukan kadar ALP rata-rata pada kelompok enamel normal  lebih rendah [5,90 (1,38 – 27,82) mg/mL] dibandingkan dengan kelompok DDE [7,76 (0,13-11,89) mg/mL] dengan perbedaan yang tidak signifikan (p > 0,05).  Berdasarkan temuan ini, kadar ALP dalam saliva tidak memiliki hubungan langsung yang kuat dengan DDE, sehingga potensinya sebagai biomarker tunggal untuk deteksi dini DDE terbatas.
Co-Authors Adang Bachtiar Adriansyah Adriansyah Aida Fitriana Andani Eka Putra Andi Aisyah Farra Arman Aulia, Rahmi Khairani Bobby Bobby Danu Prianto Dasman, Hardisman Dedi Sumantri Denas Symond Dewa Made Wedagama Dewa Made Wedagama Dewi Muarofah Didin Kustantiningtyastuti Dika, Echa Febtri Endah Mardiati Eni Rahmi Eti Yerizel Fadil Oenzil Fajriah Fajriah fajrin, fildzah Fildzah Nurul Fajrin, Fildzah Nurul Filzdah Nurul FAJRIN Firahmi Elga Fitri, Citra Friska Meininda Putri Fuccy Utami Syafitri Fuccy Utamy Syafitri Giant ERNESTO Gita Dwi Jiwanda Sovira Gita Dwi JS Hardisman Hardisman Dasman Harfindo Nismal Haria Fitri Hestia Warti Hidayati Hidayati Hilda Lestari Hirowati Ali Ida Ayu Putu Sri Widnyani Indrawati Lipoeto Lino Sefa M. Dzaky Sayyid Effendi Meiyestri Dwi Riani Meiza Nerawati Mona, Deli Muhammad Dzaky Sayyid Effendi Murni Wati Murniwati Murniwati Murniwati Murniwati Nadhifah Salsabila Netti Suharti Nita Afriani Nur Afrainin Syah Nurul Ikhsan Oryce Zahara Ovy Prima Damara Puji Kurnia Putri Mulya Sari Rahmi Khairani Ramadani, Mery Randy Fernandes Reno Wiska Wulandari Reno Wiska Wulandari Reno Wiska Wulandari Rheta Elkhaira Risa Widia Rizanda Machmud Rozi Sastra Purna Suci Rahma Sari Suci Rahma Sari Susi Susi Susi Susi susi susi Thifla Rafifa Wirza Thifla Rafifa Wirza Thifla Rafifa Wirza Tiara Adzakiyah Tiara Adzakiyah Tiara Adzakiyah tomisha, sisi Vivi Triana Widya Puspita Sari Wita Wita Wulandani Liza Putri Yandi, Satria Yufri Aldi Yunike Genisya Putri Yustini Alioes Zahara, Oryce Zia, Hanim Khalida Zulkarnain Agus