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All Journal Jurnal Ecosolum BIOTROPIA - The Southeast Asian Journal of Tropical Biology AGRIVITA, Journal of Agricultural Science Indonesian Journal of Pharmaceutical Science and Technology JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Jurnal Hasil Penelitian Industri At-Ta'dib: Jurnal Ilmiah Prodi Pendidikan Agama Islam Jurnal Pendidikan dan Pengajaran Guru Sekolah Dasar (JPPGuseda) Narra J JOURNAL OF CHEMICAL NATURAL RESOURCES (JCNaR) Journal of Patchouli and Essential Oil Products Jurnal Kedokteran Hewan SINTHOP: Media Kajian Pendidikan, Agama, Sosial dan Budaya Heca Journal of Applied Sciences Malacca Pharmaceutics Leuser Journal of Environmental Studies Grimsa Journal of Science Engineering and Technology Journal Of Carbazon Jurnal At-Tamwil: Kajian Ekonomi Syariah Sosaintek: Jurnal Ilmu Sosial Sains dan Teknologi
Khairan Khairan
Jurusan Farmasi, FMIPA, Universitas Syiah Kuala, Darussalam Banda Aceh, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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From Leaf to Lip: Tracing Contaminants in Aceh's Traditional Chewing Tobacco (Bakông Asóê) Jannah, Rizka Auliatul; Akyuni, Qurrata; Faradilla, Faradilla; Purwaendah, Elisa; Diah, Muhammad; Idroes, Rinaldi; Khairan, Khairan
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 1 (2023): October 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i1.7

Abstract

Bakông Asóe is a typical Acehnese snack loved by older people in Aceh since ancient times. This snack is made from wet tobacco which is used as chewing tobacco. The process of drying Bakông Asóê in the open triggers heavy metal contamination by air pollution from motor vehicles. The process of storing Bakông Asóê in a wet state also triggers the growth of microbes such as bacteria and fungi due to a growth medium in the form of water. The purpose of this study was to determine the content of heavy metal contamination (Pb, Cd, Se, Cu and Hg) and microbiological contamination in the form of bacteria (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa) and fungi (Candida albicans and Aspergillus niger) in Bakông Asóê which sold on the side of the road without adequate hygiene. The research refers to a qualitative research approach with the type of research that is descriptive research. This study showed that heavy metal exposure in the form of Pb, Cu and Se in the three samples was still in the safe range for consumption. However, exposure to heavy metals in the form of Cd and Hg in the three samples exceeded the consumption standard. The results of the analysis of microbiological contamination in the three Bakông Asóê samples were proven to contain bacterial and fungal contamination, where cocci-shaped bacteria were more commonly found and fungi with the genus Aspergillus sp were also more dominant in the three Bakông Asóê samples. The conclusion of this study is positive for chemical and microbiological contamination in Bakông Asóê, which is sold in Aceh, Ule Kareng and Lambaro Markets.
Evaluating Extraction Methods for Caffeine Content in Gayo Arabica Coffee Oil through Gas Chromatography-Mass Spectroscopy Khairan, Khairan; Musvira, Intan; Lala, Andi; Diah, Muhammad; Maulana, Aga; Idroes, Ghazi Mauer; Awang, Khalijah
Grimsa Journal of Science Engineering and Technology Vol. 2 No. 1 (2024): April 2024
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v2i1.31

Abstract

This study aims to determine physicochemical properties, and caffeine analysis of green bean coffee essential oil (GBCEO) and roasted bean coffee essential oil (RBCEO) by maceration and soxhlet extraction methods. The results indicated that RBCEO by maceration method have higher percentage of yield compared to GBCEO. By the same to soxhlet extraction method, RBCEO also showed higher percentage of yield compared to GBCEO. The refractive index of the GBCEOm and GBCEOs have a lower acid value compared to RBCEOm and RBCEOs. The specific gravity obtained for GBCEOm, RBCEOm, GBCEOs, and RBCEOs ranged from 0.87 to 0.97. The results showed that GBCEOm has the highest saponification value followed by RBCEOs. GBCEOm has the highest iodine value followed by RBCEOs, while RBCEOm and GBCEOs have a similar iodine value. The peroxide value showed that GBCEOs, and RBCEOs by soxhlet extraction method have higher peroxide value. The GC-MS analysis revealed that GBCEOm has higher caffeine followed by GBCEOs with the percentages area of 9.31% and 7.36% respectively. Meanwhile RBCEOm has lower caffeine followed by RBCEOs with the percentages area of 7.36% and 4.28% respectively. This finding showed that GBCEO shows higher caffeine compound compared with RBCEO.
PROBLEM-BASED LEARNING MODEL ON LEARNING OUTCOMES: QUASI EXPERIMENTAL STUDY Kazwaini, Kazwaini; Khairan, Khairan
Jurnal Pendidikan dan Pengajaran Guru Sekolah Dasar (JPPGuseda) Vol 7, No 1 (2024): JPPGuseda (Jurnal Pendidikan dan Pengajaran Guru Sekolah Dasar)
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55215/jppguseda.v7i1.9705

Abstract

This research aims to determine the influence of the Problem Based Learning model on student learning outcomes on the sub-theme of energy resource wealth in Indonesia. This research uses a 2 group quasi-experimental design. The subjects of this research were students in class IV A and IV B, consisting of 78 students. The research results show that there is a significant influence of the Problem Based Learning model on learning outcomes for the sub-theme of energy resource wealth in Indonesia. The N-Gain result in the experimental class was 74, while in the control class it was 53. With the results of hypothesis testing, H0 was rejected and Ha was accepted because tcount (3.93258) ttable (1.99167). Based on the research that has been carried out, it can be concluded that there is an influence on learning outcomes for the sub-theme of energy resource wealth in Indonesia through the Problem Based Learning modelostly in accordance with the standards. From these results, recommendations emerged that could be considered for the desired program.
Therapeutic Effects of Patchouli (Pogostemon cablin) Essential Oil in Relieving Eczema Symptoms in Infants and Toddlers: A Literature Review Deliana, Fitri; Illian, Didi Nurhadi; Nadirah, Siti; Sari, Fadia; Khairan, Khairan
Journal of Patchouli and Essential Oil Products JOURNAL OF PACTHOULI AND ESSENTIAL OIL PRODUCT : VOLUME 2, ISSUE 1 (JUNE 2023)
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jpeop.v2i1.32073

Abstract

This literature review aims to investigate and analyze the therapeutic effect of Patchouli essential oil (Pogostemon cablin) in alleviating eczema symptoms in infants and young children. Eczema is a common skin condition characterized by inflammation, itching, and redness that can significantly affect the quality of life of affected children and their families. Conventional treatments often use topical corticosteroids, which can have potential side effects. This review systematically examines relevant studies, articles, and research from reputable databases, focusing on the use of patchouli essential oil as an alternative therapeutic approach to treat eczema symptoms in the pediatric population. Several aspects are considered, including the chemical composition of patchouli essential oil, its potential mechanisms of action, and its reported efficacy in reducing inflammation and relieving itching associated with eczema. The results of the literature review suggest that patchouli essential oil possesses anti-inflammatory, antimicrobial, and antioxidant properties that may contribute to its therapeutic effect in the treatment of eczema. Several studies have reported positive results, including a reduction in erythema, itching, and overall severity of eczema symptoms in infants and young children. However, the literature also has some limitations, such as the lack of standardized protocols, varying study designs, and limited long-term follow-up data. Overall, this literature review provides valuable insights into the therapeutic effects of patchouli essential oil in alleviating eczema symptoms in infants and young children. Further well-designed studies are needed to determine the optimal dosage, formulation, and long-term safety profile. The results of this review contribute to the growing body of knowledge on alternative treatments for pediatric eczema and provide a foundation for future research and clinical applications in this area.
Antibacterial Activity of n-Hexane Dragon’s Blood Resin Extract (Daemonorops draco wild Blume) from Bener Meriah, Aceh Province, Indonesia Khairan, Khairan; Arini, Musfira; Idroes, Rinaldi; Awang, Khalijah; Jacob, Claus
Malacca Pharmaceutics Vol. 1 No. 1 (2023): June 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i1.29

Abstract

The dragon’s blood resin (Daemonorops draco wild Blume) has been used in folk medicine for pharmacological activities such as antimicrobial, antivirus, anti-inflammation, gastrointestinal disorders, blood circulation dysfunctions, antitumor, and cancer. This study was designated to evaluate the antibacterial activity of n-Hexane dragon’s blood resin extract against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231. The other purpose of this study was to determine the secondary metabolites compound of n-Hexane dragon’s blood resin extract. The antimicrobial activities of the n-Hexane dragon’s blood resin extract was determined using well diffusion method and the results showed that the extract at concentration of 15% exhibited antimicrobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231 with the diameter inhibition of 13.20 mm; 21.3 mm; and 13.0 mm respectively. The phytochemicals screening showed that the extract contains secondary metabolites in the form of flavonoids. The GC-MS analysis showed that n-Hexane dragon’s blood resin extract contains 48 chemicals compounds, and the compound at RT 26 was indicated a Drachorhodin compound (C17H 18O3) with the mass ration of m/z was 270 g/mol. Overall, the n-Hexane dragon’s blood resin extract be a good choice for antimicrobial agent against bacteria and fungi.
Prediction of Pharmacokinetic Parameters from Ethanolic Extract Mane Leaves (Vitex pinnata L.) in Geothermal Manifestation of Seulawah Agam Ie-Seu’um, Aceh Maulydia, Nur Balqis; Khairan, Khairan; Noviandy, Teuku Rizky
Malacca Pharmaceutics Vol. 1 No. 1 (2023): June 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i1.33

Abstract

The Mane plant (Vitex pinnata L.) is traditionally used as medicine in Aceh Province, Indonesia. This study aimed to predict the pharmacokinetic parameters of compounds in the ethanolic extract of Mane leaf (EEML), including the absorption, distribution, metabolism, excretion, and toxicity (ADMET), by in-silico approach. The method used was to analyze the compounds using a web-predictor server and molecular docking. Gas chromatography-mass spectrometry (GCMS) analysis of EEML showed the presence of active compounds, including phytol (60.93%), acorenol (8.56%), n-hexadecanoic acid (4.89%), trans-Z-alpha-bisabolene epoxide (2.7%) and cedrane (2.03%). Lipinski's rule of five states that all compounds had a deviation of less than 2. Pharmacokinetic parameters suggested that phytol was moderately absorbed in the gastrointestinal tract and had a toxicity level of 5 with lethal doses (LD50) >5000 mg/kg. Molecular docking results showed that phytol could be used against the targeted enzyme Staphylococcus aureus. In conclusion, our study suggests that the active compounds of EEML may have potential as a drug candidate.
Antimicrobial Properties of Medicinal Plants in the Lower Area of Ie Seu-um Geothermal Outflow, Indonesia Fakri, Fajar; Harahap, Saima Putri; Muhni, Akmal; Khairan, Khairan; Hewindati, Yuni Tri; Idroes, Ghazi Mauer
Malacca Pharmaceutics Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i2.44

Abstract

The lower area of the Ie Seu-um manifestation, located in Ie Seu-um village, Aceh Besar District, harbors several medicinal plants that exhibit potential for the treatment of infectious diseases. This study aims to assess the secondary metabolite content and in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans of medicinal plants inhabiting the geothermal region. Medicinal plants, namely Pluchea indica (L.) Less., Acrostichum aureum L., Acacia mangium L., and Calotropis gigantea (L.) Dryand., were collected within a range of 100-150 meters from the hot springs in the lower area. Methanol extracts of these medicinal plants underwent phytochemical screening and were tested for antimicrobial activity using the Kirby-Bauer disc diffusion method at a concentration of 50%. The results of phytochemical screening demonstrated positive variations in alkaloids, flavonoids, saponins, steroids, triterpenoids, and tannins for each medicinal plant. The antimicrobial activity of the methanol extracts noticeably inhibited the growth of S. aureus compared to E. coli and C. albicans. The largest inhibition zones were observed for the leaf part of A. mangium (12.70 ± 2.30 mm) against S. aureus, the aerial part of A. aureum (11.57 ± 2.01 mm) against E. coli, and the aerial part of P. indica (9.89 ± 1.11 mm) against C. albicans. Based on the research findings, medicinal plants originating from the lower area of the Ie Seu-um manifestation exhibit potential as antimicrobial agents, particularly against gram-positive bacteria.
A Perspective Study of Pogostemon cablin Benth as an Aphrodisiac Khairan, Khairan; Amanda, Rosi; Hasbi, Salsa Yubila; Diah, Muhammad; Hasballah, Kartini
Malacca Pharmaceutics Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i2.61

Abstract

Pogostemon cablin Benth also known as a patchouli plant, is a member of Lamiaceae family, and the source of patchouli essential oil. This plant is an important herb which possesses many therapeutic properties. In traditional medicinal practices, patchouli oil is used to relieve depression, stress, calm nerves, control appetite and to improve sexual interest. Up to the present moment, almost 200 volatile and non-volatile compounds have been isolated and identified from Pogostemon cablin including flavonoid, phytosterols, glycosides, terpenes, sesquiterpenes, organic acids, and others. Modern studies revealed that the patchouli plant have been used for various applications such as an antioxidant, anti-inflammatory, analgesic, antidepressant, antithrombotic, antiplatelet, fibrinolytic, antiemetic, antimutagenic, and aphrodisiac. In aromatherapy, this plant is believed to be able to improve blood circulation and sexual interest. The flavonoid compounds, such as acacetin and apigenin are believed to play an important role as an aphrodisiac. The mechanisms of action of this plant as an aphrodisiac is believed by increasing androgens and estrogen levels in dehydroepiandrosterone (DHEA), which further increases arousal sexual desire. However, some uses need to be verified and may require standardizing and authenticating the bioactivity of purified compounds through scientific methods. This perspective study discusses the aphrodisiac potential of Pogostemon cablin Benth, including their chemical constituents, health benefit, mechanism action, and the role of main bioactive compound as an aphrodisiac.
Hybrid Handwash with Silver Nanoparticles from Calotropis gigantea Leaves and Patchouli Oil: Development and Properties Salsabila, Indah; Khairan, Khairan; Kemala, Pati; Idroes, Ghifari Maulana; Isnaini, Nadia; Maulydia, Nur Balqis; El-Shazly, Mohamed; Idroes, Rinaldi
Malacca Pharmaceutics Vol. 2 No. 2 (2024): September 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i2.206

Abstract

When washing hands, handwashing is one way to prevent diseases caused by bacteria such as Staphylococcus aureus and Escherichia coli, the most common bacteria that can cause infections. The production of handwash utilizing silver nanoparticles as an active antibacterial agent remains a relatively infrequent practice. The synthesis of silver nanoparticles from the leaves of Calotropis gigantea, which grows in the geothermal area of Ie Seu-um Aceh Besar, has been carried out using the green synthesis method and hybrid green synthesis with patchouli oil. Handwash with active ingredients such as silver nanoparticles was successfully formulated, evaluated, and tested against S. aureus and E. coli. The organoleptic characteristics, pH, viscosity, foam height measurements, density, irritation, and antibacterial activity against S. aureus and E. coli were evaluated. The results showed that the organoleptic properties of the handwash with silver nanoparticles were not changed during a 30-day storage period, with pH values in the range of 9.7-10.3, and did not cause irritation upon using silver nanoparticle handwash. The best formula for handwashing with silver nanoparticles in inhibiting the growth of S. aureus and E. coli bacteria was F2, with inhibition zones of 12.9 ± 2.85 mm and 10.95 ± 0.8 mm, respectively. The formulated handwash with silver nanoparticles met the requirements of good liquid soap according to the Indonesian National Standard (SNI) with potent antibacterial activity.
Bioactive Phytochemicals from Memecylon edule: Targeting Planktonic and Biofilm States of Pseudomonas aeruginosa Suryawati, Suryawati; Idroes, Rinaldi; Hertiani, Triana; Khairan, Khairan
Malacca Pharmaceutics Vol. 3 No. 1 (2025): March 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v3i1.258

Abstract

The rise in antimicrobial resistance has prompted the search for potent antimicrobial agents, with plants from unique environments, such as geothermal areas, offering potential due to their diverse phytochemical profiles. This study evaluated the antiplanktonic and antibiofilm activity of M. edule fractions from the geothermal area, Jaboi, Sabang. Crude extracts of M. edule were sequentially fractionated using hexane, ethyl acetate, and ethanol. The resulting fractions were further analyzed for their phytochemical content and antiplanktonic and antibiofilm activities. The ethyl acetate fraction demonstrated superior antiplanktonic and antibiofilm activities compared to other fractions, inhibiting 50% of Pseudomonas aeruginosa planktonic and biofilm formation at a concentration of 10 mg/mL. The most potent fraction exhibited the phenolic content, 672.84 mg GAE/g extract, surpassing the other fractions. The GC-MS analysis shows the presence of pyrogallol, hexadecanoic acid, cedran-diol, and sitosterol. These findings highlight the potential of the ethyl acetate fraction of M. edule as a source of bioactive compounds with promising antiplanktonic and antibiofilm properties, laying the groundwork for future research into its therapeutic applications against biofilm-associated infections.
Co-Authors Abd Rahman, Sunarti Ahmad Sodiq, Ahmad Ahmad, Khairunnas Aini, Hanipah Aisya, Mauly Rahadatul Akmal Muhni Akyuni, Qurrata Alfia, Reni Septri Amalia Sutriana Amanda, Rosi Arini, Musfira Asep Rusyana Aulina, Aulina Azzahra, Putri Badriyah, Qurotul Boy M. Bachtiar Claus Jacob, Claus Deliana, Fitri Diah, Muhammad Diana Setya Ningsih, Diana Eko Suhartono El-Shazly, Mohamed Essy Harnelly Estevam, Ethiene Castellucci Faddillah, Vira Fajar Fakri FARADILLA, FARADILLA Fauzi, Fazlin M. Fikrinda Fikrinda Ghazi Mauer Idroes Gholib Gholib, Gholib Harahap, Saima Putri Hasbi, Salsa Yubila Hery Widijanto Hewindati, Yuni Tri Hifnalisa Hifnalisa Hilda Maisyarah, Hilda Idroes, Ghalieb Mutig Idroes, Ghazi M. Idroes, Ghifari Maulana Illian, Didi Nurhadi Isnaini, Nadia Iswahyudi Jannah, Rizka Auliatul Karl Herbert Schaefer, Karl Herbert Kartini Hasballah KAZWAINI, KAZWAINI Kemala, Pati Khalijah Awang Kusumo, Fitranto Lala, Andi Lubis, Vanizra F. Mahdi Abrar Mahmani, Sri Maulana, Addrian Maulana, Aga Maulydia, Nur B. Maulydia, Nur Balqis Medyan Riza Mirda, Erisna Mohd Fauzi, Fazlin Mubaraq, Farhil Muhammad Bahi Muliadi Ramli Munawita, Munawita Munira, Alya Murniana Murniana Musdalifah, Annisa Musvira, Intan Nabila, Fiki Farah Nadirah, Siti Nasrudin Ningsih, Diana S. Nova Eriana, Cut Noviandy, Teuku R. Nurul Husna Patwekar, Mohsina Prasetio, Rasi Purwaendah, Elisa Rahman, Sunarti Abd Rawanita, Mesi Rina Sriwati Rinaldi Idroes Risyad, Syukri Rizki, Risnanda Farzia Roslizawaty Roslizawaty, Roslizawaty Salaswati, Salaswati Salsabila, Indah Sari, Fadia Siregar, Tongku N. Soleman, Soleman Sreeramanan Subramaniam Suhendrayatna Suhendrayatna Suryawati Suryawati Syafruddin Syafruddin Syahputra, Nanda Syamsiar, Syamsiar Teuku Rizky Noviandy Thahar, Aufa Sabrina Thomas Schneider, Thomas Triana Hertiani Trina E. Tallei, Trina E. TRINA EKAWATI TALLEI Wasistha, Nurainun Intan Zahraty, Ifrah Zahriah, Zahriah Zubaidah R, Zubaidah Zuchra Helwani, Zuchra Zulfadli Zulfadli