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All Journal Jurnal Ecosolum BIOTROPIA - The Southeast Asian Journal of Tropical Biology AGRIVITA, Journal of Agricultural Science Indonesian Journal of Pharmaceutical Science and Technology JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Jurnal Hasil Penelitian Industri At-Ta'dib: Jurnal Ilmiah Prodi Pendidikan Agama Islam Jurnal Pendidikan dan Pengajaran Guru Sekolah Dasar (JPPGuseda) Narra J JOURNAL OF CHEMICAL NATURAL RESOURCES (JCNaR) Journal of Patchouli and Essential Oil Products Jurnal Kedokteran Hewan SINTHOP: Media Kajian Pendidikan, Agama, Sosial dan Budaya Heca Journal of Applied Sciences Malacca Pharmaceutics Leuser Journal of Environmental Studies Grimsa Journal of Science Engineering and Technology Journal Of Carbazon Jurnal At-Tamwil: Kajian Ekonomi Syariah Sosaintek: Jurnal Ilmu Sosial Sains dan Teknologi
Khairan Khairan
Jurusan Farmasi, FMIPA, Universitas Syiah Kuala, Darussalam Banda Aceh, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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Antioxidant Potential of Ethanol Extracts from Zingiberaceae Plant Leaves Maulana, Addrian; Thahar, Aufa Sabrina; Khairan, Khairan
Malacca Pharmaceutics Vol. 3 No. 2 (2025): September 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v3i2.337

Abstract

The development of disease related to oxidative stress must be addressed immediately. An approach is to identify natural antioxidant compounds in plants commonly used by communities. This study measured the potential antioxidant activity of ethanol extracts from three Zingiberaceae species leaves: ginger (Zingiber officinale var. Amarum), turmeric (Curcuma domestica Val), and temulawak (Curcuma xanthorrhiza). Phytochemical profiling was performed using specific reagents, FT-IR analysis, and GC-MS, while antioxidant activity was evaluated using DPPH and ABTS methods. The result showed the presence of saponins, flavonoids, steroids, alkaloids, tannins, fatty acid derivatives, and phytol. The IC50 values of the extracts, determined using the DPPH method, were found to be 28.75 ppm for ginger, 65.86 ppm for turmeric, and 51.41 ppm for temulawak. Using the ABTS method, the IC50 values were 35.4 ppm for ginger, 75.9 ppm for turmeric, and 58.9 ppm for temulawak. The strongest antioxidant activity of ethanol leaf extracts from Zingiberaceae family was found in ginger leaf extract with the lowest value of IC50. These results provide preliminary evidence that Zingiberaceae leaves, which are less studied compared to their rhizomes, possess notable antioxidant potential. Further studies, including the isolation of active compounds and in vivo evaluation, are required to validate these findings and explore their possible applications in the future.
Integrated Approaches for Managing Bacterial Wilt Disease (Enterobacter sp.) in Aceh Patchouli Plants Sriwati, Rina; Khairan, Khairan; Hifnalisa, Hifnalisa; Fikrinda, Fikrinda; Oktarina, Hartati; Zulfadli, Zulfadli; Wasistha, Nurainun Intan
AGRIVITA Journal of Agricultural Science Vol 47, No 3 (2025)
Publisher : Faculty of Agriculture University of Brawijaya in collaboration with PERAGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17503/agrivita.v47i3.4708

Abstract

Aceh Patchouli (Pogostemon cablin Benth.) is a significant export commodity for essential oil production in Indonesia. The wilt disease “matee tumbon” caused by Enterobacter bacteria is one of the obstacles to Aceh patchouli cultivation. This study aims to identify the most effective combination technique to control it. The study combined 25 treatment combinations in patchouli nurseries, and the five best treatment combinations were subsequently tested on patchouli plants in the field. The results showed that the five best combinations in controlling bacterial wilt disease in the nursery were 20% streptomycin sulfate + Trichoderma sp., 20% streptomycin sulfate + Bacillus thuringiensis, Trichoderma sp. + B. thuringiensis, 20% streptomycin sulfate + neem extract + B. thuringiensis, and neem extract + Trichoderma sp. + B. thuringiensis. Field results showed that the combination of neem extract, Trichoderma sp., and B. thuringiensis was effective in controlling the pathogen Enterobacter sp., causing bacterial wilt disease in Aceh patchouli plants. This combination of control techniques is an integrated approach to controlling bacterial wilt disease (Enterobacter sp.) in Aceh patchouli plants.
The Potent Antimicrobial Spectrum of Patchouli: Systematic Review of Its Antifungal, Antibacterial, and Antiviral Properties Kemala, Pati; Idroes, Rinaldi; Khairan, Khairan; Ramli, Muliadi; Tallei, Trina Ekawati; Helwani, Zuchra; Rahman, Sunarti Abd
Malacca Pharmaceutics Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i1.156

Abstract

ntention towards natural essential oils from medicinal plants has increased rapidly over the past decade as these oils have antimicrobial and antioxidant properties against various chronic diseases. One essential oil source with antimicrobial properties is the essential oil from Pogostemon cablin (Blanco) Benth. This review aims to provide information on using patchouli oil as an antimicrobial against bacterial, fungal, and viral pathogens in the last five years. There were 37 articles found in the PUBMED database by June 15, 2023. After searching, 6 of them were duplicates. A total of 2 papers were inaccessible, 4 were not research articles, and five were excluded because they were irrelevant to the scope of this study. This review shows that research related to patchouli as an antimicrobial in the last five years involves Pogostemon cablin leaf samples as silver nanoparticle bioreductors. Patchouli oil is used in membrane, nanocomposite film, and starch hydrogel manufacturing. Patchouli oil is a prestigious antimicrobial agent because it can fight numerous pathogenic microbes from bacteria, fungi, and viruses.
Exploring the Medicinal Potential of Blumea balsamifera: Insights from Molecular Docking and Molecular Dynamics Simulations Analyses Maulydia, Nur Balqis; Khairan, Khairan; Tallei, Trina Ekawati; Salaswati, Salaswati; Musdalifah, Annisa; Nabila, Fiki Farah; Idroes, Rinaldi
Malacca Pharmaceutics Vol. 2 No. 1 (2024): March 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v2i1.168

Abstract

Blumea balsamifera from the Ie-Jue geothermal area in Aceh Province, Indonesia, has been reported to have a variety of secondary metabolites. However, there is limited information about the activity of these chemical metabolites from B. balsamifera. The aim of this study is to evaluate the therapeutic potential of these compounds using molecular docking and molecular dynamics simulations. Six selective compounds were thoroughly evaluated using molecular docking techniques for their inhibitory effects on both Coronavirus protease and human interleukin receptors. Additionally, druglikeness assessments based on the Lipinski rule of five were performed to evaluate these six ligands. Our results show that stigmasterol, a key component of B. balsamifera, has demonstrated low binding free energy values across four receptors. Furthermore, molecular dynamics simulations confirmed the stability of the top ligand-receptor complex, particularly stigmasterol-1IRA, based on five parameters, indicating its stability as an inhibitor. This research highlights the potential of stigmasterol as a therapeutic agent derived from medicinal plants of B. balsamifera and underscores the value of our molecular approach in identifying opportunities for pharmaceutical development.
EFEK SITOTOKSIK HAARLEM OIL TERHADAP HL-60 CELL LINE DAN Steinernema feltiae (Cytotoxic Effect of Haarlem Oil on HL-60 Cell Line and Steinernema feltiae) Bahi, Muhammad; Jacob, Claus; Khairan, Khairan
Jurnal Kedokteran Hewan Vol 10, No 2 (2016): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v10i2.5038

Abstract

The objective of this research was to investigate cytotoxicity effect of Haarlem oil (HO) on HL-60 cell line and Steinernema feltiae (S. feltiae). The test results using trypan blue method and CellTiter-Glo assays revealed that HO showed higher cytotoxicity effect against HL-60 cell line especially at concentration of 1:10 and 1:5. Meanwhile, the MTT (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay revealed that the higher cytotoxicity effect showed at 1:5, with the cell viabilities were around 40-65%. The nematicidal assay discovered that HO at concentration of 1:5 showed higher activities compare to other concentrations with percentage viability of 70%. These studies have shown that HO shows cytotoxic effect against HL-60 cell lines, and moderate activity against S. feltiae as well.
AKTIVITAS BEBERAPA SENYAWA TURUNAN BENZOPIRAN (CHROMONES) DAN BENZOFURANON (COUMARANONES) TERHADAP Steinernema feltiae (The Activities of Benzopyran (Chromones) and Benzofuranones (Coumaranones) Derivatives against Steinernema feltiae) Khairan, Khairan; Bahi, Muhammad; Jacob, Claus; Idroes, Rinaldi
Jurnal Kedokteran Hewan Vol 10, No 1 (2016): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v10i1.3368

Abstract

This study was purposed to inquire the activities of benzopyran (chromones) and benzofuranones (coumaranones) derivatives against Steinernema feltiae (S. feltiae). The toxicity assay against S. feltiae showed that benzopyran derivatives 2, 3, 4, 6, and 9 have the highest activity on S. feltiae with viabilities percentage of 50%. The compound 9 demostrated the highest activity with LD 50 and LD values, 7.2 and 52.2 M, respectively. The activities of compound 7 and 10 showed the lowest toxicity. Interestingly, the activity of benzofuranone derivatives showed significant activities against S. feltiae. Compare to benzopyran derivatives, the benzofuranone derivatives has the highest toxicity, in particular compound 13 with LD 5.45 M. The nematicidal assay showed that benzofuranones (coumaranones) derivatives revealed higher activities than benzopyran (chromones) derivatives.Key words: chromones, benzopyran, coumaranones, benzofuranone, and Steinernema feltiae
AKTIVITAS SULFUR DAN SELENIUM NANOPARTIKEL TERHADAP CACING Steinerma feltiae DAN PERBANDINGAN TOKSISITASNYA TERHADAP SEL NEUROBLASTOMA (NEURO 2A CELL LINES) Khairan, Khairan; Idroes, Rinaldi; Bahi, Muhammad; Schaefer, Karl Herbert; Schneider, Thomas; Jacob, Claus
Jurnal Kedokteran Hewan Vol 9, No 1 (2015): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v9i1.2798

Abstract

Penelitian ini bertujuan mengetahui aktivitas sulfur dan selenium nanopartikel terhadap cacing Steinernema feltiae (S. feltiae) dan perbandingan toksisitasnya terhadap sel neuroblastoma (neuro 2A). Sulfur dan selenium nanopartikel aqueous nanoparticles dikarakterisasimenggunakan Nano Zetasizer pada pH 7 dan suhu 25 C. Dalam penelitian ini uji nematoda dilakukan terhadap S. feltiae. Hasil penelitian menunjukkan bahwa sulfur nanopartikel mempunyai aktivitas yang sangat tinggi terhadap S. feltiae dengan lethal dose 50 (LD50) berkisar pada 6,99 g/ml setelah 24 jam inkubasi. Sementara itu, live and dead assay dilakukan terhadap neuroblastoma sel (Neuro 2A cell lines). Hasil penelitian menujukkan bahwa aqueous sulfur nanopartikel (NPS) menunjukkan aktivitas yang lebih baik dibandingkan dengan aqueous selenium nanopartikel (NPSe) terhadap sel neuroblastoma (neuro 2A cell lines) dengan IC50 1 g/ml.
The antinematicidal activity of vitamin E and its derivatives on Sterinernema feltieae Khairan, Khairan; Idroes, Rinaldi; Murniana, Murniana; Diah, Muhammad
Journal of Carbazon Vol 1, No 2 (2023): December 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jocarbazon.v2i1.35776

Abstract

Vitamin E is found naturally in some foods, and also available as a dietary supplement. "Vitamin E" is the fat-soluble compounds with distinctive antioxidant activities. The vitamin E acts as an antioxidant, which protects cell membranes. Sterinernema feltieae was selected as a test organism is because this organism is a complex organism and can be used as a model for whole organisms. The objective of this study is to evaluate the activity of vitamin E and its derivatives on Sterinernema feltieae. The results showed that the derivative of vitamin E (C37H55NO3) was most active against S. feltiae with the LD50 value was 207.77 M, followed by vitamin E (C29H50O2) with the LD50 value was 209.09 M. These results indicated that derivative of vitamin E (C37H55NO3) exerts more potent toxicity than vitamin E against Sterinernema feltieae.
Garlic Mixed Olive Oil Cream Formulation and Its Activity Against A Clinical Isolate of Staphylococcus aureus Khairan, Khairan; Zahraty, Ifrah; Idroes, Rinaldi
Journal of Carbazon Vol 1, No 1 (2023): June 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jokarbazon.v1i1.32825

Abstract

Garlic or Allium sativum is known containing of organosulphur compounds. These compounds are known have potential as antimicrobial, antivirus, and anticancer. The purpose of this study is to determine the activity of garlic mixed olive oil (GMO2) cream against the clinical isolate of Staphylococcus aureus and its evaluation by observing the organoleptic, homogeneity, pH, spread ability, stickiness, and viscosity. The result showed that GMO2 was able to inhibit the growth of Staphylococcus aureus bacteria at concentrations of 25 and 50 mg/ml. Meanwhile, the formulation of GMO2 cream at concentration 25 mg/ml was done by poisoned food method showed no activity against clinical isolate of Staphylococcus aureus. In this study, vanishing cream was used as negative control. The evaluation of GMO2 cream at concentration of 25 mg/mL has stability in organoleptic and homogeneity after the cycling test. The pH value of GMO2 cream was approximately equal to vanishing cream. The results of spread ability and stickiness tests indicated that GMO2 cream had the spreading and sticking strength which satisfied with the standard cream in range 5-7 and 4 respectively. The viscosity value of GMO2 cream were decreased after the cycling test. The stability test result showed that of GMO2 cream was stable after the cycling test.
Gel Formulation of Ethyl Acetate Garlic Extraction and Its Activity Against Staphylococcus Epidermis Khairan, Khairan
Journal of Chemical Natural Resources Vol. 1 No. 2 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (837.665 KB) | DOI: 10.32734/jcnar.v1i2.1255

Abstract

Garlic is known to have antibacterial and antifungal activities. This research aims to formulate the gel materials extracted from the garlic and to investigate the antimicrobial activities to Staphylococcus epidermidis. The phytochemical screening showed that the gel materials of ethyl acetate consisted alkaloid, flavonoid, and saponin substances. The formulation of gel was synthesized with different variations of 1, 5, and 10%. In this research, the gel materials were analyzed to understand the stability, homogeneity, pH, viscosity and dispersive powers. The results showed that good abilities of gel based on the taste, aroma and consistency, while the homogeneity property of each samples is influenced by the presence of gel concentration. The viscosity property of gels accounted for 3201.02-1664.04 Cps with 2.95-3.8 cm of dispersive powers. The ability of antimicrobial showed that higher concentration of 5% and 10% gels showed greater inhibitory zones of 18,10 and 22,08 mm compared to 1% of concentration
Co-Authors Abd Rahman, Sunarti Ahmad Sodiq, Ahmad Ahmad, Khairunnas Aini, Hanipah Aisya, Mauly Rahadatul Akmal Muhni Akyuni, Qurrata Alfia, Reni Septri Amalia Sutriana Amanda, Rosi Arini, Musfira Asep Rusyana Aulina, Aulina Azzahra, Putri Badriyah, Qurotul Boy M. Bachtiar Claus Jacob, Claus Deliana, Fitri Diah, Muhammad Diana Setya Ningsih, Diana Eko Suhartono El-Shazly, Mohamed Essy Harnelly Estevam, Ethiene Castellucci Faddillah, Vira Fajar Fakri FARADILLA, FARADILLA Fauzi, Fazlin M. Fikrinda Fikrinda Ghazi Mauer Idroes Gholib Gholib, Gholib Harahap, Saima Putri Hasbi, Salsa Yubila Hery Widijanto Hewindati, Yuni Tri Hifnalisa Hifnalisa Hilda Maisyarah, Hilda Idroes, Ghalieb Mutig Idroes, Ghazi M. Idroes, Ghifari Maulana Illian, Didi Nurhadi Isnaini, Nadia Iswahyudi Jannah, Rizka Auliatul Karl Herbert Schaefer, Karl Herbert Kartini Hasballah KAZWAINI, KAZWAINI Kemala, Pati Khalijah Awang Kusumo, Fitranto Lala, Andi Lubis, Vanizra F. Mahdi Abrar Mahmani, Sri Maulana, Addrian Maulana, Aga Maulydia, Nur B. Maulydia, Nur Balqis Medyan Riza Mirda, Erisna Mohd Fauzi, Fazlin Mubaraq, Farhil Muhammad Bahi Muliadi Ramli Munawita, Munawita Munira, Alya Murniana Murniana Musdalifah, Annisa Musvira, Intan Nabila, Fiki Farah Nadirah, Siti Nasrudin Ningsih, Diana S. Nova Eriana, Cut Noviandy, Teuku R. Nurul Husna Patwekar, Mohsina Prasetio, Rasi Purwaendah, Elisa Rahman, Sunarti Abd Rawanita, Mesi Rina Sriwati Rinaldi Idroes Risyad, Syukri Rizki, Risnanda Farzia Roslizawaty Roslizawaty, Roslizawaty Salaswati, Salaswati Salsabila, Indah Sari, Fadia Siregar, Tongku N. Soleman, Soleman Sreeramanan Subramaniam Suhendrayatna Suhendrayatna Suryawati Suryawati Syafruddin Syafruddin Syahputra, Nanda Syamsiar, Syamsiar Teuku Rizky Noviandy Thahar, Aufa Sabrina Thomas Schneider, Thomas Triana Hertiani Trina E. Tallei, Trina E. TRINA EKAWATI TALLEI Wasistha, Nurainun Intan Zahraty, Ifrah Zahriah, Zahriah Zubaidah R, Zubaidah Zuchra Helwani, Zuchra Zulfadli Zulfadli