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All Journal Journal of Food and Pharmaceutical Science Jurnal Rekayasa Proses Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Pharmacon Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Majalah Farmaseutik Indonesian Journal of Chemistry Jurnal Rekayasa Proses JFIOnline Media Farmasi Indonesia Jurnal Natural Aceh International Journal of Science and Technology Jurnal Farmasi Indonesia Molekul: Jurnal Ilmiah Kimia Malacca Pharmaceutics Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy Jurnal Rekayasa Proses Indonesian Journal of Jamu
Endang Lukitaningsih
Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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PENGARUH SUHU STERILISASI TERHADAP PENYERAPAN LARUTAN D-MANITOL SEDIAAN PARENTERAL DENGAN PENGEMAS PLASTIK LOW DENSITY POLYETHILENE Lukitaningsih, Endang; Mufrod, .; Bustomi, Tomy
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 3, No 3 (2007)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Plastic can cause some problems, especially in parenteral product. Main disadvantage of using plastic container is  plastic has capability to absorp many compounds which in solution. Furthermore, it can cause decreasing of drug concentration which having an effect on efficacious of drug. This research aims to know the influence of autoclave sterilitation process and Low Density Polyethilene (LDPE) plastic container to decreasing of D-Manitol concentration in parenteral dosage form. Beside that, the other purpose is searching sterilization temperature which have high safety and effectivity. The research includes making D-Manitol 20% solution and then determination of its concentration. After that, the D-Manitol solution is divided into two groups. One group is as control solution (without plastic LDPE) and another group is as sample (with plastic LDPE). Then, both of solutions are strerilized at three temperature programs (100°C, 102°C, 105°C). The results show that sterilization by autoclave and plastic presence in D-Manitol solution can cause concentration D-Manitol decreasing. The decreasing of D-Manitol concentration is not more than 5%, so that it is accepted in accordance with rule of Indonesian Pharmacope 4th edition. The best condition of sterilization is 100°C temperature during 45 minutes. ABSTRAK Plastik dapat menimbulkan masalah, terutama dalam sediaan parenteral. Kerugian utama penggunaan pengemas plastik adalah plastik mempunyai kemampuan untuk menyerap banyak komponen dalam larutan sediaan. Selanjutnya dapat mengakibatkan berkurangnya kadar obat yang berpengaruh pada kemanjuran obat tersebut. Penelitian ini bertujuan untuk mengetahui pengaruh suhu sterilisasi autoklaf dan bahan pengemas plastik Low Density Polyethilene (LDPE) terhadap penurunan kadar larutan D-Manitol sediaan parenteral (Injeksi D-Manitol). Di samping itu bertujuan untuk mencari suhu sterilisasi yang paling aman dan efektif. Penelitian meliputi pembuatan larutan D-Manitol 20% kemudian dilakukan penetapan kadar awal. Larutan dibagi menjadi dua kelompok untuk kontrol (tanpa plastik LDPE) dan sampel (dengan penambahan plastik LDPE), kemudian disterilisasi pada tiga paket suhu (100°C, 102°C, 105°C). Hasil penelitian yang diperoleh menunjukkan bahwa perlakuan sterilisasi dengan autoklaf menggunakan variasi suhu pada larutan D-manitol tanpa penambahan plastik dan dengan penambahan plastik menyebabkan terjadinya penurunan kadar D-Manitol. Besarnya penurunan kadar D-Manitol tidak lebih dari 5%, sehingga masih dapat diterima berdasarkan Farmakope Indonesia IV. Suhu sterilisasi 100°C selama 45 menit merupakan kondisi sterilisasi yang paling efektif dan aman.
PENGARUH SUHU STERILISASI TERHADAP PENYERAPAN LARUTAN D-MANITOL SEDIAAN PARENTERAL DENGAN PENGEMAS PLASTIK LOW DENSITY POLYETHILENE Lukitaningsih, Endang; Mufrod, .; Bustomi, Tomy
Jurnal Farmasi Indonesia Vol 3, No 3 (2007)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i3.82

Abstract

Plastic can cause some problems, especially in parenteral product. Main disadvantage of using plastic container is  plastic has capability to absorp many compounds which in solution. Furthermore, it can cause decreasing of drug concentration which having an effect on efficacious of drug. This research aims to know the influence of autoclave sterilitation process and Low Density Polyethilene (LDPE) plastic container to decreasing of D-Manitol concentration in parenteral dosage form. Beside that, the other purpose is searching sterilization temperature which have high safety and effectivity. The research includes making D-Manitol 20% solution and then determination of its concentration. After that, the D-Manitol solution is divided into two groups. One group is as control solution (without plastic LDPE) and another group is as sample (with plastic LDPE). Then, both of solutions are strerilized at three temperature programs (100°C, 102°C, 105°C). The results show that sterilization by autoclave and plastic presence in D-Manitol solution can cause concentration D-Manitol decreasing. The decreasing of D-Manitol concentration is not more than 5%, so that it is accepted in accordance with rule of Indonesian Pharmacope 4th edition. The best condition of sterilization is 100°C temperature during 45 minutes. ABSTRAK Plastik dapat menimbulkan masalah, terutama dalam sediaan parenteral. Kerugian utama penggunaan pengemas plastik adalah plastik mempunyai kemampuan untuk menyerap banyak komponen dalam larutan sediaan. Selanjutnya dapat mengakibatkan berkurangnya kadar obat yang berpengaruh pada kemanjuran obat tersebut. Penelitian ini bertujuan untuk mengetahui pengaruh suhu sterilisasi autoklaf dan bahan pengemas plastik Low Density Polyethilene (LDPE) terhadap penurunan kadar larutan D-Manitol sediaan parenteral (Injeksi D-Manitol). Di samping itu bertujuan untuk mencari suhu sterilisasi yang paling aman dan efektif. Penelitian meliputi pembuatan larutan D-Manitol 20% kemudian dilakukan penetapan kadar awal. Larutan dibagi menjadi dua kelompok untuk kontrol (tanpa plastik LDPE) dan sampel (dengan penambahan plastik LDPE), kemudian disterilisasi pada tiga paket suhu (100°C, 102°C, 105°C). Hasil penelitian yang diperoleh menunjukkan bahwa perlakuan sterilisasi dengan autoklaf menggunakan variasi suhu pada larutan D-manitol tanpa penambahan plastik dan dengan penambahan plastik menyebabkan terjadinya penurunan kadar D-Manitol. Besarnya penurunan kadar D-Manitol tidak lebih dari 5%, sehingga masih dapat diterima berdasarkan Farmakope Indonesia IV. Suhu sterilisasi 100°C selama 45 menit merupakan kondisi sterilisasi yang paling efektif dan aman.
Co-Authors -, Ariyanti -, Sutriyanto Abdul Rohman Abdul Rohman Aditya Wisnusaputra Aditya Wisnusaputra, Aditya Adjara, Syafia Mustika Ag. Yuswanto Ag. Yuswanto Agung Endro Nugroho Aisyah, Andi Nur Akhmad Kharis Nugroho Alfat Fadri Amalia Miranda Amalia, Dita Amanita K. Hana Amelia Sari Andaru Dahesihdewi Andi Nur Aisyah Annisa Novarina Ardian Widyatmoko Argandita Meiftasari Ari Sudarmanto Ari Sudarmanto Arief Nurrochmad Arifah, Mitsalina Fildzah Artania Adnin Tri Suma B. S. Ari Sudarmanto Burhan, Asril Bustomi, Tomy Bustomi, Tomy Daniel Happy Putra Devyanto Hadi Triutomo Dini Maharani Dirman, Arifin Dwi Hastutik Earlia, Nanda Edy Meiyanto Effendi, Fatiha Citra Erna Prasetya Ningrum Esti Dyah Utami Etty Sulistyowati Fawzy, Salsabila Yusfita Fita Rahmawati Hanum, Faridah Hayati, Rima Hilda Ismail, Hilda I Gede Agus Juniarka I Gede Agus Juniarka, I Gede Agus Ika Puspita Sari Ika Puspita Sari Ika Puspitasari Ika Puspitasari Indah Purwantini Indah Tri Nugraha Indah Tri Nur'aini Irfan Muris Setiawan Jauhari, Fahmi Ihsanuddin Khairunissa Irnanda Kurnianto, Rifki Wahyu La Ode Muhammad Andi Zulbayu Laeli Muntafi'ah Lina Primadesa, Lina Lisa Andina Lora Johana Tamba M, Suwaldi Marbun, Prajona Marlyn Dian Laksitorini Marwati Marwati Melania Perwitasari, Melania Meti Christiana Mohammad Fahrurrozi Mufrod, . Mufrod, . Muhammad Bahi Muhammad Bahi Muhammad Fahrurrozi Mustanir Mustanir Mutia Kusuma Wardani Nabila, Klarissa Nabilah, Nada Nanang Fakhrudin, Nanang Nining Sugihartini Noegrohati, Sri Pawestri, Sekar Ayu Pudjono Lukitaningsih Pudjono Pudjono Purwantiningsih Purwantiningsih Purwantiningsih Radilla Mutia Ragil S. Dianingati Rahim, Kurnia Rahmawati, Adillah Ratna Asmah Susidarti Ratna Asmah Susidarti Ratna Budhi Pebriana Ririn Suharsanti, Ririn Rizka Humardewayanti Asdie Rochmadi Lukitaningsih Rochmadi Rochmadi Ronny Martien Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati, Rumiyati Rusydan, Azka Muhammad Ryan Radix Rahadhian, Muhammad Samsul Hadi Samsul Hadi Saputra, Lucky Octavianus Saputri, Revita Sekar Ayu Pawestri Siti Fatmawati Fatimah, Siti Fatmawati Siti Mufidatul Khasanah Sri Noegrohati Sri Noegrohati Standie Nagadi Subagus Wahyuono Subagus Wahyuono Sudarmanto, B.S. Ari Sudarmanto, Bambang Sulistyo Ari Sudibyo Martono Sugeng Riyanto Suwaldi . Suwaldi Martodihardjo Syamsu Nur Syamsu Nur, Syamsu Ulrike Holzgrabe Wardani, Ratih Kurnia Widayanti, Wasita Rachma Widyasari Putranti Wirasti, Wirasti Wiwik Supriati