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Journal : Narra J

Attitude towards Zika among frontline physicians in a dengue-endemic country: A preliminary cross-sectional study in Indonesia Yufika, Amanda; Anwar, Samsul; Maulana, Reza; Wahyuniati, Nur; Ramadana, Rizki R.; Ikram, Ikram; Mudatsir, Mudatsir; Utomo, Prattama S.; Te, Haypheng; Enitan, Seyi Samson; Sirinam, Salin; Müller, Ruth; Setiawan, Abdul Malik
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.32

Abstract

In dengue-endemic countries such as Indonesia, Zika may be misdiagnosed as dengue, leading to underestimates of Zika disease and less foreknowledge of pregnancy-related complications such as microcephaly. Objective: To assess the attitudes of frontline physicians in a dengue-endemic country toward testing for Zika infection among patients with dengue-like illnesses. Methods: A cross-sectional online survey was conducted among general practitioners (GPs) in Indonesia. The survey assessed their attitude and also collected sociodemographic data, characteristics of their medical education, professional background, and workplace, and exposure to Zika cases. A two-step logistic regression analysis was used to assess possible variables associated with these attitudes. Results: A total of 370 GPs were included in the final analysis of which 70.8% had good attitude. Unadjusted analyses suggested that GPs who were 30 years old or older and those who had medical experience five years or longer had lower odds of having a positive attitude compared to those who aged younger than 30 years and those who had medical experience less than five years, OR: 0.58; 95%CI: 0.37, 0.91 and OR: 0.55; 95%CI: 0.35, 0.86, respectively. No explanatory variable was associated with attitude in the fully adjusted model. Conclusion: Our findings point to younger GPs with a shorter medical experience being more likely to consider testing for Zika infection among their patients presenting with dengue-like illnesses. Strategic initiatives may be needed to enhance older or longer-experienced physicians' capacity in diagnosing Zika infection.
A potential treatment for erectile dysfunction: Effect of platelet-rich plasma administration on axon and collagen regeneration in cavernous nerve injury Ismy, Jufriady; Khalilullah, Said A.; Maulana, Reza; Hidayatullah, Furqan
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.880

Abstract

Recent studies highlighted the role of platelet-rich plasma (PRP) in progenitor cell homing, migration, and nerve cell regeneration while also inhibiting fibrosis and apoptosis in cavernous nerve injury (CNI). The aim of this study was to investigate the effect of PRP administration on axon and collagen regeneration in CNI. A true experimental study using a post-test-only control group design was conducted. Twenty-five male Wistar rats (Rattus norvegicus), weighing 200–300 grams, were divided into five groups: two control groups (sham procedure and negative control), and three experimental groups receiving local PRP, intraperitoneal PRP, and a combination of local and intraperitoneal PRP. The cavernous nerve was injured with a hemostasis clamp for one minute before 200 µL of 200 PRP was injected locally, intraperitoneally, or both, depending on the group. After four weeks, the rats were euthanized, tissue segments (2 mm) from each cavernous nerve and mid-penis were collected and analyzed for collagen density, axon diameter, and number of myelinated axons. Our study found that collagen growth was slower in CNI group without PRP (sham procedure) compared to all PRP groups (local, intraperitoneal, and combination). The intraperitoneal PRP group had the highest collagen density at 5.62 µm; however, no significant difference was observed in collagen density among all groups (p=0.056). Similar axon diameter was found across the groups, with no statistically significant difference observed (p=0.856). In the number of myelinated axons, a significant difference was found among all groups with significantly more axons in local PRP and combined local and intraperitoneal PRP groups compared to others (p=0.026). In conclusion, PRP administration improved a number of myelinated axons in CNI, suggesting PRP role in CNI regeneration and the potential for an innovative approach to treating erectile dysfunction associated with CNI.
Co-Authors ., Muhammad Ashabul Kahfi Abdul Malik Setiawan Adika, Dimas Afiandi, Ravi Ahmad Harisb januar Syahidan, Ahmad Harisb januar Ahmad Sidiq Akib, Faisal Alam , Syamsu Ali Mustopa, Ali Amirsyah, Mirnasari ANDIKA, ERICK Ansar, Ince Aprilia, Nyra Nazwa Ari Prasetyo Arisita, Adelia Putri Awaru, Tenri Bambang Riyanto Basir, Abdul Bintang, Inggrid Awanis Budiana, Eko P. Dahril Delfiana, Delfiana Deris Stiawan Desmawan, Deris Devi, Helena Deykha Aguilika Diana Apriyanti, Diana Diana Rachmawati Dwi Kurniawati, Dwi Eka, Aditya Ekasafitri, Nurjannah Elfrida Ratnawati Elrohi Soen, Gabriel Irfon Enitan, Seyi Samson Fadliansyah, Fauzi Fahmi, Akhmam Fardhy Wiharjo, Fardhy Farikhah, Izzah Fatin, Nadiyah Fauziyah, Asiyah Nurul Fimansyah, Yoki Firmansyah, Arrizal firmansyah, Yoki Fitri, Aisah Furqan Hidayatullah Ginanjar, Rubi Hanantyo, Burhanuddin Hasanah, Siti Nuri Alya Heru Setiawan Hudzaifah, Ahmad Hutajulu, Jovan Marito Nathaniel Ibrahim, Firmansyah Ikhwan, Haznur Ismail, Iriana Ismy, Jufriady Jimi, Romuanus Kamilia, Afina Kause, Migdes Christianto Khairunisa, Alamanda Khalilullah, Said Alfin Krissetia, Michael Lisnawanty Lisnawanty Lukman Hakim, Dori Maesaroh, Syti Sarah Masitha Arsyati, Asri Masyhur, Zulkarnaim Maulana, Farid Mauliana Mauliana, Mauliana Mauny, Muhammad Puteh Mohammad Kamal Reza Mubarak, Fawwaz Mudatsir Mudatsir Muhammad Ridha Muhammad Sony Maulana Müller, Ruth Nabarian, Tifanny Naffi, Ilham Nasution, Muhammad Nashir Nita Sari, Nita Nur Inayah Nur Indah, Araya Nur Wahyuniati, Nur Nurhayatii, Siti Nuurussa'aadah, Fathimah Oktaviani, Anna Maria Pancasakti, Ranthy Prabowoputra, Dandun M. Pratama Zurmauliriansyah, Rifzki Pratiwi, Dwi Annisa Setya Purnomo Budi Santoso Purwaningtias, Deasy Rahman Rahmat Budiarto Ramadana, Rizki R. Ramdani, Muhammad Asnur Reni Reni, Reni Risdiansyah, Deni Riyanto Riyanto Rizli, Irma Romansah, Repo Agung Rosmiati, Mia Rovianto, Eki S Gassing, Al Fadli Ramdani Safitri Linawati Said A. Khalilullah Samsul Anwar Sari, Sasa Marita Selan, Yefris A. Septiani, Sella Septiyanto, Muhamad D. Sirinam, Salin siti rodiah Sunbanu, Halani F. Sutrisno Anggoro SYAFAR, A. MUHAMMAD Syah, Herwan SYAMSU ALAM Syamsul Hadi Syamsul Rizal Tampubolon, Desi Putri Te, Haypheng Triyaka, Rendy Utomo, Prattama S. Vernanda, Wili Bordeus Veta Lidya Delimah Pasaribu Vito, Yulius Kristoforus W, Herlina Putri Wahyu Lestari Waraztuty, Ika Wiyono, Bambang Harie Yufika, Amanda Zefry Darmawan