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All Journal Farmaka Microbiology Indonesia Jurnal Kesehatan Masyarakat Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia The Indonesian Biomedical Journal Indonesian Journal of Chemistry JMM (Jurnal Masyarakat Mandiri) Pharmacology and Clinical Pharmacy Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Pengabdian Farmasi Malahayati (JPFM) Majalah Farmasetika Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Community Development Journal: Jurnal Pengabdian Masyarakat Indonesian Journal of Biological Pharmacy Proceeding of Mulawarman Pharmaceuticals Conferences Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kesehatan Sciences of Pharmacy Jurnal Ilmiah Global Farmasi Parapemikir Jurnal Ilmiah Farmasi Journal of The Indonesian Society of Integrated Chemistry Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry
TIANA MILANDA
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Other

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Journal : The Indonesian Biomedical Journal

 1 
Modulation of Caspase-3 Expression by Arcangelisia flava Post Acetaminophen-Induced Hepatotoxicity in Rat’s Liver Steffi Liem; Tina Rostinawati; Ronny Lesmana; Sri Adi Sumiwi; Tiana Milanda; Mutakin Mutakin; Irma Melyani Puspitasari; Jutti Levita
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.412

Abstract

BACKGROUND: Acetaminophen, when used at low doses is a safe drug, but at higher doses it induces apoptosis in hepatoma cells. Arcangelisia flava that grows widely in Kalimantan Island, Indonesia, contains berberine which is effective in protecting the liver. This work was aimed to study the effect of A. flava extract on the modulation of caspase-3 in acetaminophen-induced hepatotoxicity.METHODS: Thirty-five Wistar male rats were divided into groups: I the normal control (water); II the negative control (Arabic gum powder or PGA, 2% in suspension); III the positive control (silymarin); IV-VII (A. flava extract 100, 200, 400, and 800 mg/Kg of body weight (BW), respectively) for 14 days. At day 15th, group II-VII were induced with acetaminophen 1000 mg/Kg of BW per oral for 7 days along with the extracts. At day 22nd, the animals were measured for their serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and gamma-glutamyl transferase (GGT), histological examination, and Western blotting.RESULTS: Acetaminophen elevated the SGOT and SGPT (3x compared to normal group), and GGT (5x compared to normal group) of the animals in group II. Pre-treatment with higher doses of A. flava extract (group VI and VII) significantly prevented the biochemical changes induced by acetaminophen. Normal histology of the liver was showed by group I, III, VII, whereas dilated sinusoids, central vein (CV) lesion, and local haemorrage were observed in group II, IV, V and VI. Western blotting showed an inhibition of caspase-3 expression by A. flava extract in dose-dependent manner.CONCLUSION: A. Higher dose A. flava extract shows hepatoprotective activity by preventing the elevation of serum transaminases and transferase levels. Eventually, no damage in the acetaminophen-induced rat’s liver was observed. This plant modulates the expression of caspase 3 protein in dose-dependent manner.KEYWORDS: Arcangelisia sp, caspase-3, berberine, hepatoprotective activity, NSAIDs, yellow root
Co-Authors Ade Zuhrotun Adha, Syah Akbarul Adila Srebreneca AFINA DWI RACHMAWATI Ahmad Muhtadi Alam Jenuin Dwipratama Alifia Hasna Hamidah Amaliah Ihsani Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa, Anis Yohana Anita Apriliana Arif S.W Kusuma Arif S.W Kusuma ARIF SATRIA WIRA KUSUMA, ARIF SATRIA WIRA ASTININGSIH DIAH PRAVITASARI Belinda, Andhara M. Bonar C. Saragih Dewi, Lisa K. Didi Susanto Dolih Gozali Dwi Indra Purnomo Ellin Febrina Erlianti, Karina Fachry Abda El Rahman FATHIA PEBRIANI Firda Aryanti Widyana Gofarana Wilar Hanny Hafiar Haryanto Dhanutirto Hasriana Hasriana Hasriana Hasriana, Hasriana Hasrianna Hasrianna Hasrianna, Hasrianna Ida P. Santoso Indah Suasani Wahyuni Intan Timur Maisyarah Irma Erika Herawati Irma Erika Herawati Irma Melyani Puspitasari Irma Meylani Puspitasari Ivan S. Pradipta Jutti Levita Karina Erlianti Karina Erlianti Karina Erlianti Keri Lestari Kurniawan Kurniawan Kusuma, Sri A. F. Lia Mardiana Lisa K. Dewi Maisyarah, Intan Timur Mardiana, Lia Marlia Singgih Wibowo Mayang Kusuma Dewi MAYANG KUSUMA DEWI, MAYANG KUSUMA Melisa I. Barliana Melisa Intan Barliana Moelyono Muktiwardojo Mohamad Taufik Ismullah Muchtaridi Muchtaridi Muhaimin Muhaimin Muhaimin Muhaimin Muhammad F. Wardhana Muhammad Fauzi Munir Alinu Mulki Mutakin Mutakin Mutakin Mutakin Nasrul Wathoni Nimas T. I. Tarina Nurul Annisa NURUL ANNISA Pradipta, Ivan S. QONITA ZAHRA FADHILA Raden Maya Febriyanti ragavendra ravee Rani Cyinthia Hani Renny Amelia Rhisanandra, Fathia Richie Agusta Iwan Chandra Riezki Amalia Rizki Rahmadi Pratama Rizky Abdulah Ronny Lesmana Rosidah Rosidah Saragih, Bonar C. Septiyani Mustikawati Sjafril, Astri K. Soemarie, Yulistia Budianti Sofa D. Alfian Sofa D. Alfian, Sofa D. Sri A. F. Kusuma Sri A. F. Kusuma Sri A. Sumiwi Sri Adi Sumiwi Sri Agung Fitri Kusuma, Sri Agung Sriwidodo Sriwidodo Steffi Liem Suharyani, Ine Sukmawati Sukmawati Sukmawati Sukmawati Sulistiyaningsih Sulistiyaningsih Sumiwi, Sri A. Supriyatna Supriyatna Supriyatna Supriyatna Susilawati, Yaswinar Syah Akbarul Adha SYIFA HANIFAH TERESYA PUTERI Tina Rostinawati TUTUS GUSDINAR Uce Lestari Uce Lestari Ulya Nabila Vesara A. Gatera Vesara A. Gathera Wa Ode Ida Fitriah Wardhana, Muhammad F. Wijaya, Viriyanata Yasmiwar Susilawati Yaswinar Susilawati Yuli Andriani Yulistia Budianti Soemarie Yulistia Budianti Soemarie Yulistia Budianti Soemarie Yuni Elsa Hadisaputri Yuyun Wahyuni