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All Journal Journal of Food and Pharmaceutical Science Jurnal Penelitian Saintek Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis Statistika Indonesian Journal of Cancer Chemoprevention Program Kreativitas Mahasiswa - Penelitian Indonesian Journal of Biotechnology Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY JURNAL BIOLOGI INDONESIA Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan JEPA (Jurnal Ekonomi Pertanian dan Agribisnis) Majalah Farmaseutik Indonesian Journal of Chemistry Media Ilmu Kesehatan JFIOnline INTEGRITAS : Jurnal Pengabdian Jurnal Farmasi Populer: Jurnal Penelitian Mahasiswa Jurnal Kedokteran Hewan Journal of Food and Pharmaceutical Sciences Agri Analytics Journal Indonesian Journal of Pharmacology and Therapy Jurnal Pengabdian Masyarakat Manage Journal of Pharmascience
Retno Murwanti
Departemen Farmakologi Dan Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Kajian Efek Samping Pada Pasien Kanker Payudara Dengan Regimen Paclitaxel-Epirubicin-Fluorouracil di RSUD Kabupaten Temanggung Kustanto, Satya Prima; Murwanti, Retno; Nugroho, Agung Endro
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.89064

Abstract

Kanker payudara merupakan salah satu kanker yang banyak terjadi dan sering menyebabkan kematian tertingi pada wanita. Kemoterapi merupakan salah satu modalitas terapi yang direkomendasikan pada pasien kanker payudara yang dinilai efektif namun menghasilkan efek samping dan berefek toksik pada sel normal. Penelitian ini bertujuan  untuk mengetahui gambaran kejadian efek samping obat hematologi dan non hematologi yang menjalani kemoterapi. Penelitian ini dilakukan di RSUD Kabupaten Temanggung pada bulan Juni-Juli 2023 dengan rancangan cohort retrospective study melalui data sekunder dari rekam medis dan data laboratorium. Dari 47 pasien yang menjalani kemoterapi mingguan dengan regimen kombinasi paclitaxel 60mg/m2, epirubicin 50mg/m2 dan fluorouracil 300mg/m2 diamati, kejadian efek samping hematologi yang paling banyak dialami oleh pasien adalah anemia sebanyak 70.2%, leukopenia 55.3%, neutropenia 27.7% dan peningkatan SGOT dan SGPT 12.8%. Efek samping non hematologi yang paling banyak terjadi adalah rambut rontok 91.5%, mual 82.9%, stomatitis 61.7%, kuku menghitam 48.9%, reaksi hipersensitivitas 46.8%, neuropati perifer 31.9%, sembelit 27.7% dan diare 10.6%.
Narative Review: Kejadian Dan Mekanisme Kardiotoksisitas Pada Pasien Kanker Payudara Setelah Penggunaan Trastuzumab Sari, Laras Ratna; Murwanti, Retno; Rahmawati, Fita
Majalah Farmaseutik Vol 20, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i3.97047

Abstract

Kardiotoksisitas adalah terjadinya disfungsi jantung sebagai kerusakan listrik atau otot, yang mengakibatkan jantung menjadi lebih lemah dan tidak efisien dalam memompa darah. Kardiotoksisitas dapat disebabkan oleh beberapa hal seperti agen kemoterapi, pengobatan radioterapi, komplikasi dari anoreksia nervosa, efek samping dari asupan logam berat. Kardiotoksisitas juga terjadi pada pasien kanker payudara yang diberikan terapi trastuzumab. Tujuan dari tinjauan artikel ini yaitu untuk mengetahui kejadian kardiotoksisitas setelah penggunaan trastuzumab dan mekanisme efek kardiotoksisitas trastuzumab pada pasien kanker payudara. Metode yang digunakan pada artikel ini yaitu menggunakan beberapa pencarian menggunakan PubMed, ScienceDirect dan Google Cendekia untuk penelitian yang membahas efek kardiotoksisitas trastuzumab pada pasien kanker payudara dari tahun 2018 sampai dengan 2023. Dari total 171 artikel, yang kemudian dievaluasi berdasarkan kriteria inklusi dan eksklusi. Sebanyak 157 artikel dikeluarkan dan 14 artikel yang memenuhi kriteria inklusi. Mekanisme terjadinya kardiotoksisitas oleh trastuzumab melalui mekanime penghambatan HER2 dan autophagy. Kesimpulannya, Pemilihan trastuzumab sebagai pilihan terapi pada pasien kanker payudara harus dipertimbangkan dengan cermat dan diperlukan pemantauan fungsi jantung.  
Analyzing the Potential of Herbal Plant Research for Alzheimer's Disease in Diabetes: A Bibliometric Approach Marzuki, Ahmad; Rahmayani, Almira; Khafi, Muhammad; Hertiani, Triana; Murwanti, Retno
Majalah Farmaseutik Vol 20, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i3.97209

Abstract

Alzheimer’s disease is a progressive neurologic dementia disorder and the fifth leading cause of death among elderly individuals. Its pathogenesis is closely linked to diabetes-induced brain insulin resistance, which accelerates beta-amyloid accumulation, exacerbating disease severity. This condition significantly impacts quality of life and healthcare costs, necessitating effective treatment strategies. Medicinal plants offer a promising avenue, with bibliometric analysis identifying trending active compounds for potential development as therapies for diabetic Alzheimer’s. This study analyzed 200 articles from the Scopus database, employing Scopus and VOSviewer 1.6.20 to visualize bibliometric trends by publication, country/territory, subject area, and keyword co-occurrence. Results indicate a recent decline in research activity, with China leading in publications across pharmacology, medicine, and biochemistry. Notably, flavonoids like “quercetin,” “kaempferol,” and “gallic acid” emerged as prominent topics.Keywords: Alzheimer’s diabetes, Bibliometrics, Herbal medicine, Extracts
Kajian Pustaka: Sediaan Kosmesetika Penumbuh Rambut dari Berbagai Herbal Nusantara Budastra, Wayan Cintya Ganes; Riandari , Teti Mariam; Martien , Ronny; Murwanti, Retno
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 1 (2023): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i1.5594

Abstract

Kerontokan rambut dapat menjadi permasalahan serius ketika dalam jumlah yang abnormal dan terjadi secara terus-menerus hingga berujung kebotakan. Kosmesetika penumbuh rambut berbahan dasar herbal dapat menjadi pilihan terapi yang tepat sebab terkait dengan keamanan penggunaan jangka panjang maupun efektivitasnya. Berbagai bentuk sediaan kosmesetika herbal penumbuh rambut telah dikembangkan yakni emulsi, gel, emulgel, krim, serum, hair tonic maupun sediaan yang dimodifikasi dengan sistem teknologi nano. Artikel review ini bertujuan untuk mengetahui sediaan kosmesetika herbal terbaik yang memenuhi spesifikasi farmasetik yang telah ditetapkan dan aktivitasnya sebagai penumbuh rambut secara in vivo. Penelitian ini berbasis systematic literature review. Berdasarkan eksplorasi literatur yang telah dilakukan dapat diketahui bahwa sediaan kosmesetika herbal terbaik dalam meningkatkan pertumbuhan rambut dan memenuhi kriteria karakteristik farmasetik adalah adalah sediaan hair tonic daun kangkung (Ipomoea aquatica Forsk.) (5%) dengan rerata peningkatan panjang rambut sebesar (2,785 ± 0,021 cm) dan bobot rambut (0,767 ± 0,057 mg/cm2) selama 21 hari. Evaluasi farmasetik hair tonic daun kangkung telah memenuhi persyaratan SNI sediaan hair tonic yang telah ditetapkan. Hair loss can be a serious problem when it is in abnormal amounts and occurs continuously leading to baldness. Herbal-based hair growth cosmeceuticals can be the right choice of therapy because it is related to the safety of long-term use and its effectiveness. Various dosage forms of herbal hair growth cosmeceuticals have been developed, namely emulsions, gels, emulgels, creams, serums, hair tonic and preparations modified with nano technology systems. This review article aims to determine the best herbal cosmeceutical preparations that meet the established pharmaceutical specifications and their activity as hair growth in vivo. This research is based on systematic literature review. Based on the literature exploration that has been carried out, it can be seen that the best herbal cosmeceutical preparation in increasing hair growth and meeting the criteria for pharmaceutical characteristics is the preparation of kale leaf hair tonic (Ipomoea aquatica Forsk.) (5%) with an average increase in hair length of (2.785 ± 0.021 cm) and hair weight (0.767 ± 0.057 mg/cm2) in 21 days. Pharmaceutical evaluation of kale leaf hair tonic has met the requirements of SNI hair tonic preparations that have been established.
Pengaruh G-CSF terhadap ANC recoverypada pasien kanker dengan neutropenia Ningsih, Diana Rachma; Murwanti, Retno; Nugroho, Agung Endro
MEDIA ILMU KESEHATAN Vol 12 No 2 (2023): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v12i2.958

Abstract

Background: Neutropenia can increase morbidity in cancer patients because it can cause an increased risk of infection, delay or discontinue chemotherapy, and decrease the dose of cytotoxic agents which affect the patient's response and clinical outcome. The administration of G-CSF can increase ANC levels in neutropenic patients. The effectiveness of G-CSF was assessed by increasing ANC levels compared to before the administration of G-CSF.Objective: This study aims to determine the effect of G-CSF administration on ANC levels in cancer patients with neutropeniaMethods: This research was conducted at Dr. Kariadi General Hospital Semarang in October-December 2022 period with retrospective cohort method. The sample was cancer patients who experienced neutropenia and were given G-CSF.Results: Administration of G-CSF significantly increased ANC values (p-value 0.00 <0.05), increased by 921.07 ± 647.20 in the administration of filgrastim and 933.13 ± 558.89 in the administration of lenograstim and shortened the duration of ANC recovery (p-value 0.00 <0.05), recovery was 1.5 days shorter with filgrastim and 1.9 days with lenograstim.Conclusion: G-CSF Filgrastim and Lenograstim administration can increase ANC levels and shorten the duration of neutropenia treatment
New Insights of Response Surface Methodology Approach in Optimizing Total Phenolic Content of Zanthoxylum acanthopodium DC. Fruit Extracted Using Microwave-Assisted Extraction and the Impact to Antioxidant Activity Sumaiyah, Sumaiyah; Murwanti, Retno; Illian, Didi Nurhadi; Lubis, Muhammad Fauzan; Tampubolon, Keshia
Indonesian Journal of Chemistry Vol 24, No 6 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.95922

Abstract

Zanthoxylum acanthopodium DC., a unique spice plant from North Sumatra, is rich in beneficial secondary metabolites, particularly phenolic compounds. This study utilized the microwave-assisted extraction method to enhance the extraction of these bioactive compounds. The goal was to determine the optimal extraction conditions, including solvent concentration (X1), microwave power (X2), and extraction time (X3) to maximize the total phenolic content (TPC) of Z. acanthopodium fruit. A Box-Behnken design, part of response surface methodology, was used with three factors at three levels: X1 (50%, 75%, and 100% ethanol in water), X2 (180, 300, and 450 W), and X3 (3, 8.5, and 14 min). The phenolic compounds in the optimized extract were identified using LC-HRMS, and its antioxidant activity was measured using radical scavenging activity assays. The statistical analysis indicated a significant quadratic model (p-value < 0.05), with a high R2 of 86.25%. Optimal conditions for maximum TPC (159.637 ± 5.72 mg GAE/g) were achieved with 50% ethanol, 450 W, and 8.5 min, outperforming conventional extraction methods. Compared to the non-optimized extract, the optimized extract also exhibited strong antioxidant activity, particularly in DPPH radical inhibition. This method successfully optimized TPC in Z. acanthopodium fruit, enhancing its antioxidant properties.
PERLAKUAN AKUNTANSI ATAS PENGELOLAAN LIMBAH MEDIS Studi kasus pada Puskesmas Puger Kabupaten Jember Ledi, Ledi Klarismawati; Norita Citra Yuliarti; Retno Murwanti
Populer: Jurnal Penelitian Mahasiswa Vol. 1 No. 4 (2022): Desember : Jurnal Penelitian Mahasiswa
Publisher : Universitas Maritim AMNI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3027.735 KB) | DOI: 10.58192/populer.v1i4.296

Abstract

Penerapan akuntansi atas pengelolaan limbah medis pada Puskesmas Puger bertujuan untuk diketahui perlakuan akuntansi atas pengolahan limbah yang dilakukan Puskesmas Puger yang meliputi identifikasi, pengukuran, pengakuan, penyajian, dan pengungkapan. Jenis penelitian ini bersifat deskripstif komparatif, dengan data primer didapat dari narasumber, dan untuk data sekunder didapat dari media perantara. bahwa perlakuan akuntansi pada Puskesmas Puger meliputi identifikasi Puskesmas Puger masih belum terlaksanakannya identifikasi dalam biaya lingkungan sesuai dengan teori Hansen dan Mowen. Tindakan pengukuran pada Puskesmas Puger telah memenuhi syarat pada unsur-unsur pengukuran di KDPPLK. Penyajian biaya lingkungan sebaiknya dilakukan secara terpisah pada laporan keuangan, dan pengungkapan biaya lingkungan pada CALK harus tersistematis. Hal tersebut akan membantu bagi manajemen Puskesmas Puger dalam memahami secara mudah.
Evaluation of the Potential In Vitro effects of Plantago major L. on Wound Healing in Human Umbilical Vein Endothelial Cells (HUVEC) Amalia, Latifa; Murwanti, Retno; Hertiani, Triana; Purnomo, Kurnia Rahayu
Indonesian Journal of Cancer Chemoprevention Vol 15, No 2 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss2pp87-95

Abstract

 The treatment of skin wounds remains a major concern in the field of medicine, particularly in the case of chronic wounds resulting from various disorders such as diabetes. The utilization of herbs or herbal preparations for the purpose of healing skin wounds presents a therapeutic challenge within the realm of traditional medicine. Plantago major L. is known to have bioactive compounds that have wound healing activity such as aucubin. This study aimed to determine the in vitro wound healing potential of Plantago major L. extract (PLE). The study involved several assays, including phytochemical examination of PLE using TLC, cell viability testing using MTT assay, and wound healing testing using scratch assay on human umbilical vein endothelial cells (HUVEC). The results confirmed the presence of aucubin as one of the compounds in PLE. It was observed that PLE with 125 μg/mL exhibited the highest wound closure percentage at 90.66%. This study shows that PLE possesses wound healing capabilities.Keywords: Plantago major L., PLE, cytotoxic assay, wound scratch assay, HUVEC.
Unveilling Aucubin’s Pharmacological Landscape: A Bibliometric Study on Antioxidant and Anti-Inflammatory Activities Amalia, Latifa; Murwanti, Retno; Hertiani, Triana
Majalah Farmaseutik Vol 21, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v21i1.99621

Abstract

Aucubin is an iridoid glycoside known to have various pharmacological activities. Current research data shows that the pharmacological activities are very diverse and complex, so bibliometric analysis is used to facilitate understanding and provide references for further research directions. Publications related to the pharmacological activities of aucubin were obtained through the Web of Science Core Collection (WoSCC) database, which were then analyzed using Vosviewer 1.6.20 software. A total of 152 publications were obtained from the period 2013-2023, consisting of 142 articles and ten review articles. The articles came from 45 countries, 204 institutions, 862 authors, and 42 journals. Based on keyword analysis, the most frequently appearing pharmacological activities were "antioxidant" and "anti-inflammatory" that can be the primary development directions in the future.
Exploring the Anti-cancer Effect of Ethanol Extract of Jamaican Cherry (Muntingia calabura L.) Leaves on CT26 Colorectal Cancer Cells through WNT Signaling Rizkita, Anggraini Ihza; Effendi, Adha Maula; Fitri, Dafina Aisya; Nursani, Rabila; Luthfiyyah, Annisa Tiara; Arifka, Vigha Ilmanafi; Murwanti, Retno
Majalah Obat Tradisional Vol 30, No 1 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.94297

Abstract

The prevalence rate of mortality in colorectal cancer is comparatively elevated. A standard or effective treatment has not been developed to resolve this issue. Utilizing Muntingia calabura, which is known to contain rutin with anti-cancer properties, is one of the strategies that can be implemented. The present study focuses on the potential therapeutic effects of M. calabura as an anti-cancer agent in colorectal cancer. Specifically, this study investigates the anti-cancer properties of rutin against colorectal cancer. The results of this study showed that the ethanolic extraction of M. calabura contained approximately 0.727 mg/mL of rutin. Additionally, the cytotoxicity assessment revealed that the rutin fraction was moderately cytotoxic, with a value of 70.808 μg/mL. The results of molecular docking experiments demonstrated a high degree of accuracy in predicting the interaction between rutin and β-catenin. Furthermore, the quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay revealed a significant reduction in the expression of the β-catenin gene within the cells exposed to the extract. In conclusion, M. calabura extract exhibits anti-cancer properties by influencing the WNT signaling pathway in CT26 cells.
Co-Authors Abdul Rohman Adam Hermawan Agung Endro Nugroho Agung Endro Nugroho Ahmad Marzuki Alexxander, . Alexxander, . Amalia, Latifa Anami Riastri Andayana Puspitasari Gani Andayana Puspitasari Gani Andayana Puspitasari Gani Annisa, Siti Nur Anselma Ivanawati Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Rahman Hakim Arifka, Vigha Ilmanafi Aris Haryanto Ariska Deffy Anggarany, Ariska Deffy Ashfannada, Nuqya Asri Mega Putri Azizah Amin Azmi Rahmadani Bambang Sulistiyo Ari Sudarmanto Bani Adlina Shabrina Bayu Irawan, Muhamad Bayu Prio Septiantoro Beni Lestari Budastra, Wayan Cintya Ganes Cahyo Nurani, Sekar Cindy Puspita Sari Devina Martina Devita Anggraeni Devita Anggraeni Devyanto Hadi Triutomo Dewi Kartikawati Paramita Dhania Novitasari Dhirgo Adji Dhirgo Adji Diana Rachma Ningsih Dwi Brilyani Sandy Dwi Salim, Rozin Dyah Afritasari Dyah Aryani Perwitasari Dyah Widiastuti Dyaningtyas Dewi Pamungkas Putri Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Edy Meiyanto Effendi, Adha Maula Erna Prawita Setyowati Erna Prawita Setyowati Fikriansyah Fikriansyah Fita Rahmawati Fitri, Dafina Aisya Fitriana Hayyu Arifah Gagas Pradani Nur Ilmawati Gani, Andayana Puspitasari Ginna Zabrina Hayati, Farida Hendri Wasito Herwandhani Putri Hidayah, Alifia Brilliani Hilyatul Fadliyah I Gusti Ngurah Agung Dewantara Putra Ida Ayu Putu Sri Widnyani Idlohatud Dilalah Ika Puspita Sari Illian, Didi Nurhadi Imono Argo Donatus, Imono Argo Ina Kusrini Iren Wati Siahaan Jenie, Riris Istighfari Juang Juansa Khafi, Muhammad Khasanah, Aisyah Nur Khoerul Anwar Khoerul Anwar Kustanto, Satya Prima Layung Sekar Sih Wikanthi Ledi, Ledi Klarismawati Lodyta Nawang Tika lubis, muhammad fauzan Lukman Hakim Luthfiyyah, Annisa Tiara Martien , Ronny Mentari Widiastuti Miftahus Sa&#039;adah Mustofa Mustofa Naisbitt Iman Hanif, Naisbitt Iman Nanang Fakhrudin Nanang Fakhrudin, Nanang Nanda Saifullah Sulaiman, Teuku Nastiti Wijayanti Ngurah Agung Dewantara Putra, I Gusti Nindi Wulandari Nindya Budiana Putri Nindya Budiana Putri Ningsih, Diana Rachma Norita Citra Yuliarti, Norita Citra Novrizal Abdi Sahid , Muhammad Nursani, Rabila Nurul Fathiyah F Nurul Mukhlisa Pratiwi, Rima Dwi Prawitasari, Saptya Prisnu Tirtanirmala Probowulan, Diyah Purnomo, Kurnia Rahayu Purwantiningsih Purwantiningsih Rahmawaty Rachmady Rahmayani, Almira Retno S. Sudibyo Retno Sunarminingsih Sudibyo Riandari , Teti Mariam Rima Munawaroh Risa Umari Yuli Aliviyanti Ritmaleni, Ritmaleni Rizkita, Anggraini Ihza Rohmad Yudi Utomo Rohman, Abdul Rommy Sagala, Reynelda Juliani Sardjiman . Sari Haryanti Sari Haryanti Sari, Laras Ratna Shofa Annur Siswadi Siswadi Sri Susilowati Sri Tasminatun Sri Wahdaningsih Subagus Wahyuono Sudarsono Sudarsono Sugeng Riyanto Sugiyanto . Sugiyanto . Sulaiman, T.N Saifullah Sumaiyah, Sumaiyah Susi Ari Kristina Suwijiyo Pramono Suwijiyo Pramono Tamhid, Hady Anshory Tampubolon, Keshia Thoriq Ziyad, Thoriq Tiffany, Ghea Rachella Triana Candraningrum Triana Hertiani Triawan Adi Cahyanto Ulfa Afrinurfadhilah Darojati Wahyu Utaminingrum Widya Leontin Susanti Yoce Aprianto Yosi Bayu Murti Yundari, Yundari Zahrotul Ulum Ziana Walidah, Ziana