Linda Astari, Linda
Departemen/Staf Medik Fungsional Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya

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Efek Penambahan Fototerapi Sinar Biru Terhadap Manifestasi Klinis Akne Vulgaris Derajat Sedang Dhyah Aksarani Handamari; M. Yulianto Listiawan; Linda Astari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 3 (2018): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.746 KB) | DOI: 10.20473/bikk.V30.3.2018.185-192

Abstract

Latar Belakang: Penggunaan terapi lini pertama pada akne vulgaris (AV) kadang memberikan hasil yang kurang memuaskan dan juga menimbulkan efek samping.Banyak peneliti melaporkan respons positif pasien AV sedang (AVS) yang diobati dengan fototerapi sinar biru. Penggunaan fototerapi sinar biru menurunkan prosentase jumlah lesi lebih besar dibandingkan tanpa fototerapi.Tujuan: Membuktikan efek penambahan fototerapi sinar biru terhadap manifestasi klinis AVS. Metode: Desain penelitian adalah eksperimental analitik dengan menggunakan metode uji klinis terkontrol, pemilihan pasangan serasi, dan desain paralel yang membandingkan penambahan fototerapi sinar biru terhadap terapi standar (kontrol) akne vulgaris derajat sedang. Subjek penelitian adalah semua pasien AVS yang memenuhi kriteria, yang datang berobat di Unit Rawat Jalan Kesehatan Kulit dan Kelamin Divisi Kosmetik RSUD Dr. Soetomo Surabaya pada Desember 2017 sampai Februari 2018. Hasil: Efek penambahan fototerapi sinar biru terhadap penurunan jumlah komedo dan  papul/pustul pada AVS tidak berbeda bermakna dibandingkan tanpa penambahan fototerapi sinar biru, namun berbeda bermakna pada penurunan jumlah nodul. Efek penambahan fototerapi sinar biru terhadap penurunan porfirin dan jumlah sebum pada AVS tidak berbeda bermakna dibandingkan tanpa penambahan fototerapi sinar biru, namun berbeda bermakna pada penurunan jumlah pori-pori. Simpulan: Penambahan fototerapi lebih baik pada lesi inflamasi dan membantu penurunan jumlah pori pasien AV.
Management of Eumycetoma Tjokorde Istri Nyndia Vaniari; Sunarso Suyoso; Linda Astari; Yuri Widia; Sylvia Anggraeni; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.232-238

Abstract

Background: Mycetoma is a chronic inflammatory disease of the skin that can extend to the fascia, tendons, muscles, and bones. Caused by a bacterium called actinomycetoma and a fungus called eumycetoma are responsible for mycetoma, both of which must be distinguished because they require different medical therapy. Eumycetoma is a localized disease, chronic, and growing slowly. Most of eumycetoma patients had delays in seeking medical care. Purpose: To provide an overview and discuss various aspects of eumycetoma, including its epidemiology, etiology, pathogenesis, classification, clinical picture, diagnosis, differential diagnosis, and therapy. Review: Eumycetoma infection begins as infectious agents enter through the skin with a minor trauma caused by objects contaminated with fungi, forming granular or granulomatous lesions with tract and sinus in there. The infection can spread from the site of inoculation into the muscles and bones. The diagnosis is based on anamnesis (chronic and painless), the triad of tumefaction, draining sinuses and grains, and laboratory investigation. It’s a difficult case, often recur and difficult to be surgical excisison, so that the best first option therapy is the combination of itraconazole and terbinafine itself as an alternative to surgical therapy at least 6 months. Conclusion: Eumycetoma is an infection caused by a fungus with granulomatous lesions with sinus formation and grains in it. The best first option therapy is the combination of itraconazole and terbinafine although it’s still an early case.
Evaluasi Penggunaan Terapi Topikal Tretinoin 0,1% pada Striae Albae Densy Violina Harnanti; M Yulianto Listiawan; Linda Astari; Willy Sandhika
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 2 (2019): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.9 KB) | DOI: 10.20473/bikk.V31.2.2019.98-103

Abstract

Latar belakang: Striae distensae (SD) adalah jaringan parut linier pada epidermis dan dermis akibat peregangan kulit yang melebihi batas elastisitasnya. Striae albae (SA) ditandai dengan garis hipopigmentasi dan terjadinya atrofi pada epidermis dan dermis. Hal tersebut dapat mengganggu fungsi sawar kulit bahkan gangguan transepidermal water loss (TEWL). Tujuan: Mengevaluasi perubahan klinis dan luas kolagen pasien SA sebelum dan setelah  terapi  tunggal krim tretinoin 0,1% selama 3 bulan. Metode: Penelitian eksperimental analitik yang membandingkan perubahan klinis dan persentase luas kolagen pasien SA sebelum dan setelah  terapi  tunggal krim tretinoin 0,1% selama 3 bulan di Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin Divisi Kosmetik dan Tumor Bedah Kulit Rumah Sakit Umum Daerah (RSUD)  Dr. Soetomo Surabaya. Hasil: Panjang lesi SA sebelum dan setelah terapi krim tretinoin 0,1% tidak didapatkan perbedaan bermakna (p=0,341), begitu pula lebar lesi SA sebelum dan setelah terapi juga tidak didapatkan perbedaan yang bermakna (p=0,341). Persentase luas  kolagen sebelum dan setelah terapi krim tretinoin 0,1% didapatkan perbedaan yang bermakna (p=0,0001). Visual Analog Scale (VAS) Improvement grade dengan skala 2 didapatkan pada 10 (90,9%) sampel penelitian sedangkan skala 3 didapatkan pada 1 (9,1%) sampel penelitian. Hasil penilaian VAS patient satisfaction grade didapatkan 10 (90,9%) sampel penelitian memberikan skala 6 dan 1 (9,1%) memberikan skala 7. Simpulan: Penggunaan krim tretinoin 0,1% pada SA selama 3 bulan tidak menunjukkan perubahan klinis yang bermakna, tetapi dapat meningkatkan persentase luas kolagen secara bermakna. 
Pola Pergeseran Penyebab Kandidiasis Vulvovaginalis Linda Astari; Zahruddin Ahmad
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 1 (2019): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (114.772 KB) | DOI: 10.20473/bikk.V31.1.2019.14-23

Abstract

Latar belakang: Kandidiasis vulvovaginalis (KVV) merupakan penyakit infeksi dengan gejala dan keluhan keradangan pada vulva dan vagina yang disebabkan oleh jamur spesies Candida. C. albicans merupakan spesies terbanyak penyebab KVV, tetapi kejadian yang disebabkan oleh spesies non-albicans tampak semakin meningkat dengan berbagai komplikasi yang ditimbulkannya. Tujuan: Mengevaluasi pola pergeseran spesies penyebab KVV untuk meningkatkan keberhasilan pengobatan pasien. Metode: Studi retrospektif dengan sumber data sekunder yang tersedia dari hasil penelitian KVV di Divisi Infeksi Menular Seksual (IMS) Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya periode tahun 1997 – 2017. Hasil: Sebanyak 7 penelitian mengenai KVV telah didapatkan dalam rentang waktu tersebut. Pasien KVV sebagian besar adalah wanita yang sudah menikah, usia seksual aktif, dan mengeluhkan adanya duh tubuh berwarna putih disertai rasa gatal pada kemaluan. Mayoritas C. albicans didapatkan pada penelitian tahun 1997, 2010, 2015, dan 2017, sebesar 100%, 52,8%, 71,4%, dan 62,1%, sedangkan mayoritas C. non-albicans pada penelitian tahun 2004, 2005, dan 2009, sebesar 65,2%, 52,6%, dan 52,9%. Kesimpulan: Penelitian ini telah menunjukkan pola pergeseran spesies penyebab KVV selama 20 tahun terakhir, yaitu dari dominasi C. albicans pada 1997, kemudian C. non-albicans pada tahun 2004, 2005, dan 2009, kembali lagi pada dominasi C. albicans yaitu pada tahun 2010, 2015, dan 2017.
Long Term Effects of Combination of Metabolite Product Amniotic Membrane Stem Cell (MP-AMSC) and Vitamin C after Fractional CO2 Laser for Photoaging Treatment Vidyani Adiningtyas; Muhammad Yulianto Listiawan; Linda Astari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 2 (2020): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.2.2020.85-92

Abstract

Background: Metabolite Products Amniotic Membrane Stem Cell (MP-AMSC) originating from the amniotic membrane has a skin rejuvenation effect by stimulating collagen synthesis. Vitamin C functions as an antioxidant in photoaging treatment. It is expected that the application of a combination of MP-AMSC and vitamin C after fractional CO2 laser treatment as Laser-Assisted Drug Delivery (LADD) to provide better long-term effects on clinical improvement of photoaged skin. As the drug penetration reaching the target, long-term effects and no side effects are expected. This promises as an option for photoaging therapy in the future. Purpose: This study aimed to evaluate the long-term effects of a combination of topical MP-AMSC mixtures and vitamin C after fractional CO2 laser treatment on wrinkles, spots, pores, and skin tones. Methods: Thirty adult women with photoaged skins were selected as samples, and were observed for wrinkles, spots, pores, and skin tones examination. The observation involved computer-simulated photographic devices, Facial Skin Scope System Janus-II for three months after the topical administration of MP-AMSC mixture and vitamin C, three times fractional CO2 laser, tretinoin 0.025% cream, and sun protection factor (SPF) 30 sunscreen as maintenance therapy. Result: The data analysis result was not statistically significant (p>0.05). Conclusion: There was a long-term effect of the application of a mixture of topical MP-AMSC and vitamin C after fractional CO2 laser treatment, and no side effect was observed.
Topical Epigallocatechin Gallate (EGCG) 1% for Chronic Plantar Ulcers in Leprosy Riyana Noor Oktaviyanti; Cita Rosita Sigit Prakoeswa; Diah Mira Indramaya; Esti Hendradi; Sawitri Sawitri; Linda Astari; Damayanti Damayanti; Muhammad Yulianto Listiawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 2 (2020): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.2.2020.134-140

Abstract

Background: Chronic plantar ulcers in leprosy (CPUL) increase morbidity, increase medical costs, cause loss of productivity, and decrease quality of life. CPUL is a severe complication of leprosy disease with a 10-20% incidence. In general, CPUL consume a significant amount of time to heal. Green tea extract contains high amount of Epigallocatechin gallate (EGCG). EGCG functions as antiinflammatory, antimicrobial, and immunomodulator. This suggests that EGCG is effective for dermal wound treatment by facilitating reepithelialization. Purpose: To investigate the effect of topical EGCG 1% on the CPUL healing process. Methods: The topical EGCG 1% were applied every three days for eight weeks. Size of the ulcers, side effects and possible complications were monitored weekly. Result: There were significant clinical and statistical differences in the size and depth of the ulcers (p=0.000), as observed in the EGCG group. There was no side effect and complication found. Conclusions: Topical EGCG 1% was effective for CPUL healing. Sixty three point six percent of the ulcers were clinically healed, 31.8% demonstrated improvement, and 4.6% no effect was observed.
Combination of Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E for Photoaging Retha Retha; Sawitri Sawitri; Rahmadewi Rahmadewi; Afif Nurul Hidayati; Muhammad Yulianto Listiawan; Evy Ervianti; Linda Astari; Cita Rosita Sigit Prakoeswa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 1 (2020): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.1.2020.1-6

Abstract

Background: It is hypothesized that combination of amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO2 laser as laser assisted drug delivery (LADD) provides better long-term effects on clinical improvement of photoaging. This is promising as an option for photoaging therapy in the future. Purpose: The study aimed to evaluate long-term effects of improving the degree of wrinkles, polarized black spots, ultraviolet (UV) black spots, pores, and skin tones in subjects who have received a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD. Methods: Thirty adult women with photoaging who had been treated with topical AMSC-MP mixed therapy with vitamin E and CO2 fractional laser three times, were then given maintenance therapy, tretinoin cream 0.025% and sunscreen SPF 30. Observation of improvement of wrinkles, polarized black spots, UV black spots, pores, and skin tones were performed computer-stimulated photographs, Janus-II Facial Skin Scope System, three times every month for three months after the last treatment. Results: The evaluation of wrinkles, polarized black spots, UV dark spots, pores and skin tones from the assessment for three months after being receiving treatment of a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD on photoaging obtained p>0.05. Conclusion: There was a long-term effect of the topical mixture of AMSC-MP with vitamin C and CO2 fractional laser on photoaging, and there was no side effect observed.
The Effectiveness of 5% Tea Tree Oil cream, 10% Tea Tree Oil cream, and 5% Permethrin Cream for Scabies Treatment in Pediatric Patients Chesia Christiani Liuwan; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Evy Ervianti; Sawitri Sawitri; Cita Rosita Sigit Prakoeswa; Linda Astari; Farhat Surya Ningrat; Kurniati Kurniati; Endang Wahyu Fitriani; Irmadita Citrashanty; Regitta Indira Agusni; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.200-205

Abstract

Background: Scabies, an infectious disease caused by Sarcoptes scabiei mites, is still one of the most common skin diseases found in developing countries, including Indonesia. The 5% permethrin cream for scabies treatment has been investigated as having 2–3 time to cure scabies. Tea Tree Oil (TTO) is one of the agents that has been proven to have acaricidal potential as an anti-inflammatory, antibacterial, and antipruritic agent. It has minimal side effects in topical use. Purpose: To evaluate the effectiveness of 5% TTO cream and 10% TTO cream in scabies treatment of pediatric patients. Methods: This was an experimental, analytical study with controlled clinical trial methods, and a double-blind, parallel design comparing 5% TTO cream (treatment 1), 10% TTO cream (treatment 2), with 5% permethrin cream (control) to children with scabies. Result: The 5% TTO cream gave a cure rate of 61.5% and was significantly different from the 5% permethrin cream groups with a p-value = 0.044 in the first week of the study. The 5% permethrin cream gave a cure rate of 15.4%, and the cure rate of 10% TTO cream was 53.8% in the first week of the study. Conclusion: There was a significant difference between the 5% TTO cream and 5% permethrin cream in the first week of the study. The highest and fastest cure rates were found in the 5% TTO cream treatment group.
In Vitro Antifungal Susceptibility Testing of Tea Tree Oil (TTO) 5% Compared with Nystatin against Candida sp. as Important Agent of Oral Candidiasis in HIV/AIDS Patients Eva Lydiawati; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Rahmadewi Rahmadewi; Cita Rosita Sigit Prakoeswa; Christina Avanti; Endang Wahyu Fitriani; Erwin Astha Triyono; Linda Astari; Iskandar Zulkarnain
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.189-194

Abstract

Background: Oral candidiasis is the most common clinical manifestation in a person infected with HIV which has been linked with the severity of the disease. Candida albicans responsible for most oral candidiasis. The increased resistance to the available antifungal drugs can reduce the efficacy of therapy. Therefore, it will be crucial to discover novel antifungal agents. One of them is tea tree oil (TTO) or Melaleuca alternifolia which has a potent antifungal effect to inhibit the growth of Candida sp.  Purpose: To evaluate the antifungal susceptibility of TTO 5% compared with nystatin against Candida sp. taken from HIV/AIDS patients. Methods: The study assessed the antifungal effect of TTO 5% and nystatin against 33 isolates of Candida sp. that was isolated from the oral cavity of 30 HIV/AIDS patients in Dr. Soetomo General Academic Teaching Hospital Surabaya, Indonesia. Antifungal susceptibility was evaluated by the disc diffusion method. The diameter of the inhibition zone was determined as the result of this study. Result: The most strains found in this study was Candida albicans (84.8%). The mean inhibition zone of nystatin against all strains was 23.24 mm whether it was 17.55 mm for TTO 5%. The inhibition zone of both TTO 5% and nystatin in Candida non-albicans were tended to be higher than in Candida albicans. It revealed that the inhibition zone of TTO 5% significantly lower than nystatin (P = 0.00; P < 0.05).Conclusion: Therefore, the antifungal susceptibility of nystatin was significantly higher than TTO 5% against Candida albicans and non-albicans.
The Efficacy of Lactobacillus plantarum as Adjunctive Therapy of Bacterial Vaginosis: A Double-blind, Randomized, Placebo-controlled Trial Ridha Ramadina Widiatma; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Cita Rosita Sigit Prakoeswa; Sawitri Sawitri; Ingrid Suryanti Suryono; Linda Astari; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 32 No. 3 (2020): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V32.3.2020.214-220

Abstract

Background: Bacterial vaginosis (BV) is a clinical syndrome caused by the changing of Lactobacillus spp., a producer of hydrogen peroxide, in the normal vagina with a high concentration of anaerobic bacteria, Gardnerella vaginalis and Mycoplasma hominis. This study reports a resistance of BV therapy regimens, high recurrence rates, and side effects of an antibiotic. Therefore, adjunctive therapy for BV management is needed. Research has reported the therapeutic effects of probiotic in BV; however, the results are inconsistent. Purpose: To evaluate the efficacy of standard therapy using metronidazole and Lactobacillus plantarum for BV measured by the cure rate and vaginal flora balance. Methods: A randomized, double-blind, placebo-controlled trial, 30 subjects were randomized to take metronidazole 500 mg twice a day for seven days with weekly evaluation. The Lactobacillus plantarum or placebo group was evaluated every 4 weeks. The cure rate and vaginal flora balance were evaluated using the Amsel criteria and Nugent score before and after the intervention. Result: A total of 30 subjects returned for 28-day follow-up, of which 60% subjects of the antibiotic/probiotic group were cured compared to 40% in the antibiotic/placebo group (p>0.05). Conclusion: There was no difference in the increase of cure rate and vaginal flora balance between the treatment group and significant control group.
Co-Authors Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Alarik L., Albertus Alimsardjono, Lindawati Alpha Fardah Athiyyah Alya Nuha Andini Amanda Gracia Manuputty Anang Endaryanto Anggraeni Noviandini Anggraeni, Sylvia Ardhiah Iswanda Putri Arifa Mustika Astindari Astindari Astindari Astindari, Astindari Aulia, Syifa Auliya, Arsya Axelia, Presstisa Gifta Bagus Bagus Bagus Haryo Kusumaputra, Bagus Haryo Bramantono Bramantono, Bramantono Brigita Ika Rosdiana Budi Prasetyo Budi Utomo Budi Utomo Budiono Budiono Chesia Christiani Liuwan Christina Avanti Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti David Sontani Perdanakusuma Densy Violina Harnanti Desiana Widityaning Sari Dewi Puspitorini Dhyah Aksarani Handamari Diah Mira Indramaya DINAR ADRIATY Dwi Murtiastutik Dwi Ratna Adisty Dwiyanti Puspitasari, Dwiyanti Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Evy Ervianti Fadila, Arisia Farhat Surya Ningrat Hadiwidjaja, Farsha Naufal Hari Sukanto, Hari Harningtyas, Citra Dwi Hartanto, Felix I Gusti Ayu Agung Elis Indira I Gusti Nyoman Darmaputra Indah Purnamasari Indiastuti, Danti Nur INDROPO AGUSNI Ingrid Suryanti Suryono Irmadita Citrashanty Irmadita Citrashanty, Irmadita Iskandar Zulkarnain Iskandar Zulkarnain ISWAHYUDI ISWAHYUDI Kathrin Kezia Henry Kinanti Prabawaningrum Kurniati Kurniati M. Yulianto Listiawan ManikRetno Wahyunitisari Mappamasing, Hasnikmah Maylita Sari Maylita Sari, Maylita Medhi Denisa Medhi Denisa Alinda, Medhi Denisa Meita Ardini Pratamasari, Meita Ardini Merilyne Merilyne Musofa Rusli Ngesti Kumalasari, Diah Noviannisa, Farah Ayu Nyoman Suryawati Pepy D. Endraswari Pepy Dwi Endraswari, Pepy Dwi Prakoeswa, Cita Rosita Priangga Adi Wiratama Puspowati, Erindah Putri Hendria Wardhani Putri, Melati Adinda Rahmadewi Rahmadewi Rahmadewi Rahmatari, Bandaru RATNA WAHYUNI Regitta Indira Agusni Renata Prameswari Retha Retha Ridha Ramadina Widiatma Riyana Noor Oktaviyanti Sawitri Sawitri Sawitri Selvia Yuliani Dwi Ratih Sanggarwati Sepling Paling Sheilaadji, Maria Ulfa Shinta Dewi Rahmadhani Soetojo SHINZO IZUMI Siti Kurniawati Sulaksanaswastho Suyoso Sunarso Suyoso Sunarso Suyoso Sunarso Suyoso Sunarto, Olivia Awwalin Susanto, Ester Chateline Tjokorde Istri Nyndia Vaniari Trisniartami Setyaningrum Vidyani Adiningtyas Widyantari, Septiana Willy Sandhika Yuri Widia, Yuri Yuri Widya Zahruddin Ahmad