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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease ISM (Intisari Sains Medis) : Jurnal Kedokteran JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal EduHealth Molucca Medica

Linda Astari, Linda

Departemen/Staf Medik Fungsional Ilmu Kesehatan Kulit Dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya

Author-ID : 3287335

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Profile of Tinea Corporis and Tinea Cruris in Dermatovenereology Clinic of Tertiery Hospital: A Retrospective Study Selvia Yuliani Dwi Ratih Sanggarwati; Manik Retno Wahyunitisari; Linda Astari; Evy Ervianti
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.34-39

Background: Tinea corporis and cruris are dermatophytes that infect the skin, and they are caused by Trichophyton sp., Microsporum sp., and Epidermophyton sp. Dermatophyte fungal-infect keratin-containing skin classified by the body’s location, such as tinea corporis (skin besides haired area, body, hands, or feet) and tinea cruris (groin & perineal region). Purpose: To evaluate the clinical profiles and treatments of tinea corporis and cruris at Dermatology and Venereology (DV) outpatient clinic Dr. Soetomo General Academic Hospital in 2018. Methods: A retrospective-descriptive study based on medical records of DV outpatient clinic Dr. Soetomo General Academic Hospital, Surabaya. Data collected from August to December 2019. Tinea corporis and cruris profiles evaluation based on age, sex, occupation, precipitating factors, complaints, illness duration, family history, lesion’s location and description, and therapy. Result: A total of 164 patients (35 tinea corporis, 76 tinea cruris, and 53 tinea corporis and cruris), predominantly female, age 46–55 years, came treatment less-than-a-month cases, excessive sweating, itching, tinea corporis lesion’s location on the face and body, tinea cruris in groin, tinea corporis and cruris on body and groin, erythematous macules, firm borders, active margins, scales, central healing, positive KOH 10–20% examination, miconazole cream therapy 2%, griseofulvin therapy, griseofulvin oral and ketoconazole cream 2% combination therapy. Discussion: Tinea corporis and cruris are common in females as their history and symptoms supported by the characteristics of laboratory examination, the presence of hyphae in potassium hydroxide (KOH) 10–20%. Most patients were prescribed with oral griseofulvin, especially in large lesions cases.

A Retrospective Study: Risk Factor Analysis of Secondary Bacterial Infection in Pediatric Atopic Dermatitis Patients Desiana Widityaning Sari; Sawitri Sawitri; Muhammad Yulianto Listiawan; Dwi Murtiastutik; Linda Astari; Alpha Fardah Athiyyah; Afif Nurul Hidayati
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.83-87

Background: Atopic Dermatitis (AD) is a complex multifactorial disease that includes defects in skin architecture, immune dysregulation, and changes of skin flora, and it predominantly occurs in infancy and childhood. The defects in skin barrier structures are mentioned as one of the factors that facilitates bacterial colonization. Bacterial infection in AD can worsen the inflammation. It requires treatment with antibiotics, which takes longer therapy time, higher costs, and ultimately affects the patient’s quality of life and his/her family members. Purpose: To find out the epidemiology, diagnosis, management of AD, and analyze the risk factors of secondary bacterial infection in new AD patients at the Pediatric Dermatology Division, Dermatovenereology Outpatient Clinic, Dr. Soetomo General Academic Hospital. Methods: This was a retrospective study with a total sampling method. The research data were medical records of new AD patients at the Pediatric Dermatology Division, Dermatovenereology Outpatient Clinic, Dr. Soetomo General Academic Hospital Surabaya from January 2012 to December 2018. Result: There were 404 new patients with AD at the Pediatric Dermatology Division from January 2012 to December 2018, and 210 of them were accompanied by secondary bacterial infection. There was a correlation between a history of dry skin (p=0.000) with the incidence of secondary bacterial infection in AD patients. Conclusion: In this study, AD patients with a history of dry skin had a risk of complication such as bacterial secondary infection.

The Profile of Type 1 Leprosy Reaction at Leprosy Division of Dermatology and Venerology Outpatient Clinic of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia Brigita Ika Rosdiana; Linda Astari; Astindari Astindari; Iskandar Zulkarnain; Damayanti Damayanti; Budi Utomo; M. Yulianto Listiawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.168-172

Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Type 1 leprosy reaction is a delayed hypersensitivity reaction caused by the increased response of cellular-mediated immunity to the Mycobacterium leprae antigen on the skin and nerves with a reversal result. The clinical manifestation includes inflammation which can cause skin and nerve lesions, swell, to permanent disabilities. Purpose: To describe the demographic and clinical profile of type 1 leprosy reaction at the Leprosy Division of the Dermatology and Venerology Outpatient Clinic of Dr. Soetomo General Academic Hospital in 2017â€“2019. Methods: This was a descriptive study. We used secondary data from the medical records of leprosy patients at the Leprosy Division of Dermatology and Venereology outpatient clinic, Dr. Soetomo General Academic Hospital Surabaya, from January 2017 to December 2019. Result: Out of 364 patients, 65 (17.9%) had type 1 reactions. They were mostly in productive age at 35â€“55 years old (56.9%). The patients were predominantly male (75.4%), with normal nutritional status (98.5%) and negative bacterial index (72.3%). The most common types of leprosy were BB (Borderline) with 61.6% and BL (Borderline Lepromatous) with 20.8%. All patients took WHO (World Health Organization) MDT (Multi Drug Therapy) MB (Multi-Bacillary). Conclusion: The profile of type 1 leprosy reaction at the Leprosy Division of Dermatology and Venerology Outpatient Clinic of Dr. Soetomo General Academic Hospital in 2017â€“2019 shows an average data as follows: age 35â€“55 years, male, normal nutritional status, negative bacterial index, leprosy type BB.

KANDIDIASIS VULVOVAGINALIS PADA ANAK DENGAN DIABETES MELITUS TIPE I Amanda Gracia Manuputty; Linda Astari
Molucca Medica VOLUME 13, NOMOR 2, OKTOBER 2020
Publisher : Pattimura University

Pendahuluan: Kandidiasis vulvovaginalis (KVV) merupakan suatu infeksi pada area vagina dan vulva yang disebabkan oleh jamur Candida baik spesies Candida albicans maupun Candida non-albicans. Diabetes melitus (DM) merupakan salah satu faktor predisposisi KVV yang dapat memicu dan memperburuk KVV. Metode: Dilaporkan satu kasus KVV pada anak dengan DM tipe 1 dengan kadar gula darah tidak terkendali Kasus: Seorang anak perempuan berusia 11 tahun, berat badan 20 kg dengan keluhan utama keputihan berwarna putih susu dari kemaluan sejak 2 hari, tidak berbau, gatal, tanpa rasa terbakar, disuria minimal dan edema pada kemaluan. Keluhan ini baru pertama kali dirasakan oleh pasien. Riwayat DM sejak 3 tahun lalu. Pemeriksaan fisik terdapat makula eritematus, berbatas tidak jelas, duh tubuh dan edema pada regio vulva, sedangkan regio vagina ditemukan duh tubuh berwarna putih seperti susu pecah, tanpa edema, erosi dan fisura. Hasil laboratorium gula darah acak (GDA) 396 mg/dL, HbA1C 9,1%. Pemeriksaan Gram dan sediaan basah ditemukan blastospora dan pseudohifa. Kultur dari media CHROMagar Candida menunjukan species C. albicans. Diagnosis KVV ditegakkan berdasarkan anamnesis, pemeriksan fisik dan penunjang. Hasil: Pada pasien diberikan terapi ketokonazol 2 x 100 mg per hari, nistatin 100.000 IU salep dua kali sehari, insulin prandial maupun basal, serta edukasi untuk menjaga higenitas personal. Pemberin terapi selama 2 minggy memberikan kesembuhan pada pasien. Kesimpulan: Pemberian obat anti jamur dengan dosis dan durasi yang tepat disertai GDA <200 mg/dL disertai edukasi yang sesuai akan memberikan perbaikan klinis pada pasien KVV dengan diabetes melitus tipe 1 serta mencegah rekurensi.

Disregulasi IL-17, CD4 neutrofil, IL-10, PGE-2, iNOS, dan MMP-9 di jaringan kulit terhadap kerusakan saraf dermal pada pasien erythema nodusum leprosum I Gusti Nyoman Darmaputra; Cita Rosita Sigit Prakoeswa; Anang Endaryanto; IGAA Elis Indira; Nyoman Suryawati; Evy Ervianti; Linda Astari; Bagus Bagus
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Introduction: The mechanism of nerve damage in ENL patients is important to be revealed because the problem of nerve damage is not getting enough attention in handling ENL patients. Some pro-inflammatory mediators that have been studied are risk factors for nerve damage in ENL.Aim: This study aim in knowing the mechanism of nerve damage in the relation with its risk factors, which are CD64 neutrophil, IL-17, MMP-9, and iNOS with PGE-2 and IL-10 protective factor and IL-10 in ENL patients.Method: This is an analytic cross-sectional design study with tissue samples from 30 leprosy patients with ENL in Dr. Soetomo General Hospital Surabaya. Samples from biopsy examined using IHC method to evaluate S-100, IL-10, IL-17, PGE-2, iNOS, MMP-9, and CD64 neutrophil expressions. The result calculated within 20 view field with 1000 times magnification.Result: CD64 neutrophil (p=0.022, r=-0.417), IL-17 (p=0.001, r=-0.560), iNOS (p=0.005, r=-0.502) and MMP-9 (p=0.025, r=-0.409) has significant correlation with S-100. There is no significant correlation between IL-10 (p=0.061) and PGE-2 (p=0.407) with S-100.Conclusion: Expressions of IL-17, CD64 neutrophil, MMP-9, and iNOS in tissue correlate with nerve damage in ENL patients.

The Incidence Pattern of Electrical Burns at the Department of Plastic Surgery Dr. Soetomo General Academic Hospital, Surabaya, from January 2014 to December 2017 Merilyne Merilyne; David Sontani Perdanakusuma; Linda Astari
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 1 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I12023.26-29

Highlights:1. Electrical burns may progress even when the source has been removed.2. The most common age group to suffer from electrical burns was the 26–35 years old group.3. There was a significant association between electrical burns and the productive age of male employees who work in the private sector. AbstractIntroduction: Burns are direct or indirect damage to the skin tissue and can reach internal organs. This study aimed to investigate the incidence pattern of electrical burn patients at the Department of Plastic Surgery Dr. Soetomo General Academic Hospital, Surabaya, from 1 January 2014 to 31 December 2017, focusing on the age, gender, and occupation aspect of the patients.Methods: This was a descriptive retrospective study evaluating 50 patients treated for electrical burns from 1 January 2014 to 31 December 2017 using the patients’ medical records. The parameters assessed were age, gender, occupation, cause of injury, and annual incident. The data was collected from the medical records Dr. Soetomo General Academic Hospital, Surabaya.Results: Most electrical injuries occurred in May, as many as 12 (24%) patients. There were 49 (98%) male and 1 (2%) female patients. The patients ranged from 8–60 years old, with 17 (34%) patients in the 26-35 age group. 76% of patients were private employees. Work accidents caused approximately 82% of electrical injuries.Conclusion: There was a significant association between electric burns with males at productive age and working as private employees. Many electric accidents occurred while working, especially in May.

NORWEGIAN SCABIES IN AIDS PATIENT: A CASE REPORT Pratamasari, Meita Ardini; Agusni, Indropo; Prakoeswa, Cita Rosita Sigit; Astari, Linda; Sandhika, Willy
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 2 (2016)
Publisher : Institute of Topical Disease Universitas Airlangga

Scabies is a skin infection caused by Sarcoptes scabiei var. hominis. This disease may present severe clinical manifestations in immune-compromised patient, well-known as Norwegian scabies or crusted scabies.A 36-year old man with AIDS had chief complaint thick crust almost all over his body in this case. History of household member infected by scabies before was present. Clinical findings show hyperpigmented macules unsharply marginated, covered with thick scales and accompanied by papules, fissures, and erotion. T cell CD4 level was 12 cell/Î¼L. Scraping examination showed scabies infection and so did the histopathology examination. This patient was treated by topical Permethrin 5% combined with 2-4 ointment application in between permethrin usage. Before topical scabicide was given, thick crust was previously treated by topical urea 10% and wet dressing by normal saline. On day 14 after the patient first came there was lesion improvement.

Cutaneous Aspergilosis Caused by Aspergillus Flavus: A Case Report Sheilaadji, Maria Ulfa; Agusni, Indropo; Astari, Linda; Anggraeni, Sylvia; Widia, Yuri; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 1 (2021): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.1.2021.72-77

Background: Cutaneous aspergillosis occurs relatively less frequent and therefore remains poorly characterized. Cutaneous aspergillosis can be as primary or secondary infection. Primary cutaneous aspergillosis usually involves sites of skin injury, intravenous catheter, traumatic inoculation, and associated with occlusive dressings. Secondary lesions result from contiguous extension from infected underlying structures or from widespread blood-borne seeding of the skin. Purpose: To know the skin manifestation, efflorence, examination and therapy of cutaneous aspergillosis. Case: A man complaint itchy redness macule and pimples on the right arm since 2 weeks. Initially just felt a little then expands. Patients with post operative brachial injury and uses a cast during one month. On examination there are erythematous macule unsharply marginated with papules. Potassium hydroxide examination, shows conidiophores, dichotomously branching and septate hyphae appropriate description with Aspergillosis Sp. Cultures found grow granular colonies, flat often with radial grooves, yellow at first but quickly becoming bright to dark yellow-green with age, For the identification microscope from the culture specimen there was conidia, phialde, conidiophore and vesicle that suitable with Aspergillus flavus. Patients received itraconazole 2 x 200 mg for 6 weeks and obtained satisfactory results. Discussion: Healthy hosts can develop cutaneous aspergillosis in surgical wounds, by traumatic inoculation, at sites associated with occlusive dressings. In some instances, a presumptive diagnosis of primary cutaneous aspergillosis can be made immediately by examining a potassium hydroxide preparation and culture. Conclusion: Diagnose of cutaneous aspergillosis can establish by potassium hydroxide and culture examination, therapy with itraconazole 2x 200mg give satisfactory results.

A Case Report of Tinea Capitis in Children: Utility of Trichoscopy Harningtyas, Citra Dwi; Ervianti, Evy; Astari, Linda; Anggraeni, Sylvia; Yuri Widia
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.66-72

Background: Tinea capitis (TC) is the most prevalent pediatric superficial dermatophyte infection. Scalp dermoscopy or "trichoscopy” represents a valuable, noninvasive technique for the evaluation of patients with hair loss due to TC. Purpose: To characterize trichoscopic findings in children with clinical findings suggestive of TC. Case: A 13-year-old boy was presented with a scaled plaque on his scalp that had appeared 1 month earlier. A physical examination revealed a scaly, nonerythematous, rounded lesion in the parietal area of the head. Wood's lamp yielded a blue fluorescence. Microscopic morphology from fungal culture found the typical spindle-shaped macroconidia of Microsporum canis. Trichoscopy showed mainly comma hair, corkscrew hair, morse code hair, bent hair, and zig zag hair. The patient was started on oral griseofulvin 20 mg/kg/day and antifungal shampoo for 8 weeks. The patient was cured after two months of treatment and trichoscopy returned to normal. Discussion: Fungal culture remains the gold standard in TC diagnosis, but it needs time. Trichoscopy can be an additional tool to help evaluate the diagnosis, aetiology, and follow up of this disorder. The presence of characteristic trichoscopic features (comma hairs, corkscrew hairs, Morse code-like hairs, zigzag hairs, bent hairs, block hairs, and i-hairs) is predictive of TC. The present analysis confirmed that trichoscopy is a useful method in differentiating between Microsporum and Trichophyton TC, which is important from the perspective of a different therapeutic approach. Conclusion: Trichoscopy is not only of value in the diagnosis of TC but also for the etiologic agent and follow-up after treatment in this case.

Mucocutaneous Manifestations in HIV/AIDS Patients Hidayati, Afif Nurul; Harningtyas, Citra Dwi; Damayanti, Damayanti; Astari, Linda; Indramaya, Diah Mira; Listiawan, M. Yulianto; Utomo, Budi; Budiono, Budiono; Murtiastutik, Dwi; Widyantari, Septiana; Maylita Sari; Astindari, Astindari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.156-161

Background: The main target of human immunodeficiency virus (HIV) is cluster of differentiation 4 (CD4) T lymphocytes and several other immune cells that have CD4 receptors. They are also present in skin and mucosa, such as Langerhans cells (LC). Mucocutaneous lesions are one of the first clinical presentations of immunosuppression in HIV seropositive patients that manifest at different stages of the infection and require early diagnosis and prompt treatment. Purpose: To determine the clinical characteristics and the pattern of various mucocutaneous manifestations in Human immunodeficiency virus/Acquired immune deficiency syndrome (HIV/AIDS) patients at Intermediate Care and Infectious Diseases Dr. Soetomo General Academic Hospital Surabaya. Methods: This is a descriptive retrospective study with a cross-sectional design. The study subject was classified as all HIV-AIDS patients with mucocutaneous manifestations treated in Intermediate Care and Infectious Diseases Dr. Soetomo General Academic Hospital Surabaya in 2019. Result: Out of the 614 patients who participated in the study, 72.1% were males. The majority of patients were in the age group 25–49 years (75.4%). The most common risk factor was heterosexuality (41.7%). Based on the distribution of mucocutaneous manifestations, the most common mucocutaneous manifestation was candidiasis mucocutan 387 patients (49.4%) followed by the pruritic papular eruption (PPE) 118 patients (15.1%) and human papillomavirus infection 57 patients (7.3%). Conclusion: Mucocutaneous manifestations occur throughout the course of HIV infection, and they can be considered as good clinical indicators for the progression of the disease and underlying immune status in resource-poor settings.

Co-Authors Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Alarik L., Albertus Alimsardjono, Lindawati Alpha Fardah Athiyyah Alya Nuha Andini Amanda Gracia Manuputty Anang Endaryanto Anggraeni Noviandini Anggraeni, Sylvia Ardhiah Iswanda Putri Arifa Mustika Astindari Astindari Astindari Astindari, Astindari Aulia, Syifa Auliya, Arsya Axelia, Presstisa Gifta Bagus Bagus Bagus Haryo Kusumaputra, Bagus Haryo Bramantono Bramantono, Bramantono Brigita Ika Rosdiana Budi Prasetyo Budi Utomo Budi Utomo Budiono Budiono Chesia Christiani Liuwan Christina Avanti Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti David Sontani Perdanakusuma Densy Violina Harnanti Desiana Widityaning Sari Dewi Puspitorini Dhyah Aksarani Handamari Diah Mira Indramaya DINAR ADRIATY Dwi Murtiastutik Dwi Ratna Adisty Dwiyanti Puspitasari, Dwiyanti Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Evy Ervianti Fadila, Arisia Farhat Surya Ningrat Hadiwidjaja, Farsha Naufal Hari Sukanto, Hari Harningtyas, Citra Dwi Hartanto, Felix I Gusti Ayu Agung Elis Indira I Gusti Nyoman Darmaputra Indah Purnamasari Indiastuti, Danti Nur INDROPO AGUSNI Ingrid Suryanti Suryono Irmadita Citrashanty Irmadita Citrashanty, Irmadita Iskandar Zulkarnain Iskandar Zulkarnain ISWAHYUDI ISWAHYUDI Kathrin Kezia Henry Kinanti Prabawaningrum Kurniati Kurniati M. Yulianto Listiawan ManikRetno Wahyunitisari Mappamasing, Hasnikmah Maylita Sari Maylita Sari, Maylita Medhi Denisa Medhi Denisa Alinda, Medhi Denisa Meita Ardini Pratamasari, Meita Ardini Merilyne Merilyne Musofa Rusli Ngesti Kumalasari, Diah Noviannisa, Farah Ayu Nyoman Suryawati Pepy D. Endraswari Pepy Dwi Endraswari, Pepy Dwi Prakoeswa, Cita Rosita Priangga Adi Wiratama Puspowati, Erindah Putri Hendria Wardhani Putri, Melati Adinda Rahmadewi Rahmadewi Rahmadewi Rahmatari, Bandaru RATNA WAHYUNI Regitta Indira Agusni Renata Prameswari Retha Retha Ridha Ramadina Widiatma Riyana Noor Oktaviyanti Sawitri Sawitri Sawitri Selvia Yuliani Dwi Ratih Sanggarwati Sepling Paling Sheilaadji, Maria Ulfa Shinta Dewi Rahmadhani Soetojo SHINZO IZUMI Siti Kurniawati Sulaksanaswastho Suyoso Sunarso Suyoso Sunarso Suyoso Sunarso Suyoso Sunarto, Olivia Awwalin Susanto, Ester Chateline Tjokorde Istri Nyndia Vaniari Trisniartami Setyaningrum Vidyani Adiningtyas Widyantari, Septiana Willy Sandhika Yuri Widia, Yuri Yuri Widya Zahruddin Ahmad

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