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All Journal Journal of Food and Pharmaceutical Science VALENSI Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Dentika Dental Journal Pharmaciana: Jurnal Kefarmasian Paramita: Historical Studies Journal Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Acta Pharmaciae Indonesia : Acta Pharm Indo JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Majalah Farmasetika Pharmaceutical Sciences and Research (PSR) Jurnal Ilmiah Farmasi Simplisia Journal of Food and Pharmaceutical Sciences Jurnal Kefarmasian Indonesia
Akhmad Kharis Nugroho
Department Of Pharmaceutics, Faculty Of Pharmacy Universitas Gadjah Mada Sekip Utara Yogyakarta 55281, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Other

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Journal : VALENSI

 1 
Permeasi Transdermal Losartan In Vitro dari Larutan dengan Variasi Kadar Losartan dan Propilen Glikol Annas Binarjo; Akhmad Kharis Nugroho
Jurnal Kimia Valensi Jurnal Valensi Volume 4, No.1, Mei 2014
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.262 KB) | DOI: 10.15408/jkv.v4i1.1046

Abstract

Abstrak Losartan, senyawa antagonis reseptor angiotensin II, mempunyai bioavailabilitas oral 0.25-0.35.  Bioavailabilitas yang rendah ini dapat diatasi dengan penghantaran obat secara transdermal. Enhancer sering ditambahkan ke dalam formula sediaan transdermal, misalnya propilen glikol (PG).  Penelitian ini bertujuan mempelajari pengaruh kadar propilen glikol terhadap permeasi transdermal losartan pada kadar obat yang berbeda. Penelitian dilakukan secara in vitro dengan sel difusi tipe vertikal dilakukan terhadap empat formula yaitu 2% potasium losartan (k-los) :15% PG (F1), 10% k-los :15% PG (F2), 2% k-los :20% PG (F3), dan 10% k-los: 20% PG (F4) dengan dapar sitrat pH 5 sebagai mediumnya.  Kulit punggung tikus jantan galur wistar digunakan sebagai membran, PBS pH 7,4 sebagai medium kompartemen reseptor, dan HPLC untuk pengukuran kadar k-los dalam kompartemen reseptor dengan detektor UV. Hasil penelitian menunjukkan bahwa peningkatan kadar k-los dari 2% ke 10% pada kadar PG 15% meningkatkan fluks, sedangkan pada kadar 20% tidak berpengaruh terhadap fluks.  Peningkatan kadar PG dari 15% ke 20% justru menurunkan fluks pada kadar k-los 2%, dan tidak berpengaruh pada kadar k-los 10%.  Nilai lag time tidak berbeda diantara semua fomula. Hal ini berarti penggunaan enhancer PG lebih dari 15% justru merugikan permeasi transdermal. Kata Kunci : transdermal, losartan, propilen glikol, enhancer   Abstract Losartan is an angiotensin receptor antagonis which has low oral bioavailability (0.25-0.35).  Transdermal drug delivery system is needed as one solution for this low oral bioavailability drug.  Propilen glikol (PG), as enhancer, is frequently added in transdermal dosage form.  This research was purposed to explore the effect of PG as losartan permeation enhancer in various concentration of potasium losartan (k-los). The research was carried out in vitro using vertical tipe difusion cel for 4 formulas, i.e. 2% potasium losartan (k-los) :15% PG (F1), 10% k-los :15% PG (F2), 2% k-los :20% PG (F3), and 10% k-los: 20% PG (F4) using citric buffer pH 5 as donor medium, while PBS pH 7,4 was used as receptor medium.  The dorsal skin of white wistar male rat was used as membrane.  HPLC with UV detector was used to determine the concentration of k-los appear in receptor compartment. The results show that increasing of k-los concentration from 2% to 10% can increase the flux if PG concentration is 20%, but it does not have any significant effect to the flux if the PG concentration is 15%.  Increasing PG concentration from 15% to 20% decrease the flux permeation in k-los concentration of 2%, and does not have any significant effect in concentration of k-los of 10%.  The lag time permeation does not has any significant differencess.  It means that PG as enhancer in the concentration above 15% doesn’t have any adventages. Keywords : transdermal, losartan, propilen glycol, enhancer
Co-Authors Achmad Fudholi Achmad Fudholi Achmad Fudholi ACHMAD FUDHOLI Achmad Fudholi Achmad Fudholi Achmad Fudholi Agatha Budi Susiana Lestari Agung Endro Nugroho Agus Siswanto Agus Siswanto Agus Siswanto Agus Siswanto Ahmad Hamim Sadewa Amalia, Dita Annas Binardjo Annas Binarjo Annisa, Viviane Ardian Dewangga Arief Rahman Hakim Artemisia, Rahma Beti Pudyastuti BUDIPRATIWI WISUDYA NINGSIH Chandra Saputra Citrariana, Shesanthi Defilia Anograh Riani Diyah Fatmasari Eka Indra Setyawan Elisa Issusilaningtyas Endang Lukitaningsih Endang Lukitaningsih Endang Lukitaningsih Endang Lukitaningsih Eny Masruriati ERNA PRAWITA SETYOWATI Erna Prawita Setyowati Erna Prawita Setyowati Fajar Rakhmatullah Fransiska Lisa Anindya Putri Harsanti, Dian Dwi Harsanti, Dian Dwi Ika Dewi Ana Ika Puspitasari Isdwiani, Renita Isdwiani, Renita Iwan Dwi Prahasto Iwan Dwi Prahasto Lina Widyastuti Lucia Hendriati Lukman Hakim Lukman Hakim Lukman Hakim Lutfan Lazuardi Marchaban Marchaban Marchaban Marchaban, Marchaban Marlyn Dian Laksitorini Marlyn Dian Laksitorini, Marlyn Dian Martien, Ronny Muhammad Novrizal Abdi Sahid Murhayanti, Rika Mustofa Mustofa Nanda Dwi Akbar Nindya - Kusumorini Novi Hastuti NURI ARI EFIANA Nuri Ari Efiana Nuryanti Nuryanti Nuryanti Nuryanti Oktavia Eka Puspita, Oktavia Eka Oktavia Indrati, Oktavia Pawestri, Sekar Ayu Pinandi Sri Pudyani Purwantiningsih Purwantiningsih Purwantiningsih Puspa Dwi Pratiwi Respati, Anindita Kresna Respati, Anindita Kresna Rika Murhayanti Rima Yulia Senja, Rima Yulia Rohman, Abdul Ronny - Martien RONNY MARTIEN Ronny Martien Ronny Martien Ropiqa, Meri Rosyida, Niswati Fathmah Sekar Ayu Pawestri Sekar Ayu Pawestri Sisca Devi Sisca Devi Siti Fatmawati Fatimah, Siti Fatmawati Sudibyo Martono Sudibyo Martono Sudibyo Martono SUDIBYO MARTONO Sudibyo Martono Sudibyo Martono Sunarto Ang Supraptiyah, Cicilia Supraptiyah, Cicilia Suwaldi . SUWALDI SUWALDI Suwarto, Tiekha Kencanasari Suwarto, Tiekha Kencanasari Suwijiyo - Pramono Teguh Ariyanto Teuku Nanda Saifullah, Teuku Nanda W. Widjijono Yahya Febrianto Yosi Bayu Murti