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FORMULASI ORALLY DISINTERGRATING TABLET (ODT) EKSTRAK ETANOL DAUN KEMANGI (Ocimum americanum L.) DENGAN VARIASI KONSENTRASI EXPLOTAB® Yulistia Budianti Soemarie; Hayatus Sa'adah; Tri Marginingsih
Jurnal Ilmiah Manuntung Vol 4 No 1 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i1.142

Abstract

Bad breath is usually caused by bacteria and leftovers in the mouth. Utilization of natural ingredients that can be used to overcome the problem of bad breath one of them by using basil leaves (Ocimum americanum L.), which has activity as an antibacterial. The development of the preparations was done on basil leaves to overcome bad breath is by formulating the basil leaves ethanol extract into the Orally Disintegrating Tablet (ODT) preparation. The purpose of this study was to investigate the effect of explotab® concentration variations on the physical properties of ODT and to determine the best of concentrations of Explotab® that fulfill the physical properties of ODT. The type of research conducted was an experimental study. Research object was basil leaves ethanol extract formulated into ODT with Explotab® 2% w/b, 4% w/w, 6% w/b and 8% w/w variation. Physical evaluations test then conducted including : the uniformity of weight evaluation, the hardness test, the friability test, and the dissolved time. The results showed that the explotab® concentration variations had an effect on the physical properties of tablets and the formula with the Explotab® 8% b/b concentration was the best formula that could produce the best ODT tablet with physical properties. Keywords : Basil leaves (Ocimum americanum L.), Explotab®, Orally Disintegrating Tablet (ODT)
UJI AKTIVITAS ANTIOKSIDAN RUMPUT JUKUT PENDUL (Kyllinga nemoralis) Nabila, Regina Syifa; Soemarie, Yulistia Budianti; Ramadhani, Juwita
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1267

Abstract

Antioxidants are compounds that play an important role in preventing the impact of free radicals that cause various degenerative diseases. Synthesized antioxidants have carcinogenic properties over a long period of time, hence the need for natural sources of antioxidants that have fewer side effects. Jukut pendul grass (Kyllinga nemoralis) is one of the wild plants that has potential as a natural antioxidant. This study aims to compare the antioxidant activity of ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction of jukut pendul grass (Kyllinga nemoralis). The steps of this research were samples of jukut pendul grass (Kyllinga nemoralis) obtained from Kota Baru, South Kalimantan in maceration with 70% ethanol then fractionated using 3 solvents of different polarity. Antioxidant activity testing was performed with a Uv-Vis spectrophotometer using the DPPH method at a wavelength of 515 nm. The results showed that the IC50 value of ethanol extract was 79,842 + 14,275 µg/mL, n-hexane fraction 95,632 + 8,152 µg/mL, ethyl acetate fraction 42,616 + 1,972 µg/mL and water fraction 67,384 + 11,678 µg/mL. Based on the IC50 value, jukut pendul grass (Kyllinga nemoralis) has antioxidant activity with the highest activity in the ethyl acetate fraction.
Rasionalitas Penggunaan Obat Pada Pasien Diabetes Melitus Tipe II Di Puskesmas Kota Martapura Tahun 2023 Normila, Normila; Soemarie, Yulistia Budianti; Ramadhani, Juwita
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32341

Abstract

Diabetes melitus tipe 2 dikatakan sebagai gangguan metabolisme yang umum di dunia, penyakit ini disebabkan oleh rusaknya sekresi insulin oleh sel ẞ pankreas serta ketidakmampuan jaringan tubuh dalam merespon insulin. Tujuan studi ini agar mengetahui rasionalitas pengobatan diabetes melitus tipe 2 pada pasien di Puskesmas  Kota Martapura di Kabupaten Banjar tahun 2023.  Metode yang dimanfaatkan agar studi ini ialah non-eksperimental observasional bersama rancangan studi deskriptif serta pengambilan data secara retrospektif. Sampel penelitian sebanyak 173 dengan menggunakan rekam medis pasien diabetes melitus tipe 2 yang dianalisis kesesuaiannya dengan standar PERKENI 2019 penelitian ini juga menggunakan probability sampling dalam pengambilan sampel.  Hasil penelitian berdasarkan demografi pasien pada jenis kelamin yang paling banyak ialah perempuan, sebanyak 64%, pekerjaan pasien terdapat Ibu rumah tangga 29%, paling tinggi dan rentang umur pasien ditemui 47,89% pada rentang 56-65 tahun. Jumlah penyakit penyerta pasien yang banyak ditemui DM Tipe 2 dengan  Hipertensi 46%.  Hasil evaluasi rasionalitas  ditemukan di Puskesmas Kota Martapura memiliki tepat indikasi (99%) serta  tidak tepat (1%), tepat pasien 100%, tepat obat 100%. Tepat dosis 100%,  cara pemberian obat  sebesar 100%, tepat interval waktu pemberian  98 % tidak tepat 2%, tepat lama pemberian obat sebesar 100% tepat.  
STANDARISASI DAN UJI AKTIVITAS ANTIOKSIDAN FRAKSI AIR DAUN MURBEI (Morus alba L.) DENGAN METODE DPPH Maulida, Rizqi Noor; Soemarie, Yulistia Budianti; Fauzi, Muhammad
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol 7 No 1 (2025)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/jkikt.v7i1.236

Abstract

Excessive exposure to sunlight can lead to various skin health issues, including premature aging, as the skin serves as the body’s primary external protector. Mulberry leaves (Morus alba L.) are recognized for their content of anthocyanins and phenolic compounds, which act as antioxidant agents. This study aimed to evaluate the antioxidant effectiveness of the water fraction extracted from mulberry leaves. The research process involved collecting samples, followed by remaceration with 70% ethanol, standardization tests, and fractionation through a liquid-liquid method using n-hexane, ethyl acetate, and distilled water. The water fraction yield obtained was 6.23g. In the specific standardization tests, all parameters met the required standards; however, in the non-specific tests, the ash content exceeded the requirements, registering 10.5% above the acceptable threshold of less than 42%. Antioxidant activity was assessed using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method, with quercetin as a reference. Measurement via a UV-Vis spectrophotometer revealed an IC50 value of 25.020 ± 0.223 μg/mL for the mulberry leaf water fraction, compared to an IC50 of 0.012 ± 0.009 μg/mL for quercetin, indicating that the water fraction exhibits lower antioxidant potency.
Karakteristik dan Uji Aktivitas Antiosidan Ekstrak Kolagen Sisik Ikan Gabus (Channa sp.) Su'aida, Nily; Ridha, ainur; Soemarie, Yulistia Budianti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 2 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i2.652

Abstract

This study aims to isolate collagen from the scales of snakehead fish (Channa sp.) and evaluate the antioxidant activity of the extracted collagen. Collagen was isolated using a 0.5 M acetic acid method, involving dissolution and purification procedures. The collagen extract was characterized using FTIR analysis to detect functional groups and phytochemical tests to identify active compounds. Antioxidant activity was assessed using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method to measure free radical scavenging potential. The results indicated that the collagen extract from snakehead fish scales contains bioactive compounds with significant antioxidant activity. The IC₅₀ values demonstrated a strong ability to neutralize free radicals, showing higher potency than the control. FTIR analysis detected hydroxyl (3330.21 cm⁻¹), methyl (2111.83 cm⁻¹), and carbonyl (1635.85 cm⁻¹) groups as characteristic phytochemical components of Channa sp. collagen extract. The IC₅₀ values at different concentrations were classified as very strong at low concentrations (25%), strong at moderate concentrations (50%), and moderate at higher concentrations (75%). The antioxidant activity of snakehead fish scale extract was very strong at lower concentrations but decreased as the concentration increased
Uji Aktivitas Antioksidan Dari Kulit Buah Naga Merah (Hylocereus Polyrhizus) Siti Puspitasari; Yulistia Budianti Soemarie; Aris Fadillah
Journal Scientific of Mandalika (JSM) e-ISSN 2745-5955 | p-ISSN 2809-0543 Vol. 6 No. 4 (2025)
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/10.36312/vol6iss4pp1061-1072

Abstract

Antioxidants are substances or compounds that have the ability to slow or delay, or even prevent, free radical reactions. Red dragon fruit skin has benefits as a source of antioxidants. This study aims to determine the antioxidant activity of ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction of red dragon fruit peel. The sample used in this research was the skin of red dragon fruit (Hylocereus polyrhizus) which was macerated with 70% ethanol and then fractionated using different solvents. Antioxidant activity testing was carried out using the DPPH method. The research results were shown by the IC50 value of the ethanol extract of 78.674 ± 19.618 µg/ml, the n-hexane fraction 129.942 ± 12.291 µg/ml, the ethyl acetate fraction 64.681 ± 19.820 µg/ml and the water fraction 73.038 ± 4.077 µg/ml. Based on the IC50 value obtained, the ethyl acetate fraction of red dragon fruit peel (Hylocereus polyrhizus) has the highest antioxidant activity.
Sosialisasi Penggunaan Antibiotik Yang Rasional Pada Pengunjung MTQ Kalsel 2023 Hasniah, Hasniah; Su’aida, Nily; Soemarie, Yulistia Budianti; Erlianti, Karina
Jurnal Pengabdian Kepada Masyarakat Kalam Vol. 3 No. 3 (2024): Pemberdayaan Potensi Masyarakat Untuk Peningkatan Kemampuan Hidup Sehat
Publisher : Prisani Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70704/jpk.v3i3.296

Abstract

Infectious diseases are one of the many health problems that occur in society, especially in Indonesia. The drugs commonly prescribed by doctors for the general public to overcome this problem are antibiotics. Antibiotics are drugs used by health to inhibit, kill or treat bacterial infections. However, the use of antibiotics is often misused, such as using antibiotics without a doctor's prescription, not finishing antibiotics, not using according to dosage, to treatment that should not require antibiotics. This poses a risk of antibiotic resistance. One of the factors causing this is the lack of education to the public regarding the use of drugs, especially antibiotics. The target of this activity is the people of South Kalimantan, precisely to the visitors of MTQ South Kalimantan 2023 where not a few of these people understand the use of antibiotics. This activity was carried out with the hope of educating the public about the use of good and correct antibiotics so as to prevent the development of antibiotic resistance. Based on the results of these activities, the people of South Kalimantan, namely visitors to MTQ South Kalimantan 2023, have received information on how to use antibiotics properly, correctly and rationally.
RASIONALITAS PENGGUNAAN ANTIBIOTIK PADA PASIEN DIABETES MELITUS DENGAN ULKUS DIABETIKUM DI BANJARMASIN, KALIMANTAN SELATAN, INDONESIA Annida Mujahidah Nurul Azmi; Yulistia Budianti Soemarie; Juwita Ramadhani
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 11 No. 1 (2025): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v11i1.901

Abstract

otential to cause serious complications. Antibiotic therapy is one of the treatment options for patients with diabetic ulcers. Overuse of antibiotics can lead to resistance, which can make therapy less successful. This study aims to determine the percentage of rational antibiotic use and its effect on therapy outcomes in diabetic ulcer patients. This study aims to identify the percentage of rational antibiotic use and its effect on therapeutic outcomes in diabetic ulcer patients in Banjarmasin Hospital. This study was an observational study with a cross-sectional method and data collection in this study was carried out retrospectively during the period July-December 2023. The rationality of antibiotic use was evaluated using the Gyssens method and the correlation of rationality with therapeutic outcomes was analyzed using the chi square test. The study subjects were 94 patients with diabetic ulcers who met the inclusion criteria. The rationality of antibiotic use with the Gyssens category was in category 0 (appropriate) for 65 patients (69%), category IIb (inappropriate interval) for 3 patients (3%), category IIIa (too short) for 10 patients (11%), category IIIb (too long) for 6 patients (6%), category IVa (more effective) for 3 patients (3%), and category IVc (cheaper alternative) for 7 patients (7%). The results of the Chi-Square Test state that there is a significant correlation between the rationality of antibiotic use and therapeutic outcomes in the form of a decrease in the degree of diabetic ulcers. 69% of patients received rational antibiotic therapy and 31% received irrational therapy based on the Gyssens method and there was a correlation between the rationality of antibiotic use and therapeutic outcomes in the form of a decrease in the degree of diabetic ulcers.
HUBUNGAN WAKTU TUNGGU PELAYANAN RESEP TERHADAP KEPUASAN PASIEN DI APOTEK MITRA SEHAT BANJARBARU Jannah, Mursidatul; Soemarie, Yulistia Budianti; Hasniah, Hasniah
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol 7 No 2 (2025)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/jkikt.v7i2.187

Abstract

Waktu tunggu dalam pelayanan resep merupakan indikator penting yang mencerminkan tingkat efisiensi dan efektivitas kinerja petugas farmasi dalam memproses, menyiapkan, serta menyerahkan obat kepada pasien. Semakin cepat dan tepat proses pelayanan dilakukan, maka semakin menunjukkan bahwa alur kerja dan koordinasi dalam unit pelayanan farmasi berjalan optimal. Penelitian ini bertujuan untuk mengetahui hubungan waktu tunggu dengan kepuasan pasien untuk pelayanan resep di Apotek Mitra Sehat Banjarbaru Periode 15 Oktober – 15 November 2024. Penelitian ini dilakukan dengan metode kuantitatif melalui rancangan studi cross-sectional. Intrumen digunakan berupa kuesioner yang di adopsi dari skala Likert dengan dimensi SERVQUAL, kuesioner disebarkan kepada responden yang menerima layanan resep di apotek Mitra Sehat Banjarbaru periode Oktober - November 2024. Berdasarkan hasil penelitian waktu tunggu pelayanan resep adalah 75,2% sesuai dengan standart yang diharapkan, dan 24,8% tidak sesuai. Kepuasan responden 59,4% Kepuasan sedang, 29,7% sangat puas dan 10,9% kurang puas. Hasil uji statistik SPSS menunjukan bahwa ada hubungan waktu tunggu dengan kepuasan responden (p < 0,05).
Edukasi dan Demonstrasi Pembuatan Sediaan Infusa Jahe dan Kayu manis Sebagai Analgetik Dismenore Pada Siswi SMPN 21 Banjarmasin Muliyani; Soemarie, Yulistia Budianti; Erliani, Karina; Falya, Yuniarti
Jurnal Mandala Pengabdian Masyarakat Vol. 6 No. 2 (2025): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v6i2.692

Abstract

Pengabdian kepada masyarakat dilaksanakan di SMP Negeri 21 Banjarmasin adalah salah satu sekolah menengah negeri yang terdapat di Kecamatan Banjarmasin Selatan. Sasaran pada pengabdian adalah usia remaja 12-17 tahun, dimana usia ini adalah usia remaja pendidikan menengah pertama. Permasalahan yang sering terjadi pada remaja putri yaitu nyeri haid atau dismenore sering terjadi pada usia remaja, terutama pada remaja putri yang baru mulai haid. Pengabdian kepada Masyarakat ini bertujuan memberikan solusi dengan memberikan workshop pembuatan infusa jahe dan kayu manis sebagai alternatif anti nyeri metodepembuatan yang sederhana serta bahan dasar yang mudah didapat dan tidak mahal sehingga sangat baik diberikan kepada anak remaja. Metode yangdigunakan pada kegiatan ini yaitu ceramah, diskusi serta praktek pembuatan Infusa Jahe dan Kayu Manis. Usia Responden yang mengikuti kegiatan ini sebanyak 30 siswi dari usia 12 tahun hingga 14 tahun. Usia menstruasi anak remaja paling banyak dimulai dari usia 12 tahun (56,7%) dan usia 13 tahun (26,7%) yaitu rentang early menarche . Adapun hasil pre test dan post test responden menunjukkan adanya peningkatan skor dari nilai rata-rata 48 pada pre test dan nilai rata-rata 81.33 pada saat post test.