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All Journal Althea Medical Journal Global Medical and Health Communication Majalah Kedokteran Majalah Obstetri dan Ginekologi Journal of Medicine and Health Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Teknologi Sistem Informasi dan Aplikasi Jurnal Teknologi Informatika dan Komputer Jurnal Mekanik Terapan MEDICINUS Journal of Medicine and Health
Adhi Pribadi
Department Of Obstetric And Gynecology, Faculty Of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Electrical & Electronics Engineering Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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Placental micro- and nanoplastic contamination: A systematic review of eco-exposome pathways to preterm birth and neonatal outcomes Sanjaya, I Nyoman Hariyasa; Andonotopo, Wiku; Bachnas, Muhammad Adrianes; Dewantiningrum, Julian; Pramono, Mochammad Besari Adi; Mulyana, Ryan Saktika; Pangkahila, Evert Solomon; Akbar, Muhammad Ilham Aldika; Yeni, Cut Meurah; Aldiansyah, Dudy; Bernolian, Nuswil; Wiradnyana, Anak Agung Gede Putra; Pribadi, Adhi; Sulistyowati, Sri; Stanojevic, Milan; Kurjak, Asim
Majalah Obstetri & Ginekologi Vol. 34 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V34I12026.70-83

Abstract

HIGHLIGHTS First comprehensive synthesis of human and mechanistic evidence linking placental micro- and nanoplastic (MNP) contamination to preterm birth and neonatal outcomes. Quantitative human studies demonstrate higher placental MNP burdens in preterm versus term pregnancies. Molecular pathways identified include oxidative stress, ferroptosis-driven syncytiotrophoblast senescence, trophoblast invasion impairment, inflammatory signaling, endocrine disruption, and epigenetic modifications. Clinical and policy relevance: Findings support the need for standardized biomonitoring, maternal exposure mitigation, and the integration of eco-exposome considerations into perinatal care.   ABSTRACT Objective: To systematically review emerging evidence on micro- and nanoplastic (MNP) contamination of the human placenta, explore molecular pathways underlying placental dysfunction, and evaluate associations with preterm birth and neonatal outcomes. Materials and Methods: Following PRISMA 2020 guidelines, literature searches (in PubMed, Web of Science, and Scopus) and grey sources were conducted through July 2025. Inclusion criteria comprised studies detecting MNPs in the human placenta or fetal compartments, mechanistic experiments using human placental models, or reviews addressing pregnancy outcomes. Methodological quality was assessed using AMSTAR-2, ROBIS, or the Newcastle–Ottawa Scale. Data were synthesized into three evidence domains: human biomonitoring, molecular pathways, and clinical implications. Results: Twenty studies met the inclusion criteria. MNPs were consistently detected in the human placenta, amniotic fluid, cord blood, and meconium, with higher burdens in preterm versus term placentae. Mechanistic studies demonstrated oxidative stress, ferroptosis-mediated syncytiotrophoblast senescence, impaired trophoblast invasion, inflammatory responses (IL-6, TNF-a, NLRP3 activation), endocrine disruption (altered ß-hCG and progesterone signaling), and epigenetic modifications. These pathways converge to impair nutrient and oxygen exchange and immune tolerance, increasing the risks of preterm birth, fetal growth restriction, low birth weight, and neonatal respiratory and metabolic vulnerability. Conclusion: Micro- and nanoplastic contamination of the human placenta is increasingly documented and biologically plausible as a contributor to preterm birth and neonatal morbidity. These findings support urgent investigation of exposure mitigation, standardized biomonitoring, and the integration of eco-exposome risks into perinatal clinical practice and policy.
Pregnancy Outcomes in Women Aged 20–34 vs. ?35 Years: A Cross-Sectional Study in a Tertiary Referral Center Syahputra, Farsyah Septrial Hendra; Pribadi, Adhi; Hidayat, Dini; Achmad, Eppy Darmadi; Kurniadi, Andi
Indonesian Journal of Obstetrics and Gynecology Volume 14. No. 1 January 2026
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v14i1.2460

Abstract

Objective: This study aims to compare pregnancy outcomes between mothers under and over 35 years of age at Dr. Hasan Sadikin General Hospital. Methods: An observational analytic approach with a cross-sectional design was used. Data from the medical records of 150 patients at Dr. Hasan Sadikin General Hospital in 2022 were analyzed. Patients were divided into two groups: ages 20-34 and greater than or equal to 35. Data analysis was performed using SPSS version 27.0. Results: Advanced maternal age was significantly associated with mode of delivery [OR 2.16, 95% CI (1.08-4.28), p=0.048], hypertensive disorders of pregnancy [OR 3.99, 95% CI (1.86-8.38), p<0.001], and postpartum hemorrhage [OR 2.93, 95% CI (0.99-8.79), p=0.044]. Conclusion: This study affirmed that advanced maternal age is associated with adverse maternal outcomes, namely hypertensive disorders of pregnancy and postpartum hemorrhage. Moreover, compared to mothers aged 20-34, advanced maternal age is linked with higher rates of cesarean deliveries and forceps deliveries.   Keywords: Advanced maternal age pregnancy, Adverse maternal outcomes, Neonatal outcomes, Peak reproductive years, Complications of pregnancy
Co-Authors AA Sudharmawan, AA Achmad Fauzan, Achmad Adisti Erlina Sutomo Adisti Erlina Sutomo, Adisti Erlina Akhmad Yogi Pramatirta, Akhmad Yogi Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Alifa, Dhara Aloysius Suryawan Amillia Siddiq Anak Agung Ngurah Jaya Kusuma Andanaputra, Waskita Ekamaheswara Kasumba Andi Kurniadi, Andi Andi Rinaldi Andonotopo, Wiku Andri Reza Rahmadi Anita Deborah Anwar Aqilah, Nurjihan Syarifah Arnova Reswari ASTRI ASTUTI Aziz, Muhammad Alamsyah Bachnas, Muhammad Adrianes Budi Handono Cool, Charlotte Johanna Cut Meurah Yeni Dany Hilmanto Darmawan, Ernawati Dewi, Sawitri Dharma, Wibisana Andika Krista Dida Akhmad Gurnida Djanas, Dovy Dodi Suardi Efendi Lukas Elsa Pudji Setiawati Eppy Darmadi Achmad Eric Edwin Yuliantara Evert Solomon Pangkahila Evicenna Naftuchah Riani Firmansyah, Silva Elifa Hadyana Sukandar Hanom Husni Syam Harry Kurniawan Gondo Herry Herman Hidayat, Dini I Nyoman Hariyasa Sanjaya Ismayadi, Tedi Jeffry Iman Gurnadi, Jeffry Iman Johanes C. Mose Julian Dewantiningrum Khanisyah Erza Gumilar Kurjak, Asim Laniyati Hamijoyo, Laniyati Luthfi Rahman, Luthfi Megantoro, Izzati Faustina Melsa Sagita Imaniar Miftah Pramudyo Muhammad Alif Nugraha, Laksmana Adi Krista Nugrahani, Annisa Dewi Nuswil Bernolian Pramono, Mochammad Besari Adi Pratiwi, Erlina Lutfiayu Putra, Ridwan Abdullah Rachmawati, Anita Ritonga, Mulyanusa Ritonga, Mulyanusa Amarullah Riva, Salma Nisrina Ruswana Anwar Ryan Saktika Mulyana Setyorini Irianti Solly Aryza Sri Sulistyowati Stanojevic, Milan Sulaiman, Aina Zakia Suri, Mulhamatus Latifatus Susiarno, Hadi Syahdony, Farrel Nolan Syahputra, Farsyah Septrial Hendra Trully D. Sitorus Trully D. Sitorus Utami, Hasri Larasati Wilis Dwi Pangesti Windi Nurdiawan Wiradnyana, Anak Agung Gede Putra WISNU PRABOWO Yordian, Kendry Savira