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All Journal Jurnal Perikanan dan Kelautan Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Journal of Midwifery and Nursing JKPK (Jurnal Kimia dan Pendidikan Kimia) Journal of Food and Culinary Jurnal Pengabdian Kepada Masyarakat (Mediteg) Jurnal Ilmiah Tindalung Jurnal Ilmiah Tatengkorang Jurnal Ilmiah Sesebanua Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) JURNAL PERIKANAN TROPIS Oxygenius Journal Of Chemistry Education PELAGICUS: Jurnal IPTEK Terapan Perikanan dan Kelautan Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Empathy Pengabdian Kepada Masyarakat Sciening : Science Learning Journal Jurnal Pengabdian Kepada Masyarakat Society: Jurnal Pengabdian Masyarakat Jurnal Sains dan Teknologi Abdimas Indonesian Journal JURNAL PENGABDIAN PENDIDIKAN MASYARAKAT (JPPM) Jurnal Ilmiah Pengabdian Kepada Masyarakat Innovative: Journal Of Social Science Research Jurnal Penelitian Chanos Chanos Amal Ilmiah: Jurnal Pengabdian Kepada Masyarakat Jurnal Penelitian dan Pengabdian Masyarakat JUKEJ: Jurnal Kesehatan Jompa Jurnal Pengabdian Sosial
Yana Sambeka
Program Studi Pengolahan Dan Penyimpanan Hasil Perikanan, Jurusan Teknologi Perikanan Dan Kebaharian, Politeknik Negeri Nusa Utara
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GC-MS and ADMET Profiling of Bruguiera gymnorrhiza Mangrove Leaf Extract Origin Sulawesi with Antioxidant Properties Tanod, Wendy Alexander; Dewanto, Didit Kustantio; Cahyono, Eko; Rieuwpassa, Frets Jonas; Ansar, Novalina Maya Sari; Sambeka, Yana; Ijong, Frans Gruber; Mandeno, Jefri Anthonius; Pumpente, Obyn Imhart; Triyastuti, Meilya Suzan
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 10, No 1 (2025): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v10i1.100362

Abstract

Mangrove plants, particularly Bruguiera gymnorrhiza, are recognized as sources of bioactive compounds. This study analyzed the chemical profiles, safety, and antioxidant activity of B. gymnorrhiza leaf extract origin Sulawesi, a biodiversity-rich Wallacean region. Research on B. gymnorrhiza leaves from Sulawesi remains scarce. GC-MS analysis identified inositol, fatty acid, ester, and terpenoid derivatives as major chemical profiles related to stress tolerance and remedial properties. ADMET predictions showed good intestinal absorption but suggested potential hepatotoxicity at high doses. Brine shrimp lethality tests revealed low acute toxicity with an LD₅₀ of 873.381 µg/mL, supporting in silico findings. The extract exhibited strong antioxidant activity (IC₅₀ 49.78 µg/mL), comparable to Vitamin E, and higher than reports from other regions. These results indicate that Sulawesi mangroves store valuable chemical compounds and serve as environmental health indicators. Combining chemical profiling, computational prediction, and experimental validation highlights their pharmaceutical potential while emphasizing the need for careful dose optimization and ecological monitoring. This study reinforces the importance of conserving Wallacean biodiversity and offers a foundation for safe, natural antioxidant commercialization. Future work should assess in vivo effectiveness, long-term toxicity, and the ecological impacts of pollutant immobilization in mangrove ecosystems.
Co-Authors AA Sudharmawan, AA Agneta Sartika Lalombo Aisyiah Restutiningsih Putri Utami Anggraini Barlian Aprelia Martina Tomasoa, Aprelia Martina Arie Wibowo Ashara Insavila Achmad Astri Juwita Mahihody Astri Juwita Mahihody Balansa, Walter Biahimo, Syahputra Bilqis, Dewi Shofya Cahyono, Eko Chaleb Paul Maanari Chatrina Maria Agustina Bajak Dekrist Kapai Destu Ayu Hapsari Destu Ayu Hasari Devi Nandita Choesin, Devi Nandita Dewanto, Didit Kustantio Dewanto, Didit Kustantio EKO CAHYONO Eko Cahyono, Eko Ely John Karimela Fachry Abda El Rahman Fitria Fresty Lungari Frans Gruber Ijong Frets Jonas Rieuwpassa Gaiska Faradila Patras Gansalangi Ferdinand Gansalangi, Ferdinand Gracia Christy Tooy Hardin F. Rares Hardin F. Rares Haryanti Putri Rizal Hinonaung, Jelita Siska Herlina If'all, If'all Ishak Bawias Jaka Frianto Putra Palawe Jakub Saddam Akbar Janis, Ronaldo Ferdinan Jeanne M. Tuerah Jelita Siska Herlina Hinonaung Julius Frans Wuaten Kasaluhe, Meityn Kendek, Tasya Jenifel Kundiman, Gita Artika Putri Lawendatu, Angryani Enjel Lawendatu, Angryani Enjela Maalua, Sheyla Mahihody, Astri Mahihody, Astri Juwita Makisake, Nadia Arlina Maliode, Yunita Isabela Mandalika, Ervina Dian Mandeno, Jefri Anthonius Mandiangan, Meyrijean Marlina Karundeng Marlina Ummas Genisa Maryati Agustina Tatangindatu Meili Yanti Meilya Suzan Triyastuti, Meilya Suzan Meityn Disye Kasaluhe Meityn Kasaluhe Melongkade, Regina Juliana Miftahul Jannah Miftahul Jannah Mustapa Mustapa Novalina Maya Sari Ansar Nursatya, Safira Meidina Nyctagina Mandahari Obyn Imhart Pumpente Paat, Vlagia Indira Patras, Mareike Doherty Pramardika, Dhito Dwi Rieuwpassa, Frets Sahdan Patras Siegfried Berhimpon Somba, Vira Valentine Stefan Marco Rumengan Takasihaeng, Septania Tampi, Regina Romalya Meilan Tengkue, Fiorenza Puspa Indah Tengkue, Florenza Puspa Indah Tinungki, Maria Notosori Tuerah, Jeanne Maria Umboh, Melanthon Junaedi Varisky Abraham Dumanaw Walter Balansa Wendy Alexander Tanod Wibowo, Indra Wilce Anna Cahya Kuendo Wodi, Stevy Imelda Murniati Wuaten, Grace Angel Yuliana Varala Tatontos