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Listyani, Tiara Ajeng
Universitas Duta Bangsa Surakarta
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Journal : Jurnal Buana Farma

 1 
FORMULASI DAN EVALUASI GEL EKSTRAK DAUN TAHI BELALANG PADA LUKA BAKAR KELINCI Lende, Yulianus Erman; Hidayat, Rahmat; Listyani, Tiara Ajeng
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1519

Abstract

Burn wounds are a common health issue that requires effective management. This study explores the potential of tahi belalang leaf extract (Chromolaena odorata L.) as a healing agent for burn wounds, with bioactive compounds such as flavonoids, saponins, tannins, and alkaloids that possess anti-inflammatory, antioxidant, and anti-allergic properties. The main objective is to formulate and evaluate the gel preparation of tahi belalang leaf extract as an alternative topical treatment. The research method involves plant determination, preparation, standardization of simplicia, extraction, and phytochemical screening to identify active compounds. Subsequently, gel formulations were created with varying concentrations of extract (5%, 10%, 15%) and the physical quality of the preparations was evaluated (organoleptic, homogeneity, pH, viscosity, spreadability, adhesion, irritation, and hedonic). The effectiveness of burn wound healing was tested in vivo on male rabbits, comparing the gel formula with a negative control (gel base) and a positive control (Bioplacenton®), with daily wound diameter measurements and statistical analysis using SPSS. The results showed that the gel containing 15% tahi belalang leaf extract (F3) was the most effective formulation in accelerating the healing of second-degree burn wounds in male rabbits. The presence of flavonoids, alkaloids, tannins, and saponins contributed anti-inflammatory, antioxidant, and antibacterial effects that supported tissue regeneration. Based on the ANOVA significance value of 0.028, there was a statistically significant difference among the treatment groups of the formulations.
Co-Authors Achsantya, Raden Roro Karyna Cindy Addawiyyah, Muniroh Agung Eru Wibowo Aini, Riszki Nur Aisyah Rabitha Alisi Akhmad, Khabib Alia Anna Fitriawati Aprilia Rika Alvita Apriliawan, Hidayah Aqila Widya Sari Ariyanti Ariyanti Artini, Kusumaningtyas Siwi Azizah, Dinar Bagas Ardiyantoro Chyang, Pang Jyh Danang Raharjo Deniessa, Ardelea Desy Ayu Irma Permatasari Dwi Bagus Pambudi Ekarani, Meisyah Litang Endang Suciati Fadila, Vera Nurhidayatul Fazlin Fauzi Ferdian, Erick Fitrohrezky Akbar Maulana Galuh Puspitasari Guterres, Agostinha Hafalika, Aviv Ifalahma, Darah Ika Dwi Ningrum Kharisma, Putri Nur Khilda Hilyatul 'Ulya Krisnantari, Ni Luh Novelia Kusumaningtyas Siwi Artini Kusumasedya, Willyana Pratiwi Lende, Yulianus Erman Lisa Amalia Luthfiyanti, Niken Masruroh, Sururul Kamalin Mutiara Marzalina Wardhani Nabillah Sirli Okta Maharani Natanael, Yosua Christabel Niken Luthfiyanti ningsih, endang wahyu Nugraha, Novanda Satria Nur Azmi, Tasya Nabila Nursalim, Effendi Oktaviana, Aptika Pamungkas, Rezky Ardika Pratama, Kharisma Jayak Puguh Ika Listyorini Puspitasari, Rara Ayu Rafidah Hanifah Rahardian Ariana Putri Rahmasari, Ikrima Rahmat Hidayat Ramadhani, Diza Aulia Ratna Safitri Rohmana, Vivin Marwiyati Sari, Cantyka Eka Viemala Sejati, Siti Laila Utari Septian Maulid Wicahyo Septiarini, Anita Dwi Silvia Devi Silvia Mawardani Siregar, sherina Sarifitri Siwi Artini, Kusumaningtyas Susilowati, Ucik Suwardi, Nisa Aura Rizky Tanoyo, William Tatiana Siska Wardani Tatiana, Siska Wardani Urip, Sri Khanti Veranita, Weri Wahdah Sri Rahayu Wahyu Budi Utomo Wardani, Tatiana Siska Wargani, Rizki Nugraha Yoga Pratama Yuliana, Ana Yuliana, Silvia Zanjabila, Chanida Zavitra, Mei Nanda