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All Journal HAYATI Journal of Biosciences Jurnal Gizi dan Pangan ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner Majalah Kedokteran Bandung Indonesian Journal of Biotechnology Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) ARSHI Veterinary Letters Jurnal Ilmu dan Teknologi Kayu Tropis Jurnal Kedokteran Hewan Jurnal Veteriner dan Biomedis Current Biomedicine Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Subangkit, Mawar
Sekolah Kedokteran Hewan Dan Biomedis, Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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ACUTE TOXICITY TEST OF ETHANOLIC EXTRACT OF Acalypha hispida LEAVES IN FEMALE RATS: A PHYSIOLOGICAL AND HISTOLOGICAL STUDY Alfarisi, Hamzah; Subangkit, Mawar; Sadiah, Siti; Wresdiyati, Tutik
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v14i3.16176

Abstract

This research aims to evaluate the safety of ethanolic extract of Acalypha hispida (A. hispida) leaves with acute toxicity test using 15 female rats strain Sprague-Dawley. A single dose of different doses of extract (2, 4, 8, and 16 g/kg body weight) was administrated orally, and theobservation was conducted for 14 days. The results revealed that the ethanolic extract of A. hispida leaves was relatively harmless (LD50 16 g/kg BW), did not affect body weight, and did not show clinical signs of toxicity during the observation periods. The parameters of blood serumbiochemistry of all extract-treated groups (alanine aminotransferase, aspartate aminotransferase, creatinine, and urea) did not change significantly compared to the control group. The histological observation of the liver showed a significant increase in eosinophilic cytoplasm and basophilic nuclei at all doses. However, the ethanolic extract of A. hispida leaves did not significantly affect glomerulus/Bowmans capsule ratio, glomerular cell density, and the proportion of normal cell tubule. In conclusion, the ethanolic extract of A. hispida leaves was relatively harmless with LD5016 g/kg BW and seems to be safe in low doses (2 g/kg BW).
Efek Potensial Sari Buah Apel (Malus domestica) sebagai Penumbuh Rambut pada Tikus (Rattus norvegicus) Nur Nabilla, Cintya; Andriyanto; Subangkit, Mawar
Jurnal Veteriner dan Biomedis Vol. 2 No. 1 (2024): Maret
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.1.29-34.

Abstract

Rambut berfungsi untuk memberikan kehangatan, perlindungan, keindahan serta penunjang penampilan. Kerontokan rambut yang dapat mengakibatkan kebotakan merupakan salah satu problema yang paling dikhawatirkan setiap orang. Kebotakan biasanya diobati dengan mengkonsumsi obat tertentu namun keamanan dari obat-obatan tersebut belum tentu terjamin. Bahan alami menjadi salah satu alternatif yang dapat dipilih, diantaranya adalah sari buah apel (Malus domestica). Penelitian ini bertujuan menguji dan mempelajari efektivitas sari buah apel sebagai penumbuh rambut serta menganalisis frekuensi pengolesan terbaik dengan parameter pertumbuhan rambut dan reaksi iritasi pada tikus (Rattus norvegicus). Sebanyak 6 ekor tikus dibagi menjadi 4 perlakuan pada masing-masing tikus yaitu kontrol (tidak diberi olesan), 1 kali oles sehari, 2 kali oles sehari, dan 3 kali oles sehari. Pengukuran panjang rambut tikus dilakukan pada hari ke-6, 9, 12, dan 15 serta menganalisis skor eritema dan edema atau Primary Dermal Irritation Index (PDII). Hasil penelitian menunjukkan sari buah apel memiliki efek yang signifikan sebagai pemacu pertumbuhan rambut. Pemberian olesan sebanyak 3 kali sehari menjadi kelompok dengan frekuensi pemberian olesan terbaik karena memiliki perbedaan nyata terhadap kelompok kontrol. Tidak ada reaksi iritasi yang ditimbulkan dari sari buah apel saat dilakukan uji iritasi pada tikus.
Analisis potensi hepatoprotektif minyak jintan hitam (Nigella sativa) pada kerusakan hati akibat paracetamol: Potential analysis of black cumin oil hepatoprotective (Nigella sativa) on liver damage due to paracetamol Yendri, Hamdika; Andriyanto, Andriyanto; Mustika, Aulia A.; Manalu, Wasmen; Subangkit, Mawar; Tarigan, Elpita
Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Science) Vol. 14 No. 1 (2024): Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Ve
Publisher : Fakultas Peternakan Universitas Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46549/jipvet.v14i1.353

Abstract

Abstract  A decrease in liver function can cause some clinical impact on the body. The loss of the body's ability to metabolize toxins makes metabolic remains accumulate in the blood.  This study aims to determine the potential of black cumin oil hepatoprotective. This study used 25 ddY mice. Mice were given black cumin oil for 20 days and inducted liver cell damage using paracetamol dose 300mg/KgBB. Results showed the potential of black cumin oil hepatoprotective in the group given 60μL of black cumin oil. These results were obtained from the measurement of SGPT, SGOT values and histopathological observations of the liver organs of mice. These results show that black cumin preparations are able to suppress liver damage due to paracetamol. Keywords: Black cumin; Liver; Paracetamol   Abstrak  Penurunan fungsi hati dapat menyebabkan beberapa dampak klinis pada tubuh. Kehilangan kemampuan tubuh untuk memetabolisme racun menjadikan sisa-sisa metabolisme menumpuk di dalam darah. Penelitian ini bertujuan untuk mengetahui potensi hepatoprotektif minyak jintan hitam. Penelitian ini menggunakan mencit ddY berjumlah 25 ekor. Mencit diberikan minyak jintan hitam selama 20 hari dan dilakukan induksi kerusakan sel hati menggunakan paracetamol dosis 300mg/KgBB. Hasil penelitian menunjukan adanya potensi hepatoprotektor minyak jintan hitam pada kelompok yang diberikan 60µL minyak jintan hitam. Hasil ini didapatkan dari pengukuran nilai SGPT, SGOT dan pengamatan histopatologi organ hati mencit. Hasil ini menunjukan sediaan jintan hitam mampu menekan kerusakan hati akibat paracetamol. Kata kunci: Hati; Jintan hitam; Paracetamol
Hepatoprotective Potentials of Dates Extract (Phoenix dactylifera) in Acetaminophen-Induced Mice Andriyanto, Andriyanto; Putra, Hamdika Yendri; Aurelia, Sharon; Mustika, Aulia Andi; Manalu, Wasmen; Subangkit, Mawar; Tarigan, Elpita; Irarang, Yusa
Majalah Kedokteran Bandung Vol 55, No 3 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n3.3155

Abstract

Dates (Phoenix dactylifera) are considered as a well-known fruit consumed by many people in various countries. This study aimed to examine potential effects of dates as a hepatoprotective agent in mice. This study was conducted at the Iratco Group’s eLRosa Laboratory Research Facility, Indonesia, starting from June 2022 to July 2022. Mice from ddY strain were randomly divided into 5 groups (n=5 per group) of positive and negative control groups, and treatment groups 1, 2, and 3. The negative control group as the normal baseline did not receive acetaminophen and date extract. In treatment groups, 30 µL/30 gr BW, 60 µL/30 gr BW,  and 100 µL/30 gr BW extract was given per oral to Treatment Group 1, Group 2, and Group 3, respectively for 20 days. On day 21, all  treatment groups were induced with 300mg/KgBW acetaminophen for 3 days via the intraperitoneal route. Blood tests were performed on day 24 to measure the serum transaminase level as the parameter of liver damage. The lowest level of transaminase serum was found in group 3 with the highest volume of dates extract, which was 100 µL, followed by group 2 (60 µL), and group 1 (30 µL). There was a significant difference between the positive control group and treatment groups with  no significant difference was seen between negative and the treatment groups. This study concludes that dates extract has the potential of being a hepatoprotective agent.
A comparison of the Hematology Profiles from Preventive and Curative Tests on Lissachatina fulica Snail Mucin Cream for Atopic Dermatitis Supiyani, Atin; Manalu, Wasmen; Sutardi, Lina Noviyanti; Subangkit, Mawar; Andriyanto, Andriyanto
Acta VETERINARIA Indonesiana Vol. 13 No. 3 (2025): November 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.3.296-302

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Continuous use of topical NSAIDs in AD cases has been shown to cause adverse effects. Lissachatina fulica mucin (LFM) cream, a natural alternative, has been used for wound healing and can be used as a preventative or curative agent in AD. The objective of this study is to assess the efficacy of LFM cream, exploring its potential as a preventative and curative measure in AD. A total of 36 male BALB/c mice were divided into three cream dosage groups: 0%, 5%, and 10%. The two treatments were preventive and curative, and the two testing times were 0 and 5 days, with three replicates each. Mice were induced with atopic dermatitis by applying 1% DNCB to a 1x1 cm area on their dorsal area for seven days. The preventive group used LFM cream for seven days before DNCB, while the curative group used it after DNCB. Blood samples were collected on days 0 and 5 of the treatment period and analyzed using a hematology analyzer. The data were analyzed using a two-way ANOVA with GraphPad Prism 10, followed by Tukey's test at a 95% confidence level. The toxicity test confirmed that the LFM cream is non-toxic and safe for topical use. The DNCB compound 1% exhibited four main symptoms of atopic dermatitis: pruritus, erythema, excoriation, and lichenification. LFM cream was highly effective, significantly suppressing AD symptoms, with the ADSI score remaining below 2 (p<0.05). Specifically, the curative efficacy was demonstrated by a significant decrease in the ADSI score on day 5 (p<0.05). Hematological analysis revealed statistically significant differences (p<0.05) in the number of lymphocytes, neutrophils, and thrombocytes across groups. The LFM cream is effective and safe for preventative use and successfully treats acute AD at 5% concentration.
Histopatologi hati ayam broiler (Gallus domesticus): sebuah model forensik veteriner pada 48 jam pasca kematian Shafiyyah Az Zahra; Eva Harlina; Mawar Subangkit; Rahayu Woro Wiranti; Bambang Pontjo Priosoeryanto
ARSHI Veterinary Letters Vol. 7 No. 4 (2023): ARSHI Veterinary Letters - November 2023
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.7.4.79-80

Abstract

Ilmu forensik veteriner belum mendapat perhatian yang memadai di Indonesia, sehingga perlu ditingkatkan pengembangannya. Penelitian ini bertujuan mempelajari ilmu forensik veteriner melalui histopatologi hati ayam broiler 48 jam pasca kematian. Ayam broiler sebanyak 75 ekor berumur 7 hari dieutanasia dan dibagi menjadi 25 kelompok berdasarkan jam nekropsi pasca-eutanasia (n=3). Kadaver ayam dinekropsi setiap 2 jam postmortem, organ hati dikoleksi untuk dibuat potongan histopatologi dan diwarnai dengan Hematoksilin-Eosin (HE). Histopatologi hati evaluasi dan hasil yang didapat dianalisis menggunakan software ImageJ versi 1.53a. Hubungan peubah histopatologi dengan waktu postmortem dianalisis dengan metode Pearsons. Hasil penelitian menunjukkan bahwa pembusukan dimulai pada jam ke-18 post mortem yang ditandai dengan jumlah inti sel hepatosit, jam ke-20 ditemukan bakteri pembusuk, dan jam ke-22 terjadi peningkatan jarak antar hepatosit. Berdasarkan nilai korelasi Pearson, jumlah inti sel hepatosit, jarak antar hepatosit dan keberadaan bakteri pembusuk mempunyai hubungan kuat hingga sangat kuat dengan waktu postmortem sehingga hasil ini dapat menjadi parameter penentu waktu kematian (Post Mortem Interval/PMI) pada hewan.
Pengaruh serai (Cymbopogon citratus) terhadap profil darah dan kadar asam urat pada tikus Aryani Satyaningtijas; Faisal Anthony; Muhammad Naufal Febrian Jamaludin; Anggara Widyawiratma; Muhammad Joserisal Alghifarry Pakkawaru; Damiana Rita Ekastuti; Kusdiantoro Mohamad; Mawar Subangkit; Aprilia Hardiati
ARSHI Veterinary Letters Vol. 10 No. 1 (2026): ARSHI Veterinary Letters - February 2026
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.10.1.23-24

Abstract

Lemongrass (Cymbopogon citratus) is a medicinal plant with antioxidant and antimicrobial properties. This study evaluated the effects of 20% and 80% lemongrass infusion on haematological profiles and uric acid levels in Sprague Dawley rats. Thirty rats were assigned to three groups: control, 20% infusion, and 80% infusion groups. The results showed no significant differences (P>0.05) in haematological parameters, although fluctuations in erythrocyte and leukocyte indices occurred. The 80% infusion reduced erythrocyte parameters, suggesting potential hypochromic macrocytic anaemia, while the 20% infusion reduced leukocyte counts and uric acid levels. These findings indicate that lemongrass infusion has immunomodulatory and anti-hyperuricemic effects, although higher concentrations may affect erythrocytes.
Co-Authors Aditya Primawidyawan Ahmad Faried Alfarisi, Hamzah Alya Mardhotillah Azizah Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Anggara Widyawiratma Anita Esfandiari Aprilia Hardiati Arief Boediono Aryani Satyaningtijas Aulia Andi Mustika Aulia Andri Mustika Aurelia, Sharon Aurellia, Sharon Bambang Pontjo Priosoeryanto Berry Juliandi Boenjamin Setiawan Christina Clarice Leksono D R Agungpriyono Damiana Rita Ekastuti Deded Sarip Nawawi Deni Noviana Dertina Marni Purba Dewi R Agungpriyono Dian Anggraini Diana Krisanti Jasaputra Dodi Irwan Suparno Drajat Martianto Elpita Tarigan Elpita Tarigan Elpita Tarigan Elpita Tarigan Elpita Tarigan Ermi Girsang Eva Harlina Faisal Anthony Fitri, Arni Diana Ginting, Chrismis Novalinda Gunanti Gunanti . Hamdika Yendri Hamdika Yendri Hamdika Yendri Putra Hamdika Yendri Putra Harry Murti I Nyoman Ehrich Lister I Nyoman Jaya Wistara IETJE WIENTARSIH Indra Bachtiar Irarang, Yusa Itje Wintarsih Jerica, Monica Silva Jurnila Sari Tanjung Kelvin Yaprianto Kusdiantoro Mohamad L N Sutardi Leliana Nugrahaning Widi Leliana Widi Leliana Widi Lina Noviyanti Sutardi Lindiawati, Riris Maulana, M Ridha Mayasari, Ni Luh Putu Ika Muhammad Joserisal Alghifarry Pakkawaru Muhammad Naufal Febrian Jamaludin Mustika, Aulia A. Naufal Muharam Nurdin Nopen Meisaroh Nugraha, Arifin Budiman Nur Nabilla, Cintya Prasetyaningtyas, Wahono Puspitasari, Riris Putra, Hamdika Yendri Rahayu WoroWiranti Retno Wulansari Ridi Arif Rimbawan , Rindy Fazni Nengsih Rindy Fazni Nengsih Rindy Fazni Nengsih Risa Tiuria Rita Kartika Sari Sadiah, Siti Shafiyyah Az Zahra Siti Sadiah Siti Sa’diah Sri Anna Marliyati Sri Rezeki Supiyani, Atin Surachmi Setiyaningsih Teresa Liliana Wargasetia The Fransiska Eltania Tutik Wresdiyati Vetnizah Juniantito Vetty Ramadhaniah Wahyu Widowati Wasmen Manalu Widi, Leliana Nugrahaning Wildan Mubarok Yendri, Hamdika Yusa Irarang Yusa Irarang Yusa Irarang Yusa Irarang