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All Journal Tropical Medicine Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Jurnal Teknosains Program Kreativitas Mahasiswa - Penelitian Indonesian Journal of Biotechnology Majalah Obat Tradisional Science and Technology Indonesia Indonesian Journal of Chemistry Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Molluca Journal of Chemistry Education (MJoCE) Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Journal of Multidisciplinary Applied Natural Science Occupational and Environmental Medicine Journal of Indonesia Engagement: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmacology and Therapy
Eti Nurwening Sholikhah
Departement Of Pharmacology And Therapy, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : Tropical Medicine Journal

 1 
In Vitro Antiplasmodial Activity of Brucein A Semisynthetic Compounds Priska Ernestina Tenda; Eti Nurwening Solikhah; Mahardika Agus Wijayanti
Tropical Medicine Journal Vol 2, No 1 (2012): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.321 KB) | DOI: 10.22146/tmj.4305

Abstract

Introduction: Brucein A has been known to have antiplasmodial activity. Some new compounds were synthesized to increase their antiplasmodial activity, i.e 3-benzoylbruceinA, 3-dimethyl sulphate bruceine A, 3-choro benzoyl brucein A, and 3-chloro acetyl bruceine A.However, their antiplasmodial activity have not studied yet.Objectives: To know the in vitro antiplasmodial activity of 3-benzoyl brucein A, 3-dimethyl sulphate bruceine A, 3-choro benzoyl brucein A, and 3-chloro acetyl bruceine A.Methods: Antiplasmodial activity was conducted by incubating FCR-3 strain of P. falciparum with 3- benzoyl brucein A, 3-dimethyl sulphate bruceine A, 3-choro benzoyl brucein A, and 3-chloro acetyl bruceine A in various concentrations for 72 hours. Parasitemia after incubation period of each compound was calculated by making a thin smear stained with 5% Giemsa.Results: Semisynthetic compounds of bruceine A have antiplasmodial activity in vitro with IC50 value were 2.648 ± 1.30 ng/mL for 3-benzoyl bruceine A, 1.098 ± 0.510 ng/mL for 3-dimethyl sulphate bruceine A, 50.246 ± 0.207 ng/mL for 3-chloro benzoyl bruceine A and 67.951 ± 11.517 ng/mL for 3- chloro acetyl brucein A. The IC50 value of Bruceine A as the lead compound was 3.87 ± 2.530 ng/mLConclusion: The 3-dimethyl sulphate bruceine A showed the highest antiplasmodial activity among 4 semisynthetic compounds of Bruceine A.Keywords:bruceineA, semisynthetic compound, Plasmodiumfalciparum, invitroantiplasmodial activity.
Tumor Necrosis Factor-Alpha (TNF-Alpha) And Intercellular Adhesion Molecule-1 (ICAM-1) Expression of Plasmodium Berghei Infected Swiss Mice Treated with Red Fruit (Pandanus Conoideus Lam) Ethanol Extract Demianus Tafor; Achmad Djunaidi; Widya Wasityastuti; Eti Nurwening Sholikhah
Tropical Medicine Journal Vol 3, No 2 (2013): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1852.863 KB) | DOI: 10.22146/tmj.5868

Abstract

ABSTRACTIntroduction: Malaria infection could activate T cell helper 2 CD4+ which release cytokines IL-4, IL-5, IL-10 was a kind of immunosuppressant cytokines and prevented a cerebral tissue damage from the expression intercellular adhesion molecule-1 (ICAM-1) by TNF-α, ended with a cerebral malaria. The red fruit was proved as antioxidant but its effect to reduce TNF-α and expression of ICAM-1 in cerebral tissue endothelial cell remained unknown.Objectives: to know the effect of red fruit ethanol extract toward the change of TNF-α secretion number and ICAM-1 in Swiss male mice’s cerebral endothelial cell infected with P.berghei.Methods: Sixty Swiss male mice were divided in to 6 groups, group I was not given the red fruit (BM) ethanol extract and not infected P.berghei, Group II was given BM 260mg/kg BB but not infected P.berghei, group III, IV, V were given BM  130, 260, and 520 mg/kg respectively and infected with P.berghei. Red fruit extract or carrier substance was given for 4 weeks, P.berghei was given in the early of third week. TNF-α level check was done in third and ninth day after the injection, with TNF-α ELISA kit mouse. ICAM-1 cerebral endotel cell expression check was done in third and nine day with immunohistochemistry (IHC) coloring.Results: TNF-α level in third day after infected to the groups given red fruit extract (group III, IV, and V) showed no significant difference (p=0,839) compared to group which was not given red fruit but infected (group VI). TNF-α level in ninth day after infected to groups given red fruit ( group III,IV,V) lower (p<0,05) compared to groups which was not given red fruit but infected. ICAM-1 expression in third and ninth day after treatment to group given red fruit extract was lower (p<0,05) compared to groups given red fruit extract but infected. Conclusion: Red fruit ethanol extract ( P conoideus Lam) could decrease TNF-α level and ICAM-I expression in Swiss mice’ endothelial cerebral cells after infected by P.berghei.Key word: Pandanus conoideus Lam, TNF-α, ICAM-1 expression, Plasmodium berghei, Swiss mice
The Red Fruit (Pandanus Conoideus Lam) Ethanol Extract Decreased the Nitric Oxide (NO) Levels of Plasmodium Berghei Infected Swiss Mice Malaria Model but not the Interferon Gamma (IFN-γ) Mujur Mujur; Demianus Tafor; Widya Wasityastuti; Achmad Djunaidi; Eti Sholikhah Nurwening
Tropical Medicine Journal Vol 3, No 1 (2013): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/tmj.60593

Abstract

ABSTRACTIntroduction: The immunity against malaria infection was very complex, involving humoral immunity and cellular immunity.  One of the methods to improve body immune response was using antioxidant. Red fruit (Pandanus conoideus Lam) containing carotenoid and tocopherol that have antioxidants effects increase phagocytosis activity of macrophage and proliferation activity of lymphocyte as immune response againts parasite infection.Objectives: This study was intended to know the effect of red fruit (P. conoideus Lam) ethanol extract on IFN-γ and nitric oxide (NO) levels in Plasmodium berghei infected Swiss mice malaria model.Methods: This quasi experimental study used post test only control group design. Sixty eight-week aged male Swiss mice were devided into 6 groups. Group I was not given red fruit ethanol extracts neither infected by P.berghei, group II was given 260mg/kg/day of red fruit ethanol extracts, and it was not infected by P.berghei, groups III, IV and V were given red fruit ethanol extracts at 130, 260 and 520mg/kg/day respectively and infected by P.berghei. Group VI was not given the extract, however it was infected by P.berghei as control group. The red fruit ethanol extracts or the carrier was given for 28 days and the mice were infected by P.berghei in the beginning of week 3. On the day 3 and 9 after infection, 2 mL blood was taken from 3 mice of each group for serum isolation.Results: There was not any significant difference (p>0.05) mean of IFN-γ levels in all groups neither on day 3 nor day 9 after infection. The nitric oxide levels mean of mice group which have received red fruit extracts at 130 and 260mg/kg/day on the day 9 and  in mice group which have received red fruit extracts 260mg/kg/day on day 3 were lower than they were in control group without any extract (group VI). However, the nitric oxide levels mean of mice group which have received 520mg/kg/day did not show any significant difference (p>0.05) compared with control group.Conclusion: The red fruit (P. conoideus Lam) ethanol extract did not show any significant effect on the IFN-γ levels, however at doses of 130 and 260mg/kg/day it decreased the nitric oxide level of P. berghei infected Swiss mice malaria model significantly. Keywords: Pandanus conoideus Lam, Interferon gamma (INF-γ), Nitric oxide (NO),  Plasmodium berghei, and Malaria ModelKeywordsPandanus conoideus Lam, Interferon gamma (INF-γ), Nitric oxide (NO), Plasmodium berghei, and Malaria Model
Co-Authors Achmad Djunaidi Achmad Djunaidi Adisty Ridha Damasuri Adisty Ridha Damasuri ADITYA NUGRAHA Aditya Nugraha Aflifia Birruni Sabila Agus Dwi Ananto, Agus Anak Agung Ayu Niti Wedayani Anak Agung Ngurah Nata Baskara Andi Hairil Alimuddin Arta Farmawati Asysyifa, Azzahra Bayu Putra Chairil Anwar Chairil Anwar Danang Setia Budi Demianus Tafor Demianus Tafor Dian Permata Sari Dicky Moch Rizal Dicky Moch Rizal Dwi Aris Agung Nugrahaningsih Dwi Cahyani Ratna Sari E. Elsa Herdiana Murhandarwati Ema Damayanti Erna Kristin Erwin Astha Triyono Faris Hermawan Fatimi, Hana Anisa Fitria, Anggit Gandes Retno Rahayu Hanggoro Tri Rinonce Harizal Harizal Harno Dwi Pranowo Harno Dwi Pranowo Harno Dwi Pranowo Hera Nirwati Iin Narwanti Ikhsan Nur Salim Ikhsan Nur Salim Iqmal Tahir JAKA WIDADA Jaya, Sudi Indra Jeffry Julianus Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Kasta Gurning Kurniawan, Yehezkiel Steven Laela Hayu Nurani Mae Sri Hartati Wahyuningsih Mahardika Agus Widjayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Marlinda, Wade Masriani . Maulina Diah Maulina Diah Maya Dian Rakhmawatie Mega Pandu Arfiyanti Mia Munawaroh Yuniyanti Muhammad Idham Darussalam Mardjan Muhammad Kusumawan Herliansyah Muhammad Yusron Maulana El-Yunusi Mujur Mujur Mustafa Mustafa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Muthia Rahayu Iresha Muthia Rahayu Iresha Nendrowati Nendrowati Ngatidjan Ngatidjan Nurrahma, Bira Arumndari Nursofia, Baiq Ike Pramana Pananja Putra Pratiwi, Woro Rukmi Pratiwi, Woro Rukmi Priastomo, Yoga Primahana, Gian Priska Ernestina Tenda Priyangga, Krisfian Tata Aneka Pulung, Maria Ludya RATNA SARI Ratna Sari Respati Tri Swasono Rina Susilowati Rul Afiyah Syarif Ruslin Hadanu Sabirin Mastjeh Sabirin Mastjeh Sabirin Mastjeh Sabirin Mastjeh Sabirin Matsjeh Sabirin Matsjeh Samekto Wibowo Samekto Wibowo Setyo Purwono Sitarina Widyarini Susi Iravati Susi Iravati Syarifa, Cut Alima Teguh Triyono Titik Nuryastuti Tri Joko Raharjo Tri Murini Tri Ratnaningsih Wahyu Nitari Wahyu Widyaningsih Wibowo, Susalit Setya Widodo, Irianiwati Widya Wasityastuti Winarto Haryadi Wiyono, Tri Yacobus Christian Prasetyo Yogaswara, Radite Yudha, Ervan Yuniyanti, Mia Munawaroh Zulfa Faiqoh