Article Per Year (5 Year)
p-Index From 2020 - 2025
2.976
P-Index
This Author published in this journals
All Journal Alchemy : Journal of Chemistry Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Tropical and Infectious Disease Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Majalah Obstetri dan Ginekologi SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Masyarakat Asia Humanism : Jurnal Pengabdian Masyarakat Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Jurnal Masyarakat Madani Indonesia Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Widya Medika
Aty Widyawaruyanti
Departemen Ilmu Kefarmasian Fakultas Farmasi Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 30 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search
Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Skrining Aktivitas Antimalaria Beberapa Tanaman Indonesia Hasil Eksplorasi Dari Hutan Raya Cangar, Batu-Malang, Jawa Timur Achmad Fuad Hafid; Nike Puliansari; Nur Suci Lestari; Lidya Tumewu; Abdul Rahman; Aty Widyawaruyanti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (80.387 KB) | DOI: 10.20473/jfiki.v3i12016.7-11

Abstract

Background: Malaria is the most important parasitic disease. Malaria control which depends on specific chemotherapy now complicated by resistance of Plasmodium falciparum to most commonly available antimalarial drug. Such situation has heralded the need for alternative antimalarial therapy. Objective: This research aim was to find new antimalarial candidates from some Indonesia plants collected from Cangar National Forest, Batu-Malang, East Java. Methods: Eleven samples of leaves and stem extracts were screened against Plasmodium falciparum 3D7 culture which maintained in RPMI-1640 Medium. Samples tested in concentration of 0.01, 0.1, 1, 10 and 100 µg/ml. Probit analysis was used to determine IC50. Results: In vitro antimalarial activity revealed that only three crude extracts samples from Fraxinus griffithi stem extract, Piper sulcatum leaves extract and Eucalyptus globulus stem extract had good antimalarial activity with IC50 value of 0.33, 0.20 and 0.55 µg/ml, respectively. Conclusions: Fraxinus griffithi stem extract, Piper sulcatum leaves extract and Eucalyptus globulus stem extract might be a good candidate for antimalarial natural product resources.
Anti-Hepatitis C Virus Activity of Various Indonesian Plants from Balikpapan Botanical Garden, East Borneo Rina Puspitasari; Tutik Sri Wahyuni; Achmad Fuad Hafid; Adita Ayu Permanasari; Lidya Tumewu; Aty Widyawaruyanti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.48-54

Abstract

Background: Hepatitis C Virus infection is a serious health problem that leads to chronic liver disease, liver cirrhosis, hepatocellular carcinoma, which causes high morbidity. Direct-Acting Antiviral Agents have been used as anti-hepatitis C Virus therapy. However, it was covered only in limited patients due to the high cost. Moreover, serious side effects and resistance cases were also reported in some HCV genotypes. Objective: This research aimed to find new anti-HCV from some Indonesia plants collected from Balikpapan Botanical Garden, East Borneo. Methods: Twenty-one leaf and stem barks extracts were successively extracted in n-hexane, dichloromethane, and methanol. Extracts were screened for their anti-HCV activity under in vitro culture cells in the concentration of 30 µg/mL. Plant extracts were inoculated in the Human Hepatocellular 7it and infected with HCV Japanese Fulminant Hepatitis strain 1a. Determination of 50% Inhibitory Concentration (IC50) value was further conducted at concentration of 100; 30; 10; 1; 0.1; 0.01 µg/ml of extracts. Results: In vitro anti-HCV activity revealed that among 21 plants extract, 11 extracts, namely, n-hexane extract from Luvunga scandens leaves, DCM extract from the leaf of L. scandens, Artocarpus sericicarpus, Artocarpus dadah, Eusideroxylon zwageri, Neolitsea cassiaefolia, methanol extract from A. sericicarpus and A. anisophyllus leaves, DCM extract from A. anisophyllus and A. elmeri stem bark, methanol extract from A. dadah stem bark, having potential inhibition with IC50 range 0.08 ± 0.05 to 12.01 ± 0.95 µg/mL. Conclusions: These results indicate that the eleven extracts could be good candidates as sources of anti-HCV agents.
Anti-Hepatitis C Activity of Combination of Ruta angustifolia Extract and Ribavirin Tutik Sri Wahyuni; Adita Ayu Permatasari; Chie Aoki-Utsubo; Aty Widyawaruyanti; Achmad Fuad
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.125-130

Abstract

Background: Hepatitis c virus infection is a global health problem which chronically infected 71 million people in the world. This infection has a risk of becoming liver cirrhosis and hepatocellular carcinoma. Since the current HCV therapy has been developed by direct-acting antivirals (DAA), however, most patients get limited access due to the high cost. Therefore, further development anti-HCV agent still greatly needed. Ruta angustifolia is a natural resource which was reported to possess anti-HCV activity. Ribavirin is an antiviral agent used to treat several virus infections, either DNA or RNA. Ribavirin was known to inhibit HCV infection by regulated immune system in host cells and interfering the replication of HCV by inhibit HCV RdRp. Objective: The current study evaluated the combination treatment of R. angustifolia extracts and ribavirin by in vitro culture cells of Huh 7it. Method: The study was conducted under an invitro cell culture of Huh 7it and infected with JFH1a. Result:  The result demonstrated an enhancement effect of the extract by increasing the anti-HCV activity 3.5-fold higher compared to ribavirin alone. The 50% inhibitory concentration of ribavirin by single treatment was 10.43 ± 0.18 µg/mL, while in combination with Ruta angustifolia extract was 2.80 ± 0.03 µg/mL. Further analysis of the combination by CompuSyn software mediated a synergistic effect among the combination with a combination index value of 0.691. Conclusion: These results suggested that combination of Ribavirin and Ruta angustifolia should be considered in developing anti-hepatitis C virus agents.
Antimalarial Potential of Fraction 5 from Ethanolic Leaves Extract of Artocarpus Altilis Einstenia Kemalahayati; Hilkatul Ilmi; Agriana Rosmalina Hidayati; Marsih Wijayanti; Lidya Tumewu; Suciati; Achmad Fuad Hafid; Aty Widyawaruyanti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 2 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i22023.184-192

Abstract

Background: Artocarpus altilis leaf extract (AAL.E) was separated by VLC, and six fractions were obtained. Fraction 5 (AAL.E.5) showed antimalarial activity with an IC50 value of 3.71 µg/mL. Objective: This study aimed to determine the antimalarial activity of AAL.E.5 subfractions against P. falciparum, the mechanism of action against Plasmodium Falciparum Malate quinone oxidoreductase (PfMQO), and the active substances. Methods: The AAL.E.5 was separated by open-column chromatography and eluted with chloroform-methanol gradient elution in order of increasing polarity. The antimalarial activity of all subfractions was assessed using a lactate dehydrogenase (LDH) assay against P. falciparum and the mechanism of action of the PfMQO enzyme. The profiles of the most active subfractions were analyzed using High-Performance Liquid Chromatography (HPLC). Results: The separation of fraction 5 (AAL.E.5) yielded 11 subfractions (AAL.E.5.1–AAL.E.5.11). Screening antimalarial activity at 10 μg/mL in this subfraction showed that only five subfractions (AAL.E.5.6-AAL. E.5.10) inhibited P. falciparum and two subfractions (AAL.E.5.6 and AAL.E.5.10) inhibited the PfMQO enzyme. Only subfraction 6 (AAL.E.5.6) inhibited both, with IC50 values of 6.609 µg/mL and 20.34 µg/mL. The thin layer chromatography profile of AAL.E.5.6 revealed reddish-orange spots, indicating the presence of flavonoid compounds, and was also presumed from the UV-visible to HPLC chromatogram for band I in the 300 – 400 nm range and band II in the 240–285 nm range. Conclusion: Subfraction 6 has antimalarial activity against P. falciparum and is thought to have a mechanism of action in PfMQO. Based on the TLC, HPLC, and UV-Vis spectra, subfraction 6 was assumed to be a flavonoid.
Co-Authors Abdul Rahman Achmad Fuad Achmad Fuad Hafid Achmad Toto Poernomo Achmad Yunus Adita Ayu Permanasari, Adita Ayu Adita Ayu Permatasari AGUS HARIANTO Agus Pratiwi Andang Miatmoko Budi Prasetyo Chie Aoki-Utsubo Corry, Maylisa Natalia Dahri, Baso Desak Ketut Ayu Aryani Devanus Lahardo Diyah, Nuzul Wahyuning Djoko Agus Purwanto Edhi, Narendrani Sasmitaning Einstenia Kemalahayati Erry Gumilar Dachlan, Esti Hendradi Firmansyah Ardian Ramadhani Hadi Kuncoro Hadi Poerwono Handayani, Rosita Hanifah Khairun Nisa Hasan, Muhammad Amir Hidayati, Agriana Rosmalina Hidayatus, Laila Nur Hilkatul Ilmi Hilkatul Ilmi Hilkatul Ilmi Idha Kusumawati Iis Wahyuningsih Ilmi, Hilkatul Indah Tantular Isnaeni Isnaeni Kasmawati, Henny Kholis Amalia Nofianti Lahardo, Devanus Laura Wihanto Lidya Tumewu Malaka, Muhammad Hajrul Maria Lucia Ardhani Dwi Lestari Marsih Wijayanti Masyitah Hamidah Miatmoko, Andang Misgiati, Misgiati Munandar, Tristiana Erawati Myrna Adianti Nasrul Wahdi Neni Purwitasari Ni Luh Rustini Ni Putu Ariantari Nike Puliansari Nur Illiyyin Akib Nur Suci Lestari Oktarina, Rice Disi Paramita, Diajeng Putri Pratiwi Soesilawati Purwitasari, Neni Purwitasari, Neny Retno Sari Retno Widyowati Rice Disi Oktarina Riesta Primaharinastiti, Riesta Rina Puspitasari Rini Hamsidi Roihatul Mutiah Sabar Deyulita Sabarudin Sabarudin Siti Zulaikah SOFIANA SARI Subhan Rullyansyah Suciati Suciati Suciati Suciati Sukardiman Suryanto, Suryanto Syahrani, Achmad Taslim Ersam Tri Widiandani Tutiek Purwanti Tutik Sri Wahyuni Utami Islamiati W Wahyuni, W Wicaksana, Firman Widjiati Widjiati Widjiati Widjiati Wiwied Ekasari Yusuf Alif Pratama