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All Journal Medula Wikrama Parahita : Jurnal Pengabdian Masyarakat Jurnal SOLMA Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Jamu Indonesia JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Mandala Pengabdian Masyarakat Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Buana Farma Indonesian Journal of Biological Pharmacy Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Sains Medisina Jurnal Pengabdian Masyarakat Ilmu Pendidikan FASKES : Jurnal Farmasi, Kesehatan, dan Sains Jurnal Farmasi SYIFA Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Praba: Jurnal Rumpun Kesehatan Umum Indonesian Journal of Jamu JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Praeparandi: Jurnal Farmasi dan Sains Journal of Pharmascience
Oktoba, Zulpakor
Department Of Pharmacy, Faculty Of Medicine, Universitas Lampung, Bandar Lampung, Lampung, 35145
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Molecular Docking and ADMET Analysis of Bioactive Compounds from Vitex trifolia as Potential COX-2 Anti-Inflammatory Agents Hanif Hibatulloh; Zulpakor Oktoba; Atri Sri Ulandari; Muhammad Iqbal; Recky Patala
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.460

Abstract

Legundi (Vitex trifolia) has been reported to exhibit anti-inflammatory activity; however, the specific bioactive compounds responsible for this effect remain unclear. This study aimed to evaluate the anti-inflammatory potential of bioactive compounds from V. trifolia against cyclooxygenase-2 (COX-2; PDB ID: 5KIR) using an in silico molecular docking approach, along with the analysis of their pharmacokinetic and toxicity profiles. The results showed that persicogenin exhibited the lowest binding affinity of −9.2 kcal/mol and formed hydrogen bonds with key amino acid residues, namely THR 212, HIS 207, and TYR 385. ADMET prediction results indicated that persicogenin met the drug-likeness criteria for an oral drug candidate, demonstrated good intestinal absorption (HIA: 92.29%), high membrane permeability (Caco-2 permeability > 0.9), low volume of distribution (VDss < 0.45), inhibitory activity against CYP2C19 and CYP3A4, and no hepatotoxic potential. These findings suggest that persicogenin may serve as an anti-inflammatory agent.
Inkubator Edukasi Kewirausahaan: Optimalisasi Pandan Wangi (Pandanus amaryllifolius Roxb.) Pada Kelompok Tani di Pekon Pardasuka Oktoba, Zulpakor; Afriyani, Afriyani; Putra Seta, Amanda; Noer Fathia, Syaharani; Ramadianti, Savira; Zahra Taslima, Tsania
Jurnal Pengabdian Masyarakat Ilmu Pendidikan Vol. 5 No. 2 (2026): May 2026
Publisher : Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpm-ip.vol.5i.2.1757

Abstract

The utilization and optimization of the added value of the medicinal plant Pandanus amaryllifolius Roxb. have not yet been undertaken. The Community Service (PkM) program aims to educate members of the Jaya Lestari Farmers’ Group (POKTAN) and Women Farmers’ Group (KWT). Pandan leaves can be developed into a commercially viable product specifically, a herbal tea formulation containing stevia (Stevia rebaudiana) and rosemary (Salvia rosmarinus) to serve as an antioxidant supplement for people with diabetes. The methodology used in this Community Service Program is qualitative, involving data collection through interviews, observations, educational sessions, training, and hands-on guidance in the production of herbal tea products. The PkM program was evaluated through pre-test and post-tests; data analysis revealed a significant increase in participants’ knowledge, from 60.95% to 67.95%, as well as the positive impact of entrepreneurship education on enhancing the capacity of POKTAN partners, who have successfully developed an innovation in the production of pandan wangi leaf tea.
Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Lycopersicon esculentum mill. as a Drug Candidate for Alopecia Treatment Zulpakor Oktoba; Recky Patala; Muhammad Fitra Wardhana Sayoeti; Putu Ristyaning Ayu Sangging; Tri Umiana Soleha
Journal of Pharmascience Vol. 13 No. 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24836

Abstract

Alopecia is a disorder of the hair follicles that causes hair loss, either in limited areas or throughout the entire body. This study aims to evaluate the potential and molecular interactions of compounds found in the Rampai plant (Lycopersicon esculentum Mill.). The Rampai plant is known to contain various secondary metabolites such as alkaloids, flavonoids, arbutin, amygdalin, and pectin, which have the potential to be developed as antialopecia drug candidates through an in-silico approach to androgen receptors (PDB ID: 4K7A) and ADME-Tox profile predictions. The in-silico approach was conducted using the molecular docking method to predict the interaction between the active compounds from the Rampai plant and the androgen receptor using Autodock Tools 1.5.7 and Vina software, while the ADME-Tox analysis was conducted through the pkCSM platform. The molecular docking results showed that the reference ligand (Minoxidil) had an affinity energy of −7.353 kcal/mol, while the test compound with the best affinity was isorhamnetin with a value of −8.398 kcal/mol, which was lower (more stable) than Minoxidil. In addition, the ADME-Tox prediction results for isorhamnetin show favorable pharmacokinetic characteristics, especially in terms of skin permeability, absorption and distribution. Thus, isorhamnetin has the potential as an androgen receptor antagonist and a role in the development of therapies for alopecia.
Kelalaian dalam Pelayanan Kefarmasian Implikasi Etis dan Profesional bagi Apoteker Indonesia Aryanti, Adinda; Tri Umiana Soleha; Zulpakor Oktoba; Ervina Damayanti
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i2.5305

Abstract

Negligence in pharmaceutical services is a multifaceted issue that significantly impacts patient safety, the quality of healthcare delivery, and the professional reputation of pharmacists in Indonesia. Such negligence can occur at various stages of pharmaceutical services, including prescribing, dispensing, storage, and administration of medication to patients. The causes of negligence are diverse, encompassing excessive workload, inadequate understanding and application of professional ethical codes, ineffective communication between pharmacists and other healthcare professionals, and suboptimal supervisory and audit systems. This study aims to analyze the ethical and professional implications of negligence in pharmaceutical services and to identify preventive efforts that can improve the quality of pharmaceutical services. This study employs a library research method with a qualitative descriptive approach, thoroughly reviewing scientific literature indexed in Sinta and other reputable academic sources to analyze the ethical and professional implications of negligence in pharmaceutical services. Findings reveal that negligence not only violates core professional ethical principles such as beneficence, non-maleficence, and justice but also exposes pharmacists to serious legal and disciplinary sanctions. Furthermore, negligence leads to long-term negative consequences, including diminished public trust in pharmaceutical services and the broader healthcare system, ultimately hindering national efforts to improve healthcare quality. Therefore, this study recommends continuous professional ethics training, strengthening of both internal and external supervisory mechanisms, and the innovative use of information technology to minimize negligence risks in pharmaceutical practice. The implementation of these measures is expected to enhance pharmaceutical service quality, uphold the integrity and dignity of the pharmacist profession, and provide optimal patient protection in Indonesia.
Analisis Aktivitas Antioksidan Ekstrak Daun Katang-Katang (Ipomea pes caprae) dengan Metode DPPH : Literature Review Tsania Zahra Taslima; Zulpakor Oktoba; Atri Sri Ulandari; Muhammad Iqbal
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 1 (2025): Januari : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i1.594

Abstract

Free radicals are reactive molecules that contribute to oxidative stress, triggering cellular damage and leading to degenerative diseases such as cancer, diabetes, and cardiovascular diseases. Antioxidants are required to neutralize free radicals and protect the body from oxidative damage. The leaves of Ipomoea pes-caprae (L.) R. Br. contain secondary metabolites, such as flavonoids and phenolics, which have potential antioxidant activity. This article aims to analyze the antioxidant activity of Ipomoea pes-caprae leaf extract using the DPPH method. The study employed a literature review approach using Google Scholar with specific keywords and 13 articles met the inclusion criteria with a  publication range from 2015 to 2025. The findings indicate that the extraction method and type of solvent significantly affect the effectiveness of antioxidant activity. Maceration and Soxhlet extraction methods were effective in isolating active compounds, particularly flavonoids and phenolics, while polar solvents such as ethanol and methanol produced better results compared to non-polar solvents. Antioxidant strength, determined by IC50 values, ranged from very strong to very weak. Therefore, it can be concluded that selecting the appropriate extraction method and solvent is crucial to maximizing the antioxidant potential of Ipomoea pes-caprae leaves as a natural antioxidant source for health and pharmaceutical applications.  
Potensi Aktivitas Antidiabetes Berbagai Jenis dan Varian Tanaman Mangga (Mangifera spp.) Agnes Monica Murisla; Zulpakor Oktoba; Femmy Andrifianie; Ramadhan Triyandi
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 2 (2025): April : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i2.595

Abstract

Diabetes mellitus is a chronic disease with a significantly increasing global prevalence, especially in developing countries. Current treatments use synthetic antidiabetic drugs that are generally expensive and have various side effects. This study aims to examine the potential of mango plants (Mangifera spp.) as antidiabetic agents through a systematic literature review. Literature searches were conducted through the electronic databases PubMed and Google Scholar using the keywords "Mangifera/mango" and "antidiabetic". From the search results, 25 relevant articles were obtained for further review, consisting of 15 articles on in vitro testing and 10 articles on in vivo testing. The search results identified 17 mango plant variants worldwide that have been shown to have antidiabetic activity. Each mango species has unique characteristics and different nutritional content and bioactive compounds. Various parts of the mango plant, including leaves, fruits, seeds, and bark, contain bioactive compounds such as flavonoids, tannins, saponins, and terpenoids. These compounds contribute to antidiabetic activity through several mechanisms, namely inhibition of α-glucosidase and α-amylase enzymes, increased insulin sensitivity, and reduced blood glucose levels. Mango plant secondary metabolites are not only effective, but also have the potential to be an alternative antidiabetic treatment that is more affordable and safe compared to synthetic drugs. It can be concluded that Mangifera spp. has great potential to be developed as an innovative diabetes therapy. Further research through clinical trials is needed to confirm its effectiveness as an antidiabetic agent.
Perbedaan Antara Tingkat Kepuasan Pasien Layanan Kefarmasian di Puskesmas Induk Natar dan Puskesmas Rajabasa Indah Lani Hartanti; Rasmi Zakiah Oktarlina; Zulpakor Oktoba; Asep Sukohar
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.787

Abstract

Background: Pharmaceutical services at primary health centers (puskesmas) play a vital role in supporting the quality of primary healthcare services. However, patient satisfaction with these services varies, influenced by factors such as service quality and demographic characteristics of the patients. In Lampung Province, the Induk Natar and Rajabasa Indah primary health care centers have different regional characteristics, which may influence patients perceptions and satisfaction with pharmaceutical services. Methods: This study employed an analytical observational method with a cross-sectional design. Samples were selected using systematic accidental sampling, with 100 respondents from each primary health care centers. Quantitative data were collected using the Servqual questionnaire and patient sociodemographic characteristics. Data were analyzed using the Mann-Whitney test and the Chi-Square test. Result: The reliability dimension showed the highest satisfaction level in both Induk Natar primary health care centers (90.10%) and Rajabasa Indah primary health care centers (94.05%). Conversely, the tangible dimension had the lowest satisfaction levels, with 88.60% in Induk Natar primary health care centers and 92.08% in Rajabasa Indah primary health care centers. A significant difference in patient satisfaction levels was found between the two health centers. However, no significant correlation was found between patient characteristics (age, gender, education, and occupation) and satisfaction levels (p-value > 0.05). Conclusion: Rajabasa Indah primary health care centers demonstrated a higher level of patient satisfaction compared to Induk Natar primary health care centers. A significant difference in satisfaction levels between the two centers was confirmed by the Mann-Whitney test.
Literature Review: Variasi Konsentrasi Ekstrak Rambut Jagung (Zea mays L.) Sebagai Bahan Aktif Dalam Formulasi Sediaan Farmasi Claresta Salma Eristo PNR; Afriyani Afriyani; Wahyu Alfath Firdaus; Zulpakor Oktoba
Sains Medisina Vol 4 No 4 (2026): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/snsmed.v4i4.1094

Abstract

Pemanfaatan bahan alam dalam industri farmasi mengalami peningkatan signifikan seiring meningkatnya kesadaran masyarakat akan keamanan dan keberlanjutan produk. Salah satu bahan alam yang berpotensi untuk pengembangan adalah rambut jagung (Zea mays L.) yang selama ini dianggap sebagai limbah pertanian. Penelitian menunjukkan bahwa rambut jagung mengandung senyawa bioaktif seperti flavonoid, tanin, alkaloid, polifenol, dan saponin yang memiliki berbagai aktivitas biologis. Artikel ini bertujuan untuk mengkaji variasi konsentrasi ekstrak rambut jagung sebagai bahan aktif dalam formulasi farmasi melalui pendekatan literature review. Penelusuran artikel pada basis ilmiah dianalisis dan diidentifikasi berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan. Hasil kajian menunjukkan bahwa ekstrak rambut jagung dapat diformulasikan dalam berbagai bentuk sediaan seperti gel, krim, lotion, serum, dan pelembab bibir dengan berbagai variasi konsentrasi, serta menunjukkan aktivitas biologis yang umumnya meningkat seiring dengan peningkatan konsentrasi ekstrak, namun efektivitas yang dihasilkan tidak hanya bergantung pada konsentrasi, namun juga dipengaruhi oleh jenis sediaan.
Co-Authors Abda Abda Adrifianie, Femmy Afna Nur Afni Palogan Afriyani Afriyani Afriyani, Afriyani Agaphe Suluh Brahmantio Agnes Monica Murisla Ali, Nur Fitriana Muhammad Ambarwati, Endah Andi Nafisah Andrifianie, Femmy Anisa Safitri Annisa Tamara Panjaitan Ari Irawan Ari Irawan Ari Irawan Ari Wahyuni Aryanti, Adinda Asep Sukohar Asep Sukohar Athallah, Muhammad Muzhafar Athallah, Muhammad Muzhaffar Atri Sri Ulandari Atri Sri Ulandari Atri Sri Ulandari Az Zahra, Ghina Nazhifah Bayu Anggileo Pramesona Ciptaningrum, Sekar Rahmasari Ratna Claresta Salma Eristo PNR Dhia Insyirah Antoni Endah Ambarwati Ervina Damayanti Evy Afriyani Fariha Ais Aliya Fathia, Syaharani Noer Femmy Andrifianie Femmy Andrifianie Hanif Hibatulloh Helmi Ismunandar Ihsanti Dwi Rahayu Ilyas Prabamukti Junando, Mirza Kurniawaty, Evi Lani Hartanti Makki, Callista Auli Mallarangeng, Andi Nafisah Tendri Adjeng Maulano, Muhammad Ravlizar Mega, Sri Wulan Muhammad Fitra Wardhana Sayoeti Muhammad Iqbal Muhammad Iqbal Mutiara Nauli Br. Sitinjak Noer Fathia, Syaharani Novriana, Dina NUR AFRIYANI Parabi, Muhammad Iqbal Pardilawati, Citra Yuliyanda Purba, Gemi Sabrina Putra Seta, Amanda Putri, Adhilah Marani Putu Ristyaning Ayu Putu Ristyaning Ayu Sangging Rahmadhita, Elmira Rahmasari, Sekar Ramadhan Triyandi Ramadhan Triyandi Ramadhan, Ananda Abdullah Zaki Ramadhina, Farrasyifa Ramadianti, Savira Ramdini, Dwi Aulia Rani Himayani Rasmi Zakiah Oktarlina Recky Patala Recky Patala Reval Hidayat Risti Graharti Romulya, Ari Irawan Sangging, Putu Ristyaning Ayu Silvia Sekar Ardi Nurjana Suharmanto Suri, Nurma T. Adjeng, Andi Nafisah Tiara Aninditha Tri Umiana Soleha Tri Umiana Soleha Tri Umiana Soleha Triyandi, Ramadhan Tsania Zahra Taslima Wahyu Alfath Firdaus Wardhana, Donny Kesuma Widodo, Alya Rahmah Yulianti, Mega Intan Zahra Taslima, Tsania