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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Kesehatan Andalas Berkala Ilmu Kesehatan Kulit dan Kelamin Majalah Kedokteran Andalas Majalah Patologi Indonesia Sumatera Medical Journal Health and Medical Journal JURNAL PENELITIAN PERAWAT PROFESIONAL Jurnal Ners Indonesian Journal of Global Health research Indian Journal of Forensic Medicine & Toxicology Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) International Journal of Public Health Excellence (IJPHE) Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Riset Multidisiplin dan Inovasi Teknologi Vitamedica: Jurnal Rumpun Kesehatan Umum Prosiding Seminar Nasional Unimus Cermin Dunia Kedokteran Frontiers on Healthcare Research
Satya Wydya Yenny
Department Of Dermatology And Venereology, Faculty Of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Pemberian Salep Fraksi Etil Asetat Daun Meniran (Phyllanthus Ninuri L.) Selama 5 Hari Terhadap Penyembuhan Luka Eksisi pada Tikus Putih Jantan Tobat, Sanubari Rela; Wahyuni, Fatma Sri; Yenny, Satya Wydya; Etriyel, Etriyel; Afrianti, Ria; Rani, Durrotul Nisa
Health and Medical Journal Vol 6, No 1 (2024): HEME January 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i1.1481

Abstract

Pendahuluan: Proses penyembuhan luka yang tidak tepat dapat menyebabkan luka menjadi kronis dan meningkatkan resiko infeksi sehingga memperburuk keadaan pasien. Terapi herbal merupakan bagian dari terapi tradisional, selain mudah didapat dan harga terjangkau, terapi herbal memiliki kemampuan menyembuhkan karena bekerja dalam lingkup sel dan molekuler. Tujuan penelitian: Penelitian ini bertujuan untuk mengetahui pengaruh pemberian salep fraksi etil asetat daun meniran terhadap penyembuhan luka eksisi tikus putih jantan. Metode: Pada penelitian ini hewan coba dikelompokkan menjadi 4 kelompok yang terdiri dari 1 kelompok kontrol, 2 kelompok uji dan 1 kelompok pembanding. Kelompok kontrol diberikan basis salep selama 5 hari. Kelompok uji diberikan salep daun meniran fraksi etil asetat konsentrasi 5% dan 10%, dan kelompok pembanding diberikan salep yang beredar yaitu Salep T®. Setiap kelompok diberikan persiapan selama 5 hari. Parameter yang diamati adalah persentase penyembuhan luka dan waktu epitelisasi. Kemudian dilanjutkan uji histopatologi untuk melihat serat kolagen, fibroblas dan re-epitelisasi. Hasil: Hasil uji ANOVA menunjukkan salep daun meniran fraksi etil asetat konsentrasi 10% menunjukkan persentase penyembuhan luka terbaik dengan persentase 33,78% dan waktu epitelisasi terjadi pada hari ke 7. Hasil pemeriksaan histopatologi menunjukkan salep etil asetat fraksi daun meniran 10% hampir mempunyai efek yang sama dengan salep pembanding terhadap proses penyembuhan luka yang ditandai dengan serabut kolagen tampak berdifusi sedang dan tampak menyatu, fibroblas terdiri dari >50 sel dan untuk re-epitelisasi lapisan epidermis mempunyai sudah terbentuk, namun masih ada penebalan. Kesimpulan: Pemberian salep fraksi etil asetat daun meniran (Phyllanthus ninuri L) konsentrasi 5% dapat mempercepat proses penyembuhan luka eksisi tikus putih jantan.
Combination Procedure for Acne Scars Revision, Is It Needed? Utama, Redha Cipta; Yenny, Satya Wydya; Norawati, Lilik; Arimuko, Abraham
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 4 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i4.954

Abstract

Background: The treatment of acne scars is a problem for dermatologist. Varied morphology of acne scars makes the treatment more difficult. Combination technique has high efficacy than monotherapy. The challenge is how to select best combination procedure for scar revision. Case presentation: A 43-year-old male present with acne scars since 5 years ago. Dermatological findings revealed atrophic acne scars (ice pick, boxcar, rolling) types on forehead, nose and cheeks. Diagnosis established as moderate atrophic acne scars with global acne scarring system (GASS) is 21. Patient treated with blunt canula subcision, hyaluronic acid (HA) filler, microneedling radiofrequency, 90% trichloroacetic acid chemical reconstruction of skin scars (TCA CROSS) and application of salmon polydeoxyribonucleotide (PDRN). Patient also received topical 0.05% retinoic acid, 4% niacinamide, and sunscreen for daily. After 10 days, there is flattening and disappear of ice pick and boxcar, elevating of rolling scar, GASS score is 15. Blunt cannula subcision and HA filler is safe, effective for rolling scar through fibrous band breaking and prevent re-adhesion. Microneedling RF is effective for boxcar, otherwise 90% TCA CROSS preferrable for ice pick scars. This combination procedure leading cellular necrosis in epidermis, collagen in dermis, and stimulate regeneration. Application of Salmon PDRN may promote wound healing, hydrate the epidermis, and prevent dyschromia. Conclusion: Combination of subcision, dermal filler, microneedling radiofrequency, 90% TCA CROSS, and Salmon PDRN has high efficacy for scar revision through collagen remodelling and acceleration wound healing.
Dermoscopy Evaluation of Erythema Dyschromicum Perstans Treated with Combination of Topical Steroid and Narrowband-Ultraviolet B: A Case Report Triani, Aisha; Satya Wydya Yenny
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 5 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i5.991

Abstract

Background: Erythema dyschromicum perstans (EDP), also known as ashy dermatosis, is an uncommon, acquired, and persistent skin condition identified by development of hyperpigmented macules of varying sizes on the trunk, face, and extremities. It exact cause is unknown, and there is ongoing debate surrounding its treatment. Dermoscopic assessments may prove beneficial in evaluating the effectiveness of therapeutic interventions. Case presentation: We present a case of a 20-year-old woman with numerous hyperpigmented macules of brown to slate-grey on her upper trunk, stomach, back, and extremities over the past three years. The patient reported no symptoms such as itching, numbness, or pain. Upon physical examination, mild anemia but otherwise healthy. On physical examination there are multiple brown-grey patches with reddish borders of varying sizes distributed across the body, with unaffected mucosa, scalp, palms, soles, and nails. Dermoscopic examination unveiled a widespread distribution of brown to grey backgrounds with a pinkish homogeneous appearance. Histopathological examination suitable for erythema dyschromicum perstans. The patient received a diagnosis of erythema dyschromicum perstans and underwent treatment involving a combination of topical steroids and Nb-UVB administered three times weekly for a duration of 8 weeks. Conclusion: This condition presents a cosmetic concern throughout the patient's lifetime and significantly affects their quality of life. After 8 weeks of the combination of topical steroids and Nb-UVB, there was a improvement of erythema and lesion appear lighter. This observation suggests that a treatment with a consistently favorable outcome has not been identified and necessitates further investigation.
Characteristics, Clinical, and Trichoscopic Features in Pediatric Patients with Alopecia Areata: A Single-Center Observational Study at the Dermatology Clinic of Dr. M. Djamil General Hospital Padang Yenny, Satya Wydya; Yola Fadilla; Raja Eka Citra Kalisa
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1072

Abstract

Background: Alopecia areata (AA) is an autoimmune disease that causes patchy hair loss. In children, AA can have a significant psychological impact. This study aims to identify the characteristics, clinical and trichoscopic features of AA pediatric patients at the dermatology clinic of Dr. M. Djamil General Hospital Padang. Methods: This cross-sectional analytical observational study involved pediatric patients (<18 years) with a diagnosis of AA who came to the dermatology clinic of Dr. M. Djamil General Hospital Padang between January 2020 to December 2023. Demographic data, disease history, clinical features, and trichoscopy examination results were collected and analyzed descriptively. Results: A total of 125 pediatric AA patients met the inclusion criteria. The majority of patients were female (62.4%) with a mean age of 10.5 years. The most common form of AA is patchy (80%), followed by alopecia totalis/universalis (12%) and ophiasis (8%). A history of atopy was found in 35.2% of patients. The most frequently found trichoscopic features were yellow dots (78.4%), black dots (64%), and broken hairs (56%). Conclusion: This study provides a comprehensive description of the characteristics, clinical and trichoscopic characteristics of AA pediatric patients at Dr. M. Djamil General Hospital Padang. These findings may provide a basis for the development of better management strategies for AA in children.
Efficacy of Garlic Extract (Allium sativum L.) as a Therapeutic Modality of Condyloma Acuminata: A Meta-Analysis Lestari, Andriani Fuji; Satya Wydya Yenny
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 9 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i9.1079

Abstract

Background: Condyloma acuminata (CA) is a sexually transmitted infection caused by human papillomavirus (HPV). Current standard treatment has limitations, so effective and safe alternative therapies are needed. Garlic (Allium sativum L.) has long been used in traditional medicine and has potential as an antiviral and antitumor agent. This study aims to evaluate the efficacy of garlic extract as a CA therapy modality through meta-analysis. Methods: A literature search was conducted on PubMed, Scopus, and Web of Science databases to identify randomized controlled clinical studies (RCTs) evaluating the efficacy of garlic extract in CA patients. Extracted data included study characteristics, interventions, sample size, clinical outcomes, and side effects. Statistical analysis was performed using Review Manager 5.4 software. Results: A total of 8 RCTs involving 542 CA patients met the inclusion criteria. Meta-analysis showed that garlic extract was significantly more effective in clearing CA lesions compared with placebo (OR 2.87; 95% CI 1.95-4.23; p < 0.00001). Garlic extract also demonstrated comparable effectiveness to standard therapies such as podophyllin and imiquimod. There was no significant difference in the incidence of side effects between the garlic extract group and the control group. Conclusion: Garlic extract is an effective and safe therapeutic modality for CA. Further studies with more robust designs are needed to confirm these findings and explore the mechanism of action of garlic extract on CA.
Borderline Lepromatous Leprosy with Mild Reversal Reaction in Child Fonna, Nellia; Ariani, Tutty; Rizal, Yosse; Yenny, Satya Wydya
Frontiers on Healthcare Research Vol. 1 No. 1 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n1.p7-11.2024

Abstract

Background: Childhood leprosy is an important marker of the status of the ongoing leprosy control program, as it is an indicator of active disease transmission in the community. Children are believed to be the most vulnerable group to infection with M. leprae due to their immature or nascent immunity and exposure to intrafamilial contacts. Case report: A 8 years ole male patient presented with hypopigmented patch and erythematous patch with not itchy, not pain, and loss of sensation which increasing more since 1 week ago. Initially 2 months ago, white patch that felt numbness appeared on the back, then white patches wider and spread to the chest, both arms and thighs. Dermatologic finding showed erythematous plaques, hypopigmentation macule with infiltration on cheek, back, both of arms, xerosis cutis. Decreased sensory function was found in the median, ulnar and posteriol tibial nerves. Acid-fast bacilli (AFB) staining revealed bacterial index (BI) +5 and morphological index (MI) 80%. Histopathological examination showed atrophic stratified squamous epithelium, grenz zone, many groups of foamy macrophages reached the fat layer. The patient was diagnosed Morbus Hansen borderline lepromatous leprosy type with mild reversal reaction and treated with MDT-MB drug package, vitamin B complex tablet, zinc tablet, paracetamol tablet, and 10% urea cream on dry skin 2 times a day on dry skin after bath during 2 month and the lesion was reduced. Conclusion: The rate of childhood leprosy continues to be a significant problem. There is a clear need to strengthen early detection, treatment, and regular follow up of these cases in both high and low endemic setting is essential in the prevention of deformities.
Comparison of quality of life, anxiety, and depression levels based on acne vulgaris severity Husna, Annisaul; Yenny, Satya Wydya; Desmawati, Desmawati; Akhyar, Gardenia; Masrul, Masrul; Yulistini, Yulistini
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Acne vulgaris is a chronic inflammation of the pilosebaceous unit. Although acne vulgaris is not fatal, it can cause psychological effects. This study aimed to compare the quality of life, anxiety, and depression levels based on the severity of acne vulgaris among medical students at Andalas University. Methods: This was an observational-analytic study with a cross-sectional design. It was conducted from May to June 2023. The population included the third-grade students of the Medical Study Program of the Faculty of Medicine, Andalas University, who had acne vulgaris. The respondents were 70 people, recruited with consecutive sampling techniques. This research used Lehmann classifications to classify acne severity, the Cardiff Acne Disability Index (CADI) to assess quality of life, and the Depression Anxiety Stress Scale (DASS-21) to assess anxiety and depression. The statistical analysis used the Kolmogorov-Smirnov test. Results: Most female respondents, aged 20 years old, experienced mild acne vulgaris (84.3%). Additionally, the respondents predominantly had mild quality of life disorders (80%), normal anxiety level (32.9%), and normal depression level (52.9%). The Kolmogorov-Smirnov test found no relationship between the severity of acne vulgaris with quality of life (p = 0.076), anxiety level (p = 0.623), and depression level (p = 0.751). Conclusion: The results showed that most respondents had mild acne vulgaris, mild impairment in quality of life, normal anxiety level, and normal depression level. Statistical tests revealed no significant association between the severity of acne vulgaris and these variables.
Community Empowerment of Nagari Salimpek in Developing a Herbal Cosmetic Village Based on Family Medicinal Plants (TOGA) Yenny, Satya Wydya; Gustia, Rina; Rahmatini; Usman, Elly; Asri, Ennesta; Akhyar, Gardenia; Ariani, Tutty; Sari, Mutia; Sari, Indah Indria; Yossy, Vesri; Julia, Dwi Sabtika; Ashar, Miranda; Taria, Sari Almira
Warta Pengabdian Andalas Vol 33 No 1 (2026)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.33.1.67-74.2026

Abstract

Nagari Salimpek in Alahan Panjang, West Sumatra, has a potential for wellness tourism due to its rich biodiversity, especially medicinal and cosmetic plants. However, community awareness in managing Family Medicinal Gardens (TOGA) remain limited, with only three of twenty household groups actively cultivating herbal plants. This condition emphasizes the need for community empowerment to optimize health and economic benefits from local resources. This community service program aimed to enhance local capacity in cultivating and processing TOGA as the basis for developing a Herbal Cosmetic Village. The programme began on 19 July 2025 and was evaluated over six months. Activities included educational sessions on TOGA utilization, training on herbal and cosmetic plant processing, distribution and planting of herbal seeds, and the signing of a Memorandum of Agreement (MoA) with local stakeholders. A pre-test and post-test evaluation involving 31 participants showed significant improvement in knowledge, with understanding of the “herbal center village” concept rising from 29% to 55% and awareness of Nagari Salimpek’s potential increasing from 32% to 77%. Overall, participants gained broader insights into the role of TOGA in health, cosmetics, and economic development. These results highlight the importance of continued education, mentorship, and government support to establish Nagari Salimpek as a model Herbal Cosmetic Village for wellness tourism.
Determinan Perilaku dalam Kerangka Telekonsultasi untuk Infeksi Menular Seksual pada Lelaki Suka Lelaki di Kota Batam Made Tantra Wirakesuma; Herwandi Herwandi; Satya Wydya Yenny; Rima Semiarty
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

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Abstract

Infeksi Menular Seksual masih menjadi masalah kesehatan masyarakat yang signifikan pada komunitas Lelaki Suka Lelaki, yang dipengaruhi oleh tingginya perilaku seksual berisiko, rendahnya pemanfaatan skrining rutin, stigma sosial di masyarakat, serta keterbatasan akses terhadap layanan kesehatan konvensional. Kondisi tersebut menimbulkan hambatan psikososial dan struktural dalam upaya deteksi dini Infeksi Menular Seksual. Perkembangan teknologi kesehatan menempatkan telekonsultasi sebagai pendekatan potensial untuk mengatasi hambatan tersebut, Namun demikian, kerangka telekonsultasi berbasis perilaku untuk deteksi dini IMS pada kelompok LSL belum dirumuskan secara jelas. Penelitian ini bertujuan untuk mengembangkan kerangka tersebut di Kota Batam. Penelitian ini menggunakan pendekatan kuantitatif dengan mengeksplorasi determinan perilaku dan respons komunitas terhadap layanan telekonsultasi sebagai dasar pengembangan telekonsultasi. Hasil penelitian menunjukkan bahwa kenyamanan, kerahasiaan, dan kemudahan akses merupakan faktor utama yang memengaruhi penerimaan layanan telekonsultasi. Determinan ini diharapkan dapat menjadi landasan pengembangan kerangka telekonsultasi berbasis perilaku untuk mendukung deteksi dini dan pencegahan IMS serta dapat diadopsi dalam layanan kesehatan berbasis digital.
Hubungan Ekspresi Ki-67 dan Tipe Stroma Peritumoral dengan Varian Histopatologik Karsinoma Sel Basal Silvi Yelitha; Salmiah Agus; Satya Wydya Yenny
Majalah Patologi Indonesia Vol 27 No.1, Januari 2018
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Latar belakangKarsinoma sel basal (KSB) merupakan keganasan kulit tersering pada manusia. Walaupun jarang bermetastasis KSB terutama varian agresif bersifat destruksi lokal dan dapat terjadi kekambuhan. Mekanisme terjadinya varian KSB agresif dan non-agresif masih belum dimengerti, diduga tingginya tingkat proliferasi sel yang berperan dalam patogenesis tumor ini. Tingkat proliferasi sel dapat dinilai dengan ekspresi Ki-67. Sel tumor yang menginfiltrasi stroma akan menimbulkan reaksi sel stroma peritumoral. Belum diketahui secara pasti tipe stroma peritumoral yang berperan pada varian KSB.Penelitian ini bertujuan untuk menentukan apakah terdapat hubungan ekspresi Ki67 dan tipe stroma peritumoral dengan varian histopatologik KSB.MetodeSampel yang digunakan sebanyak 40 terdiri atas 20 sampel KSB agresif dan 20 sampel KSB non agresif. Sampel diwarnai dengan pewarnaan imunohistokima (IHK) Ki-67 dan histokimia (van Gieson dan Alcian Blue).HasilKSB agresif lebih banyak mengekspresikan Ki-67 tinggi (78,3%) dan memiliki stroma tipe desmoplasia (66,7%), sedangkan KSB non-agresif lebih banyak mengekspresikan Ki-67 rendah (88,2%) dan memiliki stroma tipe miksoid (70%).KesimpulanSecara klinikopatologik ekspresi Ki-67 dan tipe stroma peritumoral berperan untuk membedakan KSB varian agresif dengan non-agresif.
Co-Authors Agustin Vira Agustin Vira Andrini Ariesti Andrini Ariesti Annisa Annisa Anum, Qaira Ariani, Tutty Arimuko, Abraham Ashal, Taufik Ashar, Miranda Asri, Ennesta Asri, Rizkia Chairani Astria Rima Rara Yuswir Astria Rima Rara Yuswir Aswiyanti Asri Desmawati Desmawati Dolly Irfandy Dwi Sabtika Julia Ennesta Asri Ennesta Asri Ennesta Asri Erlina Rustam Eryati Darwin Etriyel Myh Etriyel, Etriyel Fathiyyatul Khaira Fathiyyatul Khaira, Fathiyyatul Fatma Sri Wahyuni Fauzana Nazifah Fendri, Sandra Tri Juli Fesdia Sari Fonna, Nellia Fortuna, Fory Frien Refla Syarif Gardenia Akhyar Gusti Revilla Hendra Permana Hendra Tarigan Sibero Hendriati, Hendriati Herwandi Herwandi Husna, Annisaul Ida Rahmah Burhan Indah Indria Sari Indah Indria Sari Irdawati Izrul Julita Julita Julita Julita Kemala Sayuti Kencana, Indah Kusmarinah Bramono Lestari, Andriani Fuji Lilik Norawati Linosefa Linosefa Made Tantra Wirakesuma Mardhiati Mardhiati Masrul Djalal Melly Maya Sari Mimin Oktaviana Mohammad Rafiequl Haririy Muhammad Farel Brian Nugraha Muhammad Zidan Amriza Mutia Sari Nadya Hasriningrum Triman Nellia Fonna Netty Suharti Norawati, Lilik Noverika Windasari Novian Novian Novian Novian Nur, Fauziah Rahmah Hidayah Rahmatini . Raja Eka Citra Kalisa Rani, Durrotul Nisa Raveinal Rendra Darma Satria Rendra Darma Satria Rendra Darmasatria Resya I Noer Resya I Noer Ria Afrianti Rika Desviorita Rika Desviorita Rima Semiarty Rina Gustia Riri Prima Yolanda Ririn Lausarina Rizal, Yosse Rizki Dwayana Rizki Dwayana Roslaili Rasyid Salmiah Agus Salsabila Aulia Kasbina Salwa Azzahra Santy Saberko Sari, Indah Indria sari, Mutia Septi Mayang Sarry Sigya Octari Silvi Yelitha Siti Rahmawati Sri Lestari Sri Lestari Sugma, Lidya Aprilia Suharmanto Suharmanto Suryani, Yulia Eka Taria, Sari Almira Tobat, Sanubari Rela Triani, Aisha Tutty Ariani Tutty Ariani Utama, Redha Cipta Vesri Yossy Virnanda Trisnorizki Saputra Vitresia, Havriza Wardi, Epi Supri Wati, Westi Permata Wresti Indriatmi B. Makes Yan Wirasati Yenni Raflis Yessy Farina Salim Yessy Farina Salim Yola Fadilla Yosse Rizal Yossy, Vesri Yulistini, Yulistini Zainal Hakim