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All Journal Medical Journal of Indonesia Damianus Journal of Medicine Indonesian Journal of Cancer The Indonesian Biomedical Journal Sari Pediatri Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) The New Ropanasuri Journal of Surgery JURNAL ETIKA KEDOKTERAN INDONESIA Generics: Journal of Research in Pharmacy Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Generics : Journal of Research in Pharmacy
Rianto Setiabudy
Department Of Pharmacology, Faculty Of Medicine, Universitas Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Implikasi Klinis Variasi Jumlah Copy Gen CYP2D6 Gayatri, Anggi; Ascobat, Purwantyastuti; Setiabudy, Rianto
Generics: Journal of Research in Pharmacy Vol 3, No 2 (2023): Generics: Journal of Research in Pharmacy, Volume 3, Edisi 2, 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/halal.v%vi%i.19085

Abstract

Enzim CYP2D6 adalah salah satu varian sitokrom P450 (CYP450) yang berperan dalam metabolisme obat di hati. Isoform ini berperan dalam memetabolisme 25% obat yang saat ini beredar di pasaran. Aktivitas CYP450 dapat dipengaruhi oleh berbagai faktor seperti usia, jenis kelamin, fungsi organ pemetabolisme, jenis dan derajat penyakit, serta variasi genetik. Salah satu faktor penentu aktivitas CYP2D6 adalah sifat gene CYP2D6 yang sangat polimorfik. Faktor penentu polimorfisme gen CYP2D6 adalah mutasi pada nukleotida tunggal (single nucleotide polymorphisms (SNPs)) dan variasi jumlah copy (copy number variation (CNV)) gen CYP2D6. Kejadian mutasi gen dan variasi jumlah copy gen CYP2D6 dapat meningkatkan atau menurunkan aktivitas enzim CYP2D6 yang selanjutnya dapat menurunkan atau meningkatkan efikasi obat yang merupakan substrat CYP2D6 ataupun dapat menimbulkan toksisitas obat. Berbagai penelitian telah dilakukan untuk mengevaluasi hubungan mutase SNPs gen CYP2D6 dengan efek obat. Dalam tinjauan kali ini akan dibahas mengenai pengaruh variasi jumlah copy (copy number variation) gen CYP2D6 terhadap efek terapi ataupun efek samping obat.
Implikasi Klinis Variasi Jumlah Copy Gen CYP2D6 Gayatri, Anggi; Ascobat, Purwantyastuti; Setiabudy, Rianto
Generics: Journal of Research in Pharmacy Vol 3, No 2 (2023): Generics: Journal of Research in Pharmacy, Volume 3, Edisi 2, 2023
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/halal.v%vi%i.19085

Abstract

Enzim CYP2D6 adalah salah satu varian sitokrom P450 (CYP450) yang berperan dalam metabolisme obat di hati. Isoform ini berperan dalam memetabolisme 25% obat yang saat ini beredar di pasaran. Aktivitas CYP450 dapat dipengaruhi oleh berbagai faktor seperti usia, jenis kelamin, fungsi organ pemetabolisme, jenis dan derajat penyakit, serta variasi genetik. Salah satu faktor penentu aktivitas CYP2D6 adalah sifat gene CYP2D6 yang sangat polimorfik. Faktor penentu polimorfisme gen CYP2D6 adalah mutasi pada nukleotida tunggal (single nucleotide polymorphisms (SNPs)) dan variasi jumlah copy (copy number variation (CNV)) gen CYP2D6. Kejadian mutasi gen dan variasi jumlah copy gen CYP2D6 dapat meningkatkan atau menurunkan aktivitas enzim CYP2D6 yang selanjutnya dapat menurunkan atau meningkatkan efikasi obat yang merupakan substrat CYP2D6 ataupun dapat menimbulkan toksisitas obat. Berbagai penelitian telah dilakukan untuk mengevaluasi hubungan mutase SNPs gen CYP2D6 dengan efek obat. Dalam tinjauan kali ini akan dibahas mengenai pengaruh variasi jumlah copy (copy number variation) gen CYP2D6 terhadap efek terapi ataupun efek samping obat.
Effects of Physalis angulata extracts on bleomycin-induced rat: analysis on lung inflammation and fibrosis Wibowo, Suryo Anggoro Kusumo; Rumende, Cleopas Martin; Isbagio, Harry; Setiyono, Agus; Setiabudy, Rianto; Rachmadi, Lisnawati; Kertia, Nyoman
Medical Journal of Indonesia Vol. 34 No. 4 (2025): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257875

Abstract

BACKGROUND Scleroderma is an immune-mediated connective tissue disease, with interstitial lung disease as one of its manifestations. Physalis angulata (P. angulata) or ciplukan has shown potential in treating fibrosis, but its role in preventing lung inflammation and fibrosis remains unknown. This study aimed to evaluate the effect of P. angulata extract in a bleomycin (BLM)-induced scleroderma rat. METHODS Sprague-Dawley rats were divided into 6 groups. For lung inflammation prevention, 3 groups received: (1) BLM only, (2) BLM+50 mg/kgBW P. angulata, and (3) BLM+100 mg/kgBW P. angulata. After 14 days, rats were sacrificed and bronchoalveolar lavage (BAL) leukocyte count, interleukin-6 (IL-6) levels, and lung injury score were assessed. For fibrosis prevention, another 3 groups received the same interventions and were sacrificed after 51 days. Fibrosis score, fibrosis area, hydroxyproline, transforming growth factor-beta (TGF-β), and matrix metalloproteinase-13 (MMP-13) levels were analyzed. BLM was administered subcutaneously, while P. angulata was given orally for 14 days. IL-6, TGF-β, and MMP-13 were measured by ELISA and hydroxyproline by colorimetric method. Mean differences and p-values were calculated using appropriate statistical tests. RESULTS P. angulata extract did not prevent lung inflammation, as there were no differences in BAL leukocyte count (p = 0.126), IL-6 levels (p = 0.173), or lung injury scores (p = 0.397) between the BLM-only group and those receiving P. angulata. The extract also did not prevent lung fibrosis, with no differences in fibrosis scores (p = 0.173), fibrosis area (p = 0.359), hydroxyproline (p = 0.295), TGF-β (p = 0.374), or MMP-13 (p = 0.088) levels among groups. CONCLUSIONS P. angulata extract did not prevent the development of lung inflammation or fibrosis.
Co-Authors Adi Hidayat Adi K Aman, Adi K Agus Setiyono Agustin Iskandar Ahmad Sulaeman Akmal Taher Ali Baziad Ali Baziad Ali Sulaiman Ali Sulaiman Ali Sulaiman Alida Harahap Alida Roswita Harahap Anna Rozaliyani Arini Setiawati Aru W Sudoyo Aryati Aryati Ascobat, Purwantyastuti Astuti Giantini Bachtiar Husein Bambang Sutrisna Bambang Sutrisna Bernardus Philippi Beti E. E Dewi, Beti E. E Beti Ernawati Dewi Broto Wasisto Broto Wasisto Cleopas Martin Rumende Cosphiadi Irawan COSPHIADY IRAWAN Daldiyono H Dalima A.W. Astrawinata Dewi Muliaty Diani Kartini Djajadiman Gatot Djumhana Atmakusuma Djumhana Atmakusuma, Djumhana Elly Herwana Erlin Listiyaningsih Fadlika Harinda Frans D. Suyatna Frans Santosa Frans Santosa Gayatri, Anggi Harapan Parlindungan Ringoringo Harapan Parlindungan Ringoringo Hardi Darmawan Harry Isbagio Harry Isbagyo, Harry Haryana, Sofia M Herdiman T. Pohan Hidayati, Anggi Puspa Nur Husniah Th-Akib I Dewa Gede Ugrasena Idrus Alwi Imam Effendi Ina Susianti Timan Indra Kusuma Indrasari, Nuri Dyah INDRAYANI, LENNY Inge A. Kristanti Instiaty, Instiaty Irawan Yusuf Iskandar Wahidiyat Iskandar Wahidiyat Iwan Darmansjah Jason Sriwijaya Johannes Hudiono Julitasari Sundoro Julitasari Sundoro Jusman, Sri W Kanadi Sumapradja Kato, Mitsuyasu Laurentius A. Lesmana LENNY INDRAYANI Leonard Nainggolan Lestari Rahayu Lia Gardenia Partakusuma Lina Lasminingrum Lisnawati Rachmadi Madoka Takeuchi Marliana Sri Rejeki Marulam M. Panggabean Masahiro Takeuchi Melva Louisa Mercy T. Panjaitan Muchtaruddin Mansyur Muhammad Baharudin Murdani Abdullah Murti Andriastuti, Murti Nafrialdi Nafrialdi Noviyantih, Noviyantih Nurul Akbar Nuzirwan Acang Nyoman Kertia Primariadewi Rustamadji Priyono, Harim Pukovisa Prawiroharjo Puteri, Meidi U. Putri, Pingkan Permata R Sjamsuhidajat Rahajuningsih Dharma Rahajuningsih Dharma Rahajuningsih Dharma Rahajuningsih Dharma Rahayuningsih Setiabudy Rahayuningsih Setiabudy Rejeki, Marliana Sri Renan Sukmawan Restuti, Ratna Dwi Riadi Wirawan Rikarni Rikarni Robby Zulkarnain Rulina Suradi Rulina Suradi Sapatawati Bardososono Saptawati Bardososono Saukani Gumay Septelia I. Wanandi Settrin Chenderawasi Sidartawan Soegondo Siskawati Suparmin Siti Hafilah Sjaifoellah Noer Soehartati Gondowiardjo Sonar Panigoro Suhendro Suhendro Suyanto Sidik Suyanto Sidik Tambunan L Tambunan, Tambunan L Toar J.M. Lalisang Unggul Budihusodo Vera Yuwono Vivian Soetikno Wahono Sumaryono Wardhani, Bantari W.K. Watanabe, Yukihide Wawaimuli Arozal Wibowo, Suryo Anggoro Kusumo Windy Sahar Yahdiana Harahap Yefta Moenadjat Zita Arieselia