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All Journal Medical Journal of Indonesia Damianus Journal of Medicine Indonesian Journal of Cancer The Indonesian Biomedical Journal Sari Pediatri Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) The New Ropanasuri Journal of Surgery JURNAL ETIKA KEDOKTERAN INDONESIA Generics: Journal of Research in Pharmacy Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Generics : Journal of Research in Pharmacy

Rianto Setiabudy

Department Of Pharmacology, Faculty Of Medicine, Universitas Indonesia, Jakarta

Author-ID : 376426

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Konflik Kepentingan dalam Profesi Dokter Rianto Setiabudy; Julitasari Sundoro
Jurnal Etika Kedokteran Indonesia Vol 3, No 1 (2019)
Publisher : Majelis Kehormatan Etik Indonesia PBIDI

Sebagaimana halnya dengan pekerjaan profesional lainnya, dokter juga sering terpapar terhadap masalah konflik kepentingan (KK) dalam pekerjaannya sehari-hari. Ada banyak contoh pelanggaran etika oleh dokter yang timbul akibat masalah KK ini. Sebagian dilakukan dengan kesengajaan, sebagian lagi dilakukan tanpa sadar seolah-olah perilaku itu adalah sesuatu yang biasa dilakukan dan tidak ada yang salah dengan itu. Setidaknya ada dua pasal dalam Kode Etik Kedokteran Indonesia (KODEKI) yang memberi rambu etika terkait masalah KK ini. Untuk menghindarkan dampak negatif KK ini ada beberapa tindakan yang dapat dikerjakan, antara lain penghindaran yang menyeluruh, pengungkapan, pengambilan sikap netral, dan penggunaan bantuan pihak luar.

Tinjauan Etika terhadap Praktik Polifarmasi dalam Layanan Kedokteran Rianto Setiabudy; Ali Sulaiman; Frans Santosa; Julitasari Sundoro; Fadlika Harinda
Jurnal Etika Kedokteran Indonesia Vol 4, No 1 (2020)
Publisher : Majelis Kehormatan Etik Indonesia PBIDI

Adanya pemikiran zaman dulu di mana kombinasi obat termasuk dalam seni kedokteran (art of medicine) kini sudah harus digeser ke arah pelayanan kedokteran berbasis bukti (evidence-based medicine) dan precision medicine. Fenomena polifarmasi masih banyak dijumpai dalam layanan kesehatan di Indonesia maupun di dunia. Menurut tinjauan etik, polifarmasi merupakan praktik medis yang potensial merugikan pasien baik dari segi keselamatan (patient safety) maupun dari segi biaya pengobatan. Sebagai seorang dokter, peresepan rasional dengan mempertimbangkan risk, benefit, dan cost harus dilakukan. Dokter bertanggung jawab penuh sesuai kompetensinya dan harus memberikan penjelasan mengenai obat-obatan dan efek samping.

Selektivitas Pemisahan Isoniazid dan Asetilisoniazid dalam Plasma Manusia In-vitro secara Kromatografi Cair Kinerja Tinggi Novi Yantih; Yahdiana Harahap; Wahono Sumaryono; Rianto Setiabudy; Lestari Rahayu
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Bioanalysis method is needed to pharmacokinetic study of INH as antituberculosis. The main problem is INH structure is similar to that of acetyl isoniazid (AcINH) as its metabolite. Therefore, a selective separation method is needed to separate the INH from its metabolite and matrix. The aim of this study was to test the selectivity of separation method of INH and AcINH in human plasma in-vitro by high performance liquid chromatography (HPLC). The HPLC system used a reversed phase with UV detector and hexane sulphonate as an ion counter. The optimum conditions was obtained by using C18 as stationary phase, hexane sulphonate (pH 2.47)-methanol (65:35) as mobile phase, with flow rate of 1mL/min, and UV detector at wavelength of 265nm. The selectivity of method separation was indicated by a resolution value of ≥ 1.5. The tailing factor for INH and AcINH were 1.297, dan 1.912, respectively. The k values ware less than 10 and N values were greater than 5000 indicate good separation efficiency. The developing of HPLC was a selective for separating of INH and AcINH in human plasma in-vitro.

Partial Validation of High Performance Liquid Chromatography for Analysis of Isoniazid in Rat Plasma Novi Yantih; Siti Hafilah; Yahdiana Harahap; WAHONO SUMARYONO; Rianto Setiabudy
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 1 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Nicotinic acid derivatives such as isoniazid have the strongest anti-tuberculosis properties. For pharmacokinetics studying of isoniazid (INH), a method is needed to determine the levels of INH in plasma. Objective: The aim of this research is to partial validate of high performance liquid chromatography (HPLC) for analysis of INH in rat plasma. Method: For the preliminary study, rat plasma was used. The HPLC system used is a stationary phase C18 with length 250mm and temperature of 30°C, mobile phase hexane sulphonate acid 20mM pH 2.47–methanol (65:35). The analytical parameters in partial validated were linearity, lower limit of quantification (LLOQ), precision, accuracy, and recovery. Results: The results of linearity test of INH showed r value of 0.9996. LLOQ of this method was 0.1258μg/mL. The resulting accuracy and precision value met FDA requirements with a percent recovery ranging from 96.57–107.99%. Conclusion: The HPLC system was a valid method for analysis of INH in rat plasma.

ETIKA PENELITIAN: APA DAN BAGAIMANA? Rianto Setiabudy
Majalah Kedokteran Andalas Vol 37 (2014): Supplement 1 | Published in March 2014
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4806.358 KB)

ETIKA PENELITIAN: APA DAN BAGAIMANA?

Evaluation of Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Urinary Levels for Detecting Kidney Dysfunction in Patients With Nasopharyngeal Cancer Treated With Cisplatin-Based Treatment Marliana Sri Rejeki; Wawaimuli Arozal; Rianto Setiabudy; Djumhana Atmakusuma
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Cisplatin has a potency of causing nephrotoxicity. Serum BUN and creatinine levels have been well-known for detecting kidney dysfunction; while KIM-1 and NGAL urine levels are relatively new measurements. The study was aimed to evaluate urinary KIM-1 and NGAL level to detect kidney dysfunction in patients with advanced stage NPC who received cisplatin-based chemotherapy.Methods: The study was a cohort-prospective study with 3 subject groups, i.e. patients who had never received and who had received 75-100 mg/m2 cisplatin-based chemotherapy as well as those who had never received 40 mg/m2 cisplatin-based chemotherapy. The levels of urinary KIM-1, NGAL and serum level of BUN and creatinine were measured before and after receiving cisplatin. Statistical analyses were ANOVA, Pearson, Spearman, Kolmogorov-Smirnov test and SPSS version 22.0.Result: There was a significant difference of delta BUN level (p=0.0001) and delta urinary NGAL level (p = 0.025) before and after treatment in all three groups; while delta KIM-1 level showed no significant difference in all three groups (p=0.275). Cisplatin may cause accumulated nephrotoxicity, which has dose-dependent manner.Conclusion: Measuring urinary NGAL level can detect an early stage of kidney dysfunction; however, it still cannot replace the role of BUN. Measurement of urinary KIM-1 level cannot detect kidney dysfunction.

Survei Pengetahuan Dokter Spesialis terhadap Penggunaan Opiat pada Tatalaksana Nyeri Kanker di Rumah Sakit Pemerintah, Jakarta, 2017 LENNY INDRAYANI; RIANTO SETIABUDY; VIVIAN SOETIKNO; COSPHIADY IRAWAN
Indonesian Journal of Cancer Vol 11, No 4 (2017): October- December 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Treatment of cancer pain often requires opioids, and morphine is a gold standard in the management of severe cancer pain. Inadequate knowledge of cancer pain management causes opioid usage is not optimal. Indonesia is one of the countries with very low opioid consumption. The purpose of this study was to find out the physician’s knowledge about the management of cancer pain in choosing opioid, administration, doses, side effects, addiction and factors of opioid that barrier in pain management. This cross-sectional study was conducted in General Hospital Jakarta and a Private Hospital in Tangerang. Inclusion criteria were medical specialist who treating cancer pain. This study used questionnaires that filled out by respondents and confidential. Score of adequate knowledge was ≥ 70, and to assess the relationship between knowledge of opioid use with specialization analyzed by Chi-square test and Fisher’s exact if Chi-square requirement is not fulfilled. Statistical analysis was performed by SPSS version 20. From a total of 146 distributed questionnaires, we received 103 questionnaires (70,5%). In this study, the majority of respondents (69,9%) had inadequate knowledge. The highest rate (70,55) was found in the choosing opioid section, while the lowest rate (49,5) was found in the opioid side effects section. There is no significant relationship between physician knowledge on opioid usage and specialization (P= 0,355). Government regulation is major obstacle to opioid use, followed by lack of training, drug availability and knowledge of side effects ABSTRAK Penatalaksanaan nyeri kanker sering kali membutuhkan opiat dengan morfin sebagai gold standard menurut panduan WHO analgesic step ladder . Pengetahuan penalaksanaan nyeri kanker yang kurang menyebabkan penggunaan opiat yang tidak optimal. Indonesia merupakan salah satu negara dengan konsumsi opiat yang sangat rendah. Tujuan studi ini adalah untuk mengetahui pengetahuan dokter mengenai penanganan nyeri kanker dalam pemilihan opiat, cara pemberian, dosis, efek samping, dan adanya adiksi, serta faktor-faktor yang menjadi penghambat pada penanganan nyeri kanker. Desain penelitian ini merupakan survei potong lintang ( cross sectional ) yang dilakukan terhadap dokter spesialis yang menangani nyeri kanker di Rumah Sakit Umum Pemerintah Jakarta dan salah satu rumah sakit swasta di Tangerang. Penelitian ini menggunakan kuesioner yang diisi responden dan bersifat rahasia. Pengetahuan dianggap baik bila nilai ≥ 70. Sedangkan untuk menilai hubungan antara pengetahuan tentang penggunaan opiat dengan bidang spesialisasi dokter dianalisis dengan uji Chi-square . Hasil statistik dianalisis dengan menggunakan SPSS versi 20. Dari total 146 kuesioner yang didistribusikan, didapatkan 103 kuesioner (70,5%) yang direspons. Pada penelitian ini, mayoritas responden (69,9%) mempunyai pengetahuan yang tidak adekuat. Rerata tertinggi didapatkan pada bagian pemilihan opiat 70,55; sedangkan rerata terendah didapatkan pada bagian efek samping opiat, yaitu 47,56. Tidak terdapat hubungan bermakna antara pengetahuan dokter tentang penggunaan opiat dengan bidang spesialisasi (P= KORESPONDENSI: Lenny Indrayani Departemen Farmakologi dan Terapeutik, Universitas Indonesia. Email: lenny3ma@gmail.com Indonesian Journal of Cancer Vol. 11, No. 4 October - December 2017160 0,355). Regulasi pemerintah merupakan penghambat utama pada penggunaan opiat, disusul dengan kurangnya pelatihan, ketersediaan obat dan pengetahuan tentang efek samping.

Oxygen Hyperbaric Therapy in Patients with Radiation Proctitis Suyanto Sidik; Daldiyono H; Rianto Setiabudy; Soehartati Gondowiardjo; Vera Yuwono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 8, ISSUE 1, April 2007
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/8120071-4

Background: Cervical cancer is the most common female malignancy in developing countries, including Indonesia. It usually occurs at the age of 20 years, reaches the peak incidence at the age of 35-55 years, and afterwards, the incidence declines. Radiotherapy is the most important treatment method in cervical cancer, especially for local advanced stage or stage IIb-IVa. It is also effective for the early stage. Oxygen hyperbaric therapy (OHBT) is defined as 100% oxygen (O2) administration of 2-3 ATA (Absolute Atmospheres) pressures in a high-pressure room. OHBT accelerates wound healing by improving oxygen perfusion around the wound and by increasing angiogenesis through Nitric Oxide Synthetase (NOS). Methods: The study was conducted at Cipto Mangunkusumo hospital, while OHBT was provided at Dr. Mintoharjo Navy Hospital. Block randomization was performed, Resulting 32 patients in OHBT group and 33 patients in control group; both groups were at normal distribution. The prevalence of radiation proctitis in OHBT and control group was determined using chi-square test. Results: By comparing the prevalence of radiation proctitis between OHBT and the control group, show that OHBT could decrease proctitis prevalence by p = 0.03. Conclusions: This study indicates that OHBT may reduce the prevalence of radiation proctitis. The OHBT is save and secure to the patients. Keywords: OHBT, cervical cancer, radiotherapy, radiation proctitis

Cut-off Value of HSPG for Early Marker of Plasma Leakage in Adult Dengue Patient Settrin Chenderawasi; Rahajuningsih Dharma; Herdiman T. Pohan; Beti Ernawati Dewi; Rianto Setiabudy; Suhendro Suhendro; Aryati Aryati; Hardi Darmawan; Leonard Nainggolan; Agustin Iskandar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 3 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i3.2221

Plasma leakage is a state of increased vascular permeability due to loss of interendothelial junction and focal adhesion. Endothelium glycocalyx plays a major role in the pathogenesis of plasma leakage. Proteoglycans glycocalyx consists of heparan sulfate (HSPG) around 50-90%. Plasma leakage in dengue infection can be fatal and early detection is essential. This study aimed to determine the optimal cut-off value of HSPG levels for early marker of plasma leakage in dengue infection. The study was a retrospective cohort study as a part of the Community Based Dengue Study of the Faculty of Medicine, University of Indonesia, which was conducted between February 2010 and January 2011. Subjects were recruited by consecutive sampling. Dengue infection was confirmed by conventional PCR serotyping. Subjects were categorized into 2 groups, i.e. those with and without plasma leakage. Plasma leakage was confirmed by hemoconcentration or hypoalbuminemia or USG results. The level of HSPG was measured using the ELISA method from the first until the third day of the hospital admission. A total of 40 subjects were involved in this study, consisting of 21 with leakage and 19 without leakage. The optimal cut-off level of HSPG as a marker of early plasma leakage in dengue infection patients on the 1st day, 2nd day, and 3rd day was was 2179.73 pg/mL, 2538.66 pg/mL, and 1294.06 pg/mL, respectively. HSPG could as an early marker of plasma leakage in dengue infection with an optimal cut-off value for each of the first 3 days of the patient's fever. A pediatric study was recommended to obtain the optimal cut-off value for HSPG.

KADAR 2,3-DINOR-6-KETO-PROSTAGLANDIN-F1 DALAM URIN WANITA PASCAMENOPAUSE ALAMI DAN PRAMENOPAUSE YANG MINUM ASPIRIN 100 MG Arieselia, Zita; Setiawati, Arini; Setiabudy, Rianto; Baziad, Ali
Bahasa Indonesia Vol 10 No 2 (2011): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: The prevalence of cardiovascular diseases in women increases sharply after menopause. In postmenopausal women, thromboxane production increases while prostacyclin production decreases. Low dose aspirin (75- 150 mg) has long been known as an antiplatelet aggregator. Aspirin reduces the production of both thromboxane (potent thrombocyte aggregator and vasoconstrictor) and prostacyclin (anti thrombocyte aggregator and potent vasodilator).Methods: The present study was an open-label clinical trial with 2 parallel groups. One group consisted of 15 premenopausal women (age > 40 years) while the other group 15 postmenopausal women (for 3 - 5 years). Twenty-four hours urine was collected from each subject before and after aspirin 100 mg daily for 7 days. The concentration of prostacyclin was measured as its metabolite (2,3-dinor-6-keto-prostaglandin-F1) in urine using EIA (Enzyme Immunoassay). Thromboxane as its urinary metabolites (11-dehidrotromboksan-B2) was also measured in these same urine samples in the previous study.Results: Previous study showed that aspirin significantly reduced thromboxane in both groups, with significantly larger percentage reduction in postmenopausal women compared to premenopausal women. Results of the present study showed that aspirin reduced prostacyclin significantly in both premenopausal women (mean difference = 78.44 ng/g creatinine; p = 0.001) and postmenopausal women (mean difference = 35.71 ng/g creatinine; p <0.001), but the percentage reduction between the groups was not significantly different (46,26% vs. 40,94%; p = 0,574). The decrease in thromboxane and prostacyclin should be compared (as the decrease in the ratio of 11-dehidrotromboksan-B2 / 2,3-dinor-6-keto-prostaglandin-F1) to assess aspirin efficacy as an antithrombotic. Calculation of the ratio of 11-dehidro-tromboksanB2 / 2,3-dinor-6-keto-prostaglandin-F1 before aspirin consumption was much higher in postmenopausal women compared to that in premenopausal women (4.09 vs. 1.13; p = 0.001). The decrease in 11-dehidro-tromboksan-B2 / 2,3- dinor-6-keto-prostaglandin-F1? ratio by aspirin was found much larger in postmenopausal women compared to that in premenopausal women (1.91 vs.0.17; p = 0.022).Conclusions: It was concluded that aspirin reduced prostacyclin significantly in each group with nonsignificant percentage reduction between groups, but reduced the 11-dehidro-tromboksan-B2/2,3-dinor-6-keto-prostaglandin-F1? ratio much larger in post-menopausal women compared to that in premenopausal women.

Co-Authors Adi Hidayat Adi K Aman, Adi K Agus Setiyono Agustin Iskandar Ahmad Sulaeman Akmal Taher Ali Baziad Ali Baziad Ali Sulaiman Ali Sulaiman Ali Sulaiman Alida Harahap Alida Roswita Harahap Anna Rozaliyani Arini Setiawati Aru W Sudoyo Aryati Aryati Ascobat, Purwantyastuti Astuti Giantini Bachtiar Husein Bambang Sutrisna Bambang Sutrisna Bernardus Philippi Beti E. E Dewi, Beti E. E Beti Ernawati Dewi Broto Wasisto Broto Wasisto Cleopas Martin Rumende Cosphiadi Irawan COSPHIADY IRAWAN Daldiyono H Dalima A.W. Astrawinata Dewi Muliaty Diani Kartini Djajadiman Gatot Djumhana Atmakusuma Djumhana Atmakusuma, Djumhana Elly Herwana Erlin Listiyaningsih Fadlika Harinda Frans D. Suyatna Frans Santosa Frans Santosa Gayatri, Anggi Harapan Parlindungan Ringoringo Harapan Parlindungan Ringoringo Hardi Darmawan Harry Isbagio Harry Isbagyo, Harry Haryana, Sofia M Herdiman T. Pohan Hidayati, Anggi Puspa Nur Husniah Th-Akib I Dewa Gede Ugrasena Idrus Alwi Imam Effendi Ina Susianti Timan Indra Kusuma Indrasari, Nuri Dyah INDRAYANI, LENNY Inge A. Kristanti Instiaty, Instiaty Irawan Yusuf Iskandar Wahidiyat Iskandar Wahidiyat Iwan Darmansjah Jason Sriwijaya Johannes Hudiono Julitasari Sundoro Julitasari Sundoro Jusman, Sri W Kanadi Sumapradja Kato, Mitsuyasu Laurentius A. Lesmana LENNY INDRAYANI Leonard Nainggolan Lestari Rahayu Lia Gardenia Partakusuma Lina Lasminingrum Lisnawati Rachmadi Madoka Takeuchi Marliana Sri Rejeki Marulam M. Panggabean Masahiro Takeuchi Melva Louisa Mercy T. Panjaitan Muchtaruddin Mansyur Muhammad Baharudin Murdani Abdullah Murti Andriastuti, Murti Nafrialdi Nafrialdi Noviyantih, Noviyantih Nurul Akbar Nuzirwan Acang Nyoman Kertia Primariadewi Rustamadji Priyono, Harim Pukovisa Prawiroharjo Puteri, Meidi U. Putri, Pingkan Permata R Sjamsuhidajat Rahajuningsih Dharma Rahajuningsih Dharma Rahajuningsih Dharma Rahajuningsih Dharma Rahayuningsih Setiabudy Rahayuningsih Setiabudy Rejeki, Marliana Sri Renan Sukmawan Restuti, Ratna Dwi Riadi Wirawan Rikarni Rikarni Robby Zulkarnain Rulina Suradi Rulina Suradi Sapatawati Bardososono Saptawati Bardososono Saukani Gumay Septelia I. Wanandi Settrin Chenderawasi Sidartawan Soegondo Siskawati Suparmin Siti Hafilah Sjaifoellah Noer Soehartati Gondowiardjo Sonar Panigoro Suhendro Suhendro Suyanto Sidik Suyanto Sidik Tambunan L Tambunan, Tambunan L Toar J.M. Lalisang Unggul Budihusodo Vera Yuwono Vivian Soetikno Wahono Sumaryono Wardhani, Bantari W.K. Watanabe, Yukihide Wawaimuli Arozal Wibowo, Suryo Anggoro Kusumo Windy Sahar Yahdiana Harahap Yefta Moenadjat Zita Arieselia

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