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All Journal Medical Journal of Indonesia Indonesian Journal of Rheumatology JFIOnline Narra J Pharmaceutical Sciences and Research (PSR) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Siti Setiati
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Narra J

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Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial Putranto, Rudi; Setiati, Siti; Nasrun, Martina W.; Witjaksono, Fiastuti; Immanuel, Suzanna; Subekti, Imam; Harimurti, Kuntjoro; Siswanto, Agus; Shatri, Hamzah; Suwarto, Suhendro; Megantara, Marcelino A.
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1342

Abstract

The coexistence of depression and type 2 diabetes mellitus (T2DM) can significantly worsen disease prognosis and lower quality of life. Emerging evidence suggests that vitamin D deficiency contributes to the progression of T2DM and is closely associated with the development of depression. The aim of this study was to investigate the effects of cholecalciferol on depression in patients with T2DM, exploring its mechanisms by analyzing its impact on C-peptide, serotonin, and neurotrophin-3 levels. A double-blind, randomized, placebo-controlled clinical trial was conducted at Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from April 2021 to September 2022. Patients with T2DM and depressive symptoms were randomly assigned to two groups: received 4000 IU of cholecalciferol daily and received a placebo for 12 weeks. Depression was assessed using the Beck Depression Inventory-II (BDI-II) before and 12 weeks after the intervention. The levels of C-peptide, serotonin, and neurotrophin-3 were measured at the end of the fourth week of intervention using the enzyme-linked immunosorbent assay (ELISA) method. Between-group comparisons were made using independent Student t-tests and Mann-Whitney U tests. Paired Student t-tests or Wilcoxon tests were applied for within-group comparisons between pre- and post-intervention. A total of 70 T2DM patients with depression were included in this study, comprising 38 patients in the cholecalciferol group and 32 in the placebo group. C-peptide levels increased significantly in the cholecalciferol group compared to the placebo group (p=0.006). No significant differences were observed in serotonin and NT-3 levels between the cholecalciferol group compared to the placebo group. The cholecalciferol group had a significantly greater reduction in BDI-II scores compared to the placebo group (p<0.001). This trial highlights that taking cholecalciferol might help ease mild to moderate depression symptoms in patients with T2DM by enhancing c-peptide levels, though its effects on serotonin and neurotrophin-3 are still unclear.
Co-Authors Abdul Aziz Rani Abdul Aziz Rani Abellia, Gaby Adityo Susilo, Adityo Afistianto, Muhammad Fikri Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Agus Siswanto Aida Lydia Alimuddin, Suriani Alvina Widhani, Alvina Amalialjinan, Nadia Andreas Arie Setiawan, Andreas Arie Andri Sanityoso Andri Sanityoso Anindyanti, Risma Debby Ardi Ardian, Ardi Ari F Syam Ari Fahrial Syam Arif Mansjoer Arya Govinda Arya Govinda Roosheroe, Arya Govinda Aulia Rizka, Aulia Ayatullah Khomaini Bambang Setyohadi Bambang Sutrisna Budi I Santoso, Budi I Budi Iman Santoso Budi Tan Oto Catarina Budyono, Catarina Ceva W. Pitoyo CHAIDIR A MOCHTAR, CHAIDIR A Cleopas M Rumende, Cleopas M Dadang Makmun Dharmeizar Dharmeizar Dian Handayani Diana, Nyimas Dienillah, Syifa Sarah Dita Adhitianingsih, Dita Djumhana Atmakusuma, Djumhana Dono Antono Drupadi Harnopidjati Singh Dillon Dyah Purnamasari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edy Rizal Wahyudi Em Yunir, Em Eric Daniel Tenda Ernawati Erwinanto Esthika Dewiasty, Esthika Euphemia Seto, Euphemia Febriyani Fiastuti Witjaksono Findy Prasetyawaty, Findy Firtantyo A Syahputra, Firtantyo A Ginova Nainggolan Harrina E Rahardjo, Harrina E Harrina Erlianti Rahardjo, Harrina Erlianti Harry Isbagio Herikurniawan, Herikurniawan Heru Sundaru Idrus Alwi Ika P Wijaya, Ika P Ika Prasetya Wijaya Imam Subekti Ina Susianti Timan Indra G Mansur, Indra G Iris Rengganis Irsan Hasan Jimmy Tesiman, Jimmy Joedo Prihartono Junizaf Junizaf Kuntjoro Harimurti Laura A Siahaan, Laura A Lugyanti Sukrisman Lukman Hakim M Sadikin M Yamin Marcel Prasetyo Marcellus Simadibrata Marcellus Simadibrata Martini, Rose D Marulam Panggabean, Marulam Megantara, Marcelino A. Meilania Saraswati Merry Christianie Merry Christianie, Merry Muhammad Yamin Murdani Abdullah Nadia Ayu Mulansari, Nadia Ayu Nafrialdi Nafrialdi Nanang Sukmana Nasrun, Martina W. Noto Dwimartutie Nur Rasyid Nur Riviati, Nur Nurhadi Ibrahim Partini P Trihono, Partini P Ponco Birowo Pradana Soewondo Pudji Rahardjo Purwita W Laksmi, Purwita W Purwita Wijaya Laksmi Rachmat Hamonangan, Rachmat Radhiyatam Mardhiyah, Radhiyatam Ralph Girson Gunarsa Retnosari Andrajati Rino A Gani Rochani Sumardi, Rochani Roza Mulyana Rudi Putranto Rudy Hidayat Saraswati, Mita Hafsah Savitri, Ary Indriana Simon Salim Siti A Nuhonni, Siti A Stevent Sumantri, Stevent Suhendro Suwarto, Suhendro Suksmono Haricahyo Sumariyono Supartondo Supartondo Surahman Hakim Suzanna Immanuel Tanadi, Caroline Tedjasaputra, Shirly Elisa Teguh H Karjadi, Teguh H Teguh H. Karjadi, Teguh H. Tirza Z Tamin Tities Anggraeni Indra, Tities Anggraeni Tri B.W. Rahardjo Uiterwaal, Cuno Ummi Ulfah Madina, Ummi Ulfah vera vera, vera Vidhia Umami, Vidhia Wasilah Rochmah Widayat Djoko Santoso, Widayat Djoko Widi Atmoko Widjajalaksmi Kusumaningsih, Widjajalaksmi Wiguno Prodjosudjadi Wijaya, Indra Wismandari Wisnu Wresti Indriatmi B. Makes Wulyo Rajabto Yulia Trisna Yulia Trisna, Yulia