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All Journal Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Human Nutrition Indonesian Journal of Tropical and Infectious Disease Berkala Kedokteran MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Oto Rhino Laryngologica Indonesiana Jurnal Respirasi (JR) Medica Hospitalia Journal of Issues in Midwifery Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Babali Nursing Research Caring : Jurnal Pengabdian Masyarakat Indonesian Journal of Cancer Journal of Global Pharma Technology Journal of Community Health and Preventive Medicine (JOCHAPM) Jurnal Ilmu Kedokteran Keluarga JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Cermin Dunia Kedokteran
Nanik Setijowati
Department Of Family Medicine, Faculty Of Medicine, Brawijaya University.
Religion Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : Medica Hospitalia

 1 
The Correlation between Volatile Organic Compounds (VOC) with Leukotriene B4 and Eosinophil Counts in Chronic Obstructive Pulmonary Disease Patients Santosa, Andrew; Putra, Ngakan Putu Parsama; Listyoko, Aditya Sri; Wardoyo, Arinto Yudi Ponco; Setijowati, Nanik
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.1035

Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by increasing Leukotriene B4 (LTB4) and eosinophil counts. Volatile organic compounds (VOCs) have shown promise as non-invasive biomarkers, reflecting COPD pathophysiology. Identifying specific VOCs associated with increased LTB4 and eosinophil counts could lead to the discovery of potential biomarkers for COPD severity or progression. AIMS: This study aims to investigate the correlation between VOCs and leukotriene B4 (LTB4) levels, as well as eosinophil counts counts in COPD patients. METHOD: Using an observational-analytic method with a case-control approach, 20 COPD patients and 20 controls were enrolled from the respiratory outpatient department of Dr. Saiful Anwar General Hospital, Malang. VOC levels were measured using a breath analyzer, while LTB4 levels were determined through enzyme-linked immunosorbent assays. Spearman’s correlation tests examined associations between VOCs, LTB4, eosinophil counts, and comorbidity, with Mann-Whitney tests comparing results against the control group. Data significance was set at p < 0.05. RESULT: There were 40 COPD patients and 40 controls in this study. There were significant differences between VOCs in the COPD group and the control group (p < 0.05). LTB4 level significantly increased in the COPD group than in the control group (p < 0.001), and there was no difference in the eosinophil level. There was a correlation between LTB4 and VOC level of C2H5OH in COPD patients (p = 0.009; r = 0.410). There was no correlation between eosinophil counts and VOCs (p = 0.939). The level of VOCs was significantly different between patients with only COPD and patients with COPD and comorbid lung cancer (p < 0.05). CONCLUSION: There is a correlation between VOC and LTB4 in COPD patients.
Co-Authors Aisyah Aisyah Amalia Pradanti Widarso, Amalia Pradanti Anjelin, Isabella Kusuma Arinto Yudi Ponco Wardoyo Aslam, Achmad Bayhaqi Nasir Asmika Asmika Badrul Munir Bimo Mubyarto Catur Ari Setianto Chozin, Iin Noor Damayanti, Gita Retno DAMAYANTI, ZUHRIA PUSPITA Dasa Novita, Khuznita Dessika Rahmawati Deuina Grishelda, Irma Dewi Santosaningsih Dhelya Widasmara Dhiar Widianingtyas, Dhiar Dian Kusumaningtyas, Dian Djajalaksana, Susanthy Dwi Rahayu, Indriati Eddy, Mochammad Istiadjid Eko Arisetijono Erlangga, Eggi Eviana Norahmawati Fadli, Muhammad Luqman Fitria, Ruman Freddy, Antonius Hanggara, Dian Sukma Hatimul Asmy Hendradi Surjotomo, Hendradi Himawan, Asavita Rhena Holipah, Holipah I Wayan Agung Indrawan Ida Sri Maduretno, Ida Sri Imelda Ritunga Imowanto, Yuddy Indradmojo, Christyaji Indriati Dwi Rahayu irsan , Istan Irmansyah Irsan, Istan Irmansyah Jasin, Jessica Lingga Jemima Lewi Santoso Johan, Willy Johannes, Jeffrey Kartika Rini Kartikasari, Ulfah Kuntadi, Muhammad Lilik Zuhriyah Listuhayu, Kararawi Listyoko, Aditya Sri Maelo, Clara Angraini Mahendra, Reza Aditya Mahulette, Aisyah Nurulhisa Marini . Marini, Gita Mellyanawati Mellyanawati Michaela, Cleine Minarni Wartiningsih Muhammad, Athaya Rahmanardi Natasha Halim, Angie Nazila Tanasya Nia Novita Wirawan, Nia Novita Normawati Normawati, Normawati Novita, Khuznita Dasa Nugroho, Rafiq Sulistyo Nugroho, Soeryanto Eko Agung Nurul Laili Oktaviana, Ratih Panjaitan, Damaris Gabrielle Valentine Pardosi, Delima Silvani Paskadita, Nafiri Eldya Pradana, Wisniardhy Suarnata Prasetyadjati, Ari Pratiwi, Suryanti Dwi Pratiwi, Suryanti Dwi Prihatiningsih, Riska Dwi Putra, Ngakan Putu Parsama Putu, Ngakan rahmah, shofi nur Rahmawati Aminingrum Rakhma, Sastia Rakhmani, Alidha Nur Rusnianah, Farida Santosa, Andrew Sartono, Teguh Rahayu Siswidiyati, Siswidiyati Sitompul, Boyke Soehartono Soehartono Soplantila, Chelsy Gravia Sri Andarini Sugiri, Yani Jane Suparno Adi Santika, Suparno Adi Syahrul Chilmi, Syahrul Tantular, Rezki Tita Hariyanti Titin Andri Wihastuti Tri Wahju Astuti, Tri Wahju Triyuliarto, Dwiwardoyo Wahyudi, Mgs Ahmad Widowati, Yenny Wilmida, Anggun Diah Yoga Sedana, I Ketut Yusdianto, Adrian Yuyun Yueniwati Zaiyanah, Munsifah Zamroni Afif Zarithsyafiqah, Siti Zhakia, Jelita Zhufatul