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All Journal Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Human Nutrition Indonesian Journal of Tropical and Infectious Disease Berkala Kedokteran MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Oto Rhino Laryngologica Indonesiana Jurnal Respirasi (JR) Medica Hospitalia Journal of Issues in Midwifery Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Babali Nursing Research Caring : Jurnal Pengabdian Masyarakat Indonesian Journal of Cancer Journal of Global Pharma Technology Journal of Community Health and Preventive Medicine (JOCHAPM) Jurnal Ilmu Kedokteran Keluarga JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Cermin Dunia Kedokteran
Nanik Setijowati
Department Of Family Medicine, Faculty Of Medicine, Brawijaya University.
Religion Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : Berkala Kedokteran

 1 
EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND CARCINOEMBRYONIC ANTIGEN (CEA) RELATIONSHIP OF LUNG ADENOKARSINOMA IN SAIFUL ANWAR HOSPITA MALANG Normawati, Normawati; Pratiwi, Suryanti Dwi; Setijowati, Nanik
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4073

Abstract

Abstract: EGFR mutations is associated with sensitivity to tyrosine kinase inhibitors (TKI’s) therapy which are found in Lung Adenocarcinoma. There are some limitations in detecting EGFR mutation. CEA is also expected to predict treatment efficiency of EGFR-TKIs therapy. In this study, we investigated the relationship between serum Carcinoembryonic antigen (CEA) and Epidermal Growth Factor Receptor (EGFR) Mutations in Lung Adenocarcinoma patient. Methods : The research was conducted in Dr. Saiful Anwar General Hospital Malang. From May 2014 to November 2015, 54 lung adenocarcinoma patients who had underwent measurements of EGFR  mutation and serum CEA level were retrospectively recruited. None of them had surgery, radiotherapy, chemotherapy and  targeted therapy. EGFR mutation was detected using PCR, serum CEA levels were analyzed using electrochemical luminescence. Result: Abnormal serum levels of CEA were significantly associated with EGFR mutation (95% CI, P=0,043) with an odds ratio of 3.4 (95% CI: 1.010-11.451). The area under the ROC curve for CEA was 0.558 (95% CI, P=0.078). Conclusion: Serum CEA is associated with mutation of EGFR in lung adenocarcinoma patients.  Keywords : Lung cancer, adenocarcinoma, EGFR, CEA
Co-Authors Aisyah Aisyah Amalia Pradanti Widarso, Amalia Pradanti Anjelin, Isabella Kusuma Arinto Yudi Ponco Wardoyo Aslam, Achmad Bayhaqi Nasir Asmika Asmika Badrul Munir Bimo Mubyarto Catur Ari Setianto Chozin, Iin Noor Damayanti, Gita Retno DAMAYANTI, ZUHRIA PUSPITA Dasa Novita, Khuznita Dessika Rahmawati Deuina Grishelda, Irma Dewi Santosaningsih Dhelya Widasmara Dhiar Widianingtyas, Dhiar Dian Kusumaningtyas, Dian Djajalaksana, Susanthy Dwi Rahayu, Indriati Eddy, Mochammad Istiadjid Eko Arisetijono Erlangga, Eggi Eviana Norahmawati Fadli, Muhammad Luqman Fitria, Ruman Freddy, Antonius Hanggara, Dian Sukma Hatimul Asmy Hendradi Surjotomo, Hendradi Himawan, Asavita Rhena Holipah, Holipah I Wayan Agung Indrawan Ida Sri Maduretno, Ida Sri Imelda Ritunga Imowanto, Yuddy Indradmojo, Christyaji Indriati Dwi Rahayu irsan , Istan Irmansyah Irsan, Istan Irmansyah Jasin, Jessica Lingga Jemima Lewi Santoso Johan, Willy Johannes, Jeffrey Kartika Rini Kartikasari, Ulfah Kuntadi, Muhammad Lilik Zuhriyah Listuhayu, Kararawi Listyoko, Aditya Sri Maelo, Clara Angraini Mahendra, Reza Aditya Mahulette, Aisyah Nurulhisa Marini . Marini, Gita Mellyanawati Mellyanawati Michaela, Cleine Minarni Wartiningsih Muhammad, Athaya Rahmanardi Natasha Halim, Angie Nazila Tanasya Nia Novita Wirawan, Nia Novita Normawati Normawati, Normawati Novita, Khuznita Dasa Nugroho, Rafiq Sulistyo Nugroho, Soeryanto Eko Agung Nurul Laili Oktaviana, Ratih Panjaitan, Damaris Gabrielle Valentine Pardosi, Delima Silvani Paskadita, Nafiri Eldya Pradana, Wisniardhy Suarnata Prasetyadjati, Ari Pratiwi, Suryanti Dwi Pratiwi, Suryanti Dwi Prihatiningsih, Riska Dwi Putra, Ngakan Putu Parsama Putu, Ngakan rahmah, shofi nur Rahmawati Aminingrum Rakhma, Sastia Rakhmani, Alidha Nur Rusnianah, Farida Santosa, Andrew Sartono, Teguh Rahayu Siswidiyati, Siswidiyati Sitompul, Boyke Soehartono Soehartono Soplantila, Chelsy Gravia Sri Andarini Sugiri, Yani Jane Suparno Adi Santika, Suparno Adi Syahrul Chilmi, Syahrul Tantular, Rezki Tita Hariyanti Titin Andri Wihastuti Tri Wahju Astuti, Tri Wahju Triyuliarto, Dwiwardoyo Wahyudi, Mgs Ahmad Widowati, Yenny Wilmida, Anggun Diah Yoga Sedana, I Ketut Yusdianto, Adrian Yuyun Yueniwati Zaiyanah, Munsifah Zamroni Afif Zarithsyafiqah, Siti Zhakia, Jelita Zhufatul