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Journal : INDONESIAN JOURNAL OF PHARMACY

Antihyperurisemia activity of water extract of black seed (Coleus ambonicusLour) in balb-c mice and its standardization Andi Suhendi; Nurcahyanti .; Muhtadi .; EM Sutrisna
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.619 KB) | DOI: 10.14499/indonesianjpharm0iss0pp77-84

Abstract

Effect  of  water  extract  of  black  seed  on  uric  acid  metabolism  in hyperuricemia mice models were studied. The influence of water extract of black seed  on  uric  acid  biosynthesis  was  xamined  using  mice  treated  by  250  mg/ body  weight  potassium  oxonate  intra  peritoneal.  The result  showed  that  water extract of black seed (200 mg/kg body weight, per oral) have a significant effect in reduction in plasma uric acid levels in comparison to negative control, but less active  than  positive  control  (allopurinol).  The  levels  of  uric  acid  in  mice  plasma for negative control, black seed extract and positive control were 3.100 ± 0.346 mg/dL,  0.200  ±  0.100  mg/dL  dan  1.200  ±  0.561  mg/dL,  respectively.  The standardization  performed  by  determined  specific  and  non  specific  parameters based  on  National  Bureau  of  Food  and  Drug,  Republic of  Indonesia.  Specific parameters  of  water  extract  of  black  seed  are  phenolic  content,  and  flavonoid content  are  0.664  ±  0.035  %  and  0.400  ±  0.018  %,  respectively.  Non  specific parameters of water extract of black seed are loss of weight, water content, ash content,  ash  insoluble  acid  content,  heavy  metals  contamination  (Pb  and  Cd), and  aflatoxin  residue  are  14.93-14.99%,  6.09-7.89%, 7.12-7.49%,  5.20-6.66%, 6.405 +0.211 ppm, 0.0096 +0, not detected, respectively.Key words: antihyperuricemia effect, water extract of black seed, standardization
Co-Authors 'Aina Fahrina Anwar . Haryoto . Haryoto, . . MUHTADI . Muhtadi A Anifatussaa'dah Abdillah, Safira Mafaza Abdul Rohman Abidi, Subhan R Aflit Nuryulia Praswati Agus Salim Maulana Agus Triyono Agus Ulinuha Ahmad, Farhand Ainur Tri Hapsari Aisy, Inandrohatul Alida Rahmalia Damayanti Alvita Marshanda Purnama Puteri Amalinda Ayu Faroska Anifatussaa'dah, A Annissa, Yanis Nur Anwar, 'Aina Fahrina Ardalia Rinanda Oktaviani Arief Nurrochmad Arifah Sri Wahyuni Asti, Dhinar Aulia Tassya Fadhilla Auliya, Dhiyahul Aurum, Mursalina Nanda Ayusari Ramly, Erlya Basusena, Rahardian Surya Broto Santoso Burhanudin Ichsan Cahyaningrum, Safira Citra, Tia Mella Citradewi, Lia Intan Da'i, Muhammad Dedi Hanwar Devi Eka Nitoviani Dewi, Triana Ariska Didik Setiawan Djoko Wahyono Dwi Lestari Dwi Sarbini Dzafira, Laila Eka Prasnaparamita W Eky Wahyu Novarista Em Sutrisna Erindyah Retno Wikantyasning Erlya Ayusari Ramly Erna Herawati Erna Herawati, Erna Fadhilla, Aulia Tassya Fahriza Mei Trihatmoko Fajrina Eka Puspa Farah Salsabila Farid Adi Prasetya Faridita khoirun Nisa' Faroska, Amalinda Ayu Fauzi Ahmad Muda Fidhia Nur Rifaini Fitriani, Rizki Ainun Frida Rosenova Gunawan Setyadi Hadi, Ismanurrahman Haliza Arzeti Nurseptiria Hamimatusalma Alkautsar Hamzah, Hasyrul Handayani, Vivi Resty Hapsari, Atikah Haryoto - Haryoto Haryoto Haryoto, H Haya Nabilah Utama Heni Lutfiyati, Heni Hesti Pawarti Hesti Pawarti HI, Marsilia Rosa Sinensis Hidajah Rachmawati Hidayah Karuniawati Hidayati, Ria Husna Amalia Halwa Ichsan, Burhanudin Ida Maesaroh Ida Maesaroh, Ida Ika Trisharyanti Dian Kusumowati Jessica Rosalinda Joko Priyanto Wibowo Kasful Asra Sakika Keisya, Aulita Khairunnisa Azani Meilinasary, Khairunnisa Azani Kharisma Aulia Husna Khusnul Khotimah khusnul khotimah Kumalla, Novea Kusumastuti, Lina Ayu Laila Dzafira Lia Intan Citradewi Lina Ayu Kusumastuti Listiana Masyita Dewi M Muhtad Manggo, Tasya Faradillah Mariska Sri Harlianti Marsilia Rosa Sinensis HI Marsya, Vitania MAULANA, RIZA Muhammad Da'i Muhtad, M Muhtadi Muhtadi - Muhtadi Muhtadi Muhtadi, M Muslihah, Sayyidah Nurul Nida’ Nur Jannah Nisa', Faridita khoirun Nur Muhammad Arrizky Nurcahyanti . Nurcahyanti Wahyuningtyas Nurcahyanti Wahyuningtyas, Nurcahyanti Nurseptiria, Haliza Arzeti Nurul Tri Anggraini Oktaviani, Ardalia Rinanda Pawarti, Hesti Pawarti, Hesti Pebriani, Sonia Ardilla Peni Indaryudha Peni Indaryudha, Peni Prastiyanto, Muhammad Evy Puspa, Fajrina Eka Putri, Ega Annisa Raafika Studiviani Rahardian Surya Basusena Ranatri Puruhita Rarastoeti Pratiwi Ria Utami, Primanitha Rifaini, Fidhia Nur Rizal Maarif Rukmana, Rizal Maarif Rizki Ainun Fitriani Rizky Ainun Fitriani Rosa Sayentina Amin Sabtanti Harimurti, Sabtanti Sari Haryanti Sayyidah Nurul Muslihah Selviana, S Siti Aisyah Siti Aisyah Sofyan, Aditya Naova Studiviani, Raafika Subekti, Istiara Subhan R Abidi Tanti Azizah Sujono Tasysaningtyas, Thalia Fiandra Tia Mella Citra Tista Ayu Fortuna Trihatmoko, Fahriza Mei Utama, Haya Nabilah Vera Widyastuti Vitania Marsya Vivi Resty Handayani Wahyu Utami Weka Sidha Bhagawan Wibowo, Agustono Widyastuti, Vera Yanis Nur Annissa