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Andi Suhendi
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Biomedika

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PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL Muhtadi, .; Haryoto, .; Sujono, Tanti Azizah; Indaryudha, Peni; Suhendi, Andi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains  avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet
UJI PRAKLINIK ANTIHIPERURISEMIA SECARA IN VIVO PADA MENCIT PUTIH JANTAN GALUR BALB-C DARI EKSTRAK DAUN SALAM (Syzigium polyanthum Walp) DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L.) Muhtadi, .; Suhendi, Andi; Wahyuningtyas, Nurcahyanti; Sutrisna, EM.
Biomedika Vol 6, No 1 (2014): Biomedika Februari 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antihyperuricemia activity in vivo testing has been done of single and combined extracts of Salam (Syzigium polyanthum Walp) and Belimbing Wuluh leaves (Averrhoa bilimbi L.), and also standardized extracts. Salam leaves extraction and Belimbing Wuluh leaves carried by the water solvent. Dried extract of each ingredient had been done antihyperuricemia preclinical in vivo testing against male white mice strain Balb-C induced by potassium oxonate dose of 250 mg / kg b.w. Antihyperuricemia preclinical in vivo testing results showed that the single extracts of Salam and Belimbing Wuluh at a dose of 200 mg / kg b.w. had lower activity levels of uric acid in the blood serum of male white mice, respectively 0.640 and 0.680. While the activity of the combination of extracts of Salam-Belimbing Wuluh is 1.380.Keywords: Antihyperurisemia preclinical in vivo testing; Salam leaves extract, Belimbing Wuluh leaves extract, male white mice Balb-C
PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL Muhtadi, .; Haryoto, .; Sujono, Tanti Azizah; Indaryudha, Peni; Suhendi, Andi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v5i2.266

Abstract

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 ?g / mL. The fruit contains ? avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet
UJI PRAKLINIK ANTIHIPERURISEMIA SECARA IN VIVO PADA MENCIT PUTIH JANTAN GALUR BALB-C DARI EKSTRAK DAUN SALAM (Syzigium polyanthum Walp) DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L.) Muhtadi, .; Suhendi, Andi; Wahyuningtyas, Nurcahyanti; Sutrisna, EM.
Biomedika Vol 6, No 1 (2014): Biomedika Februari 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v6i1.283

Abstract

Antihyperuricemia activity in vivo testing has been done of single and combined extracts of Salam (Syzigium polyanthum Walp) and Belimbing Wuluh leaves (Averrhoa bilimbi L.), and also standardized extracts. Salam leaves extraction and Belimbing Wuluh leaves carried by the water solvent. Dried extract of each ingredient had been done antihyperuricemia preclinical in vivo testing against male white mice strain Balb-C induced by potassium oxonate dose of 250 mg / kg b.w. Antihyperuricemia preclinical in vivo testing results showed that the single extracts of Salam and Belimbing Wuluh at a dose of 200 mg / kg b.w. had lower activity levels of uric acid in the blood serum of male white mice, respectively 0.640 and 0.680. While the activity of the combination of extracts of Salam-Belimbing Wuluh is 1.380.Keywords: Antihyperurisemia preclinical in vivo testing; Salam leaves extract, Belimbing Wuluh leaves extract, male white mice Balb-C
PENGEMBANGAN POTENSI EKSTRAK KULIT BUAH RAMBUTAN SEBAGAI BAHAN OBAT HERBAL ANTIHIPERKOLESTEROL . Muhtadi; . Haryoto; Tanti Azizah Sujono; Peni Indaryudha; Andi Suhendi
Biomedika Vol 5, No 2 (2013): Biomedika Agustus 2013
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v5i2.266

Abstract

The rind of rambutan fruit (Nephelium lappaceum L.) has been reported to have a very strong antioxidant activity with IC50 value of 7.74 μg / mL. The fruit contains  avonoids and phenolic . This compounds are potentially as hypolipidemic effect. This study aims to determine the hypolipidemic effect of 96% of ethanolic extract of rind of rambutan fruit in wistar strain male rats. This research method is the pre- and post-control group design. 25 rats were divided into 5 groups. Group I (negative control) were treated by a solution of 0.5% CMC-Na, group II (positive control) were treatedby cholestyramine 0.8 kg / kg, whereas group III, IV and V treated by 96% of ethanolic extract of rind of rambutan with a dose of 125 , 250, and 500 mg / kg respectively. hiperkolesterlemia induction is done by giving a high cholesterol diet and feed for 4 weeks. High-cholesterol diet consists of cooking oil, quail egg yolk, water, PTU and feed high cholesterol consisting of margarine and standard feed. Treatment of mice was conducted for 2 weeks. The results showed that the 96% of ethanolic extract of rind of rambutan fruit with a dose of 125, 250, and 500 mg / kgbw have antihyperkolesterol activity 21.39 ± 6.61%, 31.15 ± 18.15%, and 60.75 ± 8, 26%.Keywords: Antihypercholestrol, Nephelium Lappaceum L., High-cholesterol diet
UJI PRAKLINIK ANTIHIPERURISEMIA SECARA IN VIVO PADA MENCIT PUTIH JANTAN GALUR BALB-C DARI EKSTRAK DAUN SALAM (Syzigium polyanthum Walp) DAN DAUN BELIMBING WULUH (Averrhoa bilimbi L.) . Muhtadi; Andi Suhendi; Nurcahyanti Wahyuningtyas; EM. Sutrisna
Biomedika Vol 6, No 1 (2014): Biomedika Februari 2014
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v6i1.283

Abstract

Antihyperuricemia activity in vivo testing has been done of single and combined extracts of Salam (Syzigium polyanthum Walp) and Belimbing Wuluh leaves (Averrhoa bilimbi L.), and also standardized extracts. Salam leaves extraction and Belimbing Wuluh leaves carried by the water solvent. Dried extract of each ingredient had been done antihyperuricemia preclinical in vivo testing against male white mice strain Balb-C induced by potassium oxonate dose of 250 mg / kg b.w. Antihyperuricemia preclinical in vivo testing results showed that the single extracts of Salam and Belimbing Wuluh at a dose of 200 mg / kg b.w. had lower activity levels of uric acid in the blood serum of male white mice, respectively 0.640 and 0.680. While the activity of the combination of extracts of Salam-Belimbing Wuluh is 1.380.Keywords: Antihyperurisemia preclinical in vivo testing; Salam leaves extract, Belimbing Wuluh leaves extract, male white mice Balb-C
Co-Authors 'Aina Fahrina Anwar . Haryoto . Haryoto, . . MUHTADI . Muhtadi A Anifatussaa'dah Abdillah, Safira Mafaza Abdul Rohman Abidi, Subhan R Aflit Nuryulia Praswati Agus Triyono Agus Ulinuha Ahmad, Farhand Ainur Tri Hapsari Aisy, Inandrohatul Alida Rahmalia Damayanti Alvita Marshanda Purnama Puteri Amalinda Ayu Faroska Anifatussaa'dah, A Annissa, Yanis Nur Anwar, 'Aina Fahrina Ardalia Rinanda Oktaviani Arief Nurrochmad Arifah Sri Wahyuni Asti, Dhinar Aulia Tassya Fadhilla Auliya, Dhiyahul Aurum, Mursalina Nanda Basusena, Rahardian Surya Broto Santoso Burhanudin Ichsan Cahyaningrum, Safira Citra, Tia Mella Citradewi, Lia Intan Da'i, Muhammad Dedi Hanwar Dewi, Triana Ariska Didik Setiawan Djoko Wahyono Dwi Lestari Dwi Sarbini Dzafira, Laila Eka Prasnaparamita W Eky Wahyu Novarista Em Sutrisna Erindyah Retno Wikantyasning Erlya Ayusari Ramly Erna Herawati Erna Herawati, Erna Fadhilla, Aulia Tassya Fahriza Mei Trihatmoko Farah Salsabila Farid Adi Prasetya Faridita khoirun Nisa' Faroska, Amalinda Ayu Fauzi Ahmad Muda Fidhia Nur Rifaini Fitriani, Rizki Ainun Fortuna, Tista Ayu Frida Rosenova Gunawan Setyadi Hadi, Ismanurrahman Haliza Arzeti Nurseptiria Hamimatusalma Alkautsar Hamzah, Hasyrul Handayani, Vivi Resty Hapsari, Atikah Haryoto - Haryoto Haryoto Haryoto, H Haya Nabilah Utama Heni Lutfiyati, Heni Hesti Pawarti HI, Marsilia Rosa Sinensis Hidajah Rachmawati Hidayah Karuniawati Hidayati, Ria Husna Amalia Halwa Ichsan, Burhanudin Ida Maesaroh Ida Maesaroh, Ida Ika Trisharyanti Dian Kusumowati Jessica Rosalinda Joko Priyanto Wibowo Kasful Asra Sakika Keisya, Aulita Khairunnisa Azani Meilinasary, Khairunnisa Azani Kharisma Aulia Husna Khusnul Khotimah khusnul khotimah Kumalla, Novea Kusumastuti, Lina Ayu Laila Dzafira Lia Intan Citradewi Lina Ayu Kusumastuti Listiana Masyita Dewi M Muhtad Manggo, Tasya Faradillah Mariska Sri Harlianti Marsilia Rosa Sinensis HI Marsya, Vitania MAULANA, RIZA Muhammad Da'i Muhtad, M Muhtadi Muhtadi - Muhtadi Muhtadi Muhtadi, M Muslihah, Sayyidah Nurul Nida’ Nur Jannah Nisa', Faridita khoirun Nur Muhammad Arrizky Nurcahyanti Wahyuningtyas Nurcahyanti Wahyuningtyas, Nurcahyanti Nurseptiria, Haliza Arzeti Nurul Tri Anggraini Oktaviani, Ardalia Rinanda Pawarti, Hesti Pawarti, Hesti Peni Indaryudha Peni Indaryudha, Peni Puspa, Fajrina Eka Putri, Ega Annisa Raafika Studiviani Rahardian Surya Basusena Ranatri Puruhita Ria Utami, Primanitha Rifaini, Fidhia Nur Rizki Ainun Fitriani Rizky Ainun Fitriani Rosa Sayentina Amin Sabtanti Harimurti, Sabtanti Sari Haryanti Sayyidah Nurul Muslihah Selviana, S Siti Aisyah Siti Aisyah Studiviani, Raafika Subekti, Istiara Subhan R Abidi Tanti Azizah Sujono Tasysaningtyas, Thalia Fiandra Tia Mella Citra Tista Ayu Fortuna Trihatmoko, Fahriza Mei Utama, Haya Nabilah Vitania Marsya Vivi Resty Handayani Wahyu Utami Widyastuti, Vera Yanis Nur Annissa