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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Kimia (Journal of Chemistry) IPTEK The Journal for Technology and Science Alchemy : Journal of Chemistry Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal AgroBiogen Indonesian Journal of Cancer Chemoprevention MPI (Media Pharmaceutica Indonesiana) UNEJ e-Proceeding Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan Journal Of Vocational Health Studies SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Kreativitas PKM Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Riayah: Jurnal Sosial dan Keagamaan Jurnal Al-Irsyad: Jurnal Bimbingan Konseling Islam Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal Pharmasci (Journal of Pharmacy and Science) Berkala Penelitian Hayati Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan International Journal of Sociology of Religion Ulul Albab: Journal Dak'wah and Social Religiosity

Sukardiman

Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, UniversitasAirlangga, Surabaya

Author-ID : 390077

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PENGEMBANGAN PRODUK JAMU DAN SIMPLISIA DARI TANAMAN LOKAL SUKU TENGGER Retno Widyowati; Sukardiman Sukardiman; Tutik Sri Wahyuni; Aty Widyawaruyanti; Kholis Amalia Nofianti
Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Vol 3 No 2 (2023)
Publisher : Sekolah Tinggi Ilmu Ekonomi Indonesia (STIESIA) Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24034/kreanova.v3i2.5672

Desa Ngadisari, Kabupaten Probolinggo memiliki beragam tanaman liar yang berpotensi dimanfaatkan untuk pengobatan. Beberapa diantaranya adalah adas, jarak, kecubung, keningar, purwoceng, krangean, kayu ampet, pulosari, dan pronojiwo. Beragamnya tanaman yang ada di sekitar masyarakat setempat merupakan kekayaan tersendiri dari daerah ini, namun tidak banyak masyarakat Desa Ngadisari yang memanfaatkannya secara baik. Hal ini terjadi karena aspek kekurangpraktisan yaitu bahan-bahannya harus diramu terlebih dahulu, selain itu banyak kios yang menjual obat modern di lokasi terpencilpun. Berdasarkan latar belakang di atas, maka dilakukan pelatihan pengembangan produk jamu dan simplisia dari tanaman lokal Bromo bagi masyarakat Suku Tengger, khususnya di Desa Ngadisari, Probolinggo. Produk tersebut berupa jamu godogan, teh herba dan simplisia yang dapat digunakan oleh masyarakat ataupun dipasarkan dengan nilai ekonomi tinggi dan bermanfaat bagi kesehatan. Hal ini dapat menciptakan peluang usaha baru bagi masyarakat Desa Ngadisari sehingga meningkatkan perekonomian dan taraf kesehatan masyarakat desa tersebut, sehingga hal ini bisa membuat lingkungan baik.

Studi Etnomedisin Tanaman Obat sebagai Penurun Rasa Nyeri Sendi pada Suku Dayak Hardiyanti, Andi Sry; Sulistiyono, Ilham Robbynoor; Widiyaningsih, Arum; Sukardiman, Sukardiman; Widyowati, Retno
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 1 (2024): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i1.6213

Etnomedisin merupakan studi tentang presepsi dan konsepsi masyarakat lokal dalam memahami kesehatan atau studi yang mempelajari sistem medis etnis tradisional. Nyeri sendi adalah peradangan sendi yang ditandai dengan pembengkakan, warna kemerahan, panas, nyeri, dan kesulitan untuk bergerak. Hingga saat ini, Suku Dayak masih menggunakan metode pengobatan tradisional yang dilakukan secara turun-temurun dengan memanfaatkan bahan-bahan alam seperti tanaman. Tujuan penelitian ini menggali informasi jenis tanaman yang digunakan oleh masyarakat Suku Dayak di Desa Sambi, Kabupaten Kotawaringin Barat, Kalimantan Tengah untuk mengobati nyeri sendi dan cara penggunaannya. Metode penelitian kuantitatif dengan pengambilan sampel secara purposive dan snowball. Informan yang ditargetkan berjumlah 20 orang yang mengetahui tentang pengobatan nyeri sendi melalui wawancara dan observasi. Hasil penelitian berdasarkan rute penggunaanya itu, secara oral terdapat 4 ramuan tanaman obat dan 8 tanaman tunggal, sedangkan digunakan secara topikal terdapat 1 tanaman. Berdasarkan jumlah tanaman dalam ramuan yang paling banyak digunakan oleh masyarakat Suku Dayak yaitu 3 tanaman dalam 1 ramuan. Kesimpulan penelitian ini adalah Suku Dayak di Desa Sambi banyak menggunakan Rhodomyrtus tomentosa, Arcangelisia flava (L.) Merr, dan Orthosiphon aristatus untuk mengobati nyeri sendi, sedangkan cara formulasinya sebagian besar direbus bersamaan dengan air sebanyak 750 mL. Ramuan tersebut dikonsumsi sebanyak 3x sehari hingga kondisi membaik untuk mengobati nyeri sendi. Ethnomedicine is a study of local people's perceptions and conceptions of health or the study of traditional ethnic medical systems. Joint pain is joint inflammation characterized by swelling, redness, heat, pain, and difficulty of moving. Dayak tribe still uses traditional healing methods that have been passed down from generation to generation using natural ingredients such as plants. This research aimed to explore the types of plants used by the Dayak tribe in Sambi Village, West Kotawaringin Regency, Central Kalimantan to treat joint pain and how they are used. Quantitative research method using purposive and snowball sampling. The targeted informants were 20 people who knew about joint pain treatment through interviews and observations. The results were based on the route of use, namely oral, there were 4 medicinal plant potions and 8 single plants,while when used topically there was 1 plant. Based on the number of plants in the potion, the most widely used by the Dayak people is 3 plants in 1 potion. The conclusion of this research was the Dayak tribe in Sambi Village mostly uses Rhodomyrtus tomentosa, Arcangelisia flava (L.) Merr, and Orthosiphon aristatus to treat joint pain, while the formulation method is mostly boiled together with 750 mL of water. The potion is consumed 3 times a day until the condition improves to treat joint pain.

Senyawa Metabolit Sekunder dan Aktifitas Afrodisiak Ekstrak Etanol Cabe Jawa (Piper retrofractum Vahl) secara In Silico Taufikurrahman; Widyowati , Retno; Sukardiman
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 1 (2024): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i1.6394

Disfungsi ereksi merupakan salah satu masalah seksual yang paling umum terjadi pada pria. Obat yang tersedia di pasaran dapat digunakan untuk mengatasi masalah ini, tetapi penggunaan obat tersebut seringkali menimbulkan efek samping yang tidak diinginkan. Penggunaan bahan alami sebagai alternatif pengobatan semakin populer, salah satunya yaitu ramuan berbahan cabe jawa (Piper retrofractum Vahl). Cabe jawa diketahui memiliki berbagai macam metabolit sekunder yang memiliki peran sebagai bioaktif diantaranya aktivitas afrodisiak. Cabe jawa diekstraksi dengan etanol 96% menggunakan metode maserasi dan dianalisa dengan menggunakan LC/MS untuk mengidentifikasi metabolit sekunder yang terkandung pada cabe jawa. Sebanyak sepuluh metabolit sekunder terdeteksi yaitu Salsolinol, Quercetin, Caffeoyl putrescin, Diferuloyl putrescine, Feruloyl tyramine, Hydroxychloroquine, Tetrahydropapaveroline, Piperine, N-Oleyl-Leucine, dan Capsaicin. Selanjutnya dilakukan uji in silico terhadap masing metabolit yang diketahui dengan ligan senyawa sildenafil sebagai pembanding terhadap aktifitasnya sebagai penghambat phosphodiesterase type 5 (PDE5) dengan protein PDB ID 2H42. Dari hasil uji in silico dengan teknik molecular docking diketahui bahwa piperin memiliki aktifitas sebagai penghambat phosphodiesterase type 5 (PDE5) dengan nilai energi ikat dan konstanta inhibisi sebesar -8,62 kkal/mol dan 0,485 uM, yang merupakan aktifitas terbaik dari sepuluh metabolit sekunder yang diketahui, namun aktifitas afrodisiak senyawa piperin ini masih lebih rendah dibandingkan dengan senyawa sildenafil. Erectile dysfunction is one of the most common sexual problems in men. Drugs available on the market can be used to treat this problem, but the use of these drugs often causes unwanted side effects. The use of natural ingredients as an alternative treatment is increasingly popular, one of which is a herb made from chili jamu (Piper retrofractum Vahl). Metabolite profiling of the chili jamu plant turns out to be different depending on the location of growth. It is thought to result in differences in natural conditions and circumstances which result in differences in aphrodisiac activity. Cabe Jawa was extracted with 96% ethanol and analyzed using LC/MS. Ten secondary metabolites were detected namely Salsolinol, Quercetin, Caffeoyl putrescin, Diferuloyl putrescine, Feruloyl tyramine, Hydroxychloroquine, Tetrahydropapaveroline, Piperine, N-Oleyl-Leucine, and Capsaicin. In silico test was done using sildenafil as a control in the phosphodiesterase type 5 (PDE5) inhibitor and PDB ID 2H42 as protein. From the results of in silico tests, it was known that piperine had activity as a phosphodiesterase type 5 (PDE5) inhibitor with binding energy and inhibition constant values of -8.62 kcal/mol and 0.485 uM.

ACUPRESSURE AND AROMATIC GINGER HERB FOR A MIGRAINE Al ‘Amali, Mayla Khayra; Imandiri, Ario; Sukardiman, Sukardiman
Journal of Vocational Health Studies Vol. 2 No. 2 (2018): November 2018 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Background: Migraine is a headache with pain attacks lasting 4 - 72 hours. Pain is usually unilateral, it is pulsating, the intensity of pain is moderate to severe and aggravated by activity, and can be accompanied by nausea, vomiting, photophobia, and phonophobia. Headaches are one of the most common disorders of the nervous system. It has been estimated that 47% of the adult population experience headaches at least once in the past year in general. According to TCM, headache is a disease with a headache accompanied by a variety of symptoms, where the cause is an external pathogen and causes in the body. Acupressure is one form of traditional treatment skills by suppressing acupuncture points with emphasis on using fingers or blunt objects on the surface of the body, in order to support promotive, effective, rehabilitative efforts. In addition to acupressure, herbal drinks can also be used to reduce pain, namely aromatic ginger. Purpose: Knowing the effect of acupressure and aromatic ginger herbs (Kaempferia galangal Linn.) combination therapy in reducing migraine complaints. Method: Acupressure at Fengchi point (GB20) 50 times, Taiyang (EX-HN5) 50 times, Sanyinjiao (SP6) 30 times, Taichong (LR3) 50 times and aromatic ginger herbs (Kaempferia galangal Linn.) 15 grams for 28 days. Result: Migraine complaints decreased from 5 times a month to 3 times a month. No more complaints of nausea, hypochondrium pain, diarrhea, and insomnia. Conclusion: Acupressure at Fengchi point (GB20) was 50 times of the pressure, Taiyang (EX-HN5) was 50 times of the pressure, Sanyinjiao (SP6) was 30 times of the pressure, Taichong (LR3) was 50 times of the pressure and the aromatic ginger herbs (Kaempferia galangal Linn.) As much as 15 grams for 28 days could reduce migraine complaints.

Standardization of Myristicin in Nutmeg (Myristica fragrans Houtt.) Fruit using TLC-Densitometric Method Engel, Daniella Elizabeth; Sudjarwo; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.12-19

Background: Myristica fragrans Houtt. (Myristicaceae family), with the main content of myristicin, has been immensely used in herbal medicine. Standardization is essential to ensure the safety of natural extracts and the quality of herbal medicines using various chemical analysis techniques. Method validation is necessary to ascertain the reliability and reproducibility of the method. Myristicin is a member of the phenylpropene group, a natural organic compound found in small amounts in nutmeg fruit, which has pharmacological effects. Objective: This study aims to determine the myristicin content in nutmeg fruit using TLC-Densitometry. Methods: Determination of myristicin in nutmeg fruit extract was performed using TLC-Densitometry with silica GF254 as stationary phase, mobile phase n-hexane: ethyl acetate (8:2 v/v), and spot visualized at 285 nm. In this study, the content of myristicin in nutmeg fruit was determined using compendial methods (AOAC), thus requiring method verification with parameters including selectivity, linearity, precision, LOD, and LOQ. Results: The validation of this method showed good linearity and selectivity with y = 0.0001x + 0.0226 (r = 0.9996) and 1.53 (>1.5), respectively. The LOD and LOQ results were low with values of 0.11 μg/spot and 0.33 μg/spot, respectively. The percentage coefficient of variation for precision was below the requirement value of not more than 4%. The average myristicin content in nutmeg fruit extract was approximately 0.0017 ± 0.0003% (w/w). Conclusion: The developed method was valid and sensitive for the quantification of myristicin content in nutmeg fruit.

Efek Ekstrak Sambiloto (Andrographis paniculata Nees) pada Ekspresi Telomerase dari Kanker Payudara Tikus yang Diinduksi dengan DMBA Yurika Sastyarina; Junaidi Khotib; Sukardiman Sukardiman
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.12

ABSTRACT It has been well documented that chemical carcinogen, 7.12 dimethylbenz(a)anthracene (DMBA), plays a role in the incidence and growth of mammary cancer. Present study was designed to investigate the influence of Andrographis paniculata extract on telomerase activities on DMBA induced breast cancer in the female rat Sprague Dawley strain. DMBA-induced mammary cancer is a useful model to investigate the changes of epithelial cells that occur during mammary cancer progression. Mammary cancer model was induced 10 times twice a week by oral DMBA 20 mg/kg body weight. Mammary cancer occurred in 75 % animals nine weeks after oral administration of DMBA, it was represented with nodule on the mammary gland and the increasing of mammary gland volume compare with normal control F(1.8) = 731.711; p < 0.001. This study was also designed to investigate the effect of Andrographis paniculata extract mammary carcinoma induced by DMBA. Administration of three different dose of Andrographis paniculata (100 mg/kg, 300 mg/kg and 1000 mg/kg) had statistically different with mammary gland volume of DMBA treated rat F (4.17) = 92.777; p<0.05. So, Andrographis paniculata has significant effect on the treatment of DMBA-induced mammary carcinoma. The Epithelial cells were harvested on day 90 and stained with routine histology staining, hematoxylineosin, for morphological qualitative analysis, immunohistochemical examination. The lesions observed from the removed samples ranged widely from benign to malignant. The results showed that DMBA induce cell proliferation, nuclear irregularities, and numerous mitoses and induced cell necrosis. The effect of Andrographis paniculata inhibits cell proliferation and induces apoptosis in cancer cells. On immunohistochemical examination, it shows that Andrographis paniculata can stimulate of telomerase enzyme. Key word: Andrographis paniculata, DMBA, mammary cancer, cell proliferation ABSTRAK Telah dilakukan penelitian efek ekstrak sambiloto (Andrographis paniculata Nees) pada ekspresi telomerase terhadap kanker payudara tikus betina (Sprague dawley) yang diinduksi dengan 7,12 dimethylbenz(a)anthracene (DMBA) menggunakan metode imunohistokimia. Diketahui model kanker payudara dengan induksi DMBA untuk menginvestigasi perubahan dari sel epitel yang terjadi selama prorses karsinogenesis kanker payudara. Pemberian ekstrak sambiloto pada tikus yang mengalami kanker payudara menyebabkan penurunan volume tumor dan ditinjau dari aspek hispatologi dan imunohistokimia adanya ekstrak sambiloto menyebabkan penghambatan proliferasi sel, penurunan ekspresi telomerase dan meningkatkan apoptosis. Kata Kunci : Andrographis paniculata,DMBA, kanker payudara, proliferasi sel

Efek Ekstrak Sambiloto (Andrographis paniculata Nees.) pada Ekspresi P53 dari Kanker Payudara Tikus yang Diinduksi DMBA Yurika Sastyarina; Junaidi Khotib; Sukardiman Sukardiman
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 2 (2011): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i2.25

ABSTRACT It has been well documented that chemical carcinogen, 7.12 dimethylbenz-(a)anthracene (DMBA), plays a role in the incidence and growth of mammary cancer. Present study was designed to investigate the influence of Andrographis paniculata extract on telomerase activities on DMBA induced breast cancer in the female rat Sprague Dawley strain. DMBA-induced mammary cancer is a useful model to investigate the changes of epithelial cells that occur during mammary cancer progression. Mammary cancer model was induced 10 times twice a week by oral DMBA 20 mg/kg body weight. Mammary cancer occurred in 75 % animals nine weeks after oral administration of DMBA, it was represented with nodule on the mammary gland and the increasing of mammary gland volume compare with normal control F(1.8) = 731.711; p < 0.001. This study was also designed to investigate the effect of Andrographis paniculata extract mammary carcinoma induced by DMBA. Administration of three different dose of Andrographis paniculata (100 mg/kg, 300 mg/kg and 1000 mg/kg) had statistically different with mammary gland volume of DMBA treated rat F (4.17) = 92.777; p<0.05. So, Andrographis paniculata has significant effect on the treatment of DMBA-induced mammary carcinoma. The Epithelial cells were harvested on day 90 and stained with routine histology staining, hematoxylineosin, for morphological qualitative analysis, immunohistochemical examination. The lesions observed from the removed samples ranged widely from benign to malignant. The results showed that DMBA induce cell proliferation, nuclear irregularities, and numerous mitoses and induced cell necrosis. On immunohistochemical examination, it shows that Andrographis paniculata can stimulate of expression of p53 protein and increase the number of epithelial cells experience apoptosis. Key words: Sambiloto (Andrographis Paniculata Ness), DMBA, mammary cancer, p53 ABSTRAK Telah terdokumentasi dengan baik bahwa karsinogen kimia, 7,12 dimetilbenz(a)antrasena (DMBA), berperan dalam kejadian dan perkembangan kanker payudara. Penelitian ini dirancang untuk mengetahui pengaruh ekstrak Andrographis paniculata ekspresi p53 dan apoptosis pada kanker payudara tikus strain Sprague Dawley yang diinduksi DMBA. Kanker Payudara yang diinduksi DMBA adalah sebuah model yang berguna untuk mengetahui perubahan sel epitel yang terjadi selama perkembangan kanker payudara. Model Kanker Payudara diinduksi DMBA secara per oral 20 mg / kg 10 kali yaitu dua kali seminggu. Kanker Payudara terjadi pada 75% hewan pada sembilan minggu setelah pemberian oral DMBA, Hal itu diwakili dengan benjolan pada kelenjar susu dan meningkatnya volume kelenjar susu dibandingkan dengan F kontrol (1,8) = 731.711; p <0,001. Penelitian ini juga dirancang untuk mengetahui pengaruh ekstrak Andrographis paniculata pada kanker payudara yang diinduksi oleh DMBA. Pada pemeriksaan imunohistokimia, hal itu menunjukkan bahwa sambiloto dapat menurunkan enzim telomerase, meningkatkan ekspresi protein p53 dan meningkatkan jumlah apoptosis sel epitel. Kata Kunci: Sambiloto (Andrographis Paniculata. Ness), DMBA, Kanker payudara, p53

IDENTIFIKASI SENYAWA FITOKIMIA EKSTRAK ETANOL 70% AKAR GINSENG KUNING (RENNELLIA ELLIPTICA KORTH.) MENGGUNAKAN LC-MS/MS DAN AKTIVITAS AFRODISIAKA SECARA IN SILICO Istiqamah, Farida; Sukardiman, Sukardiman; Widyowati, Retno
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 11, No 2 (2024)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/wiyata.v11i2.870

Abstrak Latar belakang: Rennellia elliptica Korth. secara tradisional digunakan sebagai zat afrodisiak. Dilihat dari potensinya, bukti ilmiah ekstrak tumbuhan ini sebagai penghambat phosphodiesterase-5 masih belum dilakukan Tujuan: Penelitian ini bertujuan untuk mengetahui senyawa fitokimia yang terdapat pada ekstrak etanol 70% tanaman rennellia elliptica Korth. menggunakan LC-MS/MS dan aktivitas afrodisiakan secara in silico. Metode: Ekstrak etanol rennellia elliptica Korth. dianalisis menggunakan LC-MS/MS selanjutnya senyawa tersebut digunakan sebagai senyawa ligan dalam penambatan molekuler untuk mengetahui afinitas pengikatan konstituen fitokimia tersebut terhadap protein target phosphodiesterase 5 (PDB ID: 2H42). Hasil: Ditemukan 17 komponen senyawa antara lain golongan terpenoid, fenilpropanoid, antrakuinon dan flavonoid. Berdasarkan studi in silico dari 17 senyawa yang dianalisis dengan LC-MS/MS, Dulxanthone B (∆G=-9,52 kkal/mol) menunjukkan afinitas tertinggi untuk berikatan dengan target protein. Simpulan: Senyawa fitokimia dari rennellia elliptica Korth. dapat berfungsi sebagai terapi tambahan dalam penemuan obat untuk pengobatan yang menghambat phosphodiesterase 5. Abstract Background: Rennellia elliptica Korth. is traditionally used as an aphrodisiac substance. Judging from its potential, scientific evidence of this plant extract as a phosphodiesterase-5 inhibitor has yet to be conducted. Objective: . This research aims to determine the phytochemical compounds contained in the 70% ethanol extract of the Rennellia elliptica Korth plant. using LC-MS/MS. Method: The ethanol extract of rennellia elliptica Korth. was analyzed using LC-MS/MS and then the compounds were used as ligand compounds in molecular docking to determine the binding affinity of the phytochemical constituents to the target protein phosphodiesterase 5 (PDB ID: 2H42). Results: 17 compound components were found, including terpenoids, phenylpropanoids, anthraquinones and flavonoids. Based on in silico studies of 17 compounds analyzed by LC-MS/MS, Dulxanthone B (∆G=-9.52 kcal/mol) showed the highest affinity for binding to protein targets.. Conclusions: Phytochemical compounds from Rennellia elliptica Korth. may serve as an adjunct therapy in drug discovery for treatment that inhibits phosphodiesterase 5.

Peningkatan Nilai Guna Limbah Kulit Jeruk Nipis melalui Produk Sederhana Guna Mendukung SDGs bagi Petani Jeruk di Kecamatan Ujung Pangkah, Gresik Sari, Retno; Hendradi, Esti; Rijal, Agus Syamsur; Retnowati, Dini; Suzana, Suzana; Ramadhani, Firmansyah Ardian; Miatmoko, Andang; Sulistyowati, Melanny Ika; Sukardiman, Sukardiman; Ekowati, Juni
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 1 (2025): Volume 8 No 1 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i1.18244

ABSTRAK Permasalahan di Desa Bolo Ujung Pangkah Gresik produksi jeruk nipis yang tinggi/melimpah. Sehingga harga jual menjadi rendah dan banyak produk panen tidak dapat terserap oleh pasar. Selain itu limbah kulit jeruk nipis yang terbuang juga akan meningkat. Hal ini akan mengakibatkan kerugian bagi petani. Permasalahan tersebut akan dibantu dengan kegiatan pengabdian kepada masyarakat dengan tujuan untuk menambah pengetahuan masyarakat dengan meningkatkan nilai guna limbah jeruk nipis di kecamatan Ujung Pangkah, Gresik, khususnya di desa Bolo melalui pengolahan produk berbahan ekstrak kulit jeruk nipis. Hal ini sesuai dengan tujuan Sustainable Development Goals (SDGs) 12 yaitu pemanfaatan sumber daya alam yang efisien. Kegiatan pengabdian masyarakat diawali dengan pre-test yang dilanjutkan dengan pemaparan materi dan demo pembuatan produk micellar water dan hand sanitizer dari ekstrak kulit jeruk. Selanjutnya dilakukan post-test untuk mengukur perubahan pengetahuan peserta setelah pelatihan. Berdasarkan hasil pre-test dan post-test terdapat peningkatan kemampuan dan pengetahuan peserta tentang khasiat bahan yang terkandung dari kulit jeruk. Peserta dapat meningkatkan nilai guna dari limbah kulit jeruk nipis dalam bentuk produk sederhana kaya manfaat seperti micellar water dan hand sanitizer dari kulit jeruk nipis. Kata Kunci: Kulit Jeruk Nipis, Micellar Water, Hand Sanitizer, SDGs 12 ABSTRACT The problem in Bolo Ujung Pangkah Gresik Village is the high/abundant production of limes. So that the selling price is low and many harvested products cannot be absorbed by the market. In addition, the waste of lime peels that are thrown away will also increase. This will result in losses for farmers. The problem will be helped by community service activities with the aim of increasing public knowledge by increasing the utility value of lime waste in Ujung Pangkah sub-district, Gresik, especially in Bolo village through processing products made from lime peel extract. This is in accordance with the objectives of Sustainable Development Goals (SDGs) 12, namely efficient utilization of natural resources. Community service activities began with a pre-test followed by a presentation of materials and a demonstration of making micellar water and hand sanitizer products from orange peel extract. A post-test was then conducted to measure changes in participants' knowledge after the training. Based on the results of the pre-test and post-test, there was an increase in participants' abilities and knowledge about the properties of the ingredients contained in lime peel. Participants can increase the utility value of lime peel waste in the form of simple, beneficial products such as micellar water and hand sanitizer from lime peel. Keywords: Lime Peel, Micellar Water, Hand Sanitizer, SDGs 12

Theconcept Of Multiculturalimse In Major Religions In Indonesia Sukardiman
International Journal of Sociology of Religion Vol. 2 No. 2 (2024): International Journal of Sociology of Religion
Publisher : ASTEEC

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70687/ijsr.v2i2.51

Indonesia is known as a plural and multicultural country in all aspects of culture, race, ethnicity, language and religion. So that Multiculturalism can provide an understanding of how to behave in the midst of diversity. Misunderstanding will result in potential conflict, especially that which often occurs between religious communities, so understanding the concept of multiculturalism in all religions is very important. (1) Islam, sees diversity as a necessity from God, because humans were created into tribes, nations, and many religions to get to know each other or learn from each other. (2) Christian, many Bible verses talk about multiculturalism related to compassion between fellow human beings, for example Psalm 133, Galatians 3:28, Matthew: 22:37-40. (3) Catholic, one history explains how in the Second Vatican Council, the Church opened itself to the potential for truth in other religions, so that inclusivity became the key to dialogue with other religions, (4) Hinduism is the same, many of their holy texts explain the importance of maintaining peace in the midst of diversity, for example Arthavaveda III. 8.5 and Artahavaveda III. 30.4. there is also the concept of Ahimsa, Vasudeva Kutumbhakam, Tri Kaya Parisudha, Tri Hita Karana, Satyam Siwam Sundaram, catur paramita. (5) Buddhism is the same as other religions, the greatest enemy is not other groups, but oneself is the greatest enemy in creating peace on earth, (6) Confucianism also teaches about wisdom in behaving towards other religions. The application of multicultural values from all religions certainly needs to be implemented to face challenges in the midst of a multicultural society, such as attitudes of intolerance, misinterpretation or using religion as a tool to destroy other groups by providing multicultural education in the world of education and based on religious figures in each religion.

Co-Authors A. Dinar Ambarwati Achmad Fuad Hafid Adam Hermawan Al ‘Amali, Mayla Khayra Aly, M. Ainun Najib Anak Agung Gede Sugianthara Annisa Farida Muti Arie Ika Susanty Ario Imandiri, Ario Aty Widyawaruyanti Awik Puji Dyah Nurhayati Bambang Prayogo Bambang Sugiharto Bambang Tri Purwanto Corry, Maylisa Natalia Dewi Hidayati Dini Retnowati Diyah, Nuzul Wahyuning Djoko Agus P. Djoko Agus Purwanto Dwi Ningsih Dwi Riani Oktavia Palupi Edhi, Narendrani Sasmitaning Edy Listanto Edy Meiyanto Edy Meiyanto Emma Rahmawati Emma Rahmawati Engel, Daniella Elizabeth Eny I. Riyanti Esti Hendradi Faisal Akhmal Muslikh Hadi Poerwono Handayani, Rosita Hardiyanti, Andi Sry Hasan, Muhammad Amir Hidayati, Agriana Rosmalina I.A.A. Widhiartini Idha Kusumawati Iis Wahyuningsih Ilmi, Hilkatul Isna Rahmayani Isnaeni Istiqamah, Farida Junaidi Khotib Juni Ekowati Kholis Amalia Nofianti Kusmana Kusmana Lahardo, Devanus Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Miatmoko, Andang Misgiati, Misgiati Munandar, Tristiana Erawati Noor Erma NS Nur Fadilla Achmad Nurhidayah - Nuri Nuri Oka Adi Parwata Prasetyanti, Intan Kris Pratama, Edo Purwitasari, Neny Putri, Anisa Yustikka Rahmawati, Emma Ramadhani, Firmansyah Ardian Rarastoeti Prastiwi Retno Sari Retno Widyowati Riesta Primaharinastiti, Riesta Rijal, Agus Syamsur Roihatul Mutiah Shigeru Sasaki Shigeru Sasaki Siti Maimunah Siti Zulaikah Suciati Suciati Sudjarwo Sudjarwo Sudjarwo Suharjono, Suharjono Sulistiyono, Ilham Robbynoor Sulistyowati, Melanny Ika SUZANA, SUZANA Taufikurrahman Taufikurrahman Taufikurrahman Toto Hadiarto Tri Dewanti W. Tri J. Santoso Tri Sundari Tri Widiandani Tutik Sri Wahyuni Tutuk Budiati Wicaksana, Firman Widiyaningsih, Arum Widyowati , Retno Widyowati, Rr. Retno Wijayanti Pujitono Win Darmanto Wiwied Ekasari Yurika Sastyarina Yurika Sastyarina Yurika Sastyarina Yusuf, Helmy

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