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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Kimia (Journal of Chemistry) IPTEK The Journal for Technology and Science Alchemy : Journal of Chemistry Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal AgroBiogen Indonesian Journal of Cancer Chemoprevention MPI (Media Pharmaceutica Indonesiana) UNEJ e-Proceeding Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan Journal Of Vocational Health Studies Jurnal Kreativitas PKM Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Riayah: Jurnal Sosial dan Keagamaan Jurnal Al-Irsyad: Jurnal Bimbingan Konseling Islam Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal Pharmasci (Journal of Pharmacy and Science) Berkala Penelitian Hayati Jurnal Ilmiah Kesehatan (JIKA) Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan International Journal of Sociology of Religion Jurnal Inen Paer
Sukardiman
Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, UniversitasAirlangga, Surabaya
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Senyawa Metabolite Sekunder dan Aktifitas Afrodisiak Ekstrak Etanol Cabe Jawa (Piper retrofractum Vahl) Secara In silico: Secondary Metabolite Compounds and Aphrodisiac Activity of Ethanol Extract of Cabe Jawa (Piper retrofractum Vahl) With In silico Methode Taufikurrahman, Taufikurrahman; Widyowati, Retno; Sukardiman, Sukardiman
Jurnal Sains dan Kesehatan Vol. 6 No. 5 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i5.2391

Abstract

Erectile dysfunction is one of the most common sexual problems in men. Drugs available on the market can be used to treat this problem, but the use of these drugs often causes unwanted side effects, the use of natural ingredients as an alternative treatment is increasingly popular, one of which is a herb made from chili jamu (Piper retrofractum Vahl). Metabolite profiling of the chili jamu plant turns out to be different depending on the location of growth, it is thought to result in differences in natural conditions and circumstances which result in differences in aphrodisiac activity. Cabe Jawa extracted with 96% ethanol was analyzed using LC / MS, detected as many as ten secondary metabolites namely, Salsolinol, Quercetin, Caffeoyl putrescin, Diferuloyl putrescine, Feruloyl tyramine, Hydroxychloroquine, Tetrahydropapaveroline, Piperine, N-Oleyl-Leucine, Capsaicin. From the results of in silico tests, it is known that piperine has activity as a phosphodiesterase type 5 (PDE5) inhibitor with binding energy and inhibition constant values of -8.62 kcal/mol and 0.485 uM. Keywords:          Piper retrofractum Vahl, Secondary metabolite, Aphrodisiac   Abstrak Disfungsi ereksi merupakan salah satu masalah seksual yang paling umum terjadi pada pria. Obat yang tersedia di pasaran dapat digunakan untuk mengatasi masalah ini, tetapi penggunaan obat tersebut seringkali menimbulkan efek samping yang tidak diinginkan., penggunaan bahan alami sebagai alternatif pengobatan semakin populer, salah satunya yaitu ramuan berbahan cabe jamu (Piper retrofractum Vahl). Metabolit profiling dari tanaman cabe jamu ternyata berbeda-beda tergantung dari lokasi tumbuhnya, hal tersebut diduga mengakibatkan perbedaan kondisi dan keadaan alam yang berakibat pada perbedaan aktivitas afrodisiak. Cabe jamu yang diekstrak dengan etanol 96% di analisa dengan menggunakan LC/MS, terdeteksi sebanyak sepuluh metabolite sekunder yaitu, Salsolinol, Quercetin, Caffeoyl putrescin, Diferuloyl putrescine, Feruloyl tyramine, Hydroxychloroquine, Tetrahydropapaveroline, Piperine, N-Oleyl-Leucine, Capsaicin. Dari hasil uji in silico diketahui bahwa piperine memiliki aktifitas sebagai penghambat phosphodiesterase type 5 (PDE5) dengan nilai energi ikat dan konstanta inhibisi sebesar -8,62 kkal/mol dan 0,485 uM. Kata Kunci:         Piper retrofractum Vahl, Metabolite sekunder, Afrodisiak
Optimization of Self-Nanoemulsifying Drug Delivery System Combining Red Ginger and Aromatic Ginger Extracts to Improve Solubilization and Stability Hindiana, Linda; Widyowati, Retno; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.355-363

Abstract

Background: Red ginger (Zingiber officinale var. rubrum) and aromatic ginger (Kaempferia galanga L.) are traditional Indonesian medicinal plants with proven pharmacological activity, but their poor aqueous solubility requires formulation strategies to enhance solubilization and physical stability. Objective: This study aimed to optimize and evaluate a Self-Nanoemulsifying Drug Delivery System (SNEDDS) combining red ginger and aromatic ginger. Methods: The optimization was conducted by varying the oil-to-Smix ratio and extract concentration, while the internal Smix composition (Tween 80: PEG 400 = 1:2.8 w/w) remained constant to isolate the effect of oil–surfactant proportion. Virgin coconut oil (VCO), Tween 80, and PEG 400 were used as the oil phase, surfactant, and co-surfactant, respectively. Three formulas were prepared based on oil-to-Smix (w/w): Formula A (1:4.68, 500 mg extract), Formula B (1:10.6, 500 mg extract), and Formula C (1:10.6, 460 mg extract). Physical characterization included visual observation, centrifugation, particle size, polydispersity index (PDI), and transmittance before and after thermodynamic stability tests. Results: Formula A was unstable and exhibited precipitation. Before stability testing, Formula C showed improved dispersion, with a 41.5% reduction in droplet size and a 79.9% decrease in PDI relative to Formula B. After stability testing, Formula C demonstrated markedly better performance, including an 85.5% smaller droplet size, 81.4% lower PDI, and a 2.4% increase in transmittance compared with Formula B. These quantitative improvements indicated that Formula C exhibited more optimal solubilization capacity and physical stability. Conclusion: This study concludes that extract concentration and the oil-to-Smix ratio significantly influence SNEDDS characteristics, and Formula C represents the most favorable formulation for further development.
Formulation, Physical Characterization, and Stability Study of Nanoemulgel Containing Jatropha curcas Leaves Extract Aly, M. Ainun Najib; Pratama, Edo; Shobahah, Jauharotus; Munandar, Tristiana Erawati; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.407-413

Abstract

Background: Jatropha curcas extract has been identified as a promising herbal remedy for various skin disorders. However, its application is limited by its low water solubility and poor skin permeability. Nanotechnology-based strategies provide a way to overcome these limitations. Objective: This study aimed to develop a new drug delivery system for J. curcas extract as a topical treatment for skin conditions. Methods: J. curcas extract was obtained through maceration. The system included a Carbopol 940-based gel and a J. curcas extract (JCE 10% w/w) nanoemulsion (NE) created using a high-energy method with an ultrasonic homogenizer. The appearance, pH, viscosity, spreadability, particle size, polydispersity index, and zeta potential of the nanoemulgel were assessed to verify its physical properties. Results: The optimal formulation produced a dark green nanoemulgel with a distinctive leafy smell and a semi-solid texture. Physical characterization of the JCE-NE-gel included a pH of 6.3, particle size of 142.67 nm, polydispersity index of 0.248, zeta potential of -23.23 mV, viscosity of 87.881 cP, and spreadability of 6.13 cm. Stability testing showed no significant differences after accelerated stability testing and thermal cycling. Conclusion: The study demonstrated that J. curcas extract (JCE-NE-gel) was successfully incorporated into a nanoemulgel formulation (F4), showing excellent physical properties and stability.
PENGEMBANGAN PRODUK JAMU DAN SIMPLISIA DARI TANAMAN LOKAL SUKU TENGGER Widyowati, Retno; Sukardiman, Sukardiman; Wahyuni, Tutik Sri; Widyawaruyanti, Aty; Nofianti, Kholis Amalia
Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Vol 3 No 2 (2023): Mei
Publisher : Sekolah Tinggi Ilmu Ekonomi Indonesia (STIESIA) Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24034/kreanova.v3i2.5672

Abstract

Desa Ngadisari, Kabupaten Probolinggo memiliki beragam tanaman liar yang berpotensi dimanfaatkan untuk pengobatan. Beberapa diantaranya adalah adas, jarak, kecubung, keningar, purwoceng, krangean, kayu ampet, pulosari, dan pronojiwo. Beragamnya tanaman yang ada di sekitar masyarakat setempat merupakan kekayaan tersendiri dari daerah ini, namun tidak banyak masyarakat Desa Ngadisari yang memanfaatkannya secara baik. Hal ini terjadi karena aspek kekurangpraktisan yaitu bahan-bahannya harus diramu terlebih dahulu, selain itu banyak kios yang menjual obat modern di lokasi terpencilpun. Berdasarkan latar belakang di atas, maka dilakukan pelatihan pengembangan produk jamu dan simplisia dari tanaman lokal Bromo bagi masyarakat Suku Tengger, khususnya di Desa Ngadisari, Probolinggo. Produk tersebut berupa jamu godogan, teh herba dan simplisia yang dapat digunakan oleh masyarakat ataupun dipasarkan dengan nilai ekonomi tinggi dan bermanfaat bagi kesehatan. Hal ini dapat menciptakan peluang usaha baru bagi masyarakat Desa Ngadisari sehingga meningkatkan perekonomian dan taraf kesehatan masyarakat desa tersebut, sehingga hal ini bisa membuat lingkungan baik.
Evaluation of Anti-inflammatory Activity of Mixture of Kencur Extract (Kaempferia galanga L.) with Glucosamine and Chondroitin In Vivo in Mice (Rattus Novergicus) Masyrobatin, Masyrobatin; Paramita, Angggun Putri; Sukardiman, Sukardiman; Suharjono, Suharjono
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1027

Abstract

Glucosamine and chondroitin are commonly used in osteoarthritis therapy and are classified as SYSADOA. Both act as chondroprotective and anti-inflammatory agents, though their efficacy remains debated. Efforts have been made to enhance their anti-inflammatory effects by combining them with Kaempferia galanga L. (kencur) extract. This study aims to evaluate the anti-inflammatory effectiveness of a combination of kencur extract, glucosamine, and chondroitin in vivoin rats (Rattus norvegicus). The anti-inflammatory activity was tested on male white Wistar rats using the paw edema test. The increase in paw volume was measured and converted into the percentage of edema inhibition. Histopathological analysis to count neutrophil inflammatory cells was performed using Hematoxylin and Eosin (HE) staining. Data analysis was conducted on both the percentage of edema inhibition and the neutrophil cell counts. The results showed that the combination of glucosamine (45 mg/kg BW) and chondroitin (36 mg/kg BW) with kencur extract at doses of 600 mg, 900 mg, and 1200 mg/kg BW exhibited anti-inflammatory activity. The combination with 600 mg/kg BW of kencur extract showed a specific percentage of edema inhibition. The combination of glucosamine and chondroitin with 900 mg/kg BW of kencur extract showed the best anti-inflammatory activity, which was equivalent to 1200 mg/kg BW of kencur extract and superior to the effects of glucosamine and chondroitin alone.
Radikalisme agama dalam persepektif Sosiologi Agama Sukardiman, Sukardiman
Jurnal Inen Paer (JIP) Vol. 2 No. 1 (2024): Jurnal Inen Paer Edisi Desember
Publisher : Pusat Studi Kebudayaan Universitas Nahdlatul Ulama Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69503/jip.v2i1.947

Abstract

Religious radicalism is a common phenomenon found in the world community, religious and cultural differences are often used as negative energy to suppress other religious groups with the argument of the scriptures. radicalism in the name of religion seems to be justified, even though there is an error in the perspective of the holy book text, because it does not see from a historical point of view the verse came down and the social context of today's society. In this paper, the author uses the literature study method, which is an activity carried out in an effort to explore, examine, and identify and identify knowledge based on the results of previous research or studies related to radicalism in the name of religion. In the context of the sociology of religion, the essence of religion is the glue of social cohesion between humans, we can see this in the perspective given by sociological figures, such as ibn Khaldun, Max Weber, and Emile Dhurkeim. In the context of Islam itself, it also teaches about religious inclusiveness, one of which is very visible in the vision of Islamic plurality, where the prophet made a constitution called the Medina Pilgrimage which regulates the lives of three major religions, namely Christianity, Judaism and Islam. However, in the current era Islam is experiencing a global stigma, thus creating what is called Islamophobia, even though Islam is not what western people think. So the conclusion is Islam never teaches about violence, but Islam teaches about peace. Key word: religious Radicalism, Islam, Sociology of Religion.
Co-Authors A. Dinar Ambarwati Achmad Fuad Hafid Adam Hermawan Al ‘Amali, Mayla Khayra Aly, M. Ainun Najib Anak Agung Gede Sugianthara Annisa Farida Muti Arie Ika Susanty Ario Imandiri, Ario Aty Widyawaruyanti Awik Puji Dyah Nurhayati Bambang Prayogo Bambang Sugiharto Bambang Tri Purwanto Dewi Hidayati Dini Retnowati Diyah, Nuzul Wahyuning Djoko Agus P. Dwi Ningsih Dwi Riani Oktavia Palupi Edy Listanto Edy Meiyanto Edy Meiyanto Emma Rahmawati Emma Rahmawati Engel, Daniella Elizabeth Eny I. Riyanti Esti Hendradi Faisal Akhmal Muslikh Hadi Poerwono Handayani, Rosita Hardiyanti, Andi Sry Hindiana, Linda I.A.A. Widhiartini Idha Kusumawati Iis Wahyuningsih Isnaeni Istiqamah, Farida Junaidi Khotib Juni Ekowati Kholis Amalia Nofianti Kusmana Kusmana Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Masyrobatin, Masyrobatin Melanny Ika Sulistyowaty Miatmoko, Andang Misgiati, Misgiati Munandar, Tristiana Erawati Noor Erma NS Nur Fadilla Achmad Nurhidayah - Nuri Nuri Oka Adi Parwata Paramita, Angggun Putri Prasetyanti, Intan Kris Pratama, Edo Purwitasari, Neny Putri, Anisa Yustikka Rahmawati, Emma Ramadhani, Firmansyah Ardian Rarastoeti Prastiwi Retno Sari Retno Widyowati Rijal, Agus Syamsur Roihatul Mutiah Shigeru Sasaki Shigeru Sasaki Shobahah, Jauharotus Siti Maimunah Siti Zulaikah Sudjarwo Sudjarwo Sudjarwo Suharjono, Suharjono Sulistiyono, Ilham Robbynoor Sulistyowati, Melanny Ika SUZANA, SUZANA Taufikurrahman Taufikurrahman Taufikurrahman Toto Hadiarto Tri Dewanti W. Tri J. Santoso Tri Sundari Tutik Sri Wahyuni Tutuk Budiati Widiyaningsih, Arum Widyowati , Retno Widyowati, Rr. Retno Wijayanti Pujitono Win Darmanto Wiwied Ekasari Yurika Sastyarina Yurika Sastyarina Yurika Sastyarina Yusuf, Helmy