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All Journal Jurnal Teknologi Dan Industri Pangan Jurnal Kimia (Journal of Chemistry) IPTEK The Journal for Technology and Science Alchemy : Journal of Chemistry Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal AgroBiogen Indonesian Journal of Cancer Chemoprevention MPI (Media Pharmaceutica Indonesiana) UNEJ e-Proceeding Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan Journal Of Vocational Health Studies Jurnal Kreativitas PKM Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia Riayah: Jurnal Sosial dan Keagamaan Jurnal Al-Irsyad: Jurnal Bimbingan Konseling Islam Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal Pharmasci (Journal of Pharmacy and Science) Berkala Penelitian Hayati Jurnal Ilmiah Kesehatan (JIKA) Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Sukardiman
Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, UniversitasAirlangga, Surabaya
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Evaluation of Anti-inflammatory Activity of Mixture of Kencur Extract (Kaempferia galanga L.) with Glucosamine and Chondroitin In Vivo in Mice (Rattus Novergicus) Masyrobatin, Masyrobatin; Paramita, Angggun Putri; Sukardiman, Sukardiman; Suharjono, Suharjono
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 2 (2025): Volume 7 Nomor 2 Agustus 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i2.1027

Abstract

Glucosamine and chondroitin are commonly used in osteoarthritis therapy and are classified as SYSADOA. Both act as chondroprotective and anti-inflammatory agents, though their efficacy remains debated. Efforts have been made to enhance their anti-inflammatory effects by combining them with Kaempferia galanga L. (kencur) extract. This study aims to evaluate the anti-inflammatory effectiveness of a combination of kencur extract, glucosamine, and chondroitin in vivoin rats (Rattus norvegicus). The anti-inflammatory activity was tested on male white Wistar rats using the paw edema test. The increase in paw volume was measured and converted into the percentage of edema inhibition. Histopathological analysis to count neutrophil inflammatory cells was performed using Hematoxylin and Eosin (HE) staining. Data analysis was conducted on both the percentage of edema inhibition and the neutrophil cell counts. The results showed that the combination of glucosamine (45 mg/kg BW) and chondroitin (36 mg/kg BW) with kencur extract at doses of 600 mg, 900 mg, and 1200 mg/kg BW exhibited anti-inflammatory activity. The combination with 600 mg/kg BW of kencur extract showed a specific percentage of edema inhibition. The combination of glucosamine and chondroitin with 900 mg/kg BW of kencur extract showed the best anti-inflammatory activity, which was equivalent to 1200 mg/kg BW of kencur extract and superior to the effects of glucosamine and chondroitin alone.
Standardization of Myristicin in Nutmeg (Myristica fragrans Houtt.) Fruit using TLC-Densitometric Method Daniella Elizabeth Engel; Sudjarwo; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.12-19

Abstract

Background: Myristica fragrans Houtt. (Myristicaceae family), with the main content of myristicin, has been immensely used in herbal medicine. Standardization is essential to ensure the safety of natural extracts and the quality of herbal medicines using various chemical analysis techniques. Method validation is necessary to ascertain the reliability and reproducibility of the method. Myristicin is a member of the phenylpropene group, a natural organic compound found in small amounts in nutmeg fruit, which has pharmacological effects. Objective: This study aims to determine the myristicin content in nutmeg fruit using TLC-Densitometry. Methods: Determination of myristicin in nutmeg fruit extract was performed using TLC-Densitometry with silica GF254 as stationary phase, mobile phase n-hexane: ethyl acetate (8:2 v/v), and spot visualized at 285 nm. In this study, the content of myristicin in nutmeg fruit was determined using compendial methods (AOAC), thus requiring method verification with parameters including selectivity, linearity, precision, LOD, and LOQ. Results: The validation of this method showed good linearity and selectivity with y = 0.0001x + 0.0226 (r = 0.9996) and 1.53 (>1.5), respectively. The LOD and LOQ results were low with values of 0.11 μg/spot and 0.33 μg/spot, respectively. The percentage coefficient of variation for precision was below the requirement value of not more than 4%. The average myristicin content in nutmeg fruit extract was approximately 0.0017 ± 0.0003% (w/w). Conclusion: The developed method was valid and sensitive for the quantification of myristicin content in nutmeg fruit.
Optimization of Self-Nanoemulsifying Drug Delivery System Combining Red Ginger and Aromatic Ginger Extracts to Improve Solubilization and Stability Linda Hindiana; Retno Widyowati; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.355-363

Abstract

Background: Red ginger (Zingiber officinale var. rubrum) and aromatic ginger (Kaempferia galanga L.) are traditional Indonesian medicinal plants with proven pharmacological activity, but their poor aqueous solubility requires formulation strategies to enhance solubilization and physical stability. Objective: This study aimed to optimize and evaluate a Self-Nanoemulsifying Drug Delivery System (SNEDDS) combining red ginger and aromatic ginger. Methods: The optimization was conducted by varying the oil-to-Smix ratio and extract concentration, while the internal Smix composition (Tween 80: PEG 400 = 1:2.8 w/w) remained constant to isolate the effect of oil–surfactant proportion. Virgin coconut oil (VCO), Tween 80, and PEG 400 were used as the oil phase, surfactant, and co-surfactant, respectively. Three formulas were prepared based on oil-to-Smix (w/w): Formula A (1:4.68, 500 mg extract), Formula B (1:10.6, 500 mg extract), and Formula C (1:10.6, 460 mg extract). Physical characterization included visual observation, centrifugation, particle size, polydispersity index (PDI), and transmittance before and after thermodynamic stability tests. Results: Formula A was unstable and exhibited precipitation. Before stability testing, Formula C showed improved dispersion, with a 41.5% reduction in droplet size and a 79.9% decrease in PDI relative to Formula B. After stability testing, Formula C demonstrated markedly better performance, including an 85.5% smaller droplet size, 81.4% lower PDI, and a 2.4% increase in transmittance compared with Formula B. These quantitative improvements indicated that Formula C exhibited more optimal solubilization capacity and physical stability. Conclusion: This study concludes that extract concentration and the oil-to-Smix ratio significantly influence SNEDDS characteristics, and Formula C represents the most favorable formulation for further development.
Formulation, Physical Characterization, and Stability Study of Nanoemulgel Containing Jatropha curcas Leaves Extract M. Ainun Najib Aly; Edo Pratama; Jauharotus Shobahah; Tristiana Erawati Munandar; Sukardiman
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.407-413

Abstract

Background: Jatropha curcas extract has been identified as a promising herbal remedy for various skin disorders. However, its application is limited by its low water solubility and poor skin permeability. Nanotechnology-based strategies provide a way to overcome these limitations. Objective: This study aimed to develop a new drug delivery system for J. curcas extract as a topical treatment for skin conditions. Methods: J. curcas extract was obtained through maceration. The system included a Carbopol 940-based gel and a J. curcas extract (JCE 10% w/w) nanoemulsion (NE) created using a high-energy method with an ultrasonic homogenizer. The appearance, pH, viscosity, spreadability, particle size, polydispersity index, and zeta potential of the nanoemulgel were assessed to verify its physical properties. Results: The optimal formulation produced a dark green nanoemulgel with a distinctive leafy smell and a semi-solid texture. Physical characterization of the JCE-NE-gel included a pH of 6.3, particle size of 142.67 nm, polydispersity index of 0.248, zeta potential of -23.23 mV, viscosity of 87.881 cP, and spreadability of 6.13 cm. Stability testing showed no significant differences after accelerated stability testing and thermal cycling. Conclusion: The study demonstrated that J. curcas extract (JCE-NE-gel) was successfully incorporated into a nanoemulgel formulation (F4), showing excellent physical properties and stability.
Co-Authors A. Dinar Ambarwati Achmad Fuad Hafid Adam Hermawan Al ‘Amali, Mayla Khayra Aly, M. Ainun Najib Anak Agung Gede Sugianthara Andang Miatmoko Annisa Farida Muti Arie Ika Susanty Ario Imandiri, Ario Aty Widyawaruyanti Awik Puji Dyah Nurhayati Bambang Prayogo Bambang Sugiharto Bambang Tri Purwanto Daniella Elizabeth Engel Dewi Hidayati Dini Retnowati Diyah, Nuzul Wahyuning Djoko Agus P. Dwi Ningsih Dwi Riani Oktavia Palupi Edo Pratama Edy Listanto Edy Meiyanto Edy Meiyanto Emma Rahmawati Emma Rahmawati Eny I. Riyanti Esti Hendradi Faisal Akhmal Muslikh Firmansyah Ardian Ramadhani Hadi Poerwono Handayani, Rosita Hardiyanti, Andi Sry I.A.A. Widhiartini Idha Kusumawati Iis Wahyuningsih Isnaeni Istiqamah, Farida Jauharotus Shobahah Junaidi Khotib Juni Ekowati Kholis Amalia Nofianti Kusmana Kusmana Linda Hindiana M. Ainun Najib Aly Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Masyrobatin, Masyrobatin Melanny Ika Sulistyowaty Misgiati, Misgiati Noor Erma NS Nur Fadilla Achmad Nurhidayah - Nuri Nuri Oka Adi Parwata Paramita, Angggun Putri Prasetyanti, Intan Kris Pratama, Edo Purwitasari, Neny Putri, Anisa Yustikka Rahmawati, Emma Rarastoeti Prastiwi Retno Sari Retno Widyowati Rijal, Agus Syamsur Roihatul Mutiah Shigeru Sasaki Shigeru Sasaki Siti Maimunah Siti Zulaikah Sudjarwo Sudjarwo Sudjarwo Suharjono Sulistiyono, Ilham Robbynoor Sulistyowati, Melanny Ika SUZANA, SUZANA Taufikurrahman Taufikurrahman Taufikurrahman Toto Hadiarto Tri Dewanti W. Tri J. Santoso Tri Sundari Tristiana Erawati Munandar Tristiana Erawati Munandar Tutik Sri Wahyuni Tutuk Budiati Widiyaningsih, Arum Wijayanti Pujitono Win Darmanto Wiwied Ekasari Yurika Sastyarina Yurika Sastyarina Yurika Sastyarina Yusuf, Helmy