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Fructose Intake Related with Serum Uric Acid Level in Young Adults Desmawati, Desmawati; Fasrini, Ulya Uti; Afriani, Nita; Sulastri, Delmi
Jurnal Gizi dan Pangan Vol. 14 No. 3 (2019)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.31 KB) | DOI: 10.25182/jgp.2019.14.3.135-140

Abstract

This study aimed to clarify the correlation of fructose intake with uric acid level and blood pressure in young adults. This study used a cross-sectional design, conducted in Padang, West Sumatera province of Indonesia in 2014. The subjects consist of 109 students of Medical Faculty of Andalas University, aged 18–23 years old, were randomly selected to participate. Data on fructose intake were obtained using food frequency questionnaire. Uric acid levels was determined by the enzymatic colorimetric method. Resting blood pressure was measured twice using a sphygmomanometer. Data were analyzed using Rank-Spearman correlation test. The median of fructose intake was 74.3 g (min 23.4–max 160.2). The median of systolic blood pressure was 117 mmHg (min 100–max 145) and median of diastolic blood pressure was 70 mmHg (min 60–max 90). The mean uric acid levels was 5.2±1.56  mg/dl and 25% of the male subject had high uric acid levels. Fructose intake had no significant correlation with SBP (r=0.026; p=0.851) nor with DBP (r=0.051; p=0.712).  However, there was a strong correlation between fructose intake with uric acid level (r=0.660; p<0.001). The study found that fructose intake shows a strong correlation with uric acid level but not with blood pressure in young adult.
Nutritional Status Among Workers: Impact, Interventions, and Global Implications: A Systematic Review Fadillah Ulva; Delmi Sulastri
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.45682

Abstract

The nutritional status of workers significantly influences occupational health, with both undernutrition and overnutrition posing substantial global challenges. Among the employed population, poor dietary practices, food scarcity, and strenuous work circumstances contribute to anemia, obesity, and various other health complications. This systematic review aim is to aggregate data on employee nutritional status, identify effective workplace interventions, and examine the global implications of worker nutrition on public health and productivity. A comprehensive literature search was conducted by PubMed, ScienceDirect, and Google Scholar with PRISMA guidelines. Papers examining dietary trends, nutritional status, and health impacts among workers published from 2015 to 2024 were included. After screening and comprehensive evaluation, ten studies met the inclusion criteria. The findings reveal a dual burden of malnutrition among employees: a significant prevalence of anemia among women and manual laborers, alongside rising rates of overweight and obesity among sedentary and night shift workers. Food insecurity and substandard nutrition quality were widespread among low-income and migrant workers. Despite long-term design and sustainability challenges, worksite nutrition interventions and educational programs demonstrated potential in altering workers' health outcomes. Employee nutrition is essential for sustaining health, enhancing productivity, and reducing health inequities. Multisectoral measures, such as modifications to the work environment, nutritional education, and the provision of healthy office lunches, are recommended. The cultivation of a productive and healthy global workforce hinges on the prioritization of public health issues, particularly the imperative to address workers' nutrition
Prevalensi dan Faktor Risiko Anemia pada Pekerja Perempuan di Rumah Sakit : Literature Review Study Sesmeri Haryani; Delmi Sulastri
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.48065

Abstract

Anemia, particularly iron deficiency anemia (IDA), is a major global health issue among women of reproductive age, including female hospital workers such as nurses, midwives, and other healthcare personnel. This study aims to review the literature on the prevalence and risk factors of anemia among female hospital workers. A systematic review design with a descriptive narrative synthesis approach was employed, following the PRISMA guidelines. Literature was retrieved from PubMed, Scopus, and Google Scholar using relevant keyword combinations. Out of 10,203 articles identified, six studies met the inclusion criteria. Findings revealed a high prevalence of anemia among female workers, especially those under 40 years of age, experiencing heavy menstruation, having poor dietary habits, and working night shifts. Anemia's impact includes fatigue, reduced productivity, and increased risk of work-related errors. Therefore, a comprehensive intervention strategy involving regular screening, nutritional education, and gender-responsive workplace policies is essential to improve women's occupational health in the healthcare sector.
Strenghening Anemia Prevention Among Adolescent in Timor Leste : A Systematic Review Joaninha Cavalho de Jesus; Delmi Sulastri
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.48160

Abstract

Abstract Anemia remains a significant public health concern in Timor-Leste, particularly among adolescents, primarily due to rapid developmental changes and inadequate nutrition. Its impact includes fatigue, diminished concentration, and lowered immune function. Promoting nutritional awareness among teenagers can lead to healthier eating habits, increased iron consumption, and better adherence to supplement regimens. Supplementing with iron and folic acid has proven effective in preventing iron deficiency and supporting proper growth. Enhancing education about nutrition is vital in mitigating anemia and fostering both academic performance and overall adolescent well-being.A systematic review was conducted in line with PRISMA guidelines, using databases such as PubMed, Google Scholar, and Science Direct to locate pertinent studies. The review focused on empirical investigations that aimed to improve adolescent anemia prevention, utilizing qualitative, quantitative, or mixed-method approaches. From an initial pool of 568 studies, 10 met the eligibility requirements and were included in the final synthesis. Key findings emphasized the critical role of nutrition education and the consistent use of iron supplements. The review also highlighted the need for future studies to concentrate on strategies that enhance long-term adherence.
ADRB2 Gene Polymorphism and Physical Activity with Energy Balance in Obesity Patients Hafizth, Hendi; Sulastri, Delmi; Amir, Arni
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1587

Abstract

Obesity is recognized as a major global health problem due to its negative impact on quality of life and its strong association with various metabolic disorders. Energy imbalance, defined as a condition in which energy intake consistently exceeds energy expenditure, is considered a central mechanism in the development of obesity. This study aimed to examine the relationship between physical activity, ADRB2 gene polymorphism zygosity (rs1042713), and energy balance among individuals with obesity. A quantitative cross-sectional design was implemented, involving 48 obese participants selected using a total sampling technique. Data were obtained through structured interviews, anthropometric measurements, and genetic testing. Statistical analyses were conducted using the Chi-square test, Fisher’s exact test, and logistic regression analysis. The results indicated a statistically significant association between physical activity and energy balance status (p-value = 0,003). No significant association was identified between ADRB2 gene zygosity and energy balance (p-value = 1,000). The findings highlight the important role of physical activity in preventing excess energy accumulation among obese individuals, while the genetic variation examined did not show a significant contribution in this study. Limitations include the cross-sectional design, which precludes causal inference, and the relatively small sample size, which limits the generalizability of the results. Promotion of an active lifestyle remains a fundamental strategy in adult obesity management.
EVALUASI PEMBERIAN TABLET TAMBAH DARAH PADA REMAJA PUTRI Susanti, Susi; Sulastri, Delmi; Desmawati, Desmawati
Jurnal Kesehatan - STIKes Prima Nusantara Vol 12 No 1 (2021): JURNAL KESEHATAN
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v12i1.442

Abstract

Upaya menurunkan prevalensi anemia dengan cara pemberian suplemen­tasi Tablet Tambah Darah (TTD) sejak remaja. Namun pelaksanaannya di Kabupaten Pasaman Barat belum berjalan dengan efektif. Cakupan pemberian Tablet Tambah Darah (TTD) pada remaja putri pada tahun 2019 masih ada yang belum mencapai target 30%. Puskesmas yang rendah cakupannya yaitu hanya 1,5%. Penelitian ini bertujuan mengetahui gambaran input, proses dan output dalam evaluasi pemberian Tablet Tambah Darah (TTD) pada remaja putri di Puskesmas Air Bangis Kabupaten Pasaman Barat Tahun 2019. Penelitian dilakukan secara kualitatifdengan teknik wawancara mendalam dan Focus Group Discussion (FGD), Informan ditentukan secara purposive sampling yang berjumlah sebanyak 29 orang. Penelitian dilakukan pada bulan Januari s/d Desember 2020 di Dinas Kesehatan, Instalasi Farmasi Kabupaten Pasaman Barat, Puskesmas Air Bangis dan Sekolah.Analisis data dilakukan dengan analisis konten (analisis isi) dan validasi data dengan triangulasi sumber, teknik dan teori. Hasil penelitian pada komponen input Puskesmas Air Bangis memiliki SDM yang belum cukup, buku pedoman tidak ada, alokasi dana masih kurang, sarana dan prasarana belum memadai. Pada proses yang belum sesuai yaitu pendistribusian Tablet Tambah Darah (TTD), pencatatan dan pelaporan serta pemantauan. Sedangkan pada output cakupan belum tercapai, ketepatan waktu dan distribusi belum sesuai dengan buku pedoman penanggulangan dan pencegahan anemia pada remaja putri dan wanita usia subur tahun 2018. Kesimpulanadalah bahwa dalam pelaksanaan komponen input, proses dan output belum sesuai dengan pedoman yang dianjurkan. Disarankan untuk menambah SDM, meningkatkan perencanaan alokasi dana, melakukan sosialisasi, meningkatkan ketersedian sarana dan prasarana, melakukan kerjasama lintas sektor dengan membuat MoU untuk meningkatkan komitmen.
Genetic Factors Causing the Prevalence of Anemia in Young Girls and Stunting in Toddlers: A Systematic Literature Review Afrina Mizawati; Nursyirwan Effendi; Delmi Sulastri; Rozi Sastra Purna
Jurnal Penelitian Pendidikan IPA Vol 9 No 9 (2023): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i9.4822

Abstract

The prevalence of anemia in adolescents at the national level is still considered quite high. Several factors are associated with the incidence of anemia in female adolescents, namely energy intake, protein intake, iron intake, vitamin C intake, tea or coffee drinking habits, investment in worms, knowledge, education and type of parental occupation, family income, and menstrual patterns as well as genetics. Stunting is also still a problem in Indonesia due to insufficient nutritional intake for quite a long time. Stunting occurs when the fetus is still in the womb and only appears when the child is two years old. anemia caused by malnutrition at an early age increases infant and child mortality. anemia in young women and also stunting in children is very dangerous. Where the purpose of research is to explain Genetic Factors Causing the Prevalence of Anemia in Young Girls and Stunting in Toddlers. A review is conducted on the state-of-the-art methods using the preferred reporting items for reviews and meta-analyses (PRISMA) guidelines. We review literature from several publications and analyze genetic factors that cause the prevalence of anemia in young women. The prevalence of anemia among young women is also caused by genetic factors. Young women tend to experience anemia because during this period they experience growth and development. The risk of anemia increases with physiological shifts such as menstrual periods. To prevent anemia, the government has planned a program for the Prevention and Control of Iron Nutrition Anemia in women of childbearing age which aims to reduce the prevalence of iron deficiency anemia in high school and junior high school students.
Environmental Determinants of Childhood Stunting in Timor-Leste: A Narrative Review Ivo da Costa Soares; Delmi Sulastri
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.58677

Abstract

Childhood stunting remains a major public health problem in Timor-Leste, with one of the highest prevalence rates in Southeast Asia. In addition to inadequate nutrition, environmental determinants such as poor sanitation, unsafe drinking water, inadequate hygiene practices, food insecurity, and poor living conditions contribute substantially to impaired child growth and chronic undernutrition. This narrative review aimed to explore and synthesize evidence regarding environmental determinants associated with childhood stunting in Timor-Leste. A narrative review approach was employed using literature obtained from PubMed, Scopus, ScienceDirect, and Google Scholar. Articles published between 2015 and 2025 were screened based on predefined inclusion criteria. Six original studies focusing on environmental determinants of childhood stunting in Timor-Leste were included in the review. Data were synthesized narratively according to major environmental themes. The reviewed studies consistently demonstrated that poor sanitation, unsafe drinking water, food insecurity, household poverty, inadequate housing conditions, and recurrent infectious diseases were major determinants of childhood stunting in Timor-Leste. Children living in rural and socioeconomically disadvantaged households were more vulnerable to chronic undernutrition due to limited access to sanitation, healthcare services, and adequate nutrition. Environmental conditions were also associated with increased exposure to infectious diseases that impair nutrient absorption and child growth. Environmental determinants play a substantial role in the persistence of childhood stunting in Timor-Leste. Addressing stunting therefore requires integrated and multisectoral interventions that combine nutrition-specific programs with environmental health improvements, particularly in water, sanitation, hygiene, food security, and rural health services.
The Influence of Maternal Nutrition on Fetal Epigenetic Programming and Its Implications for Long Term Health: A Systematic Literature Review Waldatul Hamidah; Delmi Sulastri
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.58090

Abstract

Latar Belakang: Nutrisi maternal merupakan faktor determinan kritis yang mempengaruhi pemrograman epigenetik janin selama masa kehamilan. Modifikasi epigenetik akibat paparan nutrisi intrauterin dapat berdampak permanen terhadap ekspresi gen dan kesehatan keturunan jangka panjang. Tujuan: Menganalisis pengaruh status nutrisi maternal terhadap mekanisme epigenetic programming janin serta implikasinya terhadap kesehatan jangka panjang keturunan. Metode: Systematic literature review dilakukan dengan pencarian artikel melalui database PubMed, Scopus, Google Scholar, dan CINAHL menggunakan kata kunci "maternal nutrition", "epigenetic programming", "fetal programming", dan "long-term health outcomes" rentang tahun 2015–2024. Inklusi artikel memenuhi kriteria PRISMA dengan total 25 artikel dianalisis secara mendalam. Hasil: Defisiensi asam folat, vitamin D, zinc, dan omega-3 terbukti menginduksi perubahan metilasi DNA dan modifikasi histon yang memengaruhi ekspresi gen terkait metabolisme, imunitas, dan perkembangan neurokognitif. Overnutrisi maternal menunjukkan dampak epigenetik melalui jalur mTOR dan sitokin inflamasi. Implikasi jangka panjang mencakup peningkatan risiko obesitas, diabetes mellitus tipe 2, gangguan kardiovaskular, dan gangguan neurodevelopmental. Simpulan: Optimalisasi nutrisi maternal merupakan intervensi kritis dalam pencegahan penyakit tidak menular generasi berikutnya melalui modifikasi jalur epigenetik. Kata Kunci: nutrisi maternal, epigenetic programming, kesehatan janin, kesehatan jangka panjang, systematic review Abstract Background: Maternal nutrition is a critical determinant factor influencing fetal epigenetic programming during pregnancy. Epigenetic modifications arising from intrauterine nutritional exposure can permanently affect gene expression and long-term offspring health. Objective: To analyze the influence of maternal nutritional status on fetal epigenetic programming mechanisms and its implications for long-term offspring health. Methods: A systematic literature review was conducted by searching articles through PubMed, Scopus, Google Scholar, and CINAHL databases using keywords "maternal nutrition", "epigenetic programming", "fetal programming", and "long-term health outcomes" covering 2015–2024. Article inclusion followed PRISMA criteria with 25 articles analyzed in depth. Results: Deficiencies in folic acid, vitamin D, zinc, and omega-3 were proven to induce DNA methylation changes and histone modifications affecting gene expression related to metabolism, immunity, and neurocognitive development. Maternal overnutrition showed similar epigenetic impacts through the mTOR pathway and inflammatory cytokines. Long-term implications include increased risk of obesity, type 2 diabetes mellitus, cardiovascular disorders, and neurodevelopmental disorders in offspring. Conclusion: Optimization of maternal nutrition is a critical intervention in preventing non-communicable diseases in the next generation through epigenetic pathway modification.
The Influence Of Maternal Nutrition On Fetal Epigenetic Programming and Its Implications For Long-Term Health: A Literature Review Waldatul Hamidah; Delmi Sulastri
Jurnal Ners Vol. 10 No. 3 (2026): JULI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i3.60274

Abstract

AbstrakNutrisi maternal merupakan salah satu faktor lingkungan utama yang berperan dalam pemrogramanepigenetik janin dan menentukan kesehatan jangka panjang keturunan. Periode prakonsepsi dan kehamilanmerupakan fase kritis yang memengaruhi pembentukan epigenom melalui berbagai mekanisme biologis,termasuk DNA methylation, histone modification, dan regulasi microRNA. Literatur review ini bertujuan untukmenganalisis pengaruh nutrisi maternal terhadap pemrograman epigenetik janin serta implikasinya terhadapkesehatan jangka panjang. Metode yang digunakan adalah literature review dengan menelaah berbagaipublikasi ilmiah nasional dan internasional yang diterbitkan pada periode 2003–2025 dan membahas hubunganantara nutrisi maternal, epigenetik, fetal programming, dan Developmental Origins of Health and Disease(DOHaD). Hasil kajian menunjukkan bahwa nutrien yang terlibat dalam one-carbon metabolism, seperti folat,vitamin B12, kolin, dan metionin, berperan penting dalam pembentukan pola metilasi DNA yang mengaturekspresi gen selama perkembangan janin. Sebaliknya, kondisi maternal undernutrition maupun maternalobesity dapat menyebabkan perubahan epigenetik yang meningkatkan risiko obesitas, diabetes melitus tipe 2,hipertensi, penyakit kardiovaskular, serta gangguan neurodevelopmental pada keturunan. Selain itu, plasentaberperan sebagai mediator utama yang menghubungkan status nutrisi maternal dengan perkembangan janinmelalui regulasi epigenetik. Dengan demikian, optimalisasi status gizi perempuan sejak masa prakonsepsihingga kehamilan merupakan strategi penting untuk mendukung kesehatan ibu dan anak serta mencegahpenyakit kronis lintas generasi.Kata Kunci: nutrisi maternal, epigenetik, fetal programming, DNA methylation, DOHaD
Co-Authors Abdiana Adang Bachtiar Afdhal, Fitrah Afriani, Nita Afriwardi Afriwardi Afrizal Afrizal Alfin Rahma Fadhilah Amara Azka Shafrina Amel Yanis Amir, Aprima Yona Andani Eka Putra Ariadi Ariadi Ariani, Peny Arni Amir Azrimaidaliza Defrin Defrin Desmawati Desmawati Desmawati Desmawati Dessy Arisany Dian Isti Angraini Dian Isti Angraini Dolly Irfandy Eldi Sauma Endrinaldi Erasta, Junira Eva Chundrayetti Eva Chundrayetti Evynatra Evynatra Evynatra, Evynatra Fadillah Ulva Faisaelia, Rezka Nanda Fannya, Puteri Fasrini, Ulya U Finny Fitry Yani Firdawati Firdawati Firdawati, Firdawati Fitrah Afdhal Fivi Melva Diana, Fivi Melva Friska Eka Fitria Hafizth, Hendi Hafni Bachtiar Hardisman Hasmiwati Hema Malini, Hema Heriawita Heriawita, Heriawita Hermawan, Nur Sefa Arief Hudila Rifa Karmia Huvaid, Sevilla Ukhtil Ida Rahmah Burhan Ida Rahmah Burhan Ika Nur Saputri Ilmiawati Indah Gemala Inke Malahayati Insani, Aldina Ayunda Iqbal Muhammad Helmi Ivo Da Costa Soares Izmi Fadhilah Nasution Jamsari Jamsari Joaninha Cavalho de Jesus Linosefa Linosefa Lipoeto NI Masrul Mayetti Mayetti Mizawati, Afrina Mudjiran Mudjiran Mudjiran Mudjiran Nasrul Zubir Neherta, Meri Nice Rachmawati Masnadi Novita Sari Nur Indrawaty Lipoeto Nur Mala Sari Nursyirwan Effendi, Nursyirwan Nurul Ramadhini Nur’afifah, Fauziah Nuzulia Irawati Oktarina, Mika Putra, Abdi Setia Putri Aisyah Mirza Putri, Miftahul NS Rauza Sukma Rita Rizanda Machmud Rizanda Mahmud` Roni Gunawan Rosfita Rasyid Roslaili Rasyid Roza Mulyana Rozi Sastra Purna Sari, Vivi Sary, Annisa Novita Sesmeri Haryani silvia thamrin Sri Mulyanti Susi Susanti Susi Susanti Syukriadi Syukriadi Thamrin, Silvia Ulya Uti Fasrini Utama, Bobby Indra Wahyuni, Yosha Putri Waldatul Hamidah Waldatul Hamidah Yulia Masna Yulistini, Yulistini Yuniar Lestari Yusrawati Yusrawati Yusti Siana