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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Media Kesehatan Masyarakat Indonesia JURNAL GIZI INDONESIA Journal of the Medical Sciences (Berkala Ilmu Kedokteran) El-Hayah : Jurnal Biologi Jurnal Kesehatan Masyarakat Indonesian Journal of Cancer Chemoprevention Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Universa Medicina Biosaintifika: Journal of Biology & Biology Education YARSI Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Medica Arteriana (Med-Art) Journal of Telenursing (JOTING) Diponegoro International Medical Journal (DIMJ) Narra J Bioscientia Medicina : Journal of Biomedicine and Translational Research Life Science Jurnal Locus Penelitian dan Pengabdian JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Biomedicine and Clinical Sciences Folia Medica Indonesiana
Neni Susilaningsih
Anatomy Histology Department, Faculty Of Medicine, Diponegoro University, Semarang, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Universa Medicina

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Production of tumor necrosis factor-a is increased in urinary tract infections Neni Susilaningsih; Bambang Joni Karjono; Ratna Damma Purnamawati
Universa Medicina Vol. 31 No. 3 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.167-174

Abstract

BACKGROUND Urinary tract infection (UTI) is a common source of bacteriemia. The most common cause of UTI is Escherichia coli (E. coli). Tumor Necrosis Factor (TNF)-á gene polymorphism has been reported to be responsible for an excessive production of TNF-á and eventual disruption of pro-inflammatory cytokine regulation. The aim of this study was to compare TNF-á serum levels and TNF-á allele polymorphisms in patients with UTI due to E.coli and in non- UTI controls. METHODS A cross-sectional study was conducted at Dr. Kariadi Central Hospital and the Center for Biomedical Research, Faculty of Medicine, Diponegoro University, Semarang. In 68 patients with UTI the TNF-á serum levels were determined by means of ELISA and compared to those of non-UTI controls (n=55). TNFá- 308G>A gene polymorphism was analyzed by polymerase chain reaction restriction fragment length using the NcoI enzyme. Fragments were visualized on polyacrylamide gel with silver staining. RESULTS TNF-á serum level in patients with UTI had a median of 8.9 pg/mL, which was significantly higher than the median of 3.7 pg/mL in the control group (pA gene polymorphisms found in the patient group were G/G=61 (90%), G/A=7(10%) and A/A=0, while in the control group were G/G=48 (87%), G/A=7 (13%) and A/A =0. There was no significant differences (p=0.578) in gene polymorphisms between the two groups. CONCLUSIONS TNF-á serum levels in patients with UTI due to E. coli were significantly higher than in non-UTI controls, but for the TNF-á-380 gene polymorphisms no significant difference was found between the two groups. There are presumably more important factors than host genotype that influence UTI pathogenesis.
Co-Authors , Yan Wisnu Prajoko Abdul Hakam Abdul Mughni Abraham Simatupang Aditya Purnama Agnes Stella Valentina Akhmad Ismail Almaz, Ayyasi Izaz Ambariyanto , Ar, Ardiyana Ari Suwondo Ariyanto, Diaza O. Asri, Hairul Astika Widy Utomo, Astika Widy Awal Prasetyo Azhar, Abu Bambang Joni Karjono Bambang Witjahjo Bambang Witjahjo Bernadus Parish Budiono Budiono, Bernardus Parish Bulandari, Beatrice LA. Cahyono, Chemy Wiryawan Catharina Suharti Damma Purnawati, Ratna Desy Armalina Dimarti, Safira Chairani Dwi Marliyawati Elvira Yunita Endang Sri Lestari Eriawan Agung Nugroho Eriawan Agung Nugroho, Eriawan Agung Eva Annisa Fahmi Syarif Fanti Saktini Ferry Sandra Fidela Hanan Zivana Fifin Luthfia Rahmi Fuadi, Ahmad F. Hardhono Susanto Hardian Hardian Hari Peni Julianti Helmia Farida Hermawan Istiadi Iffiyana, Alifatul Ignatius Riwanto, Ignatius Indah Saraswati Joni Karjono, Bambang Kanti Yunika Kurniaty, Linggom Kusuma, Nauval Marta Mahabuana, Bintang Mahendra, Vito Maria Eka Patri Y Maria Mexitalia Mario Sadar Bernitho Hutagalung Maryam Restiwijaya Meiny Suzery Muhammad Nur Mulyadi Djojosaputro, Mulyadi Muniroh, Muflihatul Muttaqien, Rizal Arief, Najatullah Najatullah Najatullah, Najatullah Nani Maharani Nugrahadi, Dimas Erlangga Nugroho, Trilaksana Parish Budiono Prabowo, Erik Prihharsanti, Christina H.N. Pritadesya, Maharani Prizka Purnawati, Ratna Dama Purnomo, Hery D. Putri, Ajeng Kurniasari Rahajeng, Herera Rampengan, Derren DCH. Ratna Damma Purnamawati Ratna Damma Purnawati Renni Yuniati Respati, Danendra RK. Retno Murwani Ryco Giftyan Ardika Selamat Budijitno Sigit Adi Prasetyo Sigit Adi Prasetyo, Sigit Adi Silaban, Hertina Sri Susilowati Suhartono, Suhartono Supandi Andy SyarofilAnam, Moh. Tanti Ajoe Kesoema, Tanti Ajoe Tjandra, Kevin C. Tobing, Romauli Tri Widyawati, Tri Trilaksana Nugroho Udadi Sadhana, Udadi Ulfa Nurullita Utami, Widoasti Putri Wahyu Haris Prabowo Widiastiti, Nyoman Suci Yan Wisnu Prajoko Yuriz Bakhtiar Zhafran Hafizhki