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Journal : JURNAL GIZI INDONESIA

Histopathological changes in pregnant mice's hepar and kidney following exposure to kelor (Moringa oleifera) leaf extract Armalina, Desy; Susilaningsih, Neni; Saraswati, Indah
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 2 (2025): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.2.145-151

Abstract

Background: Moringa provides extra dietary benefits. The immune system is significantly influenced by the nine necessary amino acids, calcium, iron, potassium, magnesium, zinc, and vitamins A, C, E, and B that are included in this food. Previous studies state that moringa causes liver and kidney damage. Another study found that moringa has an abortive effect.Objectives: This study aimed to determine how exposure to kelor (moringa oleifera) leaf extract affected the hepar and kidney in pregnant mice and found the secondary metabolite of the moringa leaves.Materials and Methods: An experimental laboratory design was conducted in 24 pregnant female Balb/c mice. They were randomized into four groups. Group K was not given anything. Group P1-P3 were given moringa leaf extract during pregnancy at days with a dose dose of 10, 20, and 30 mg in 10, 20, and 18 days, and termination was done to take the organs and make the tissue processing.Results: We found no dead mice and no aggression during the experiment. Significant statistics differed between the experimental group in the microscopic appearance of the kidney and hepar. This study found degeneration and inflammation in the hepar and kidney in the treatment group. Qualitative phytochemical tests on leaves contained alkaloids, flavonoids, phenolics, tannins, and steroids.Conclusion: The ethanol extract of Moringa leaf has shown a mild heparin and kidney effect compared to the control.
Co-Authors , Yan Wisnu Prajoko Abdul Hakam Abdul Mughni Abraham Simatupang Aditya Purnama Agnes Stella Valentina Akhmad Ismail Almaz, Ayyasi Izaz Ambariyanto , Ar, Ardiyana Ari Suwondo Ariyanto, Diaza O. Asri, Hairul Astika Widy Utomo, Astika Widy Awal Prasetyo Azhar, Abu Bambang Joni Karjono Bambang Witjahjo Bambang Witjahjo Bernadus Parish Budiono Budiono, Bernardus Parish Bulandari, Beatrice LA. Cahyono, Chemy Wiryawan Catharina Suharti Damma Purnawati, Ratna Desy Armalina Dimarti, Safira Chairani Dwi Marliyawati Elvira Yunita Endang Sri Lestari Eriawan Agung Nugroho Eriawan Agung Nugroho, Eriawan Agung Eva Annisa Fahmi Syarif Fanti Saktini Ferry Sandra Fidela Hanan Zivana Fifin Luthfia Rahmi Fuadi, Ahmad F. Hardhono Susanto Hardian Hardian Hari Peni Julianti Helmia Farida Hermawan Istiadi Iffiyana, Alifatul Ignatius Riwanto, Ignatius Indah Saraswati Joni Karjono, Bambang Kanti Yunika Kurniaty, Linggom Kusuma, Nauval Marta Mahabuana, Bintang Mahendra, Vito Maria Eka Patri Y Maria Mexitalia Mario Sadar Bernitho Hutagalung Maryam Restiwijaya Meiny Suzery Muhammad Nur Mulyadi Djojosaputro, Mulyadi Muniroh, Muflihatul Muttaqien, Rizal Arief, Najatullah Najatullah Najatullah, Najatullah Nani Maharani Nugrahadi, Dimas Erlangga Nugroho, Trilaksana Parish Budiono Prabowo, Erik Prihharsanti, Christina H.N. Pritadesya, Maharani Prizka Purnawati, Ratna Dama Purnomo, Hery D. Putri, Ajeng Kurniasari Rahajeng, Herera Rampengan, Derren DCH. Ratna Damma Purnamawati Ratna Damma Purnawati Renni Yuniati Respati, Danendra RK. Retno Murwani Ryco Giftyan Ardika Selamat Budijitno Sigit Adi Prasetyo Sigit Adi Prasetyo, Sigit Adi Silaban, Hertina Sri Susilowati Suhartono, Suhartono Supandi Andy SyarofilAnam, Moh. Tanti Ajoe Kesoema, Tanti Ajoe Tjandra, Kevin C. Tobing, Romauli Tri Widyawati, Tri Trilaksana Nugroho Udadi Sadhana, Udadi Ulfa Nurullita Utami, Widoasti Putri Wahyu Haris Prabowo Widiastiti, Nyoman Suci Yan Wisnu Prajoko Yuriz Bakhtiar Zhafran Hafizhki