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All Journal PROSIDING SEMINAR NASIONAL Jurnal Kesehatan Masyarakat Indonesia JURNAL LITBANG Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Journal of Natural Sciences and Mathematics Research JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Inovasi Teknik Kimia JURNAL GIZI DAN KESEHATAN ad-Dawaa : Journal of Pharmaceutical Sciences Journal of Holistics and Health Sciences (JHHS) JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Generics: Journal of Research in Pharmacy Proceeding ISETH (International Summit on Science, Technology, and Humanity) Indonesian Journal of Midwifery (IJM) Indonesian Journal of Pharmacy and Natural Product Indonesian Journal of Community Empowerment (IJCE) Prosiding Seminar Nasional Unimus Generics : Journal of Research in Pharmacy Jurnal Siti Rufaidah

Jatmiko Susilo

Universitas Ngudi Waluyo

Author-ID : 396491

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Engineering Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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PENETAPAN KADAR Co.TRIMOKSAZOL YANG DILAKUKAN DENGAN MENGGUNAKAN SPEKTROFOTOMETER ULTRAVIOLET SECARA SIMULTAN.KLT Jatmiko Susilo
JURNAL LITBANG Vol 4, No 3 (2006): Sain dan Teknologi
Publisher : JURNAL LITBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.033 KB)

Abstract Background* Co-trimoxazol is an combined antibiotics consist of Sulphametoxazol and Trimetoprim (5:1). This substance is related with tetrahydropholic acid synthesis in bacteria to produce imidine and purine. The maximum wavelength of Sulphamethoxazol at 255-257 and Trimetoprim : 287 t 2 nm may be used for concentration assay and the different of polarity properties of these substances may be separated by thin layer chromatography. Objectives : The objective of this research is comparing two methods, UV Spectrophotometry by Simultaneously and by TLC. Method : The research's methodology is experimental laboratory that comparing it's recovery weight of each substance by simultaneously - TLC method. Statistically, Analysis of variants - test and t-test are used to compare between it's standard deviations and means. Results : Sulphamethoxazol and Trimetoprim in Ethanol 95%-NaOH 0,1N (1:3) is show peak absorption at 257 and 289 nm wavelength. Recovery of Sulphamethoxazol is (98.20 + 0.40) Yo and Trimetoprim : (93.69 + 0.75) %. Statistically, the accuracy test, Sulphamethoxazol Fo : 2.325 < F tab (P:0,05, dbf:9,1)=297, andTrimetoprimFo:0.126 <F tab(P:0,05, dbf:1,;7):5.59, andtheprecision test of Sulfametoksazol and Trimetoprim are t cal. : 0.666 < t table (P=0.05; dbt=l0) : 1.81 and tcal. = 0.376 < t tab (P:0,05, dbt: 9) =1.83.. Conclusion : Recovery of Sulphamethoxazol is (98.20 +0.40) % and Trimetoprim (98.69 + 0.75) o/o. The precicion and accuration of these methods are not significantly different, Simultaneously more efficient than TLC. Keywords : Co-Trimo xazol, UV Spectrophotometry Simultaneously-TlC

STABILITAS ASAM ASCORBAT DALAM KOMBINASI DENGAN SENG SULFAT Jatmiko Susilo; Siti Fitriyah; Titis Setyowati
Jurnal Kesehatan Masyarakat Indonesia Volume 4. No. 1. Tahun 2007
Publisher : Universitas Muhammadiyah Semarang

Latar belakang. Asam askorbat bersifat mudah terdegradasi oleh suhu, cahalta atau logam dan dalam larutan. Pengaruh Seng sulfas dalam kombinasi dan perbedaan suhu penyimpanan akan berpengaruh terhadap stabilitas Asam askorbat. Stabilitas didasarkan atas penurunan kadar selama penyimpanan. Tajuan penelitian untuk mengetahui pengaruh suhu penyimpanan dan Seng sulfat terhadap stabilitas asam askorbat. Metode penelitian adalah eksperimental. dilakukan penetapan kadar Asam askorbat tunggal dan dalam kombinasi dengan seng sulfat yang disimpan selama 3 hari pada suhu 30 , 40, 50, 60 dan 70 "C dan lama penyimpanan 0, 5, 10, 15, 20 dan 25 hari pada suhu kamar. Hasil diuji dengan Uji-Anava. Hasil : menunjukkan adanya penurunan kadarAsam askorbat baik tunggal maupun dalam kombinasi oleh pengaruh suhu dan lama penyimpanan, namun dari uji statistik Fo=0.046<Ftab.(P;0,05;dbf:5,4)=5.l9 dan Fo=3.229<Ftab. (P:0,05;dbf:6; 5)=4.95berarti ticlak ada pengaruh suhu , Seng sulfut dan lama penyimpanan terhadap stabilitas Asam askorbat secara bermakna. Simpulan: Suhu sampai dengan 70 "C, dan atau adanya Seng sulfas disimpan selama 3 hari serta lama penyimpanan pada suhu kamar tidak berpengaruh secara signifikan terhadap stabilitas kimia Asam askorbat. Saran ; Perlu dilakukan uji stabilitas Asam askorbat dalam sediaan polifarmasi (multivitamin)Kata kunci ; stabilitas, Asam askorbat, kombinasi dengan Seng sulfat, Suhu, waktu penyimpanan

In Vitro Inhibition Capacity in Ca Oxalate Formation by Lemon (Citrus Lemon) Juice Endang Tri Wahyuni Maharani; Jatmiko Susilo; Arifiani Agustin Amalia
Journal of Natural Sciences and Mathematics Research Vol 1, No 2 (2015): December
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

This research aims to determine the inhibition capacity of lemon juice (Citrus lemon) in the formation of calcium oxalate in a variety of concentrations of 5%, 7.5%, 10% which is then compared to pure citric acid. Lemon juice contains citric acid that can inhibit calcium oxalate’s formation. Inhibitory activity found in lemon juice is examined by observing its inhibition capacity towards the formation of calcium oxalate crystal. At the end of the treatment process the turbidity level is compared to citric acid acting as an inhibitor in the formation of calcium oxalate and then the percentage of the inhibition capacity is calculated. Result of the study shows that the optimum concentration of the lemon juice (Citrus lemon) and citric acid is 10%. The inhibition capacities in calcium oxalate formation by lemon juice with concentration variations of 5%, 7.5%, 10% are 47.06%, 73.68%, 94.19% and by citric acid with concentration variations of 5%, 7.5 %, 10% are 29.90%, 30.85%, 42.30%. It can be concluded that the higher the concentration of lemon juice and citric acid used the higher the inhibition capacity of calcium oxalate. Based on the inhibition capacity percentage, lemon juice is more effective in inhibiting the formation of calcium oxalate compared to citric acid and it can function as an alternative to prevent the formation of kidney stone. © 2015 JNSMR UIN Walisongo. All rights reserved

The Effect of Bilimbi Juice Levels and Soaking Time on The Growth of Aspergillus flavus, L. in Corn Kernels Jatmiko Susilo; Agitya Resti Erwinarti; Zaira Ri Apriarti
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 5, No 2 (2020): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v5i2.21362

produces aflatoxin compounds that are hepatocarcinogenic. The study intends to analyze the effect of concentration and soaking time of corn kernels in bilimbi (Averrhoa bilimbi) juice on the growth of Aspergillus flavus. The experimental research, corn kernels soaked in star fruit juice concentrations of 5, 10, and 15% v/v, for 10, 20, and 30 minutes. Corn kernels are taken and planted in AFPA media. Microscopic observations every hour to observe the growth of Aspergillus flavus from planting to growth. Data were analyzed using two-way ANOVA, followed by LSD test with 95% CI. Research shows there is a decrease in pH caused by increased levels of star fruit juice. Concentrations of bilimbi fruit and soaking time can inhibit the growth of Aspergillus flavus in corn kernels. The optimal inhibitory potential was found at 15% v/v with a soaking time of 30 minutes.

Uji Daya Hambat Ekstrak Etanol Kulit Buah Terong Ungu (Solanum melongena L.) Terhadap Staphylococcus aureus dan Escherichia coli Dewi Purnamasari; Rissa Laila Vifta; Jatmiko Susilo
Jurnal Inovasi Teknik Kimia Vol 3, No 1 (2018)
Publisher : Fakultas Teknik Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/inteka.v3i1.2126

Kulit terong ungu (Solanum melongena L.) mengandung senyawa bioaktif flavonoid dan alkaloid yang dapat menghambat pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli. Penelitian dilakukan dengan tujuan mengetahui aktifitas antimikroba ekstrak etanol kulit terong ungu (Solanum melongena L.) terhadap Staphyloococcus aureus dan Escherichia coli. Pengujian antibakteri dilakukan menggunakan metode sumuran dengan 5 kelompok perlakuan. Jenis penelitian adalah eksperimental murni dengan post tes control design yang menggunakan kontrol positif Ciprofloxacin, kontrol negatif Aquadest, serta tiga variasi kontrol perlakuan. Konsentrasi ekstrak yang digunakan adalah 15%, 30%, dan 45% dengan pengamatan diameter zona hambat.. Data dianalisis menggunakan SPSS uji One Way ANOVA. Hasil penelitian menunjukkan peningkatan diameter zona hambat pada variasi konsentrasi 15%, 30%, dan 45%. Aktifitas penghambatan yang sebanding dengan kontrol positif diperoleh pada konsentrasi 45% dengan rata-rata diameter zona hambat 2,68±0,16 cm pada Staphylococcus aureus dan 2,90±0,16 cm pada Escherichia coli (p-value 0.000).. Aktifitas daya hambat ekstrak etanol kulit buah terong menunjukkan spektrum luas bakteriostatik yang mana dapat menghambat bakteri gram positif dan gram negatif. Kata kunci: antibakteri, escherichia coli, kulit terong ungu, staphyloococcus aureus,

Efficacy of Petai (Parkia speciosa, HASSK) leaf extract as an antidyslipidemic herb in Rattus norvegicus induced by high-fat feed Jatmiko Susilo; Anita Widya Astuti; Dewi Larasati
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.13761

This study aims to analyze the effect of Petai (Parkia speciosa, HASSK) leaf extract on total cholesterol, triglycerides, LDL and HDL levels in dyslipidemic rat models induced high-fat feed. The pre and post-test with control group design using 30 rats were divided into 5 groups, namely positive, normal, and Petai leaf extract at doses of 100, 200 and 400 mg/kg BW. All rats were fed high fat diet for 14 days. The extract group was given Petai leaf extract orally from day 14 to day 28. Lipid profiles were tested using enzymatic spectrophotometry method. Petai leaf extract was identified to contain flavonoid compounds. The research showed that the Petai leaf extract at a dose of 100, 200 and 400 mg / kg BW were able to decrease total cholesterol: (-32.06 ± 3.63), (-47.23 ± 2.98), and (-49,18 ± 2.66), mg / dL; triglyceride: (-11.12 ± 3.99), (-37.31 ± 0.65), and (-43.01 ± 1.17) mg / dL; LDL: (-17.14 ± 9.30), (-46.51 ± 1.99), and (-46.51 ± 1.99) mg / dL; and increasing HDL levels: (6.44 ± 0.21), (8.42 ± 0.73), and (12.1 ± 0.43) mg / dL respectively. This study proves that Petai leaf extract has anti-dyslipidemic activity in rat models by reducing total cholesterol, triglycerides, and LDL and increasing HDL levels.

Uji Aktivitas Antioksidan Ekstrak Etanol Bunga Telang (Clitoria Ternatea L.) dari Kabupaten Lombok Utara dan Wonosobo menggunakan Metode FRAP Supiani Rahayu; Rissa Vifta; Jatmiko Susilo
Generics: Journal of Research in Pharmacy Vol 1, No 2 (2021): Generics: Journal of Research in Pharmacy, Volume 1, Edisi 2, 2021
Publisher : Diponegoro University

Bunga telang (Clitoria ternatea L.) merupakan tanaman khas dari kabupaten Lombok Utara dan Wonosobo yang mengandung senyawa metabolit sekunder flavonoid, senyawa flavonoid pada bunga telang memiliki aktivitas antioksidan. Kandungan flavonoid salah satunya dipengaruhi oleh kondisi geografis dan ketinggian tempat. Pada penelitian ini bertujuan untuk mengetahui kandungan flavonoid serta aktivitas antioksidan dari kabupaten Lombok Utara dan Wonosobo. Rendemen ekstrak etanol bunga telang dari kabupaten Lombok Utara sebesar 19,44% dan Wonosobo sebesar 27,7%. Kadar flavonoid total dari kabupaten Lombok Utara sebesar 59,37 mgQE/g dan Wonosobo sebesar 63,09 mgEQ/g. Aktivitas antioksidan dari kabupaten Lombok Utara dan Wonosobo masing-masing nilai IC50 sebesar 4,19 ppm dan 3,08 ppm

Aktivitas Imunomodulator dan Kandungan Fenol Ekstrak Terpurifikasi Rimpang Jahe Merah (Zingiber officinale Rosc. Var.Rubrum) Fania Putri Luhurningtyas; Jatmiko Susilo; Richa Yuswantina; Erma Widhihastuti; Firman Wahyu Ardiyansah
Indonesian Journal of Pharmacy and Natural Product Vol. 4 No. 1 (2021)
Publisher : Universitas Ngudi Waluyo

Rimpang jahe merah (Zingiber officinale Rosc. Var.Rubrum)Â terbukti mempengaruhi sel imun dengan menurunkan level TNF-Î± dan IFN-Æ” pada kelompok perlakuan. Adanya senyawa pengotor pada ekstrak seperti lemak, resin, gula, serat, pati dapat menyebabkan penurunan aktivitas pada uji farmakologis. Penelitian ini dilakukan untuk mengetahui pengaruh purifikasi ekstrak rimpang jahe merah terhadap aktivitas imunomodulator dan kandungan fenolnya. Penarikan metabolit sekunder pada rimpang jahe merah menggunakan maserasi dengan pelarut etanol 96%. Purifikasi ekstrak dilakukan dengan cara partisi, dimurnikan dengan pelarut n-heksana. Penentuan kandungan fenol diuji menggunakan metode Folin-Ciocalteu. Metode bersihan karbon pada hewan coba bertujuan untuk mengetahui aktivitas imunomodulator berdasarkan nilai konstanta fagositosis. Hasil pengujian kadar fenol total ekstrak kasar jahe merah sebesar 338,567 mg GAE/g sampel dan ekstrak purifikasi n-heksana sebesar 862,883 mg GAE/g sampel. Aktivitas imunomodulator ekstrak purifikasi jahe merah tidak berbeda signifikan dengan kelompok kontrol positif Phyllanthus niruri (p>0,05). Hasil pengujian diketahui bahwa ekstrak terpurifikasi rimpang jahe merah memberikan hasil yang signifikan baik kadar fenol maupun aktivitas imumodulator dibandingkan sediaan ekstrak kasarnya.Red ginger rhizome (Zingiber officinale Rosc. Var.Rubrum) was shown to affect immune cells by reducing TNF-Î± and IFN-Æ” levels in the treatment group. The presence of impurities in extracts such as fat, resin, sugar, fiber, starch can cause a decrease in activity in pharmacological tests. This study was conducted to determine the effect of purification of red ginger rhizome extract on immunomodulatory activity and phenol content. Withdrawal of secondary metabolites from red ginger rhizome used maceration with 96% ethanol solvent. Extract purification was carried out by partitioning, purified with n-hexane solvent. Determination of phenol content was tested using the Folin-Ciocalteu method. The method of carbon clearance in animals aims to determine the immunomodulatory activity based on the value of the phagocytosis constant. The total phenol content of the crude extract of red ginger was 338.567 mg GAE / g sample and purified extract of n-hexane was 862.883 mg GAE / g sample. The immunomodulatory activity of the purified red ginger extract was no meaningful difference between with the positive control group of Phyllanthus niruri (p>0,05). The test results showed that the purified extract of red ginger rhizome gave significant results in both phenol content and immunomodulatory activity compared to the crude extract preparation

Genetic Risk Factors for Idiopathic Urolithiasis: The Causative Role of Genes in Stones Formation Jatmiko susilo
Indonesian Journal of Pharmacy and Natural Product Vol. 4 No. 2 (2021)
Publisher : Universitas Ngudi Waluyo

Background: The genetic factor of urolithiasis plays an important role in the etiology. Elucidation of responsible genes can lead to better targeted gene therapy and prevention in the future. This article aims to explain various genetic factors that play a role in kidney stone formationÂ Method: A review article on urolithiasis based on a genetic approach is reported to underlie stone formation. A total of 41 abstracts and research articles published by internationally reputed journals were selected based on the keywords genetic factors and urolithiasis.Â Summary: A deeper understanding of the genetic factors that play a role in the mechanisms of stone formation and advances in molecular and pharmacogenomics have revolutionized diagnosis and treatment, and paved the way for the identification of new therapeutic targets and treatment approaches based on genetic engineering.

Program Pendampingankader Lanjut Usia Melalui Kegiatan Bina Keluarga Lansia Di Desa Lerep Kecamatan Ungaran Barat Richa Yuswantina; Rissa Laila Vifta; Jatmiko Susilo
INDONESIAN JOURNAL OF COMMUNITY EMPOWERMENT (IJCE) Vol. 1 No. 1 (2019): Indonesian Journal of Community Empowerment Mei Vol.1 No.1
Publisher : UNIVERSITAS NGUDI WALUYO

Lansia atau lanjut usia merupakan individu yang berumur 60 tahun atau lebih. Penduduk Indonesia yang berusia 60 tahun ke atas atau lanjut usia (lansia) diperkirakan meningkat menjadi 80 jutaÂ pada 2030, atauÂ naik 23 sampai 24 persen.Â Banyaknya lansia sebenarnya bukan suatu ancaman jika mereka produktif. Sektor seperti kesehatan merupakan komponen yang perlu mendapatkan perhatian lebih pada lansia.Pengabdian Kepada Masyarakat dengan tema Program Pendampingan Kader Lanjut Usia Melalui Kegiatan BinaÂ Keluarga Lansia Di DesaÂ Â Â Â Lerep Kecamatan Ungaran Barat diawali dengan perencanaan melalui survey lapangan. Survey lapangan dilakukan awal pada bulan Januari dengan menemui Kepala Desa Lerep. Program Kerja diawali dengan agenda sosialisasi.Â Sosialisasi dilakukan pada tanggal 05 Februari 2019 bertempat di RW 02 Desa Lerep. SosialisasiÂ kegiatanÂ bertujuanÂ untukÂ memberikanÂ paparanÂ mengenaiÂ program kerja yang akan dilakukan. Program Kerja dari tim pengabdian kami terdiri dari 3 materi pokok yaitu : Pengetahuan Lansia, Penyuluhan Lansia dan Pemberian Softskill pada Lansia.Pelaksanaan kegiatan diawali dengan pemberian pretest kepadaÂ para peserta kemudian penyampaian materi dan dilanjutkan dengan evaluasi menggunakan postest untuk menganalisa sejauhmana pengaruh pemberian materi dapat meningkatkan pemahaman peserta mengenai pengetahuan lansia. Hasil evaluasi menunjukkan bahwa terjadi peningkatan pengetahuan antara sebelum dan sesudah pelaksanaan kegiatan penyampaian materi, dengan persentase pretest 75,2 dan posttest 85,6.Â Â Kata kunci : Lansia, Pengabdian, Desa Lerep

Co-Authors Abigail Wulandari Adinda Febriana Aditya Ardian Syahputri Agitya Resti Erwinarti Agitya Resti Erwiyani Al Hajar Fuadatus Zurroh Alfi Setiyowati Ana Hidayati Mukaromah Ana Puji Astuti Anita Eka Pratiwi Anita Widya Astuti Arif Arika Sendi Arifiani Agustin Amalia Aryanti, Ika Fajrin Kurnia Avian Tri Wahyudi Baiq Nadiah Rahmawati Bambang Purwanto Bq. Nabila Brigita Afrillia Dedi Haswan Dewi Larasati Dewi Purnamasari Dian Oktianti Dono Indarto Endang Tri Wahyuni Maharani Endang Tri Wahyuni Maharani Endang Triwahyuni Maharani Erma Widhihastuti Febriana, Adinda Firman Wahyu Ardiyansah Hati, Anita Kumala Hayaza, Yazid Himatul Ulya INDAH KURNIAWATI Inka Puji Lestari Isfaizah Jayawarsa, A.A. Ketut Kartika Sari Kartika Sari Kartika Sari Luhurningtyas, Fania Putri Mahita Mustika Putri Mona Saparwati Muchsin Doewes Nayla Salsabilla Neli Diah Pratiwi Niken Dyaharesti Ninda Izza Aulia Nova Hasani Furdiyanti Nur Cholifah Nur Hasanah Nurul Fahmi Hidayah Oni Yulianta W Puji Lestari Purnama, Siswanta Jaka Restiana Kartika MH Resty Erwiyani, Agitya Richa Yuswantina Riksa Ariyani Rini Susanti Rini Susanti Riska Kurnia Oktaviani Rissa Vifta Salsabiela Dwiyudrisa Suyudi Septi Lamana Siswanta Jaka Purnama Siti Fitriyah Siti Haryani Siti Qoyimah Siva Dwi Kemala Sari Soleha Kurniawati Supiani Rahayu Titis Setyowati Vifta, Rissa vifta, rissa laila Wahyuni, Ardianti Zaira Ri Apriarti

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