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Journal : Jurnal Kesehatan

 1 
Hypolipidemic and Hypoglycemic Potentials of Garlic Extract in High-Fat Diet and Streptozotocin-Induced Wistar Rats Veronica, Veronica; Girsang, Ermi; Chiuman, Linda
Jurnal Kesehatan Vol 16 No 2 (2025): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v16i2.5003

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels and often associated with hypercholesterolemia. Garlic (Allium sativum Linn.), rich in bioactive compounds such as allicin, saponins, and flavonoids, has been widely reported to possess lipid- and glucose-lowering properties. This study aimed to evaluate the hypolipidemic and hypoglycemic effects of garlic extract in Wistar rats subjected to a high-fat diet and streptozotocin (STZ) induction. A laboratory experimental design with a post-test-only control group was employed. For cholesterol assessment, hypercholesterolemic rats were administered garlic extract at doses of 0.05, 0.10, and 0.20g/head/day, while diabetic rats induced with STZ received doses of 100, 250, and 500 mg/kg body weight per day, with corresponding control groups. Garlic extract significantly reduced mean cholesterol levels in a dose-dependent manner (130.60mg/dL, 121.80mg/dL, and 112.00mg/dL for 0.05, 0.10, and 0.20g/head/day, respectively). In contrast, mean blood glucose levels showed a marginal decrease with increasing doses (282.80 mg/dL, 271.20mg/dL, and 269.27mg/dL at 100, 250, and 500mg/kgBW/day, respectively). However, no statistically significant differences were observed among groups (p=0.706, one-way ANOVA). These findings suggest that garlic extract exhibits a potent cholesterol-lowering effect in hypercholesterolemic rats but has a limited impact on blood glucose reduction under the tested conditions. Further studies are warranted to determine the optimal dosage and underlying mechanisms of action. 
Co-Authors Abdul Harris Afnesia, Utari Agung Joni Saputra Al Iksani, Irna Salwa Andri Andri Angellia Debora Suryawan, Angellia Debora Anggraeni, Mella Antonius, Cayadi Sidarta Arta Moro Sundjaja, Arta Moro Arum Nadya Octania Asep Ali Thabah, Asep Ali Asri, Helmalia August Halomoan Siregar Aulia Andhikawati Aulia I, Shafira Aurelia, Aurelia Azizah Az'zahra Chandra, Stefani Chiuman, Linda David David Deddy Deddy Denni, Denni Dikjayasa, Parisatria Edhie Budi Setiawan, Edhie Budi Efendi, Ade Irfan Elly Ingkiriwang Ellynia, Ellynia Emma Rochima Eveline, Christina Fifa Argentina Girsang, Ermi Habibie, Sitty Ainsyah Harahap, Sarah Geltri Hardini, Alifia Henny Lestari, Henny Husna, Selma Novaliza Indra, Evta Irenita, Novembriani Irennita, Novembriani Istanto, Freddy H. Juliater Simamarta JUNIANTO JUNIANTO Keysha Amelia Citra Kho, Ferry Khoerunnisa, Nurani Koto, Siti Khadijah Kristina Kristina Kurniabudi, Kurniabudi Laksman, Myrna Mantiri, Dessy Mega Suryandari Michaela, Janice Aveline Miranda, Airin Mudrik Alaydrus Mulyono , Herry Muryono, Tupan Tri Musthopa, Andrean Alief Nasution, Syafrani Putri Nawangwulan, Wening Nawangwulan, Wening Ramadhani Siti Ng, Martha Nia, Nia Nopriyati, Nopriyati Novi Indah Susanthi, Novi Indah Panjaitan, Denti Masti Pratama, Gilar Budi Pratiwi, Sekar Widyastuti R, Meiliana Lindawaty Rabecca Christin Chandra Rachmi, Irsafanti Rendy Sarudin Rodhiah, Rodhiah Roozana Maria Ritonga Rusmawardiana Rusmawardiana, Rusmawardiana S, Abdullah Ade Suryobuwono Safitri, Tasrika Nur Salikur, Salikur Saputra, Antoni Setiawan, Ferdy Trisanto Setiawan, Ivon Silaban, Herlan Siska Amonalisa Silalahi Sitanggang, Tina Novianti Surja, Stephanie Susan, Y. Syahzuni, Barlia Annis Tianto, Agus Tirtadidjaja, Andari Tirtadijaja, Andari Umaisaroh Umaisaroh Verano, Raka Vincent Vincent, Vincent Wening Ramadhani Siti Nawangwulan Wibawa, Callysta Wijayanti, Lady Ayu Sri Winnie Winnie Yana Erlyana, Yana Yosi Pahala, Yosi Yulianti Keke Yurrita Mailintina