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All Journal Journal of Food and Pharmaceutical Science Jurnal Informatika Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Abdimas Dewantara Media Farmasi WIDYA LAKSANA Aplikasia: Jurnal Aplikasi Ilmu-Ilmu Agama PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journals of Ners Community Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Cendekia Eksakta Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Indonesia Berdaya Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Mitra Masyarakat (JPMM) Journal of Food and Pharmaceutical Sciences Jurnal Pengabdian Masyarakat Panacea Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia

Iis Wahyuningsih

Fakultas Farmasi, Universitas Ahmad Dahlan

Author-ID : 411469

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Protection Effect of Self-Nanoemulsifying Drug Delivery System (SNEDDS) Piroxicam as Ulcerogenic Agent towards Malondialdehid Level and Protein Expression of Caspase-3, COX-1, COX-2 at Rat Gastric Iis Wahyuningsih; Kurnia Ambarwati; Erninda Ayu Hapsari; Afifah Fauziyyah; Azis Ikhsanudin; Deasy Vanda Pertiwi; Wahyu Widyaningsih
Journal of Food and Pharmaceutical Sciences Vol 8, No 2 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.732

The aim of this study was to determine the protection effect of SNEDDS piroxicam ulcerogenic agent against malondialdehyde (MDA) level and protein expression of caspase-3, COX-1, COX-2. The research was conducted using the test animals as much as 30 male white Sprague dawley (SD) rats aged 1-2 months with a weight of 100-200 grams divided into 5 groups. Treatment was given for 28 days orally. On the 29th day blood samples were also taken for the determination of MDA (Malondialdehid) levels by Thiobarbituric Acid Reactive Substance (TBARs) method using a visible spectrophotometer. Rats were sacrificed, then gastric organs were taken for immunohistochemical testing of caspase-3 and COX-1 expression, COX-2. The statistical analysis showed that the piroxicam SNEDDS group and the piroxicam suspension group decreased expression of the caspase-3 protein, increased COX-1 expression, decreased COX-2 and significantly decreased MDA levels. The piroxicam-containing SNEDDS (Self-Nanoemulsifying Drug Delivery System) form has protection against ulcogenic piroxicam.

IMPLEMENTASI SIKADES (SISTEM INFORMASI KEPENDUDUKAN DESA) UNTUK KEMUDAHAN LAYANAN ADMINISTRASI DESA BERBASIS WEB MOBILE Fiftin Noviyanto; Tedy Setiadi; Iis Wahyuningsih
Jurnal Informatika Vol 8, No 1 (2014): Januari
Publisher : Universitas Ahmad Dahlan

Disadari bahwa kondisi penyelenggaraan pelayanan masyarakat saat ini masih dihadapkan pada sistem pemerintahan yang belum efektif dan efisien serta kualitas sumber daya manusia aparatur yang belum memadai. Hal ini terlihat dari masih banyaknya keluhan dan pengaduan dari masyarakat baik secara langsung maupun melalui media massa, terkait dengan prosedur yang berbelit-belit, tidak ada kepastian jangka waktu, biaya yang harus dikeluarkan, persyaratan yang tidak transparan, petugas yang tidak profesional, sehingga menimbulkan citra yang kurang baik terhadap pemerintah. Perkembangan teknologi yang ada dapat digunakan untuk membantu penyelesaian masalah layanan publik tersebut. Salah satunya adalah web mobile.Metode yang digunakan pada penelitian ini adalah waterfall. Pengguna sistem ini meluputi: Warga, Dukuh, Lurah dan Camat. Sistem dirancang untuk menerima masukkan data dari warga terkait administrasi surat menyurat. Selanjutnya dilakukan verifikasi data oleh Dukuh dan Lurah sedangkan Camat dapat memantau warga dan administrasinya setiap desa dalam wilayah pemerintahannya.Penelitian ini berhasil mengimplementasikan SIKADES (Sistem Informasi Kependudukan Desa) yang memanfaatkan teknologi Web Mobile, untuk kemudahan layanan. Berdasarkan pengujian sistem serta pelatihan yang dilaksanakan sistem ini telah layak dikembangkan dan memungkinkan pengembangan untuk daerah lain. Â Â Kata kunci : Sistem informasi, kependudukan, web mobile

Self-nanoemulsifying drug delivery system (SNEDDS) of piroxicam: evaluation on anti-inflammantory activity in wistar rats Yudha Rizky Nuari; Iis Wahyuningsih; Sekar Prabawati
Pharmaciana Vol 11, No 2 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used for arthritis, gout, and other musculoskeletal disorders. Piroxicam is poorly soluble in water and according to the biopharmaceutical drug classification system (BCS) is classified as a Class II drug with good permeability but poor dissolution. The self-nanoemulsifying drug delivery system (SNEDDS) has been extensively employed to improve the dissolution and absorption of water-insoluble drugs within the gastrointestinal tract, leading to enhanced oral bioavailability and increased therapeutic effect of the loaded drugs. Therefore, the present study aims to evaluate the anti-inflammatory activity of piroxicam-loaded SNEDDS as compared to conventional piroxicam suspension that was observed in male Wistar strain rats. The SNEDDS was tailored from a mixture of oleic acid, tween 80, and propylene glycol. Twenty male Wistar strain rats (aged 2-3 months, weighed 150-250g) were selected and were divided equally into 4 different groups receiving 1% PVP, SNEDDS carrier, piroxicam suspension (1.8 mg/Kg BW), and SNEDDS piroxicam (1.8 mg/Kg BW). Acute inflammation was induced by a carrageenan-induced paw edema model where the carrageenan was injected sub plantar in the hind paw of the rats to induce edema. Several parameters including paw edema volume, AUC0-6, and percent anti-inflammatory effect, were measured to evaluate the anti-inflammatory activity experienced in each group. At the end of this study, the piroxicam SNEDDS group significantly demonstrated better protection from paw edema compared to the piroxicam suspension group (Ï<0.05), suggesting that SNEDDS may enhance the anti-inflammatory activity of piroxicam.

Development of black cumin seed oil (Nigella sativa L.) SNEDDS into solid-SNEDDS and its characterization Rodhia Ulfa; Dwi Utami; Iis Wahyuningsih
Pharmaciana Vol 11, No 2 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Black cumin seed oil (MBJH) (Nigella sativa L.) is a well-known herb with pharmacology activities such as anticancer and anti-thrombocytopenia. The limitation of MBJH has poor absorption when using oral dosage form. The liquid SNEDDS (Self-nanoemulsifying drug delivery system) of MBJH as an alternative formulation. However, the disadvantage of liquid-SNEDDS of MJBH was the interaction between the active ingredients with soft gelatin capsules. Hence, this study proposed to develop solid-SNEDDS as a new formulation of MBJH. Solid-SNEDDS of MBJH was prepared from liquid-SEDDS of MBJH by adsorption to solid carrier method, consisting of aerosil and crospovidone as the adsorbent. The characterization of S-SNEDDS was determined by emulsification time and percentÂ transmittance. MicromeriticsÂ properties of S-SNEDDS such as the angle of repose, bulk and tap density parameter, compressibility index, and Hausner ratio were measured Â before and after stored in stress condition (40 ÌŠ C Â± 2 ÌŠ C and relative humidity of 75% Â± 5% for 14 days). The result showed S-SNEDDS of MBJH with aerosil absorbent had better S-SNEDDS performance in both characteristics and micromeritics properties under stress conditions than crospovidone absorbent. In conclusion, the s-SNEDDS of black cumin oil by solid aerosil carrier method is promising for future research development of S-SNEDDS dosage form.

EFEK ULCEROGENIC DISPERSI PADAT IBUPROFEN-POLIVINILPIROLIDON (PVP) PADA TIKUS PUTIH JANTAN Ririt Vita Febrianti; Iis Wahyuningsih
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ibuprofen is an anti inflammatory, analgesic, and antipyretic agent. It has low solubility and bioavailability.The administration of ibuprofen in a long time and high dose can increased of side effect at gastrointestinal (pepticulcer). This study was aimed to determine the influence its solid dispersions formation on ulcerogenic effect ofibuprofen buprofenis compared with ibuprofen alone and physical mixture. Solid dispersion of Ibuprofen-PVP(1:1) was prepared by solvent method. The ulcerogenic test was conducted by observing is white rat, dividedrandomly into 5 groups are healthy group (aquadest), suspending agent control (PVP 1%), drug (ibuprofen) at adose of 360 mg/kg body weight, group solid dispersion (ibuprofen-PVP) and group physical mixture(ibuprofen-PVP). Rats gastric was observed of formation ulcer and evaluated by scoring then followed thecalculation by the index ulcer. The results showed that the number of ulcer index of ibuprofen is 6,67. Number ofulcer index of solid dispersion was 4,00 and physical mixture was 3,34. The ulcerogenic effect of solid dispersionand physical mixture difference was significant (p<0,05) compared with ibuprofen alone. Ulcerogenic effectadministration of solid dispersion was smaller than ibuprofen alone and statistically no different (p>0,05)compared with physical mixture.

FORMULASI TABLET SERBUK PISANG RAJA (Musa xparadisiaca AAB) SEBAGAI PENUTUP TUKAK LAMBUNG PADA TIKUS Iis Wahyuningsih
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Mucoadhesive is a topic of current interest in the design of drug delivery systemand treatment of peptic ulcers. This concept is based on the strength of adhesion of aprotective material to the mucosa. King Banana (Musa xparadisiaca AAB) is oftenused in the treatment of abdominal pain. It has been suspected having muchoadhesivestrength to cover peptic ulcer. The study was armed to formulate king banana tabletwhich has muchoadhesive ability to protect gastric mucosa become ulcer. The aim ofpeptic ulcer cover test was to see the ability of king banana tablet to covered ulcer at thegroups test that received different treatment of the negative control group (solvent), thebanana tablet suspension group, and sucralfate group. The ulcer severity wasdetermined by scoring method. All experimental data were tested by SPSS analyticalstatistics. The result showed that king banana tablet has similar strength to peptic ulcercover of sucralfat and not significantly different.

Reducing ulcerogenic effect of self-nano emulsifying drug delivery system of piroxicam Iis Wahyuningsih; Wahyu Widyaningsih; Silviana Wulandari
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Piroxicam is antiinflammatory non-steroidal (AINS) drug group that has anti-inflammatory, analgesic and antipyretic effects. Like most other AINS drugs, piroxicam has low solubility and has gastrointestinal (ulcerogenic) side effects on long-term use. The nano-emulsifying drug delivery system (SNEDDS) is one of the technologies that can be used to overcome it. This study aims to determine the effect of ulcerogenic SNEDDS piroxicam compared with piroxicam formulas instead of SNEDDS. This study uses white rats male strain SD age 2-3 months and weight 100-200 grams of 40 rats. Rats divided into 5 groups. Group I was a normal control group, the test animals were given only water. Group II was a suspending control group treated with a 1% polyvinylpyrrolidone (PVP) solution, group III is a carrier control group treated with SNEDDS carrier which is a mixture of tween 80, virgin coconut oil (VCO) and polyethylene glycol (PEG) 400, group IV was a group of piroxicam drugs suspended with piroxicam 1.08 mg/kg in 1% PVP, group V was treated with SNEDDS piroxicam.Treatment was done for 28 days. After treatment, the gastric of rats were taken to be observed for ulcerogenic effects. Observations were made macroscopically by looking at ulcer scores followed by histopathological observations of tissue. The ulcer score data from each group were analyzed using one-way ANOVAand LSD test. The results showed that the normal control group, 1% PVP suspension and carrier group had a ulcer index of 0.0, 0.0 and 0.0, while the piroxicam suspension group and the SNEDDS group had an ulcer index of 0.88 and 0.0. These results were confirmed by histopathologic results of SNEDDS piroxicam to decrease the effect of pyroxicam ulcerogenic with results in the piroxicam suspension group has ulcer with necrosis by neutrophil infiltration, lymphocytes and mast cells in the mucosal tunica to submucosa. In the SNEDDS piroxicam group there is erosion with necrosis of the mucosal tunica epithelium with infiltration of lymphocytes and mast cells in submucosal tunica. It can be concluded the SNEDDS piroxicam can decrease the ulcerogenic effect.

BIOAVAILABILITAS TABLET IBUPROFEN PADA PEMBERIAN BERSAMAAN DENGAN EKSTRAK AIR HERBA PEGAGAN (Centella asiatica (L) Urban) PADA KELINCI JANTAN Depprelia Wahyu Sutanti; Iis Wahyuningsih
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The tendency to use herbal drug simultaneously with synthetic drug may result inan interaction. Based on research, aqueous extract of Centella asiatica (L) Urbancontains saponin (asiaticoside and madecassoside) compounds that inhibit CYP450and is a safe herbal alternative that is used for anti-inflammatory treatment. The aim ofthis study was to investigate the effect of aqueous extract of Centella asiatica (L) Urbanto the ibuprofen tablet bioavailability in male rabbits. Both compounds are metabolizedby CYP450 enzymes in the same way with different mechanism. The cross over designwith the same subject was used in this study. The samples consisted of 400 mg ibuprofenwith 0%b/v, 25%b/v, 50%b/v dan 100%b/v aqueous extract of Centella asiatica (L)Urban respectively. The blood were taken after 0; 0,5; 1; 1,5; 2; 2,5; 3; 3,5; 4; 6; 8; 10hours after samples treatment, then the ibuprofen plasma concentration weredetermined spectrophotometrically. The results then were used to evaluat thebioavailability parameters: tmaks, Cpmaks, and AUC and were analyzed using ANOVAtest in the same way as well as the 95% trust standart. The results showed, the use ofibuprofen tablet stimultaneously with aqueous extract of Centella asiatica (L) Urbanincreased Cpmaks dan AUC, but there were no influence to the tmaks value. The use ofibuprofen tablet stimultaneously with 50 %b/v and 100 %b/v aqueous extract ofCentella asiatica (L) Urban had a significant influence to the bioavailability ofibuprofen.

Optimization of thin layers of coated turmeric extract (Curcuma longa L) tablets using a dipping method Adi Permadi; Sapto Yuliani; Iis Wahyuningsih; Ibdal Satar
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Turmeric extracts have many benefits, such as an anti-oxidant, anti-inflammatory, and neuro-protector for dementia. The turmeric extracts can be prepared in the form of a thin layer of coated tablets through a dipping method using the dip coating and Simplex lattice design (SLD) methods. The quality of the thin layers of coated tablets is much related to the formulation in the coating process. This research aims to formulate and optimize the coating composition of HPMC, PEG-400, and dip time. Consequently, the TSLT meets the standard requirements. The core tablets were made by using the wet granulation method with the formulation of turmeric extract, erosol, lactose, gelatin, and aquades. Before the core tablets had been produced, the eligibility of granules was initially evaluated based on the standard requirements. Subsequently, the core tablets that meet the standard requirements were printed and replicated. The coating processes on core tablets were performed by dipping into the coating solution in the various duration of dipping times: 5, 30, and 60 seconds. The coating solution consists of HPMC, PEG-400, glycerine, sunset yellow, and distillate water. Then, produced TSLTs were evaluated based on the hardness, friability, and disintegration time. The best optimization process for the mixture of HPMC and PEG-400 indicates a more positive value of R (R = 0.2024).

Pengembangan Produk Tablet Oral Disintegrasi Piroksikam Rohmiati Rohmiati; Iis Wahyuningsih; Any Guntarti; Iin Narwanti; Hilma Putri; Shinta Desy Anwar; Firda Rahmadani; Tedi Rustandi; Muhammad Rido Islamy
Media Farmasi: Jurnal Ilmu Farmasi Vol 15, No 1: Maret 2018
Publisher : Universitas Ahmad Dahlan

Piroksikam digunakan sebagai analgetik dan antiinflamasi yang sering dialami oleh kalangan lansia yang mempunyai kesulitan menelan. Salah satu upaya yang dapat dilakukan untuk mengatasi masalah tersebut yaitu dengan sediaan Orally Disintegrating TabletÂ (ODT). Avicel PH 102 merupakan bahan disintegran yang biasa digunakan sebagai penyusun ODT, karena mempunyai daya disintegran yang sangat baik. Tujuan penelitian ini untuk mengembangkan piroksikam menjadi bentuk sediaan ODT. Metode pembuatan ODT dilakukan dengan metode kempa langsung. Variasi konsentrasi Avicel PH 102 yang digunakan untuk formula 1 sebesar 15% dan formula 2 sebesar 20%. Tablet hasil formulasi diperiksa karakteristik fisik yang meliputi identifikasi tablet, kerapuhan, kekerasan, ketebalan, waktu hancur, bentuk dan ukuran tablet, laju disolusinya serta dilakukan penetapan kadar. Metode analisa kadar piroksikam baik pada penentuan disolusi maupun pada penentuan kadar, dilakukan verifikasi metode spektrofotometri UV-Vis terlebih dahulu meliputi spesifisitas, presisi, dan akurasi. Formula terbaik selanjutnya dilakukan uji hedonik. Hasil verifikasi untuk ketiga uji memenuhi persyaratan sehingga dikatakan metode uji valid. Hasil uji fisik tablet dikatakan memenuhi syarat kecuali untuk uji kerapuhan. Data laju disolusi dan penetapan kadar tablet piroksikam memenuhi syarat FI V yaitu laju disolusi tidak kurang dari 75%(Q + 5%) dan hasil penetapan kadar F1 dan F2 berturut-urut sebesar 95,22 Â± 3,09% dan 95,14 Â± 4,26%. Dari penelitian ini dapat disimpulkan bahwa piroksikam dapat dibuat dalam bentuk sediaan ODT karena menghasilkan sediaan tablet dengan sifat fisik yang baik kecuali pada uji kerapuhan. Formula yang dipilih yaitu formula 2, karena waktu hancur dan disolusi tablet lebih baik dibandingkan dengan formula 1.

Co-Authors AA Sudharmawan, AA Adi Permadi Adi Permadi, Adi Ag. Yuswanto Aji Setya Bakti Alam, Samsul Anggreni, Nova Annas Binarjo Anwar, Shinta Desy Anwar, Shinta Desy Any Guntarti Any Guntarti Arif Budi Setianto Aty Widyawaruyanti Azis Ikhsanudin Bakti, Aji Setya Danang Prasetyaning Amukti Deasy Vanda Pertiwi Defita Sari Depprelia Wahyu Sutanti Depprelia Wahyu Sutanti Ernidawati Erninda Ayu Hapsari Fadilah, Nur Aini Fauziyyah, Afifah Febrianika Ayu Kusumaningtyas Febrianti, Ririt Vita Fiftin Noviyanto Fiftin Noviyanto Firda Rahmadani Firda Rahmadani, Firda Fransisca, Indriyani Riski Fresiva, Urva Galang Pergiawan Ramadhan Gita Puspita Gustinanda, Rizky Handaningrum, Karunia Nining Hensi Setya Oktavia Hilma Putri Ibdal Satar Iin Narwanti Iin Narwanti Ikhsan Jaya Guntur Wicaksono Ilyas, Jenny Ima Dinny Rahmawaty Imam Riadi Indriyani Riski Fransisca Islamy, Muhammad Rido Islamy, Muhammad Rido Jenny Ilyas Kaffah, Silmi khusnul khotimah Kurnia Ambarwati Lina Widiyastuti Magfirah Septiani Yusuf Maghfirah, Rahmayani Moch Saiful Bachri Mochamad Saiful Bachri Muhammad Rido Islamy Muhammad Riski Pratama Muhammad Yusron Maulana El-Yunusi Narwanti, Iin Nazilah Shofi Risqina Nining Sugihartini Nining Sugihartini Nur Mahdi Nuri Ari Efiana Oci Widyastuti Oktavia, Hensi Setya Pelita, Putri Dina Pratama, Muhammad Riski Purwitasari, Neny Putri Dina Pelita Putri, Hilma Putri, Hilma Rahmawaty, Ima Dinny Rakhmawati, Kartika Rauhatun Napsah Reski Mulia Retno Widyowati Rindi Ibrahim Lasanudin Ririt Vita Febrianti Risqina, Nazilah Shofi Rodhia Ulfa Rohmiati Rohmiati Rohmiati, Rohmiati Rohmiati, Rohmiati Ronny Martien Ronny Martien Rustandi, Tedi Samsul Alam Sapto Yuliani Sapto Yuliani Sari, Defita Satar, Ibdal Sekar Prabawati Sembiring, Rinawati Shinta Desy Anwar Silviana Wulandari Sri Mulyaningsih Sri Mulyaningsih Sri Sulistyorini, Sri Srimuliani Arbie Sugiyanto - Sugiyanto Sugiyanto Sukardiman Sutanti, Depprelia Wahyu Tedy Setiadi Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyuningtyas, Winda Wicaksono, Ikhsan Jaya Guntur Widyasari Putranti Widyastuti, Oci Winda Wahyuningtyas Wiwied Ekasari Wulandari, Silviana Wulandari, Silviana Yenni Latief Yudha Rizky Nuari Yunda Maymanah Rahmadewi Yunda Maymanah Rahmadewi Yuswanto, Ag

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