Article Per Year (5 Year)
p-Index From 2020 - 2025
4.777
P-Index
This Author published in this journals
All Journal Journal of Food and Pharmaceutical Science Jurnal Informatika Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Abdimas Dewantara Media Farmasi WIDYA LAKSANA Aplikasia: Jurnal Aplikasi Ilmu-Ilmu Agama PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journals of Ners Community Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Cendekia Eksakta Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Indonesia Berdaya Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Mitra Masyarakat (JPMM) Journal of Food and Pharmaceutical Sciences Jurnal Pengabdian Masyarakat Panacea Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Iis Wahyuningsih
Fakultas Farmasi, Universitas Ahmad Dahlan
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 73 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 73 Documents
Search

 4   5   6   7   8 
Formulasi Solid Snedds (Self-Nano Emulsifying Drug Delivery System) Furosemid Dengan Pengering Aerosil Dan Aktivitas Diuretiknya Pelita, Putri Dina; Wahyuningsih, Iis; Yuliani, Sapto
Journals of Ners Community Vol 13 No 1 (2022): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i1.1745

Abstract

Furosemid adalah obat golongan diuretika yang umum digunakan dalam terapi edema yang terkait dengan penyakit heart failure dan pada pengobatan hipertensi. Furosemid termasuk dalam Biopharmaceutical Class System (BCS) IV yang diketahui memiliki kelarutan dan permeabilitas yang rendah. Untuk mengatasi masalah tersebut dibuat sediaan Self-Nano Emusifying Drug Delivery System (SNEDDS). SNEDDS memiliki keterbatasan dalam hal stabilitas sehingga dilakukan penelitian lanjutan dengan membuat sediaan SNEDDS dalam bentuk padatan atau Solid SNEDDS (S-SNEDDS). Tujuan penelitian ini adalah memformulasi SNEDDS furosemid menjadi S-SNEDDS furosemid dan menentukan pengaruh S-SNEDDS furosemid terhadap aktivitas diuretikapada tikus dibandingkan dengan SNEDDS furosemid maupun furosemid saja tanpa modifikasi. Metode pembuatan S-SNEDDSfurosemid pengering aerosil dilakukan dengan metode absorbtion to solid carrier kemudian dilanjutkan pengujian karakterisasi kejernihan, waktu emulsifikasi, sifat alir, bulk density dan tapped density. Selanjutnya dilanjutkan uji aktivitas diuretika pada 25 ekor tikus jantan galur Wistar yang dibagi menjadi 5 kelompok yaitu kelompok normal, kontrol negatif diberi pembawa S-SNEDDS, perlakuan 1 diberi suspensi furosemid, perlakuan 2 diberi SNEDDS furosemid, perlakuan 3 diberi S-SNEDDSfurosemid dengan dosis 5,04 mg/KgBB. Seluruh kelompok diberikan perlakuan secara peroral lalu diperiksa volume urin yang dikeluarkan tikus pada jam ke 1, 2, 3, 4, 5 dan 6 setelah pemberian. Volume urin yang diperoleh di masing-masing kelompok dihitung rata-rata dan standar deviasinya kemudian dianalisis statistik dengan LSD dengan IBM SPSS (Statistical Product and Service Solution) 25 for Windows. S-SNEDDS furosemid dengan pengering aerosil memiliki karakteristik persen transmitan 96,94 ± 0,13 %, waktu emulsifikasi 7,40 ± 1,14 detik, sudut diam 31,71 ± 2,24, carr’s index 8,74 ± 0,49 dan hausner ratio 0,99 ± 0,10 dan dinyatakan memenuhi persyaratan. Hasil pengujian secara in vivo S-SNEDDS furosemid dengan pengering aerosil dapat meningkatkan volume urin kumulatif yang berbeda bermakna dengan kelompok kontrol negative pada dengan signifikansi lebih dari 0,05. Berdasarkan hasil penelitian dapat disimpulkan bahwa S-SNEDDS furosemid dengan pengering aerosil memiliki karakter dan aktivitas diuretika lebih baik dibandingkan dengan SNEDDS furosemid dan furosemid tanpa modifikasi.
PENGARUH PENGERING AEROSIL DAN KROSPOVIDON TERHADAP KARAKTERISTIK FISIK SOLID-SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM KURKUMIN Wahyuningsih, Iis; Kyllingga, Muhammad Rhapis
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2664

Abstract

Curcumin belongs to BCS II with low solubility but high permeability. In previous studies, a curcumin SNEDDS formulation was developed with a curcumin concentration of 7 mg/mL, VCO (11%), Tween 80 (65.66%), and PEG 400 (23.34%); however, this formulation had the drawback of being incompatible with capsule shells. The objective of this study was to formulate and characterise solid SNEDDS curcumin using aerosil and crospovidone as drying agents. The S-SNEDDS formulation was prepared using the absorption-to-solid carrier method with aerosil and crospovidone as drying agents, followed by characterisation using parameters such as clarity, emulsification time, static angle test, bulk density, tapped density, Carr’s index, Hausner ratio, and droplet measurement. The resulting S-SNEDDS curcumin formulations contained 0.5 g of aerosil drying agent per mL and 3 g of crospovidone. The formulations exhibited the following characteristics: clarity of 96.28±0.00% and 95.35±0.01%, emulsification time of 52.58±0.75 seconds for aerosil in AGF and 56.14±0.42 seconds in distilled water, while crospovidone yielded 48.63±1. 84 seconds and 50.58±0.45 seconds, angle of repose 19.77±2.03º and 41.41±3.35º, bulk density and tapped density 0.56±0.00 and 0.63±0.01 for aerosil, and 0.50±0.00 and 0.57±0. 01 for crospovidone, Carr’s index and Hausner ratio 11.33±2.08% and 1.13±0.03 for aerosil, and 12.66±2.51% and 1.15±0.03 for crospovidone, with droplet sizes of 77.08 nm and 198.2 nm. Aerosil-dried S-SNEDDS produced granules with better characteristics.
PENGEMBANGAN SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) EKSTRAK DAUN SENGGUGU (Clerodendron serratum [L.]Spr.) Kusumawati, Erna; Wahyuningsih, Iis; Khasnah, Nur
Jurnal Ilmiah Manuntung Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.416

Abstract

Senggugu leaf (Cloredendrom serratum[L.]Spr.) is one of the natural ingredients that has a pharmacological effect in overcoming cancer since it contains flavonoid componds that prevents the development of cancer cells. However, the application of senggugu leaf extract through oral is not acceptable. Therefore, it requires the development of SNEDDS (Self- Nanoemulsifying Drug Delevery Sytem). Objectives: This study aims to formulate SNEDDS of senggugu leaf extract by using tween 80 surfactant and PEG 400 cosurfactane and Virgin Coconut Oil Phase in order for the optimal SNEDDS character to be obtained. Before making the DX 12 formula, a formula trial was made to determine the lower an upper values of each component. After that, a formula was made bases on the DX12. In order to make the optimal formula characterization, it is carried out of the optimal formula of SNEDDS, including particle size, zeta potential, and nanoemulsion stability in the artificial digestive system for 4 hours. The optimal characteristics that have been obtained has a transmitance percentage of 97,99±0,39 % within the emulsification time of 23,57 ±1,06 seconds, a droplet size of 12,5 ±0,436 nm, a polidispersity index of 0,320±0,005, a zeta potensial value of -30,6 ± 0,3 mV, and a stable nanoemulsion formed in the artifical disgetive tract. The results showed that the proportion of VCO 10,55%, tween 68%, and 21,45% PEG400 and 200 mg/mL extract was able to form a good formula for senggugu leaf extract SNEDDS.
Co-Authors AA Sudharmawan, AA Adi Permadi Adi Permadi, Adi Ag. Yuswanto Aji Setya Bakti Alam, Samsul Anggreni, Nova Annas Binarjo Anwar, Shinta Desy Anwar, Shinta Desy Any Guntarti Any Guntarti Arif Budi Setianto Aty Widyawaruyanti Azis Ikhsanudin Bachri, Mochamad Saiful Bakti, Aji Setya Danang Prasetyaning Amukti Deasy Vanda Pertiwi Defita Sari Depprelia Wahyu Sutanti Depprelia Wahyu Sutanti Efiana, Nur Ari Ernidawati Erninda Ayu Hapsari Fadilah, Nur Aini Fauziyyah, Afifah Febrianika Ayu Kusumaningtyas Febrianti, Ririt Vita Fiftin Noviyanto Fiftin Noviyanto Firda Rahmadani Firda Rahmadani, Firda Fransisca, Indriyani Riski Fresiva, Urva Galang Pergiawan Ramadhan Gita Puspita Gustinanda, Rizky Handaningrum, Karunia Nining Hensi Setya Oktavia Hilma Putri Ibdal Satar Iin Narwanti Iin Narwanti Ikhsan Jaya Guntur Wicaksono Ilyas, Jenny Ima Dinny Rahmawaty Imam Riadi Indriyani Riski Fransisca Islamy, Muhammad Rido Islamy, Muhammad Rido Jenny Ilyas Kaffah, Silmi Khasnah, Nur khusnul khotimah Kurnia Ambarwati Kyllingga, Muhammad Rhapis Lasanudin, Rindi Ibrahim Lina Widiyastuti Magfirah Septiani Yusuf Maghfirah, Rahmayani Moch Saiful Bachri Muhammad Rido Islamy Muhammad Riski Pratama Muhammad Yusron Maulana El-Yunusi Narwanti, Iin Nazilah Shofi Risqina Nining Sugihartini Nining Sugihartini Nur Mahdi Nuri Ari Efiana Oci Widyastuti Oktavia, Hensi Setya Pelita, Putri Dina Pratama, Muhammad Riski Purwitasari, Neny Putri Dina Pelita Putri, Hilma Putri, Hilma Rahmawaty, Ima Dinny Rakhmawati, Kartika Rauhatun Napsah Reski Mulia Retno Widyowati Ririt Vita Febrianti Risqina, Nazilah Shofi Rodhia Ulfa Rohmiati Rohmiati Rohmiati, Rohmiati Rohmiati, Rohmiati Ronny Martien Ronny Martien Rustandi, Tedi Samsul Alam Sapto Yuliani Sapto Yuliani Sari, Defita Satar, Ibdal Sekar Prabawati Sembiring, Rinawati Shinta Desy Anwar Silviana Wulandari Sri Mulyaningsih Sri Mulyaningsih Sri Sulistyorini, Sri Srimuliani Arbie Sugiyanto - Sugiyanto Sugiyanto Sukardiman Sutanti, Depprelia Wahyu Tedy Setiadi Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyuningtyas, Winda Wicaksono, Ikhsan Jaya Guntur Widyasari Putranti Widyastuti, Oci Winda Wahyuningtyas Wiwied Ekasari Wulandari, Silviana Wulandari, Silviana Yenni Latief Yudha Rizky Nuari Yunda Maymanah Rahmadewi Yunda Maymanah Rahmadewi Yuswanto, Ag