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All Journal Journal of Food and Pharmaceutical Science Jurnal Informatika Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Abdimas Dewantara Media Farmasi WIDYA LAKSANA Aplikasia: Jurnal Aplikasi Ilmu-Ilmu Agama PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journals of Ners Community Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Cendekia Eksakta Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Indonesia Berdaya Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Mitra Masyarakat (JPMM) Jurnal Bakti Untuk Negeri Journal of Food and Pharmaceutical Sciences Jurnal Pengabdian Masyarakat Panacea Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia
Iis Wahyuningsih
Fakultas Farmasi, Universitas Ahmad Dahlan
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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PENGARUH PENGERING AEROSIL DAN KROSPOVIDON TERHADAP KARAKTERISTIK FISIK SOLID-SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM KURKUMIN Wahyuningsih, Iis; Kyllingga, Muhammad Rhapis
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2664

Abstract

Curcumin belongs to BCS II with low solubility but high permeability. In previous studies, a curcumin SNEDDS formulation was developed with a curcumin concentration of 7 mg/mL, VCO (11%), Tween 80 (65.66%), and PEG 400 (23.34%); however, this formulation had the drawback of being incompatible with capsule shells. The objective of this study was to formulate and characterise solid SNEDDS curcumin using aerosil and crospovidone as drying agents. The S-SNEDDS formulation was prepared using the absorption-to-solid carrier method with aerosil and crospovidone as drying agents, followed by characterisation using parameters such as clarity, emulsification time, static angle test, bulk density, tapped density, Carr’s index, Hausner ratio, and droplet measurement. The resulting S-SNEDDS curcumin formulations contained 0.5 g of aerosil drying agent per mL and 3 g of crospovidone. The formulations exhibited the following characteristics: clarity of 96.28±0.00% and 95.35±0.01%, emulsification time of 52.58±0.75 seconds for aerosil in AGF and 56.14±0.42 seconds in distilled water, while crospovidone yielded 48.63±1. 84 seconds and 50.58±0.45 seconds, angle of repose 19.77±2.03º and 41.41±3.35º, bulk density and tapped density 0.56±0.00 and 0.63±0.01 for aerosil, and 0.50±0.00 and 0.57±0. 01 for crospovidone, Carr’s index and Hausner ratio 11.33±2.08% and 1.13±0.03 for aerosil, and 12.66±2.51% and 1.15±0.03 for crospovidone, with droplet sizes of 77.08 nm and 198.2 nm. Aerosil-dried S-SNEDDS produced granules with better characteristics.
PENINGKATAN PENGETAHUAN ANGGOTA KELOMPOK WANITA TANI GUYUP RUKUN KALIMUNDU DALAM PEMBUATAN DAN PEMASARAN TEH CELUP BUNGA TELANG Wahyuningsih, Iis; Sri Rejeki, Marsudi Endang; Kintoko, Kintoko; Khusnul, Latifah
Jurnal Bakti untuk Negeri Vol 5 No 02 (2025): Jurnal Bakti Untuk Negeri
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/ab3yf030

Abstract

This community service activity aimed to improve the knowledge and skills of the members of  KWT Guyub Rukun in Kalimundu in the production and marketing of butterfly pea flower tea bags. A total of 20 participants took part in a series of four  sessions: post-harvest handling, tea bag production, packaging, and marketing including the determination of the cost of goods sold. Pretest and posttest evaluations indicated an increase in participants’ understanding across all sessions. In the post-harvest training, participants showed better comprehension of proper harvesting time and drying methods that help maintain material quality. In the tea-making session, all indicators showed score improvement, with pretest scores ranging from 33.33% to 91.67%, and increasing to 100% on most posttest questions. During the packaging session, participants began to understand the importance of using packaging that meets standards and has attractive visual appeal. Meanwhile, the marketing and COGS session showed significant improvement, especially in identifying effective promotional media and understanding cost components, with some indicators increasing from 12 to 16 correct responses. These results reflect the effectiveness of the training in enhancing the technical and entrepreneurial capacities of KWT members, and mark a strategic step in empowering women through locally based economic development.  
Surfactant Variations in Capsanthin-loaded Nanostructured Lipid Carrier: Formulation, Characterization, and Stability Study Efiana, Nuri Ari; Shofa-ulhusna, Fatihah; Paramita, Lathifah Aurora; Heavena, Indana Azza; Masyfiyah, Salsabila Fariha; Muhamed, Farahidah; Permadi, Adi; Wahyuningsih, Iis
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.335-344

Abstract

The stability of drugs and nanocarriers is a crucial factor in guaranteeing their efficacy and quality. Nanostructured lipid carriers (NLCs) as lipid-based nanocarriers provide benefits in overcoming the stability and other issues associated with the drug. Surfactants play a crucial role in imparting the desired characteristics of lipid based systems, including stability, particle size, size distribution, and zeta potential. This study aimed to develop a capsanthin-loaded NLC formulation with an optimal surfactant combination that exhibits the required properties and stability. Three formulations were prepared applying Tween 20 and Span 80 in ratios of 5:1, 2:1, and 1:1 for F1, F2, and F3, respectively. Capsanthin, as an active ingredient, originates from paprika powder. NLC properties regarding transmittance, particle size, polydispersity index (PI), zeta potential, loading capacity (LC), and loading efficiency (LE) were characterized. Furthermore, stability studies were also conducted in this research. The results showed that F1 exhibited desirable characteristics, including transmittance percentage, particle size, PI, zeta potential, LC, and LE of 87.22±2.64%, 255.4±46.88 nm, 0.54±0.13, -39.51±3.02 mV, 12.59±0.35%, and 35.40±3.07%, respectively. Moreover, the physical stability studies exhibited that F1 provided a more stable system compared to other formulations. Additionally, the chemical stability indicated that degradation occurred in the paprika powder, not in the NLC. In conclusion, NLC can protect capsanthin, as evidenced by the stable capsanthin levels in NLC compared to those in paprika powder.
Peningkatan Pengetahuan Siswa SMK Kesehatan Bantul tentang DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) Kosmetik melalui Edukasi Kesehatan Utami, Fella Arifatul Wahyu; Wahyuningsih, Iis; Isrovanigoro, Isrovanigoro; Arib, Faisal Nur
Indonesia Berdaya Vol 7, No 2 (2026)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.20261457

Abstract

Remaja merupakan kelompok konsumen kosmetik yang besar namun rentan terhadap paparan produk ilegal dan informasi yang tidak tervalidasi di media sosial. Kurangnya literasi mengenai keamanan produk dapat berdampak buruk bagi kesehatan kulit. Kegiatan Program Pemberdayaan Umat (PRODAMAT) ini bertujuan untuk meningkatkan pengetahuan dan literasi keamanan produk kecantikan pada siswa SMK Kesehatan Bantul melalui edukasi DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang) Kosmetik. Metode yang digunakan adalah edukasi partisipatif dengan desain evaluasi pre-test dan post-test melalui tahapan persiapan, pre-test, intervensi edukasi, dan post-test. Intervensi mencakup pemaparan materi dan diskusi interaktif tentang DAGUSIBU Kosmetik. Hasil evaluasi terhadap 18 peserta menunjukkan peningkatan skor rata-rata pengetahuan secara signifikan dari 65,00±12,95 menjadi 95,56±7,05. Analisis uji Wilcoxon Signed Ranks menghasilkan nilai p = 0,000 (p 0,05), didukung dengan nilai rata-rata N-gain sebesar 0,909 yang termasuk dalam kategori efektivitas tinggi. Simpulan dari kegiatan ini adalah edukasi DAGUSIBU Kosmetik efektif dalam meningkatkan domain kognitif siswa sebagai fondasi perilaku penggunaan kosmetik yang aman dan rasional. Program ini diharapkan dapat membangun kesadaran kritis remaja dalam menghadapi tren di era digital.
Self-Nano Emulsifying Drug Delivery System (SNEDDS) Kurkumin sebagai Kandidat Agen Terapi pada Model Hewan Demensia Paneri, Jerry Dwi; Wahyuningsih, Iis; Yuliani, Sapto
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kurkumin, yang berasal dari Curcuma longa, menunjukkan potensi neuroprotektif, namun aplikasi klinisnya terbatas oleh bioavailabilitas yang rendah. Sistem penghantaran obat seperti self-nanoemulsifying drug delivery system (SNEDDS) dikembangkan untuk meningkatkan bioavailabilitas kurkumin. Penelitian ini bertujuan untuk menentukan proporsi optimal minyak kelapa murni (virgin coconut oil/VCO), Tween 80, dan PEG 400 dalam formulasi SNEDDS kurkumin. Penelitian ini meliputi optimasi formulasi menggunakan desain simplex lattice, karakterisasi fisikokimia, evaluasi in vivo, serta analisis statistik menggunakan SPSS. Formulasi SNEDDS yang optimal terdiri atas VCO (11%), Tween 80 (65,66%), dan PEG 400 (23,34%), dengan dosis kurkumin sebesar 35 mg/5 mL. Formulasi ini menunjukkan waktu emulsifikasi sebesar 32 ± 0,83 detik, transmitansi 99,39% ± 0,22%, ukuran droplet 13,18 ± 0,03 nm, indeks polidispersitas 0,131 ± 0,004, serta potensial zeta −13,0 ± 1,74 mV. Studi in vivo menunjukkan bahwa pemberian SNEDDS kurkumin pada dosis 7 mL/kg dan 12 mL/kg berat badan secara signifikan meningkatkan memori spasial pada tikus model demensia. Peningkatan kognitif tersebut tidak menunjukkan perbedaan yang signifikan dibandingkan dengan kelompok yang diberi sitikolin. Temuan ini menunjukkan bahwa SNEDDS yang diformulasikan dengan VCO, Tween 80, dan PEG 400 mampu meningkatkan penghantaran kurkumin dan memperbaiki memori spasial, sehingga mendukung potensinya sebagai terapi neuroprotektif.
Peningkatan Pengetahuan Siswa SMK Kesehatan Bantul tentang DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) Kosmetik melalui Edukasi Kesehatan Fella Arifatul Wahyu Utami; Iis Wahyuningsih; Isrovanigoro Isrovanigoro; Faisal Nur Arib
Indonesia Berdaya Vol. 7 No. 2 (2026)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.20261457

Abstract

Remaja merupakan kelompok konsumen kosmetik yang besar namun rentan terhadap paparan produk ilegal dan informasi yang tidak tervalidasi di media sosial. Kurangnya literasi mengenai keamanan produk dapat berdampak buruk bagi kesehatan kulit. Kegiatan Program Pemberdayaan Umat (PRODAMAT) ini bertujuan untuk meningkatkan pengetahuan dan literasi keamanan produk kecantikan pada siswa SMK Kesehatan Bantul melalui edukasi DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang) Kosmetik. Metode yang digunakan adalah edukasi partisipatif dengan desain evaluasi pre-test dan post-test melalui tahapan persiapan, pre-test, intervensi edukasi, dan post-test. Intervensi mencakup pemaparan materi dan diskusi interaktif tentang DAGUSIBU Kosmetik. Hasil evaluasi terhadap 18 peserta menunjukkan peningkatan skor rata-rata pengetahuan secara signifikan dari 65,00±12,95 menjadi 95,56±7,05. Analisis uji Wilcoxon Signed Ranks menghasilkan nilai p = 0,000 (p < 0,05), didukung dengan nilai rata-rata N-gain sebesar 0,909 yang termasuk dalam kategori efektivitas tinggi. Simpulan dari kegiatan ini adalah edukasi DAGUSIBU Kosmetik efektif dalam meningkatkan domain kognitif siswa sebagai fondasi perilaku penggunaan kosmetik yang aman dan rasional. Program ini diharapkan dapat membangun kesadaran kritis remaja dalam menghadapi tren di era digital.
Nanoemulsion Formulation Combination of Virgin Coconut Oil (VCO) and Candlenut Oil (Alleurites mollucanus) for Hair Growth in Male White Rats (Rattus novergicus) Rindi Ibrahim Lasanudin; Mochamad Saiful Bachri; Iis Wahyuningsih; Nur Ari Efiana
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 1 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i1.4348

Abstract

Having healthy and thick hair is the dream of many people, but some people have problems related to their hair. Hair problems that often occur are hair loss, thin hair or baldness, so to overcome these problems hair growth products have been made. Virgin Coconut Oil VCO and candlenut oil can be used as natural ingredients that can grow hair. The aim of this research was to determine the best nanoemulsion formulation for a combination of candlenut oil and VCO; and to determine the difference between applying nanoemulsion, conventional candlenut oil, conventional VCO and the oil emulsion on hair growth in male rats. This nanoemulsion formulation uses a combination of candlenut oil and VCO in a ratio of 1:1, 1:3 and 3:1. The nanoemulsion obtained was subjected to organoleptic, pH, viscosity, flow type and % transmittance. The best formulation was then tested for droplet size and zeta potential as well as hair growth activity tests using male rats. It was found that the best nanoemulsion formula was a nanoemulsion with a combination of 1:3 with a yellow color, a distinctive odor and clear with a droplet size of 14.42 ± 0.03 nm, a zeta value of -27.8 ± 1.02 mV, the length of the hair produced in the test hair growth activity was 17.14 ± 0.42 mm and hair weight was 699.37 ± 7.91 mg.
Optimasi Perbandingan Tween 80 dan Polietilenglikol 400 Pada Formula Self Nanoemulsifying Drug Delivery System (SNEDDS) Minyak Biji Jinten Hitam Iis Wahyuningsih; Widyasari Putranti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 12 No. 02 Desember 20
Publisher : Universitas Muhammadiyah Purwokerto

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Abstract

ABSTRAK Minyak biji jinten hitam (Nigella sativa Linn.), dengan kandungan utama timokuinon mempunyai aktivitas sebagai antikanker yang cukup poten. Beberapa penelitian tentang aktivitas antikanker timokuinon telah dilakukan, namun hasilnya belum maksimal. Dalam penelitian ini akan dilakukan modifikasi penghantaran self nanoemulsifying drug delivery system (SNEDDS) minyak biji jinten hitam yang diharapkan dapat meningkatkan efektivitasnya sebagai antikanker karena SNEDDS akan meningkatkan kelarutan timokuinon yang terkandung dalam minyak biji jinten hitam (MBJH), sehingga lebih banyak zat aktif yang akan sampai pada sel kanker, selain itu formula SNEDDS MBJH diduga tidak mengalami effluks oleh sel kanker. Asam oleat dipilih sebagai fase minyak, tween 80 sebagai surfaktan dan propilenglikol sebagai kosurfaktan. Tahapan penelitian yang dilakukan adalah: (1) penentuan batas bawah dan batas atas masing-masing komponen (2) optimasi formula SNEDDS MBJH menggunakan sistem DX 9 dengan parameter %T dan waktu emulsifikasi (3) validasi persamaan yang dihasilkan DX9 (4) SNEDDS hasil optimasi yang dihasilkan dikarakterisasi ukuran, zeta potensial, stabilitas termodinamiknya dan persentase transmitan menggunakan spekrofotometer. Photon correlation spectroscopy (PCS) digunakan untuk mengetahui ukuran SNEDDS dan polidispersibility index, Zeta Sizer Analysis untuk mengukur muatannya. Kata kunci: karakteristik, minyak biji jinten hitam, SNEDDS. ABSTRACT Black cumin (Nigella sativa Linn.) seed oil has been known for possessing anticancer activity, with thymoquinone as the active ingredient. Previously reported data show that anticancer activity of thymoquinone is relatively low. In this research, we modify black cumin seed oil with self nanoemulsifying drug delivery system (SNEDDS) formula, so it’s effectivity as anticancer can be improved. SNEDDS increases solubility of thymoquinonone and improves its delivery to cancer cells. We used oleic acid as oil phase, tween 80 as surfactan, and propilenglycol as cosurfactan. The steps in this research were determination of upper limit and lower limit of each components, optimization of SNEDDS formula using DX 9 system, equation validation obtained from DX 9, and characterization of SNEDDS based on its size, zeta potensial, thermodynamic stability, and thermodynamic transmitans. Key words: black cumin seeds oil, characterization, SNEDDS.
Co-Authors AA Sudharmawan, AA Ag. Yuswanto Aji Setya Bakti Alam, Samsul Anggreni, Nova Annas Binarjo Anwar, Shinta Desy Anwar, Shinta Desy Any Guntarti Any Guntarti Arib, Faisal Nur Arif Budi Setianto Aty Widyawaruyanti Azis Ikhsanudin Bakti, Aji Setya Danang Prasetyaning Amukti Deasy Vanda Pertiwi Defita Sari Depprelia Wahyu Sutanti Depprelia Wahyu Sutanti Efiana, Nuri Ari Erninda Ayu Hapsari Fadilah, Nur Aini Faisal Nur Arib Fauziyyah, Afifah Febrianika Ayu Kusumaningtyas Febrianti, Ririt Vita Fella Arifatul Wahyu Utami Fiftin Noviyanto Fiftin Noviyanto Firda Rahmadani Firda Rahmadani, Firda Fransisca, Indriyani Riski Fresiva, Urva Galang Pergiawan Ramadhan Gita Puspita Gustinanda, Rizky Handaningrum, Karunia Nining Heavena, Indana Azza Hensi Setya Oktavia Hilma Putri Ibdal Satar Iin Narwanti Ikhsan Jaya Guntur Wicaksono Ilyas, Jenny Ima Dinny Rahmawaty Imam Riadi Indriyani Riski Fransisca Islamy, Muhammad Rido Islamy, Muhammad Rido Isrovanigoro Isrovanigoro Isrovanigoro, Isrovanigoro Jenny Ilyas Kaffah, Silmi khusnul khotimah Khusnul, Latifah Kintoko Kintoko Kurnia Ambarwati Kyllingga, Muhammad Rhapis Lina Widiyastuti Magfirah Septiani Yusuf Maghfirah, Rahmayani Masyfiyah, Salsabila Fariha Moch Saiful Bachri Mochamad Saiful Bachri Muhamed, Farahidah Muhammad Rido Islamy Muhammad Riski Pratama Nazilah Shofi Risqina Nining Sugihartini Nining Sugihartini Nur Ari Efiana Nur Mahdi Nuri Ari Efiana Oci Widyastuti Oktavia, Hensi Setya Paneri, Jerry Dwi Paramita, Lathifah Aurora Pelita, Putri Dina Permadi, Adi Pratama, Muhammad Riski Purwitasari, Neny Putri Dina Pelita Putri, Hilma Putri, Hilma Rahmawaty, Ima Dinny Rakhmawati, Kartika Rauhatun Napsah Rejeki, Marsudi Endang Sri Reski Mulia Retno Widyowati Rindi Ibrahim Lasanudin Ririt Vita Febrianti Risqina, Nazilah Shofi Rodhia Ulfa Rohmiati Rohmiati Rohmiati, Rohmiati Rohmiati, Rohmiati Ronny Martien Ronny Martien Rustandi, Tedi Samsul Alam Sapto Yuliani Sapto Yuliani Sari, Defita Satar, Ibdal Sekar Prabawati Sembiring, Rinawati Shinta Desy Anwar Shofa-ulhusna, Fatihah Silviana Wulandari Sri Mulyaningsih Sri Mulyaningsih Sri Sulistyorini, Sri Srimuliani Arbie Sugiyanto - Sugiyanto Sugiyanto Sukamto, Ika Sumiyarsi Sukardiman Sutanti, Depprelia Wahyu Tedy Setiadi Utami, Fella Arifatul Wahyu Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyuningtyas, Winda Wicaksono, Ikhsan Jaya Guntur Widyasari Putranti Widyastuti, Oci Winda Wahyuningtyas Wiwied Ekasari Wulandari, Silviana Wulandari, Silviana Yenni Latief Yudha Rizky Nuari Yunda Maymanah Rahmadewi Yunda Maymanah Rahmadewi Yuswanto, Ag