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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan BALI MEDICAL JOURNAL (BMJ) Media Penelitian dan Pengembangan Kesehatan MPI (Media Pharmaceutica Indonesiana) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Serambi Engineering Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Pharmaceutical Journal of Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Humanism : Jurnal Pengabdian Masyarakat Berkala Ilmiah Kimia Farmasi Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan Jurnal Info Kesehatan
Retno Widyowati
Departemen Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
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Journal : Science and Technology Indonesia

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Assessment of Antioxidant Activity, Total Phenolic and Flavonoid Contents of Albizia saponaria L. Bark Extract Lukman, Lukman; Rosita, Noorma; Widyowati, Retno
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.494-501

Abstract

Langir (Albizia saponaria L.), belonging to the family of the Fabaceae, is a medicinal endemic plant of South Sulawesi, Indonesia. The Albizia genus shows antioxidant, antibacterial, anthelmintic, antidandruff, and anti-inflammatory properties. In this study, total phenolic (TP) and total flavonoid (TF) extracts from the bark of A. saponaria were screened for robust antioxidant activity in order to identify potential sources of new compounds for use in pharmaceutical formulations in the future. TP and TF of the 96% ethanol extract and fractions (hexane, ethyl acetate, butanol, and water) were calculated by the Folin–Ciocalteu and aluminum chloride procedures, respectively. Furthermore, the antioxidant activity was determined by DPPH free radical scavenging method and ABTS assay. Generally, both extract and fractions showed significant radical scavenging activities. Ethyl acetate fraction exhibited more potent radical scavenging activity in the DPPH method (IC50 35.27 ± 2.85 µg/mL) and ABTS assay (IC50 60.04 ± 0.98 µg/mL), followed by 96% ethanol extract, and hexane, butanol, and water fractions. Furthermore, the highest TP (4.50 ± 0.01 mg/g GAE) and TF (3.55 ± 0.04 mg/g QE) were obtained from ethyl acetate fraction. There was a strong correlation between antioxidant activity with TP (DPPH, R2 = 0.6436; ABTS, R2 = 0.7676) and TF content (DPPH, R2 = 0.5533; ABTS, R2 = 0.5961). The extract’s antioxidant properties may be attributable to its higher phenolic and flavonoid content. In summary, the phenolic and flavonoid content of the ethyl acetate fraction indicates its potential utility as a source of antioxidants.
Co-Authors Achmad Fuad Hafid Akbar, Achmad Naufal Maulana Aly, M. Ainun Najib Amalia, Savira Rizky Meisya Anggara Satria Putra, Anggara Satria Arum Widiyaningsih Aty Widyawaruyanti Bambang Prajogo Eko Wardoyo Bambang Prajogo EW Bobsaid, Jihan Burhan Ma'arif Corry, Maylisa Natalia Devitri, Nabilah Apsari Dewi Lestari Dewi Melani Hariyadi Djoko Agus Purwanto Edhi, Narendrani Sasmitaning Ekapratista, Belinda Nabilah Favian Rafif Firdaus Firdaus, Favian Rafif Fridayanti S, Septia Indah Haliza, Nabila Nur Hani Plumeriastuti Haq, Nimas Rizqi Firdausy Hardiyanti, Andi Sry Hardiyanti, Merry Hasan, Muhammad Amir Hening Laswati Putra Hidayati, Agriana Rosmalina Hindiana, Linda Idha Kusumawati Iis Wahyuningsih Ilmi, Hilkatul Imam Subadi Irawati Sholikhah Istiqamah, Farida J. A. Pangkahila Jaelani, Mochammad Iqbal Kholis Amalia Nofianti Lahardo, Devanus Laksmi, Farika Dyani Laksmi Luthfiatu Kanina Luthfiatu Kanina Ma'arif, Burhan Mabluhatus Solehah Mahalaksmi, Alika Sabrina Mangestuti Agil Marta Ika Riyana Miatmoko, Andang Munandar, Tristiana Erawati Naima, Fathnin Ulya Najlaa, Fatimah Ahla Nareswari, Andwynanda Bhadra Neni Purwitasari Niluh Indrawati Noorma Rosita Novian, Farah Kusuma Wardhani Nur Irhamni Sabrina Pilipus Kopeuw Pradnyanantha, I Putu Bagus Pramesti, Ragil Putri Pratama, Edo Pratiwi Soesilawati Purwitasari, Neni Purwitasari, Neny Putri, Anisa Yustikka Putri, Yushalluuna Bekti Pasuka Rahman, Ave Rakhmawati - - Rania, Athaya Putri Rice Disi Oktarina Riesta Primaharinastiti, Riesta Rizkyah, Chaerini Sahu, Ram Kumar Salam, Anisa Rakhmania Samudra, Rizka Putra Sari, Trisiyana Sholika SETIAWAN, Catur Dian Shaffiqa, Nurul Sri Wahyuni, Tutik Subhan Rullyansyah Suciati Suciati Suciati Suciati Sudjarwo Sudjarwo Sukardiman Sulistiyono, Ilham Robbynoor Suryadi, A. Mu’thi Andy Syahrani, Achmad Taufikurrahman Taufikurrahman Tri Widiandani Tutik Sri Wahyuni Ummah, Rokhmatul Wardhana, Brahma Wisnu Kusuma Wardoyo, Bambang Prajogo Eko Wicaksana, Firman Widiyaningsih, Arum Windianto, Farhan Rizqi Wiwied Ekasari Wiwik Handayani Yakub, Nikolas Zulfah, Yasmin