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All Journal Jurnal Kedokteran Brawijaya Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Research Journal of Life Science STOMATOGNATIC- Jurnal Kedokteran Gigi Global Medical and Health Communication Biology, Medicine, & Natural Product Chemistry MNJ (Malang Neurology Journal) Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Majalah Kesehatan FKUB Jurnal Penelitian Pendidikan IPA (JPPIPA) Journal of Islamic Medicine Indonesian Contemporary Nursing Journal (ICON Journal) JURNAL TEKNIK INFORMATIKA DAN SISTEM INFORMASI Oto Rhino Laryngologica Indonesiana JASIEK (Jurnal Aplikasi Sains, Informasi, Elektronika dan Komputer) Jurnal Ilmiah Kesehatan Rustida Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Jurnal Health Sains Jurnal Klinik dan Riset Kesehatan International Journal of Science and Society (IJSOC) International Journal of Radiology and Imaging Journal of Community Health and Preventive Medicine (JOCHAPM) DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Jurnal Ilmu Kedokteran Keluarga Plexus Medical Journal
Yuyun Yueniwati
Departement Of Radiology, Faculty Of Medicine, Universitas Brawijaya/Dr. Saiful Anwar General Hospital, Jl. Jaksa Agung Suprapto No. 2, Malang 65112
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Hubungan Kadar Trombosit dengan Gambaran Luas Lesi Tuberkulosis Paru melalui Foto Chest X-Ray Alimsjah, Yohanes Audric; Yueniwati, Yuyun; Nugroho, Rafiq Sulistyo
Jurnal Klinik dan Riset Kesehatan Vol 4 No 2 (2025): Edisi Februari
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.04.2.4

Abstract

Background: Pulmonary tuberculosis (TB) is a chronic inflammatory disease accompanied by changes in particular haematological parameters within the blood. The changes in the composition of blood cells can be potential biomarkers to assist tuberculosis diagnosis beside using clinical, microbiological, and radiological tools. Platelets play a vital part in chronic inflammation since they contain different sorts of mediators that are involved in lung damage which is reflected in the extent of lesions on radiological examination. Aim: The research aims to compare the platelets level between minimal/moderate versus extensive lesions in the patient with TB. Methods: The research was a retrospective, cross-sectional study of patients with pulmonary tuberculosis who were treated at Saiful Anwar Hospital from January 2022 to December 2023. The results of the research were analyzed using the Chi-Square method. Results: Patients with extensive pulmonary TB lesions have platelet levels that tend to be high, in contrast to patients with minimal/moderate pulmonary TB lesions tend to have low platelet levels. Conclusion: There was a significant relationship between platelet levels and the extent of pulmonary tuberculosis lesions.
Infrared Thermography in Detecting Peripheral Arterial Disease in Diabetic Foot: A Scoping Review Adiantara, Ken Rangga Galang; Kristianto, Heri; Yueniwati, Yuyun
Jurnal Health Sains Vol. 5 No. 3 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i3.1235

Abstract

Early and accurate assessment of peripheral arterial disease (PAD) is crucial given its fatal complications such as amputation. Infrared thermography (IRT) offers various advantages in studying PAD. This study aims to map the use of Infrared thermography in detecting Peripheral Arterial Disease in diabetic feet. This review applies the scoping review method to review the literature related to Infrared thermography in detecting vascular disorders in diabetic legs. Article searches are conducted on five databases, namely Google Scholar, PubMed, EBSCO, ScienceDirect, and ProQuest. The Boolean keywords and codes used are "Infrared Thermography" AND "Diabetic foot" AND "Peripheral Arterial Disease". Searches are limited to articles published between 2018 and 2024. The journal selection process follows PRISMA's guidelines. The search process yielded 1,969 article titles relevant to the keywords and Boolean operators used. After being selected based on the research topic, 8 articles were left for analysis. IRT can be a useful tool for detecting PAD in diabetic foot. IRT can help track the progression of PAD and classify the foot as PAD without or prone with high accuracy
Ethanol extract of Cyclea barbata Miers induces follicle development through 17ß-estradiol level and LHR expression Noviyanti, Noviyanti; Yueniwati, Yuyun; Rahardjo, Bambang; Permatasari, Galuh W.
Majalah Obstetri & Ginekologi Vol. 33 No. 3 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I32025.195-203

Abstract

HIGHLIGHTS Docking analysis revealed that there are four novel compounds in barbata, including Zearalenone, Bis(2-ethylhexyl) phthalate, Benzanthrone, and Octytldecyl phthalate have stronger affinity -9.7; -9.6; -9,2; and -7.7 kcal/mol, respectively. The extract of barbata leaves increased follicle development (75%) by elevating estrogen levels and LHR expression at all doses.   ABSTRACT Objective: Infertility, often linked to anovulation from impaired follicular maturation, affects millions globally. Cyclea barbata Miers, a plant with estrogen-like properties, may enhance follicle development through hormonal modulation. This study evaluated the ethanol extract of C. barbata leaves for its ability to promote in vitro follicle development by increasing 17ß-estradiol levels and luteinizing hormone receptor (LHR) expression. Materials and Methods: Molecular docking analysis identified four novel compounds in C. barbata, Zearalenone, Bis(2-ethylhexyl) phthalate, Benzanthrone, and Octyl decyl phthalate, with binding affinities of -9.7, -9.6, -9.2, and -7.7 kcal/mol to estrogen receptor alpha (ESRa). Secondary follicles (2-3 mm) from goat ovaries were cultured in vitro using TCM-199 medium supplemented with 10% FBS, PMSG, hCG, and C. barbata extract at 25, 50, or 100 ppm for six days. Follicle maturation was assessed via microscopy for size, cumulus-oocyte complex formation, and polar body extrusion. 17ß-estradiol levels and LHR expression were analyzed using one-way ANOVA and LSD tests. Results: The 100 ppm dose achieved 75% follicle maturation, significantly higher than 25% at lower doses and controls. It increased 17ß-estradiol levels (36.83 ± 2.33 pg/mL, p < 0.000) and LHR expression (261.874 ± 54.606, p < 0.000), with dose-dependent effects confirmed by statistical analysis. Conclusion: C. barbata extract at 100 ppm enhances follicular maturation by elevating 17ß-estradiol and LHR expression, likely due to its estrogenic compounds. Further in vivo and clinical studies are needed to confirm its therapeutic potential for ovulatory disorders.
Combined Vitamin D and Magnesium Supplementation Improves Insulin, HOMA Indices, Blood Glucose, and Oxidative Stress Markers in Diabetic Rats Azzahra, Balqis Faizah; Yueniwati, Yuyun; Permatasari, Happy Kurnia; Rahayu, Rachmi Fauziah; Tifani, Amara Syifa; Fauzi, Adam
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3905

Abstract

BACKGROUND: Diabetes mellitus (DM) is characterized by disturbances in glucose homeostasis, chronic low-grade inflammation, and heightened oxidative stress. Alterations in vitamin D status and magnesium homeostasis are frequently observed in DM and have been implicated in impaired insulin secretion, decreased insulin sensitivity, and dysregulated antioxidant responses. Although both micronutrients have independently demonstrated potential benefits on glycaemic regulation and oxidative balance, the synergistic therapeutic effects of combined vitamin D and magnesium supplementation remain insufficiently elucidated in experimental models of type 2 DM. Therefore, this study was conducted to determine the effects of combined vitamin D and magnesium supplementation on insulin dynamics, glycaemic control, and oxidative stress markers in streptozotocin-induced diabetic rats.METHODS: Twenty-four male Wistar white rats were divided into 4 groups: normal control, diabetic control, metformin group, and vitamin D + magnesium group. DM was induced using streptozotocin–nicotinamide injection. Glycaemic parameters including insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and homeostatis model assessment of β-cell function (HOMA-β), were evaluated from fasting serum using immunoassay-based analyses; while oxidative stress markers including superoxide dismutase (SOD) and malondialdehyde (MDA) were measured from plasma using colorimetric spectrophotometric methods.RESULTS: Vitamin D and magnesium combination achieved the greatest reduction in blood glucose. The mean insulin level and HOMA-β index in the vitamin D + magnesium group were significantly higher than in both the diabetic control and metformin groups (p<0.001). In the same group, HOMA-IR and MDA levels were significantly lower, whereas SOD activity was significantly higher compared with diabetic group and metformin group (p<0.001).CONCLUSION: The combination of vitamin D and magnesium increases insulin and HOMA-β level and decreases HOMA-IR, SOD, and MDA expressions in diabetic Wistar rats.KEYWORDS: diabetes mellitus, magnesium, vitamin D, insulin resistance, inflammation
Co-Authors Abd. Rasyid Syamsuri Ade Lina Nur Fadlilah Adiantara, Ken Rangga Galang Agung Setyawan Agus Naba Agustina, Tanti Ahmad DW, Ahmad Aldita Husna Violita Aldita Husna Violita Alfred Julius Petrarizky Alfrina Hany Alimsjah, Yohanes Audric Andrijani Sumarahinsih Arief Iskandar Atsil Lathifa, Jauza Ayu Hardianti Pratiwi Azmi, Mukhammad Azzahra, Balqis Faizah Bambang Rahardjo Basya Adnani Basyar Adnani Begum Fauziyah Berlian Cyntia Devi, Berlian Cyntia DAVID SANTOSO Dewi Kartikawatiningsih Diana Lyrawati Dina Dewi SLI Dini Rachma Erawati Diptya, Ibnu Djatmiko, Ahmad Eko Arisetijono Erawati, Dini Rachma Erlangga, Eggi Esther Palupi Fahanani, Agwin Fahmi Fahmi Fahanani, Agwin Faizah Azzahra, Balqis Fatimah Kunti Hentihu Faturrohmaniah, Ari Fauzi, Adam Habiba Aurora Hafiedz Maulana Handoko, Edi Handono Kalim Happy Kurnia Permatasari Heri Kristianto Husnul Khotimah Irawan, Paulus Lucky Tirma Iriana Maharani, Iriana Johan Andoyo Effendi Noor Johan Andoyo Effendi Noor Karimah Karimah Karimah Ken Rangga Galang Adiantara Lathifa, Jauza Atsil M. Yunus Maharina, Luths Margaretha Berek Masruroh Rahayu Mohamad Hidayat Mokhamad Fahmi Rizki Syaban Muhammad Zacky Hafiyyan Maulana Mukhamad Fathoni Mukhammad Fathoni N. Diana Yulisa Nabilla Hardiyanti, Ginanda Nanik Setijowati Nasir Aslam, Achmad Bayhaqi Nasywa Talitha Zahran Ni Kadek Indah Sunar A Noviyanti Noviyanti, Noviyanti Ns. Rinik Eko Kapti Nugroho, Rafiq Sulistyo Nur Permatasari Nurdiana, Farah Permatasari, Galuh W. Prabata, Adam Pradana, Wisniardhy Suarnata Pradhana, Satwika Purnama, Avief Destian Rachma Erawati, Dini Rachmi Fauziah Rahayu Rahmawan, Fajri Andi Rinik Eko Kapti, Rinik Eko Rislan Faiz Muhammad Rislan Faiz Muhammad Ropitasari Ropitasari Rulli Rosandi Safira Dita Arviana Sakdullah, Istianah Sarni J. Ishak Servasius Ratu Banin Shahdevi Nandar Kurniawan, Shahdevi Nandar Sigma Nur Rismawati Siti Maimunah Tifani, Amara Syifa Titin Andri Wihastuti Tony Suharsono Tony Suharsono, Tony Tri Mukti Lestari Wahyudi, Mgs Ahmad Widya Addiarto Wulansari, Yunita Wahyu Yudisthira, Dewangga Yulian Wiji Utami Yunita Wahyu Wulansari, Yustina Ni Putu yusniawati