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All Journal VALENSI Jurnal Kimia (Journal of Chemistry) Journal of Mathematical and Fundamental Sciences Journal of Islamic Pharmacy Indonesian Journal of Chemistry JOPS (Journal Of Pharmacy and Science) Jurnal Farmasi Higea Jurnal Ilmiah Pharmacy Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Makara Journal of Science Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Farmasi Galenika

Hadi Kuncoro

Faculty Of Pharmacy, Universitas Mulawarman, Samarinda 75123, Indonesia

Author-ID : 4295749

Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

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Uji Aktivitas Antioksidan dan Formulasi Gel Ekstrak Etanol Daun Jeruk Nipis (Citrus aurantifolia): Antioxidant Activity Test and Gel Formulation of Lime Leaf Ethanol Extract (Citrus aurantifolia) Bayu Tri Andika; Dewi Rahmawati; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Citrus aurantifolia leaves have several pharmacological properties such as antibacterial and antioxidant activity. The main objective of this study was to determine the antioxidant activity and obtain the best gel formula from the lime leaves ethanolic extracts. Five different concentrations of Citrus aurantifolia leaves extract namely FI, FII, FIII, FIV, and FV were tested for its antioxidant activity using the DPPH method. Furthermore, the lime leaves extract gel were formulated using carbopol 940. The gels were then evaluated for various parameters including organoleptic, homogeneity, pH, spreadability and viscosity to select best formulation. The extraction process was conducted using maceration method. The results of the DPPH radical scavenging activity showed that lime leaves extract with concentration 60,84 ppm has the preeminent IC50 value. The preparation of lime leaf ethanol extract gel obtained was clear white, clear green, green, brownish green, dark green, homogeneous, and had a characteristic smell of lime leaf. Evaluation of dispersion of 5-5.4 cm, pH of 5.1-5.8, and viscosity of 4.44-6.39 Pa.s. From the evaluation results, it can be concluded that formula 2 is the best formula.

Studi Evaluasi Efek Samping Penggunaan Vaksin COVID-19 Terhadap Masyarakat Sebatik Timur: Study Evaluating the Side Effects of the Use of the COVID-19 Vaccine on the Eastern Sebatik Community Lutfiatun Nisak; Juniza Firdha Suparningtyas; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Vaccination is an effective prevention of disease transmission and an obligation to ensure the availability of vaccines, especially during this COVID-19 pandemic where the availability of vaccines has an Emergency Use Approvel (EUA) permit so that further research is needed on the effects. This study aims to see the effect of using the COVID-19 vaccine on people in East Sebatik. The research design used was a prospective non-experimental method with data collection techniques, namely purposive sampling. The subjects of this study were 100 people who were vaccinated against COVID-19 stage 1 and stage 2 in East Sebatik, especially those carried out by the East Sebatik Health Center. The result of this research is that the majority of respondents based on gender characteristics are women as many as 68 respondents (68%). The majority of respondents based on age characteristics are in the adult age group (26-45 years) as many as 54 respondents (54%). The majority of respondents based on the characteristics of the history of the disease were non-complicated as many as 67 respondents (67%). COVID-19 vaccine is currently restricted to age ? 18 years. The majority respondents based on side effect after the COVID-19 vaccine dose 1 was pain in the area of the injection site, which was 39 respondents (39%). And the majority of respondents based on side effect after COVID-19 vaccine dose 2 were 17 respondents (17%).

Analisa Tingkat Pengetahuan dan Perilaku Masyarakat Terhadap Penggunaan Antibiotik di Kelurahan Dawi-Dawi, Kecamatan Pomalaa, Kabupaten Kolaka, Provinsi Sulawesi Tenggara: Analysis Of Community Knowledge and Behavior Level on The Use of Antibiotics Kelurahan Dawi-Dawi, Kecamatan Pomalaa, Kabupaten Kolaka, Southeast Sulawesi Province Devitha Farah Mahdiyah; Dewi Mayasari; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Antibiotics are an effective therapy diseases caused by bacteria so that patients or the public sometimes use them as self-medication drugs. Due to the lack of knowledge and behavior of the community this can lead to cases of antibiotic resistance. The purpose was to determine the level of knowledge and behavior of the community towards the use of antibiotics in Kelurahan Dawi-Dawi, Southeast Sulawesi province. The knowledge and behavior of the community was obtained using a simple descriptive method, cross sectional, with an instrument in the form of a questionnaire that could be distributed to the community to be analyzed regarding the level of knowledge and behavior. This research has involved 196 test respondents. The results showed that the profile of the characteristics of the respondents were mostly female, 35-44 years old, last graduated from high school and worked as a housewife. For the overall results of Kelurahan Dawi-Dawi, Southeast Sulawesi province, having sufficient knowledge 42.9% and sufficient behavior 49.0%. The results of the test of the relationship between knowledge and people's behavior were obtained for the correlation coefficient value using the Spearman formula is Has a moderate correlation of 0.357, a significance of 0.000 with the direction (+).

A Known Naphthalene, Isoeleutherol, from the Herb of Lygodium microphyllum Kuncoro, Hadi; Farabi, Kindi; Rijai, Laode; Julaeha, Euis; Shiono, Yoshihito; Supratman, Unang
Makara Journal of Science Vol. 22, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

A known naphthalene, isoeleutherol (1), was isolated from the herb ofLygodium microphyllum. The chemical structure of 1 was determined on the basis of spectroscopic data mainly UV, IR, HRTOFMS, 1D-and 2D-NMR spectroscopy, aswell as by comparing with compounds previously reported. Isoeleutherol was isolated from this plant for the first timeand showed moderate antioxidant activity against DPPH (2,2-diphenyl-1-picrylhydrazyl) with IC50 value of 53.96 ± 2.87 μg/mL.

STABILITAS BETASIANIN DARI SARI KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) TERHADAP SUHU, pH DAN KONDISI PENYIMPANAN Hadi Kuncoro
Jurnal Ilmiah Pharmacy Vol 9, No 2 (2022)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v9i2.421

Betasianin merupakan pigmen yang masuk dalam golongan betalain. Stabilitas dari betasianin dapat dipengaruhi oleh suhu, pH dan kondisi penyimpanan. Kulit buah naga merah (Hylocereus polyrhizus) merupakan salah satu tumbuhan yang memiliki senyawa betasianin yang sudah banyak diteliti dan memberikan manfaat. Penelitian ini bertujuan melakukan pengujian stabilitas betasianin dari sari kulit buah naga merah terhadap suhu, pH dan kondisi penyimpanan. Metode yang digunakan ialah dengan mengukur absorbansi dari betasianin menggunakan spektrofotometer UV-Vis dengan setiap perlakuan suhu, pH dan kondisi penyimpanan yang berbeda serta waktu penyimpanan kulit yang berbeda. Hasil yang didapatkan diantaranya ialah kadar betasianin dari sari kulit buah naga merah pada suhu dingin, suhu sejuk serta suhu ruang mengalami peningkatan dan mengalami penurunan pada suhu pemanasan. Kadar betasianin pada pH dengan rentang 1-5 mengalami peningkatan dan mengalami penurunan pada pH 6-8. Kadar betasianin pada kondisi penyimpanan wadah tertutup atau terbuka dengan periode selama 14 hari mengalami penurunan kadar dan pada wadah tertutup, penurunan kadar betasianin lebih rendah dibandingkan dengan wadah terbuka. Kadar betasianin pada kulit buah naga segar lebih tinggi dibandingkan dengan kulit buah naga yang disimpan dalam kulkas selama dua minggu. Sehingga, dapat disimpulkan bahwa kadar betasianin dari sari kulit buah naga merah stabil pada suhu ruang dengan pH 5 dan dengan kondisi penyimpanan wadah tertutup serta dengan kulit buah naga segar.

Evaluasi Ketepatan Penggunaan Obat pada Pasien Lupus Eritematosus Sistemik (LES) di RSUD Kanujoso Djatiwibowo Kota Balikpapan Tahun 2020-2021: Evaluation of Medication Use in Patients with Systemic Lupus Erythematosus (SLE) at Kanujoso Djatiwibowo Hospital Balikpapan in 2020-2021 Alida Adelia Islami; Fahriani Istiqamah Jafar; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.609

Optimasi Formula Sediaan Krim Ekstrak Kulit Putih Buah Semangka (Citrullus lanatus (Thunb.) Matsum & Nakai) sebagai Antijerawat: Optimization of Cream Formula from Watermelon White Skin Extract (Citrullus lanatus (Thunb.) Matsum & Nakai) as an Antiacne Ni Made Mela Santi; Nurul Fitriani; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.631

Potensi Antiradikal bebas DPPH dan Tabir Surya Ekstrak Tunggal dan Kombinasi Kulit Jeruk Lemon (Citrus limon (L.) Osbeck ) dan Kulit Jeruk Manis (Citrus aurantium L.) Rosanti Wahyu Saputri; Satriani Badawi; Hadi Kuncoro
Jurnal Farmasi Higea Vol 14, No 2 (2022)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v14i2.438

Kulit buah jeruk lemon (Citrus limon (L.) Osbeck) dan jeruk manis (Citrus aurantium L.) mengandung golongan senyawa fenolik dan flavonoid yang dapat bertindak sebagai antioksidan dan tabir surya. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan tabir surya ekstrak etanol kulit buah jeruk lemon dan jeruk manis dalam bentuk ekstrak tunggal maupun kombinasinya. Kedua sampel dimaserasi menggunakan pelarut etanol 70%. Aktivitas antioksidan ditentukan dengan metode penghambatan radikal bebas 2,2-diphenyl-1-picrylhydrazyl menggunakan spektrofotometer UV-Vis, efektivitas tabir surya ditentukan dengan menghitung nilai %Te, %Tp, dan SPF dengan metode spektrofotometri. Nilai IC50 ekstrak kulit lemon, ekstrak kulit jeruk manis, dan kombinasinya (1:1, 1:2, dan 2:1) secara berturut-turut adalah 610,94 ppm; 437,52 ppm; 501,18 ppm; 398,11 ppm; dan 485,25 ppm. Hasil ini menunjukkan kombinasi dengan perbandingan 1:2 memiliki aktivitas antioksidan yang lebih baik dibandingkan sampel lainnya. Hasil uji aktivitas tabir surya menunjukkan nilai %Te dan %Tp ekstrak menurun dengan peningkatan konsentrasi dan nilai SPF seluruh ekstrak dengan konsentrasi 800 ppm termasuk dalam kategori proteksi maksimal.

Pengaruh Kemoterapi terhadap Kadar Hematologi pada Pasien Kanker Payudara di RSUD dr. Kanujoso Djatiwibowo Balikpapan: The Effect of Chemoterapy on Hematological Levels in Breast Cancer Patients at RSUD dr. Kanujoso Djatiwibowo Balikpapan Annisa Nabilah; Wisnu Cahyo Prabowo; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.697

Breast cancer is a malignant disease of breast tissue that can originate from the duct epithelium or lobules. Breast cancer therapy can be done with several types of therapy, one of which is chemotherapy. The most common side effect of chemotherapy is myelosuppression, a decrease in blood cell levels because chemotherapy agents are toxic to blood-forming organs. This research was conducted to understand the effect of chemotherapy in reducing blood cell levels in breast cancer patients who received chemotherapy at RSUD dr. Kanujoso Djatiwibowo Balikpapan for the period July 2022 to June 2023. This research is descriptive with a cross-sectional design. Of the 82 samples, 50 patients (60%) had erythrocyte levels below normal; hemoglobin in 79 patients (96%); hematocrit in 75 patients (91%); neutrophils in 20 patients (24%); leukocytes in 25 patients (30%); and thrombocytes in 7 patients (9%). The most common hematological levels below normal are hemoglobins and hematocrits. Keywords: ca mamae, hematology, mielosuppresion Abstrak Kanker payudara merupakan penyakit keganasan pada jaringan payudara yang dapat berasal dari epitel duktus maupun lobulusnya. Terapi kanker payudara dapat dilakukan dengan beberapa macam terapi, salah satunya adalah kemoterapi. Efek samping kemoterapi yang paling umum adalah mielosupresi yaitu penurunan kadar sel darah karena agen kemoterapi bersifat toksik terhadap organ pembentuk darah. Penelitian ini dilakukan untuk mengetahui gambaran pengaruh kemoterapi dalam menurunkan kadar sel darah pasien kanker payudara yang menerima kemoterapi di RSUD dr. Kanujoso Djatiwibowo Balikpapan periode Juli 2022 sampai Juni 2023. Penelitian ini bersifat deskriptif dengan desain cross-sectional. Dari 82 sampel, pasien dengan kadar eritrosit dibawah normal sebanyak 50 pasien (60%); hemoglobin 79 pasien (96%); hematokrit 75 pasien (91%); neutrofil 20 pasien (24%); leukosit 25 pasien (30%); dan trombosit 7 pasien (9%). Kadar hematologi di bawah normal paling banyak adalah hemoglobin dan hematokrit. Kata Kunci: kanker payudara, hematologi, mielosupresi

Evaluasi Penggunaan Obat pada Pasien Artritis Gout di Instalasi Rawat Jalan Rumah Sakit Pupuk Kaltim Bontang Periode 2022: Evaluation of Drug Use in Gout Arthritis Patients in the Outpatients Installation of Pupuk Kaltim Bontang Hospital Period 2022 Silvia Ningsih Manurung; Hadi Kuncoro; Junaidin Junaidin
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 18 (2023): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v18i1.722

Arthritis gout is a disease due to deposition of monosodium urate (MSU) crystals in the joints, kidneys, and other connective tissues as a result of hyperuricemia which can cause pain, swelling, impaired joint movement, and even tophi. Without rational treatment, there will be overdiagnosis and inadequate management which can aggravate gout. This study used observational studies and descriptive methods in 87 samples at the outpatient installation of Pupuk Kaltim Hospital Bontang Period 2022. The results of the study of patient characteristics based on age were most in the age group 46-55 years with a total of 25 patients (28.7%), based on gender more occurred in men with a total of 75 male patients (86.2%), based on the most symptoms were pain with a total of 69 cases (68.3%), and based on the highest diagnosis was acute gouty arthritis with a total of 76 patients (87.3%). The results showed that the most widely used antipyretic therapy was Allopurinol, which was used by 62 patients, followed by Colchicine which was used by 47 patients. For analgesic, antipyretic, and anti-inflammatory therapy, NSAIDs were used by 23 patients and Paracetamol was used by 6 patients. Keywords: gout arthritis, characteristics, treatment pattern Abstrak Artritis gout adalah penyakit akibat deposisi kristal monosodium urat (MSU) di sendi, ginjal, dan jaringan ikat lainnya sebagai akibat dari hiperurisemia yang dapat menimbulkan nyeri, bengkak, gangguan gerak sendi, dan bahkan tophi. Tanpa pengobatan yang rasional, akan terjadi overdiagnosis dan tata laksana yang tidak adekuat yang dapat memperparah gout. Penelitian ini menggunakan studi observasional dan dengan metode deskriptif pada 87 sampel di instalasi rawat jalan Rumah Sakit Pupuk Kaltim Bontang Periode 2022. Hasil penelitian karakteristik pasien berdasarkan usia terbanyak pada kelompok usia 46-55 tahun dengan jumlah 25 pasien (28,7%), berdasarkan jenis kelamin lebih banyak terjadi pada laki-laki dengan jumlah sebanyak 75 pasien laki-laki (86,2%), berdasarkan gejala paling banyak adalah nyeri dengan jumlah 69 kasus (68,3%), dan berdasarkan diagnosis paling tinggi adalah artritis gout akut dengan jumlah 76 pasien (87,3%). Hasil penelitian menunjukkan terapi antipirai yang paling banyak digunakan adalah Allopurinol yaitu sebanyak 62 pasien, diikuti dengan Kolkisin yang digunakan oleh 47 pasien. Untuk terapi analgesik, antipiretik, dan antiinflamasi golongan NSAID digunakan oleh 23 pasien dan Paracetamol digunakan oleh 6 pasien. Kata Kunci: artritis gout, karakteristik, pola pengobatan

Co-Authors Abdul Mun’im Ace Tatang Hidayat Aditya Fridayanti Afif Ruchaemi Aji Yudha Wijaya Al Arofatus Naini Ali Sadikin Alida Adelia Islami Amir, Muhammad Andi Tenri Kawareng Angga Cipta Narsa Annisa Nabilah Aprilia Putri Firdaus Arsyik Ibrahim Aty Widyawaruyanti Azminah Azminah Bayu Tri Andika Crissty Magglin Daryono Desi Harneti Putri Huspa Devitamara Ayu Devitha Farah Mahdiyah Dewi Mayasari Dewi Rahmawati Diana Kurnia Apriani Diana Lestari Dwinita Aquastini Emma Susilowati Shabir Enggar Wijayanti Erwin Samsul Euis Julaeha Fahriani Istiqamah Jafar Fajar Prasetya Fajar Prasetya Falencia Ega Aprillia Fatmawati Eka Putri Febrina Mahmudah Fikriah, Ika Ganjar Firmansyah Gemini Alam Hajrah Hajrah Herman Herman Ika Rahayu Intan Hawina Anjari Islamudin Ahmad Iswahyudi Iswahyudi Junaidin Junaidin Jutti Levita Khemasili Kosala Kindi Farabi Kindi Farabi Laode Rijai Lisna Meylina Lizma Febrina Lutfiatun Nisak M Arifuddin M. Arifuddin Mahfuzun Bone Mira Susanti Mirhansyah Ardana Mohamad Nurul Azmi Muhammad Akbar MUHAMMAD AMIR MASRUHIM Mukti Priastomo Nadia Rahma Kusuma Dewi Nadiyah Amalia Aprilliani Ni Made Mela Santi Nisa Naspiah Noor Erma Sugijanto Noor Linda Febrianie Novia Anggraini Novita Eka Kartab Putri Nur Masyithah Nurul Fitriani Oktaviany Triana Putri Anggreini Rahmadani, Agung Rahmi Annisa Riama Rita Manullang Risna Agustina Risna Agustina Risyandi Anwar Rolan Rusli Rosanti Wahyu Saputri Rusmini Rusmini Satriani Badawi Silvia Ningsih Manurung Siti Anisah Nur Fajriyati Sri Adi Sumiwi Sukartiningsih Sukartiningsih Suparningtyas, Juniza Firdha Supriatno Salam Syarifah Irhamnah Taslim Ersam Tri Woro Widyanti Unang Supratman Viriyinata Wijaya Wanda Millenia Alwie Welinda Ayu Wisnu Cahyo Prabowo Wisnu Cahyo Prabowo Wisnu Cahyo Prabowo Yoshihito Shiono Yurika Sastyarina Yuspian Nur

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