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All Journal VALENSI Jurnal Kimia (Journal of Chemistry) Journal of Mathematical and Fundamental Sciences Journal of Islamic Pharmacy JOPS (Journal Of Pharmacy and Science) Jurnal Farmasi Higea Jurnal Ilmiah Pharmacy Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Makara Journal of Science Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan

Hadi Kuncoro

Faculty Of Pharmacy, Universitas Mulawarman, Samarinda 75123, Kalimantan Timur, Indonesia

Author-ID : 4295749

Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

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Analisis Minimalisasi Biaya (Cost-Minimization Analysis) Pasien Gastritis Rawat Inap di RSUD Abdul Wahab Sjahranie Samarinda Muhammad Akbar; Mirhansyah Ardana; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 7 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Biaya pelayanan kesehatan, khususnya biaya obat, telah meningkat beberapa tahun terakhir, salah satunya adalah obat gastritis. Tingkat kejadian penyakit gastritis di Indonesia adalah 40, 8%, dan angka kejadian gastritis di beberapa daerah di Indonesia cukup tinggi dengan prevalensi 274.396 kasus dari 238.452.952 jiwa penduduk. Banyak masyarakat membutuhkan obat-obat yang lebih ekonomis dan efisien, sehingga dibuat suatu analisis yaitu analisis farmakoekonomi yang menggambarkan dan menganalisa biaya obat untuk sistem perawatan kesehatan. Salah satunya adalah CMA (Cost-Minimization Analysis) dimana metode ini digunakan untuk mengetahui atau membandingkan dua atau lebih terapi yang memiliki biaya paling minimal dan memiliki nilai ekonomis. Penelitian ini menggunakan metode penelitian deskriptif dengan pengambilan data secara retrospektif. Sampel pada penelitian ini terdapat 15 kasus pada periode 2017. Obat gastritis yang paling sering digunakan di RSUD Abdul Wahab Sjahranie yaitu ranitidine dan pantoprazol dimana 5 kasus yang menggunakan terapi ranitidine dan 10 kasus yang menggunakan terapi pantoprazole. Hasil penelitian menunjukkan obat Ranitidin memiliki biaya paling minimal yaitu sebesar Rp.5.200.079,- dibandingkan dengan Pantoprazol sebesar Rp.14.256.345,-.

Pengaruh Pemberian Infusa Daun Kerokot terhadap Kadar MDA (Malondialdehida) pada Hewan Coba Devitamara Ayu; Lizma Febrina; Welinda Ayu; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 9 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Tanaman kerokot (Lygodium microphylum) menunjukan adanya aktivitas antioksidan dengan nilai IC50 65 µ.g/ml. Tujuan penelitian ini untuk mengetahui senyawa metabolit sekunder yang terkandung dalam daun kerokot dan mengetahui pengaruh pemberian infusa daun kerokot terhadap malondialdehida (MDA) pada hewan coba yang telah dipaparkan asap rokok. Digunakan metode TBARS (Thiobarbituric Acid Reactive Substance) yang diukur menggunakan Spektofotometer UV-Vis untuk menganalisis kadar MDA. Hewan coba sebanyak 20 ekor dibagi 4 kelompok yaitu kelompok kontrol normal, paparan asap rokok selama 7 hari, kelompok paparan asap rokok 14 hari serta kelompok infusa daun kerokot. Hasil fitokimia menunjukan bahwa infusa daun kerokot mengandung flavonoid dan tanin. Pengujian kadar MDA menunjukan hasil penurunan kadar MDA setelah pemberian infusa daun kerokot dosis 600 mg/kg BB.

Uji Fitokimia Ekstrak Kulit Buah Salak (Salacca zalacca) dan Pengaruh Ekstrak terhadap Pertumbuhan Bakteri Streptococcus mutans dan Jamur Candida albicans Emma Susilowati Shabir; Agung Rahmadani; Lisna Meylina; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 8 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Snakefruit (Salacca zalacca) is one of Indonesian native plant that the pericarp of snakefruit can be used because it has activity as an antimicrobial. This study aims to identify the metabolite content of snakefruit pericarp and to investigate the potential of snakefruit pericarp extracts in inhibiting the growth of Streptococcus mutans and Candida albicans. Snakefruit pericarp was extracted by reflux method using ethanol 96%, and an extract was tested by phytochemical qualitatively and antimicrobial activity of extract was carried out using the well method, by using concentrations are 5, 10, 15, and 20%. The results showed that the extracts contains secondary metabolites i.e. alkaloids, flavonoids, saponins and tannins. Extract of snakefruit pericarp can inhibit the growth of Streptococcus mutans and Candida albicans at 5% concentration and the inhibiting activity increased together with higher concentrations of extract.

Terapi Kombinasi Air Perasan Daging Buah Mengkudu (Morinda citrifolia L.) dan Mentimun (Cucumis sativus L.) untuk Menurunkan Tekanan Darah pada Pasien Hipertensi Novia Anggraini; Wisnu Cahyo Prabowo; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Noni (Morinda citrifolia L.) and cucumber (Cucumis sativus L.) fruit are plants that have antihypertensive activity. The active ingredient scopoletin, anthosianin, xeronin in noni and high potassium in cucumber can lower blood pressure. This study aims to determine the characteristic description, hedonic quality test and the effect of giving a combination noni and cucumber squeezed water flesh of fruit on reduction in the systolic and diastolic blood pressure of hypertension patients in Muara Jawa District, East Kalimantan. The research method used was quasi experimental and research procedures measuring pre and post test being given treatment for 7 days. The highest percentage of respondents collected data obtained are aged 36-45 years as much as 45%, women70%, junior high school education 45%, family history 60%, frequent exercise habits 55% and normal BMI 45%. The highest percentage of sample hedonic quality test collected data obtained are the flavor test was sweet by 65%, the aroma test was sharp by 75% and the texture test was soft by 75%. The results of statistical tests using the paired sample t-test method showed a significant decrease in systolic blood pressure p = 0.000 < ? (0.05) of 12.3 mmHg and diastolic blood pressure p = 0.000 < ? (0.05) of 5.4 mmHg. Based on the results of the study, it can be concluded that giving a combination noni and cucumber squeezed water flesh of fruit can have reduced effect on systolic and diastolic blood pressure of hypertension patients.

Pemberian Kombinasi Buah Alpukat (Persea americana) dan Rebusan Air Daun Salam (Syzygium polyanthum) Terhadap Penurunan Tekanan Darah pada Pasien Hipertensi Wanda Millenia Alwie; Nur Masyithah; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Avocado and bay leaves contain flavonoids which can have an effect on lowering blood pressure. This study aims to determine the characteristics of hypertension patient respondents including age, gender, education, occupation, family history and antihypertensive drugs consumed and to determine the effect of giving a combination of avocado juice and bay leaf water boiled in Samarinda Ulu District. The research method used was a quasi-experimental design and research procedures by measuring before and after treatment. The collection of data on the characteristics of respondents obtained the highest percentage is the category of female gender as much as 67%, age 56-60 years as much as 42%, elementary education as much as 33%, work housewife 58%, having a family history of 75 % and the antihypertensive drug that was consumed by amlodipine was 100%. The results of data analysis using the independent sample T test showed that the p-value for the control-treatment systolic group and the control-treatment diastolic group was 0.000 (p-value

Pengaruh Pemberian Kombinasi Jus Buah Naga (Hylocereus polyrhizus) dan Air Rebusan Daun Kersen (Muntingia calabura) pada Penderita DM (Tipe 2): Effect of Combination of Dragon Fruit (Hylocereus polyrhizus) Juice and Kersen Leaf (Muntingia calabura) Boiled Water in DM (Type 2) Patients Aprilia Putri Firdaus; Mukti Priastomo; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diabetes mellitus is a disease characterized by an increase in blood glucose levels, which prevalence in East Kalimantan in 2018 is the third highest in Indonesia. Kersen leaves and dragon fruit are believed to regulate blood glucose levels in people with type 2 diabetes mellitus and can be used as a complementary therapy. This study aims to see the characteristics, determine the organoleptic assessment of the combination of dragon fruit juice with kersen leaves boiled water and its effect on blood glucose levels, blood pressure, heart rate, body weight, and the frequency of polyuria, polyphagia, and polydipsia in patients type 2 diabetes mellitus at Klinik Semoga Sehat Samarinda. The research method used was quasi experimental with pre-test and post-test procedures. The data obtained from the characteristics were 70% aged 50-59 years, 70% women, 50% diploma/bachelor, 60% housewives. For organoleptic assessment, it was found that 70% liked the taste, texture, aroma and color and 50% did not feel bitter. The combination of dragon fruit with kersen leaves boiled water had an effect on reducing blood glucose levels significantly (P 0.05) and there was a change in the frequency of polyuria, polyphagia, polydipsia by 80% did not urinate frequently and were not often thirsty and 90% were less hungry.

Pengaruh Lama Penyimpanan Ekstrak Etanol Daun Sirih Hitam (Piper betle L. var Nigra) Terhadap Aktivitas Antibakteri: The Effect of Storage Time Extract Etanol Black Betel Leaf (Piper betle L. var Nigra) To Antibacterial Activity Falencia Ega Aprillia; Mirhansyah Ardana; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Black Betel Leaf (Piper betle L. var Nigra) contains compounds that act as antibacterials, namely alkaloids, flavonoids, saponins, tannins, steroids and phenolic compounds. Acne or acne vulgaris is an inflammatory reaction in the sebaceous follicles, which is caused by the Propionibacterium acnes bacteria. This study aims to prove that black betel leaf (Piper betle L. var Nigra) has antibacterial activity and has a long-lasting effect on the ethanol extract of black betel leaf against propionibacterium acne. The method includes sample extraction with 70% ethanol and then followed by antibacterial testing with the well method. In addition, the extract was prepared into a test solution and stored for 7 days at room temperature. The results of antibacterial testing using well diffusion can be concluded that the ethanol extract of black betel leaves with a concentration of 5%, 10%, 15%, 20% has the ability to inhibit the growth of propionibacterium acne bacteria. The effect of the extract storage time on day 7 had the largest inhibition zone.

Pengaruh Pemberian Jus Daging Buah Jambu Biji (Psidium guajava) Terhadap Penurunan Kolesterol Pada Pasien Hiperkolesterolemia: The Administration Effect from Guava Fruit Juice (Psidium guajava) Towards Cholesterol Reduction on Hypercholesterolemia Patients Nadiyah Amalia Aprilliani; Hajrah Hajrah; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Red guava (Psidium guajava) fruits contain lots of vitamin C with 183,5 mg/ 100g. Vitamin C has been researched to have an antioxidant activity that can lower total cholesterol levels. This study aims to analyze meat guava juice's effect in reducing total cholesterol levels in hypercholesterolemia patients in Samarinda. The research method is quasi-experimental, pre-test and post-test with control design, with purposive sampling as a sampling method. In the study research, as many as ten people were divided into two groups, group one was given a dose of 250 g once a day, and group two was given a dose of 125 g twice a day and both treatments were given 14-days. Cholesterol data is taken by strip-test method and data analysis using paired T-Test. The analysis results obtained a p-value for the treatment group one of 0.018, for treatment group two of 0,00, and the difference between groups one and two of 0,00. The analysis results showed p-value

Uji Antioksidan Daun Kokang (Lepisanthes amoena) dengan Metode DPPH: Antioxidant Analysis of Kokang Leaves (Lepisanthes amoena) Using DPPH Method Siti Anisah Nur Fajriyati; M Arifuddin; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Kokang Leaf (Lepisanthes amoena) as a traditional cosmetic for the Dayak Benuaq and Tunjung tribe is very important to be developed in medicine because it is contain secondary metabolites as antioxidants. This research was conducted with the aim of knowing the yield of kokang leaves (Lepisanthes amoena), the profile of TLC, and knowing the fraction with the greatest antioxidants in kokang leaves (Lepisanthes amoena). The research used DPPH, KLT, and yield calculation method. The yield obtained in ethanol extract 96% = 23%; N-Hexan = 9.448%; Ethyl Acetate = 1.37%; Ethanol 70% = 9.95%. TLC test results using N.Hexan : Ethyl Acetate (2: 1) eluent and then sprayed with 10% H2SO4, in 96% ethanol extract there were 7 stains, N-Hexan Fraction 9 stains, Ethyl Acetate Fraction 5 stains, and Ethanol Fraction 70 % 1 stain. The qualitative test results after spraying DPPH on TLC, there were yellow spots on a purple background indicating antioxidant activity. The IC50 results were obtained in 96% Ethanol Extract 6.8171 ppm, N-Hexan Fraction 10.0184 ppm, Ethyl Acetate Fraction 5.0107 ppm, and Ethanol 70% Fraction 24.7343 ppm. Based on the results above, it can be concluded that the ethyl acetate extract has the highest antioxidant activity with 5.0107 ppm being able to inhibit DPPH radicals.

Parameter Non Spesifk dan Pengujian Toksisitas Ekstrak Etanol Daun Kokang (Lepisanthes amoena) Terhadap Larva Udang Artemia salina leach : Non-Specific Parameters and Toxicity Testing of Ethanol Extract of Kokang Leaf (Lepisanthes amoena) Against Shrimp Larvae Artemia salina leach Syarifah Irhamnah; Novita Eka Kartab Putri; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

The kokang leaves Lepisanthes amoena (Hassk.) Leenh) is a family of Sapindaceae which has been widely used as a traditional medicine, even now there are many formulas for the preparation of kokang leaves. The purpose of this study was to determine non-specific parameters, profile of TLC and to determine the acute toxicity of ethanol extract of kokang leaves against shrimp larvae of Artemia salina leach. The ethanol extract of kokang leaves was obtained by meseration method using 70% ethanol with a yield of 20.97%. The determination of non-specific parameters includes specific gravity, drying losses, total ash content, acid insoluble ash content. The ethanol extract of kokang leaves was analyzed by TLC profile using chloroform: acetone (8: 2) as eluent. Toxicity testing using the BSLT method and data were analyzed using Reed-Muench analysis. The results of the research to determine the non-specific parameters obtained are the average density 0.81 g; shrinkage in drying an average of 1.73%; total ash content on average 18.76%; acid insoluble ash content averaged 2.31%. The results of the TLC profile analysis were observations at UV 254 nm with an Rf value of 0.8. The results of observations on UV 366 nm showed two stains with Rf values of 0.7 and 0.8. The results of the acute toxicity test showed an LC?? value of 154.170 ppm. The conclusion based on the research results obtained non-specific parameters of kokang leaves. Based on the results of the TLC profile analysis of the compounds contained in the ethanol extract of kokang leaves, it tends to be non-polar. The LC?? value obtained shows that the ethanol extract of kokang leaves is toxic with a value of 154.170 ppm

Co-Authors Abdul Mun’im Aditya Fridayanti Afif Ruchaemi Aji Yudha Wijaya Ali Sadikin Alida Adelia Islami Amir, Muhammad Angga Cipta Narsa Aprilia Putri Firdaus Arsyik Ibrahim Aty Widyawaruyanti Azminah Azminah Bayu Tri Andika Crissty Magglin Daryono Devitamara Ayu Devitha Farah Mahdiyah Dewi Mayasari Dewi Rahmawati Diana Kurnia Apriani Diana Lestari Dwinita Aquastini Emma Susilowati Shabir Enggar Wijayanti Erwin Samsul Erwin Samsul Euis Julaeha Fahriani Istiqamah Jafar Fajar Prasetya Fajar Prasetya Falencia Ega Aprillia Fatmawati Eka Putri Febrina Mahmudah Fikriah, Ika Ganjar Firmansyah Gemini Alam Hajrah Hajrah Herman Herman Ika Rahayu Islamudin Ahmad Iswahyudi Iswahyudi Khemasili Kosala Kindi Farabi Laode Rijai Lisna Meylina Lizma Febrina Lutfiatun Nisak M Arifuddin M. Arifuddin Mahfuzun Bone Mira Susanti Mirhansyah Ardana Muhammad Akbar MUHAMMAD AMIR MASRUHIM Mukti Priastomo Nadia Rahma Kusuma Dewi Nadiyah Amalia Aprilliani Ni Made Mela Santi Nisa Naspiah Noor Erma Sugijanto Noor Linda Febrianie Novia Anggraini Novita Eka Kartab Putri Nur Masyithah Nurul Fitriani Oktaviany Triana Rahmadani, Agung Rahmi Annisa Riama Rita Manullang Risna Agustina Risna Agustina Rolan Rusli Rosanti Wahyu Saputri Rusmini Rusmini Satriani Badawi Siti Anisah Nur Fajriyati Sukartiningsih Sukartiningsih Suparningtyas, Juniza Firdha Supriatno Salam Syarifah Irhamnah Taslim Ersam Tri Woro Widyanti Unang Supratman Viriyinata Wijaya Wanda Millenia Alwie Welinda Ayu Wisnu Cahyo Prabowo Wisnu Cahyo Prabowo Yoshihito Shiono Yurika Sastyarina Yuspian Nur

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