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All Journal JURNAL GIZI INDONESIA Majalah Kedokteran Bandung The Indonesian Biomedical Journal Public Health of Indonesia Media Ilmu Kesehatan Jurnal Kesehatan Jurnal Analis Medika Biosains (JAMBS) Abdi Dosen : Jurnal Pengabdian Pada Masyarakat PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Jurnal Aisyah : Jurnal Ilmu Kesehatan AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Kesehatan Tambusai International Journal of Islamic Education, Research and Multiculturalism (IJIERM) JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Buletin Kedokteran dan Kesehatan Prima International Journal of Health and Pharmaceutical (IJHP)
Widya Yanti Sihotang
Universitas Prima Indonesia
Religion Aerospace Engineering Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Aisyah : Jurnal Ilmu Kesehatan

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Formulation and Physical Characteristics of Effervescent Granules from Sunkist Peels Ethanol Extract Maya Sari Mutia; Stephanie Raibalaki; Siti Rahma; Anita Zahra; Ali Napiah Nasution; Widya Yanti Sihotang
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.2087

Abstract

Citrus fruit has a sweet taste and attractive shape, which is also enriched various health benefits. Some studies have been performed to investigate the pharmacology effects from the Sunkist peel extract. However, none of this study was look for the development of pharmaceutical products. Hence this study was performed to investigate the pharmaceutical formulation as an effervescent granule from Sunkist peel extract. This study was an experimental study to investigate the optimum formulation that was made by wet granulation methods. There were three formulation of Sunkist peel extract effervescent granule that were combination of organic acids (citric acid and tartaric acid), sodium bicarbonate as base compound, and some sweetener including aspartame, lactose, and mannitol. After that, the formulation was evaluated the physical properties including organoleptic, flow rate, dissolution time, foam height, pH, and angle of repose. The result of this study showed that these three formulations of Sunkist Peel extract effervescent granule showed significant different in almost all of physical properties including: flow rate (P-Value = 0.027), dissolution time (P-Value less than 0.05), foam height (P-Value = 0.004), and angle of repose (P-Value: 0.043), except the degree of acidity or pH (P-Value = 0.128). Third formulation (F3) reveals the best physical properties as a Sunkist peel extract effervescent granule. Overall, it can be concluded that the third and second formulation fulfils a well physical properties of effervescent granule for Sunkist peel extract.
Co-Authors Adeline Sacharissa Firdaus Adrisya Lubis, Putri Anggie Aminuyati Anggraini, Sari Anita Zahra Aulia, Wan Syarifah Buenita, Buenita Chairul, Muhammad Damanik, Anggi Oktavia Damayanti, Etha Wilda Hasiani Dina, Sarah Edison, Rizki Edmi Edy Fachrial Elmiam, Dwi Faridahanum, Faridahanum Fitri Aidani Ulfa Harahap Ginting, Anandestra Ginting, Chrismis Novalinda Ginting, Rapael Ginting, Tarianna Girsang, Ermi Hakim, Mia Amara Hamsi, Ulpah Zahara Harahap, Emira Nadiah Haris, Muhammad Akbar Harmileni Hartono Hartono Henny Henny, Henny Hulu, Victor Trismanjaya Irwanda, Desi Danilah Kurniawan, Muhammad Aditya Leni Diana Leonardi, Felix Lilis Novitarum Lina, Juliana Mahulae, Wigma Aprinda Elizabeth Br Manihuruk, Gresika Br Saragih Maya Sari Mutia Mutia, Maya Sari Nabila, Putri Nasution, Ali Napiah NAUFAL, NAUFAL Ongko, Nicolas Xavier Pane, Putri Yunita Panjaitan, Andrean Kristianto Panjaitan, Hajijah I. L. Paska Ramawati Situmorang Purba, Sarah Putri Uli Endrianda Br Putranto Manalu Putri, Indah Juwita Dwi Rafika, Nazla Ghina Ramadhini, Amelya Putri Ratih Nur Indah Siregar Samosir, Frans Judea Santy Deasy Siregar Sari, Ajeng Mestika Septiavianti, Nadia Siagian, Masryna Siahaan, Prestony Petra Habinsaran Sibagariang, Eva Ellya Silalahi, Marlinang I. Silitonga, Impola Dinita Felicia Simangunsong, Pahala Maringan J. Simanullang, Andry Sinaga, Valentino Sinurat, Buenita Sipayung, Yelvreza Rastiani Sitepu, Enda Menaisa Siti Rahma Soleh, Ardian Stephan, Weldy Stephanie Raibalaki Suandy, Suandy SUHARTOMI . Suvina, Vivi Suyono, Tan Syahfitri, Nadia Tampubolon, Jenni Trirasetya, Mutiara Ulfa Wicaksana, Praja Dwi Widyaningsih Widyaningsih, Widyaningsih Yolanda Eliza Putri Lubis Yulizal, Ok Zahran Nst, Mhd Raja Zendrato, Erianto Zendrato, Victorwan Novri Zulfahmi Zulfahmi