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All Journal BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Matematika & Sains Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Acta Pharmaceutica Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia Jurnal Penelitian Sains JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Farmasi Indonesia SRIWIJAYA JOURNAL OF MEDICINE Jurnal Ilmu Kefarmasian Indonesia Majalah Kesehatan Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine Journal of Community Development Jurnal Permata Indonesia Pangripta Jurnal Ilmiah Kajian Perencanaan Pembangunan Jurnal Manusia dan Lingkungan Folia Medica Indonesiana
Tri Suciati
Sekolah farmasi - ITB, Jl. Ganesha 10 Bandung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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REGULATION OF ADIPOGENESIS AND KEY ADIPOGENIC GENE EXPRESSION BY MANGOSTEEN PERICARP EXTRACT AND XANTHONES IN 3T3-L1 CELLS Widowati, Wahyu; Darsono, Lusiana; Suherman, Jo; Afifah, Ervi; Rizal, Rizal; Arinta, Yukko; Mozef, Tjandrawati; Suciati, Tri
BIOTROPIA Vol. 27 No. 1 (2020): BIOTROPIA Vol. 27 No. 1 April 2020
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.545 KB) | DOI: 10.11598/btb.2020.27.1.932

Abstract

Obesity is one of the risk factors for atherosclerosis, and its occurrence and development are associated with fat accumulation and adipocyte differentiation. Thus, the suppression of adipocyte differentiation can be a potential anti-obesity approach. This study examined the effect of mangosteen pericarp extract (MPE) and xanthones (α-Mangostin (AM) and γ-Mangostin (GM)) on the expression of PPARγ, C/EBPα, SCD1, LPL, aP2, adipoQ, and FAS in 3T3-L1 cells. Concentrations of MPE and xanthones used were based on cytotoxicity assays on 3T3-L1 cells. Three different MPE concentrations (0, 25, and 50 µg/mL), three AM concentrations (0, 25, and 50 µM), and GM concentrations (0, 50, and 75 µM) were used. The expressions of PPARγ, C/EBPα, SCD1, LPL, aP2, adipoQ, and FAS genes were measured using real-time quantitative PCR. Gene expression was downregulated in cells treated with 50 µg/mL MPE and 50 µM GM. However, 25 µM and 50 µM AM did not suppress PPARγ and SCD1 expression. The 50 µM AM treatment also failed to reduce aP2 gene expression. Overall, MPE and GM demonstrated potential anti-adipogenesis and anti-obesity effects by suppressing the expression of PPARγ, C/EBPα, SCD1, LPL, aP2, adipoQ, and FAS in 3T3-L1 cells.
The Effects of Intermittent Fasting on the Size and Number of Subcutaneus Adipocytes in Obese Mouse Models Larasati, Veny; Rasyid, Riana Sari Puspita; Fertilita, Soilia; Suciati, Tri; Farhan, Muhammad
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study helps bridge the gap between systemic effects and tissue-level changes, providing a deeper understanding of how histological analysis can be used to explore the effects of intermittent fasting on adipocytes and body weight regulation. 2. This study contributes to obesity management through lifestyle modification, specifically intermittent fasting, by focusing on histological changes in adipose tissue. Abstract The accumulation of adipose tissue can have deleterious effects and lead to obesity. Intermittent fasting (IF), an approach that involves time-restricted eating, has gained popularity as an obesity treatment option because it enhances insulin sensitivity and promotes beneficial changes in glucose metabolism. This study used a time-restricted meal intake (TRM) approach to assess the effects of IF on the histological features of obese mouse models' subcutaneous inguinal adipose tissue. The investigation employed an in vivo experimental posttest-only control group design. Twenty male mice were divided into four groups: a normal control group, an obese control group, a TRM group with a high-fat diet (TRM-HF), and a TRM group with a standard diet (TRM-S). The TRM treatment was administered for fourteen days, with a fasting window from 4 p.m. to 8 a.m. The pre- and post-treatment weight analyses were conducted using the paired t-test for normally distributed data and the Wilcoxon test for non-normally distributed data (p<0.05). One-way analysis of variance (ANOVA) was employed for unpaired data on the post-treatment weight. Per field of view, there were an average of 120,500 cells (49,700–136,200) in the normal control group, 68,380±9,194 cells in the obese control group, 70,860±11,029 cells in the TRM-HF group, and 79,360±5,112 cells in the TRM-S group. The average cell sizes (μm3) were 56,730.142±19,273.257 in the normal control group, 138,934.331±27,670.558 in the obese control group, 106,827.767±20,580.501 in the TRM-HF group, and 68,689.114±8,219.727 in the TRM-S group. The number of cells in each group did not differ significantly, but there were significant variations in cell size. The mice receiving TRM treatment did not exhibit substantial body weight changes, whereas the obese control group showed a significant body weight increase. In conclusion, TRM has an effect on cell size but does not affect the quantity of adipocytes in subcutaneous inguinal fat tissue.
Edukasi Forward Head Posture dan Pencegahan Nyeri Leher Pada Pelajar di SDN 149 Palembang Wardiansah; Suciati, Tri; Rulan, Msy; Nindela, Rini; Asmara, Sima; Odiesta, Ramadhan; Zahrotunnisa, Citra
Journal of Community Development Vol. 6 No. 3 (2026): April
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v6i3.1885

Abstract

Forward Head Posture (FHP) adalah kondisi kelainan postural ditandai kepala maju yang semakin banyak dijumpai pada anak-anak usia sekolah dasar akibat kebiasaan belajar yang kurang ergonomis, penggunaan gawai secara berlebihan, serta kurangnya aktivitas fisik. Kegiatan pengabdian ini bertujuan untuk meberikan edukasi kepada siswa terkait faktor risiko FHP, dampak, dan cara pencegahannya dengan harapan dapat meningkatkan pemahaman dan kesadaran siswa untuk memiliki kebiasaan postur tubuh yang ergonomis. Kegiatan ini dilaksanakan melalui beberapa tahapan, meliputi sosialisasi program, pemberian edukasi dan pelatihan dengan bantuan media poster, serta evaluasi yang dilakukan menggunakan pretest dan posttest. Terdapat 54 siswa SDN 149 Palembang yang berpartisipasi dalam kegiatan ini. Hasil evaluasi menunjukkan bahwa nilai rata-rata pretest siswa adalah 2,78, dan meningkat 5,12 pada posttest. Kenaikan skor sebesar 2,34 menunjukkan bahwa materi edukasi yang disampaikan kepada siswa dapat meningkatkan pengetahuan mengenai topik yang disampaikan. kegiatan ini terbukti memberikan dampak yang positif dalam meningkatkan pemahaman dan kesadaran siswa terhadap pentingnya menjaga postur tubuh yang ergonomis saat beraktivitas.
Co-Authors Adipputra, Ricky Fajar Adnindya, Rulan AE. Sukmawati AE. Sukmawati, AE. Afifah, Ervi Aminatun Ana Indrayati Angga Saputra Ardesy Melizah Kurniati Arinta, Yukko Asmara, Sima Benny Permana Cita, Juang Arwafa Dalilah Dalilah Darijanto, Sasanti Tarini DEBBIE SOEFIE RETNONINGRUM Dwi Ratnaningsih, Dwi Dwiani, R. R. Sarlita Elin Julianti Ella Amalia, Ella Fauziah, Arsy Fertilita, Soilia Fith Khaira Nursal Fitrianti Fitrianti, Fitrianti Gita Dwi Prasasty Gunawarman Gusdinar, Tutus Hasbi, Alfian HENI RACHMAWATI Herlina Herlina Ilyah Abdullah, Nour Indri Seta Septadina Irda Fidrianny Iwo, Maria Immaculata Januar, M. Anis Jo Suherman Julianti, Elin Karim, Fatmawati Khairunnisa Khairunnisa Legiran Legiran Lili Fitriani Lisa Patricia Lusiana Darsono Malahayati, Putri Maria Immaculata Iwo Maria Immaculata Iwo Marlia Singgih Marlia Singgih Marlia Singgih Wibowo Mohamad, Che Wan Sharifah Robiah Muhammad Farhan Muhammad, Fadhil Munir, Ryaas Mishbachul Niknik Widanengsih Nirwan Syarif, Nirwan Nugraha, Yuda Prasetya Nurani Istiqomah Odiesta, Muhammad Ramadhan Odiesta, Ramadhan Patricia, Lisa Prasetya, Dinda Prihantini, Malinda Rahmana Emran Kartasasmita Rahmatullah, Nurul Ilmi Rahmatullah, Nurul Ilmi Rasyid, Riana Sari Puspita Resmiyani, Ubbadah Riani, Catur Rini Nindela, Rini Rizal Rizal Sani Ega Priani Sari, Mona Sasanti Tarini Darijanto Sasanti Tarini Darijanto, Sasanti Tarini Satrialdi, - Satrialdi, Satrialdi Sima Asmara Dewa Marya Mahardika Putri Solihah, Indah Sri Priatni Sri Priatni Sudiati, Titi Sujilah, Ajeng Rana Wulan Sukmadaja Asyarie Sumirtapura, Yeyet Cahyati Susanto, Eriwan Syarifah Aini Syauki Ikhsan, Diyaz T. Gusdinar T. Gusdinar, T. Titah Yudistira Tjandrawati Mozef Tutus Gusdinar Veny Larasati WAHYU WIDOWATI Wardiansah Wardiansah, Wardiansah Widanengsih, Niknik Yani Triyani Yessie Widya Sari Yusril Yusuf Zahrotunnisa, Citra