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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia IDJP (Indonesian Journal of Pharmaceutics) As-syifaa Jurnal Farmasi Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) Pharmaceutical Journal of Indonesia JURNAL FARMASI GALENIKA Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang MAHESA : Malahayati Health Student Journal Jurnal Abdimas Indonesia : Jurnal Abdimas Indonesia Indonesian Journal of Biological Pharmacy Journal of Pharmaceutical and Sciences. Medical Laboratory Journal Media Kesehatan Politeknik Kesehatan Makassar Journal of The Indonesian Society of Integrated Chemistry Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Journal of Agropharmacy Jurnal Farmasi Galenika
Patihul Husni
Departemen Farmasetika Dan Teknologi Farmasi, Fakultas Farmasi, Universitas Padjadjaran, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Plant Extract Loaded Nanoparticles Patihul Husni; Zelika Mega Ramadhania
Indonesian Journal of Pharmaceutics Vol 3, Issue 1, Jan - April 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i1.34032

Abstract

Plant extract, a natural source containing complex mixture of compounds, offers many properties such as antiparasitic, antibiotic, antioxidant, anti-hypertensive, antiviral, insecticide, anticancer, antifungal, hypoglycemic properties. Recent research has been focused on developing formulation the plant extracts not only to deliver them safely but also to enhance its therapeutic efficacy. Nanotechnology-based strategies have been proposed as a system that can be used to formulate plant extracts. Plant extract loaded nanoparticles (NPs) is aimed to facilitate in crossing the biological barriers, to increase bioavailability of poorly water-soluble phytochemicals, to encapsulate mixture compounds of different phytochemicals, to provide targeted delivery of phytochemicals to specific organs resulting in low toxicity, to get effective purification process,  to mask unpleasant taste and odor, to protect sensitive phytochemicals from biological (e.g. enzyme, pH) and environmental (e.g. light, temperature, humidity) degradation, to control release of encapsulated phytochemicals, and to provide a more flexible control over the size and shape of the NPs. This review is focused on plant extract loaded NPs including its advantages, stages for developing formulation of plant extract loaded NPs, and nanosystem used to loading plant extract. In addition, this review also depicts studies which have been conducted by many researchers in developing plant extract loaded NPs. The data were collected from published journals with 21 and 39 journals as primary and supporting literatures, respectively. Plant extracts loaded NPs could be a promising delivery system for active phytochemical contained in the plant extract which is not only to deliver them safely but also to enhance its therapeutic efficacy.Keywords: plant, extract, nanoparticle
FORMULASI KRIM EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lamk) Patihul Husni; Alika Nuansa Pratiwi; Ardian Baitariza
Jurnal Ilmiah Farmasi Farmasyifa Vol 2, No 2 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v2i2.4796

Abstract

Salah satu tanaman berkhasiat antiinflamasi adalah tanaman kelor (Moringa oleifera Lamk) sehingga berpotensi dibuat sediaan krim. Penelitian ini bertujuan untuk mendapatkan formula terbaik krim ekstrak etanol daun kelor (Moringa oleifera Lamk). Penelitian dilakukan dengan membuat sediaan krim dengan tiga formula berbeda (F1, F2 dan F3) yang mengandung ekstrak daun kelor 10% b/b. Evaluasi sediaan krim dilakukan selama 4 minggu penyimpanan meliputi uji organoleptik (warna, aroma dan bentuk), homogenitas, pH, viskositas, daya tercuci, tipe krim, dan uji iritasi. Hasil penelitian menunjukkan bahwa seluruh formula (F1, F2 dan F3) memenuhi syarat krim yang baik dan tidak mengiritasi. Formula krim yang paling baik berdasarkan uji penyimpanan selama 4 minggu adalah F3 dengan komposisi formula berupa ekstrak daun kelor 10%, asam stearat 10%, paraffin cair 2%, setil alkohol 2%, span 80 1,5%, tween 80 3,5%, gliserin 7,5%, titan dioksida 0,7%, oleum rosae 15 tetes, nipagin 0,18%, nipasol 0,02%, aquadest add 50% b/b.
FORMULASI DAN UJI STABILITAS FISIK GRANUL INSTAN SERBUK KERING TANGKAI GENJER (Limnocharis flava (L.) Buchenau.) SEBAGAI SUPLEMEN PENAMBAH SERAT Patihul Husni; Muchamad Luthfi Fadhiilah; Uswatul Hasanah
Jurnal Ilmiah Farmasi Farmasyifa Vol 3, No 1 (2020)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v3i1.5163

Abstract

Serat dibutuhkan dalam pencernaan adalah agar proses pencernaan dapat bekerja secara maksimal. Genjer (Limnocharis flava (L.) Buchenau.) merupakan tanaman yang bagian tangkainya banyak mengandung serat. Kandungan serat yang tinggi pada genjer terutama pada bagian tangkainya berpotensi untuk dikembangkan sebagai suplemen makanan penambah serat berupa granul instan. Tujuan penelitian ini adalah untuk mendapatkan formula terbaik granul instan secara fisik. Granul instan dibuat dengan metode granulasi basah menggunakan variasi konsentrasi PVP sebagai pengikat. Uji stabilitas fisik granul instan dilakukan pada suhu kamar selama satu bulan meliputi uji waktu alir, sudut diam, indeks kompresibilitas, kandungan lembab dan waktu larut. Hasil penelitian menunjukkan bahwa waktu alir granul 8-14 detik untuk 100 gram granul, sudut diam sekitar 40o, indeks kompresibilitas 11-15%, kandungan lembab sekitar 2% dan waktu larut 1-2 menit. Berdasarkan hasil uji stabilitas fisik, formula terbaik granul instan serbuk kering tangkai genjer adalah F2 dengan komposisi serbuk kering tangkai genjer 100 mg, laktosa 70%, PVP 3%, aspartam 1,5%, manitol 20%, Natrium Benzoat 0,5%, Green tea flavor 5% b/b dan etanol qs dengan total bobot granul 1000 mg.
FORMULASI DAN UJI STABILITAS FISIK CHEWABLE GUM EKSTRAK KERING TEMULAWAK (Curcuma xanthorrhiza Roxb.) MENGANDUNG KAPPA KARAGENAN Patihul Husni; Mutia Dwi Lestari; Uswatul Hasanah
Jurnal Sabdariffarma Vol 8, No 2 (2020): SABDARIFFARMA
Publisher : Prodi Farmasi - Universitas Al Ghifari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53675/jsfar.v2i2.378

Abstract

Temulawak (Curcuma xanthorrhiza Roxb.) merupakan komponen penyusun hampir setiapjenis obat tradisional yang ada di Indonesia.Kandungan dalam temulawak yang didugamemiliki efek untuk meningkatkan nafsu makan adalah minyak atsiri dan senyawakurkuminoid.Untuk meningkatkan keinginan masyarakat agar mau mengonsumsi temulawak,dilakukan pengembangan bentuk sediaan yaitu dibuat dalam bentuk chewable gum.Basis yangbiasa digunakan dalam pembuatan chewable gum adalah gelatin dan gliserin.Salah satu bahanyang memiliki karakteristik mirip dengan gelatin adalah karagenan. Tujuan penelitian iniadalah untuk membuat sediaan chewable gum dari ekstrak kering temulawak yang stabilsecara fisik dan disukai konsumen. Chewable gum dibuat dari ekstrak kering temulawakdengan berbagai variasi konsentrasi kappa karagenan sebagai pengenyal, yaitu 2%. 2,5% dan3%. Sediaan dibuat dengan cara melarutkan semua basis dengan aquadest. Data hasil evaluasidinalisis dengan One way Anova untuk mengetahui perbedaan yang bermakna secara signifikan(p 0,05). Berdasarkan hasil evaluasi dari ketiga formula yang dibuat, formulasi terbaikchewable gum ekstrak kering temulawak berdasarkan evaluasi fisik dan uji kesukaan diperolehformula 2 yang mengandung ekstrak kering temulawak 50 mg, gelatin 35%, gliserin 15%,kappa karagenan 2,5%, sodium benzoat 0,5%, stevia 20%, sorbitol 20%, dengan total bobotchewable gum 1700 mg. Pengaruh kappa karagenan sebagai bahan pengenyal terhadap sifatfisik chewable gum ekstrak kering temulawak dapat meningkatkan kepadatan sediaan.
UJI STABILITAS FISIK GEL EKSTRAK ETANOL DAUN UBI JALAR UNGU (Ipomoea batatas (L.) Lamk) Patihul Husni; Mala Fitriani; Ardian Baitariza
Jurnal Sabdariffarma Vol 9, No 2 (2021): SABDARIFFARMA
Publisher : Prodi Farmasi - Universitas Al Ghifari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53675/jsfar.v3i2.379

Abstract

Daun ubi jalar ungu (Ipomoea batatas (L.) Lamk) mengandung senyawa antosianin yang berfungsi sebagai antioksidan. Antioksidan merupakan senyawa atau zat yang dapat meredam radikal bebas. Penelitian ini bertujuan untuk mendapatkan formulasi gel ekstrak daun ubi jalar ungu yang stabil. Pembuatan ekstrak dilakukan secara maserasi menggunakan etanol 70%. Tiga formula dibuat menggunakan komposisi basis gel yang berbeda dengan dosis ekstrak daun ubi jalar ungu sebesar 6,2 %. Evaluasi fisik sediaan gel meliputi organoleptik (warna, aroma dan tekstur), homogenitas, pH, dan viskositas. Evaluasi stabilitas fisik dilakukan selama satu bulan dengan menyimpan sediaan pada suhu kamar. Hasil penelitian menunjukan bahwa sediaan berbentuk gel setengah padat, hijau muda, bau mawar, homogen, pH 5,8-6,9 dan viskositas 1500-2000 cps. Semua formula memenuhi syarat gel dan menunjukkan stabilitas fisik selama satu bulan penyimpanan pada suhu kamar.
In-Vivo Effectiveness of 5% Azadirachta indica Oil Cream as Anti-Scabies Patihul Husni; Mayang K. Dewi; Norisca A. Putriana; Rini Hendriani
Pharmacology and Clinical Pharmacy Research Vol 4, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.947 KB) | DOI: 10.15416/pcpr.v4i1.21388

Abstract

Scabies is an infectious skin disease caused by mite Sarcoptes scabiei. Neem tree (Azadirachta indica) has the potential to be used as an anti-parasite due to the presence of azadirachtin compound that is commonly found in the seeds. The aim of this study was to evaluate in-vivo effectiveness of neem oil as an anti-scabies. This study used an experimental method.  The effectiveness of the cream as an anti-scabies was tested on New Zealand white rabbits which were infected with scabies. Permethrin cream was used as a positive control and cream base was used as a negative control.  Cream was applied once daily and left for 8 hours. The data were analyzed using Kruskal Wallis and Mann Whitney. Dermal acute irritation test was performed by applying  0.5 g cream on the rabbit dorsal. We found that 5% neem oil cream was effective as an anti-scabies with 20-21 days recovery time. The recovery time is longer than permethrin cream (7-8 days), but shorter compared to negative control with recovery time over 30 days. Primary irritation index for 5% neem oil creams was 0, indicating negligible irritation category. In conclusion, A. indica cream was effective for the treatment of scabies although its recovery time is shorter than permethrin cream.  Keywords: effectiveness test, irritation test, neem oil cream, scabies
In Vitro Effectiveness of Neem Oil (Azadirachta Indica A. Juss) Shampoo as Anti Head Lice (Pediculus humanus capitis) Norisca A. Putriana; Azizul Hakim; Patihul Husni; Taofik Rusdiana
Pharmacology and Clinical Pharmacy Research Vol 4, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v4i3.25780

Abstract

Head lice (Pediculus humanus capitis), a parasite causing hair problem,  often occurs in society.The study aimed to evaluate in vitroeffectiveness of shampoo formulation containing neem oil as an anti head lice. An experimental method was used to examine the formulation of shampoo, irritation test, testing the effectiveness of shampoo against head lice (Pediculicidal activity), and testing the effectiveness of shampoo against nits (Ovicidal activity). The effectiveness test employed an in vitromethod where neem oil shampoo were tested directly towards head lices and nits isolated from humans, then the mortality was observed. To recognize the safety of the shampoo, skin and eye irritation tests were carried out by applying 0.5 ml on the skin and dripping 0.1 ml shampoo into New Zealand white rabbit’s eyes.Data were analyzed using Kruskal Wallis and Mann Whitney. The study results showed that the primary irritation index for 5%, 10%, 15%, and 20% neem oil shampoo were 0; 0111; 0.222; and 0.222, respectively. All of the shampoos were very mild irritation response category. Eye irritation tests showed that only the 20% neem oil shampoo gave a mild irritation response with degree of corneal opacity ≥ 1 and recovered after 7 days of observation. The 5%, 10%, 15%, and 20% neem oil shampoo were effective as an anti head lice. The 15% and 20% neem oil shampoo had anti head lice effectiveness activity as same as 1% permethrin lotion. In conclusion, the 15% neem oil shampoo was chosen as the best shampoo, its high anti head lice effect and light irritation response. Keywords: Head lice, neem oil (Azadirachta indica A. Juss), shampoo
FORMULASI DAN UJI STABILITAS FISIK SEDIAAN LOTION EKSTRAK KERING KULIT KAYU MANIS (Cinnamomum burmannii) Patihul Husni; Yuni Ruspriyani; Uswatul Hasanah
Jurnal Sabdariffarma Vol 10, No 1 (2022): SABDARIFFARMA
Publisher : Prodi Farmasi - Universitas Al Ghifari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53675/jsfar.v10i1.396

Abstract

Pemakaian produk topikal yang mengandung antioksidan merupakan salah satu cara untuk mencegah kerusakan kulit karena antioksidan dapat mencegah efek radikal bebas. Kulit kayu manis (Cinnamomum burmannii) mengandung senyawa antioksidan. Penelitian ini bertujuan untuk menentukan formula terbaik sediaan lotion mengandung ekstrak kering kulit kayu manis. Sediaan lotion dibuat menggunakan metode safonifikasi. Lotion dibuat dalam tiga formula dengan perbedaan konsentrasi trietanolamin. Uji stabilitas fisik (organoleptis, pH, viskositas), uji iritasi dan uji kesukaan dilakukan untuk menentukan formula terbaik. Hasil penelitian menunjukkan bahwa sediaan lotion memiliki warna coklat, kental, bau khas, homogen dengan viskositas dan pH yang memenuhi persyaratan serta tidak mengiritasi kulit. Semua formula lotion tetap stabil setelah desman selama 1 bulan pada suhu kamar. Formula terbaik berdasarkan uji stabilitas fisik dan uji kesukaan adalah F1.
Strategi Pencegahan dan Peningkatan Pengawasan BPOM Terkait Kasus Cemaran EG/DEG dalam Sirup Obat Regina Liviandari; Patihul Husni
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.341

Abstract

Contamination of ethylene glycol and diethylene glycol (EG/DEG) is suspected to be the cause of the undesirable incident of acute kidney failure in children, which occurred in Indonesia in 2022. As the institution tasked with monitoring the distribution of medicines in Indonesia, the Food and Drug Supervisory Agency (BPOM) has taken scientifically based strategic, responsive, and professional steps in handling and controlling these cases. The purpose of this article is to provide an overview of prevention strategies and increased supervision carried out by BPOM in handling cases of EG/DEG contamination in medicinal syrups. This article review was prepared through a literature study of 22 pieces of literature published between 2013-2023. The results of the literature review show that BPOM has taken responsive and professional steps in the form of strengthening the pharmacovigilance system, ensuring quality assurance in the pharmaceutical industry, monitoring the import of propylene glycol and polyethylene glycol, strengthening pre-market, post-market, and enforcement supervision, and providing information to the public as a prevention strategy and increased supervision in handling cases of EG/DEG contamination.
Review artikel: metode analisis dalam pengujian kandungan pewarna merah K10 (Rhodamin B) pada kosmetik Vista Kamilania; Patihul Husni
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.349

Abstract

Cosmetics are products used to improve the appearance of the outer body. Cosmetics are inseparable from dyes. One dye that is often misused in cosmetic products is Rhodamine B. Rhodamine B can cause liver damage and irritation of the respiratory tract and is carcinogenic. This review article aims to provide information on the use of analytical techniques to identify cosmetic products containing rhodamine B. The method used is a literature review by searching research journals with a period of 2013-2023 on Science Direct and Google Scholar using the keywords "identification of k10 red dye in cosmetics", "rhodamine B analysis in cosmetics," and "k10 red dye analysis method in cosmetics". Based on the literature review that has been carried out, identifying the content of rhodamine B dye can be done with various analysis techniques including Thin Layer Chromatography (TLC), High Performance Liquid Chromatography (HPLC), UV Vis Spectrophotometry, Ultra Performance Liquid Chromatography Tandem Mass Spectrometric (UPLC-MS), and rapid test kit. Qualitative analysis of rhodamine B content in cosmetics can be done with KLT and a rapid test kit. Quantitative analysis can be done using UV Vis, KCKT, and UPLC MS spectrophotometry methods.
Co-Authors Adi Prayitno Aditama, Agnis Agita, Kiva Agnis Pondineka Ria Aditama Ahmad Muhtadi Ahmad Muhtadi Alicia Ima Dara Alika Nuansa Pratiwi Alyanis Mufid SWM Ami Tjitraresmi Ami Tjitraresmi, Ami Anggia Diani Amalia Anggun Putri Perwira Anis Yohana Chaerunisaa, Anis Yohana Annisa Luthfiyah Handini ANUGRAHANI YUNIAR EKAWATI Apriyani, Mila Ardian Baitariza Ardian Baitariza Ardian Baitariza, Ardian Aryani, Annisa Fitri Asa Falahi Astri Sherly Inggriani Astri Sherly Inggriani ASTRI SULASTRI Ayuning Trias, Diah Aziz, Calista Sasikirana Finola Azizul Hakim Billa Nidia Hikmatiana Budianto, Muhamad Oke Cahya Lestari, Riska Carolina, Theresia Denok Risky Ayu Paramita Devani Olivia Winardi Dewi Rashati Dolih Gozali Dolih Gozali Dwi Puji Astuti Een herliani Eka Yulia Agustin Ella Masliana Dewi Erika Herawati, Irma Eryani, Mikhania Christiningtyas Fairuzati Anisah Murthadiah Fakhirah, Maitsa Alya Fakhri Rabbani FARIANTI EKO NUR KHASANAH Fauziah, Neneng Alifia Nur FIKAMILIA HUSNA Firmansyah Firmansyah Ghifari, M Alvien Hadisoebroto, Ginayanti Hazrina, Aghnia Henny Lucida Hery Diar Febryanto Hosiana, Vinny Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Imam Adi Wicaksono Indriana Agustin Claradila Frinda IRMA RAHAYU LATARISSA Januarti, Melinda Judy Handojo, Kukuh Junaedi Junaedi Junaedi Junaedi Kartika Puspitaningrum Khanifah Hidayati Puspa Negara Khoirunnisa, Arina Kurniati, Bunga Dian Kurniawan Syah, Insan Sunan Kusdi Hartono, Kusdi La Ode Zahid Al Hajri Nur Salam Layyareza, Rania Talinta Luluk Luqyana Mahdiyah Luthfiah, Annisa Mala Fitriani Mayang K. Dewi Mayang Kusuma Dewi MEGA HIJRIAWATI Melinda Januarti Melinda Januarti Muchamad Luthfi Fadhiilah Muhaimin Muhaimin Muhammad Dimas Mulyani, Tuti Sri Muthia Izati Mutia Dwi Lestari Nadya Indah Dewanti NADYA INDAH DEWANTI, NADYA INDAH Nafisa Nurfatia Hidayat Nina Wijiani Norisca A. Putriana Norisca A. Putriana Norisca Aliza Putriana Nur Aisyah NUR DIANA HADAD Nurulita Dina Ulfah Nuryani, Tri Winarsih Permatasari, Lina Putri Perwira, Anggun Putri perwita, tista Puspitaningrum, Kartika Putri, Refitha Nurul Rashati, Dewi Ratnadani Amalia Safitri Ratnawati, Aini Regina Liviandari RESTIKA ERIA PUTRI Rina Haryani Rini Hendriani Rini Silviya Riska Cahya Lestari Safitri, Manzil Salsabila, Annisa Siti Santi Sinala SHEILA PRATIWI Sigalingging, Asima Rohana Silvia, Nurfianti Siti Nur Azizah, Siti Nur Sitinjak, Bernap Dwi Putra Soewahju, Renata Bella Soraya Ratnawulan Mita Soraya Ratnawulan Mita Mita SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN Sri Agung Fitri Kusuma Sriwidodo Sriwidodo Syuhuriah, Ainin Taofik Rusdiana Tryani Sutisna Putri, Sussy Uswatul Hasanah Uswatul Hasanah Uvita Kafilatul Ikhrom Vinny Hosiana Vista Kamilania Widayanti Supraba Wirna Grace Tua Sihombing Yasarah Hisprastin Yoga Windhu Wardhana Yoshihito Shiono Yosita Aulia Mustofa Yuli Agung Prasetyo Yuni Ruspriyani YUNIKE KARUNIA PUTRI Yusuf, Marsha Afifah Zelika Mega Ramadhania, Zelika Mega