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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia IDJP (Indonesian Journal of Pharmaceutics) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) JURNAL FARMASI GALENIKA Majalah Farmasetika ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi MAHESA : Malahayati Health Student Journal Indonesian Journal of Biological Pharmacy Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Praba: Jurnal Rumpun Kesehatan Umum Journal of Agropharmacy Jurnal Farmasi Galenika
Patihul Husni
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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A Review of the Impact of Stevia Leaf (Stevia rebaudiana Bert.) as a Sweetener in Blood Glucose in Alloxan-Induced Rats Putri, Refitha Nurul; Husni, Patihul
Indonesian Journal of Biological Pharmacy Vol 4, No 2 (2024): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

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Abstract

Diabetes mellitus (DM) is a chronic condition characterized by elevated blood glucose levels due to insulin-related deficiencies and is often referred to as “The Silent Killer”. Medicinal plants have been widely explored as alternative therapies for managing DM. Among these, Stevia rebaudiana Bert. has garnered significant attention for its potent antidiabetic properties. Known as a natural sweetener 200–300 times sweeter than sucrose, Stevia boasts a zero glycemic index, making it particularly suitable for individuals with diabetes. This review aims to evaluate the antihyperglycemic potential of Stevia rebaudiana Bert. as an alternative to conventional therapies. A systematic review was conducted by acquiring data from scientific databases such as Semantic Scholar, PubMed, Scopus, OpenAlex, Crossref, and ScienceDirect, focusing on literature published between 2020–2024. Studies on diabetic rat models induced with alloxan were analyzed, with doses ranging from 20–1000 mg/kgBW and optimal doses identified between 120–150 mg/kgBW. The results demonstrated that Stevia significantly reduced blood glucose levels in diabetic rats and sustained hyperglycemia, effectively modeling type 1 diabetes. The bioactive constituents, including phenolics, alkaloids, glycosides, steviosides, flavonoids, and tannins, were identified as key contributors to its antihyperglycemic activity. In conclusion, Stevia rebaudiana Bert. exhibits promising efficacy as a natural antidiabetic agent. Its ability to reduce blood glucose levels and its zero glycemic index position it as a viable alternative to conventional antihyperglycemic therapies, especially for managing type 1 DM.
ARTIKEL REVIEW: PERSPEKTIF FARMAKOLOGI DAN PERAN APOTEKER TERHADAP PENGEMBANGAN SERTA PENGGUNAAN NUTRASEUTIKAL Sitinjak, Bernap Dwi Putra; Husni, Patihul
Farmaka Vol 22, No 3 (2024): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i3.54336

Abstract

Peningkatan derajat kesehatan dapat dilakukan dalam promotif, pencegahan (preventif), penyembuhan (kuratif), dan pemulihan (rehabilitatif). Makanan bernutrisi menjadi salah satu upaya preventif terhadap kejadian penyakit. Nutraseutikal merupakan nutrisi pada pangan yang memiliki manfaat secara farmakologi ketika dijadikan konsumsi. Oleh sebab itu artikel ini akan membahas aspek farmakologi pada kesehatan pada nutraseutikal serta peran apoteker pada penggunaannya. Review dilakukan pada artikel yang terdapat pada database Google scholar yang muncul dari hasil pencarian terkait nutraseutikal kemudian dilakukan screening dan dipilah berdasarkan judul dan abstrak lalu hasil review disajikan dalam bentuk narasi. Secara garis besar nutraseutikal dibedakan menjadi dua jenis yakni nutraseutikal tradisional dan non-tradisional. nutraseutikal tradisional bersumber dari organisme probiotik, enzim, dan senyawa kimia berupa nutrien dan metabolit hewan tumbuhan. Sementara senyawa non tradisional dapat bersumber dari pangan fortifikasi maupun pangan rekombinan. Berdasarkan hasil penelusuran menunjukkan banyaknya aktivitas antioksidan yang berpotensi mencegah stres oksidatif. Selain itu, berdasarkan hasil review tanaman hasil rekayasa genetik dapat meningkatkan konsentrasi nutraseutikal. Sehingga tidak menutup kemungkinan bahwa peran apoteker akan semakin dibutuhkan dalam penggunaan nutraseutikal khususnya pada pengembangan dan penjaminan mutu produk, pemberi KIE agar obat dapat digunakan dengan tepat oleh konsumen, serta merancang regulasi. Kata kunci: Nutraseutikal, Nutrien, Farmakologi, dan Apoteker.
Increased Toxicity Risk from Nanoparticulate System in Food and Drug Applications Hazrina, Aghnia; Muhaimin, Muhaimin; Chaerunisaa, Anis Yohana; Husni, Patihul; Wardhana, Yoga Windhu
Indonesian Food Science and Technology Journal Vol. 8 No. 2 (2025): Volume 8 Number 2, July 2025 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v8i2.40494

Abstract

Abstract— Nanotechnology involves manipulating matter at the atomic and molecular levels, leading to the creation of new materials for food and drug application with properties that are not always easily anticipated based on existing knowledge. Among the nearly infinite variety of these substances, some are toxic to biological systems, others are generally harmless, and yet others confer health advantages. The biocompatibility and distribution of these materials must be assessed prior to their use in biological and environmental. Consequently, it is essential to comprehend the toxicity of nanomaterials. Mechanisms of cellular uptake and nanoparticles dispersion in biological settings depend on their physicochemical properties. The pathways in which exposure to nanoparticles is harmful to health are through oxidative stress and inflammation. Recent research have indicated that nanoparticles may cause major health impacts when ingested, inhaled, or applied to the skin without precaution. The main sources of toxicity in nanomaterials include their size, shape, concentration, aspect ratio, crystallinity, surface charge, dissolution, and agglomeration. This review article aims to comprehensively summarize the toxicity aspects of nanoparticles for food and drug application, including physiochemical properties, mechanisms of nanoparticle toxicity, and the health risks, so as to provide an overview for future researchers to develop nanoparticulate in a safer way.
Solubility Enhancement Methods Of Efavirenz : A Review febryanto, hery diar; Eryani, Mikhania Christiningtyas; Husni, Patihul
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.64166

Abstract

Human Immunodeficiency Virus (HIV) is a global public health concern due to its progression to acquired immunodeficiency syndrome (AIDS) and the associated high morbidity and mortality rates. Efavirenz (EFV), an antiretroviral drug, is widely used to manage HIV/AIDS. However, EFV exhibits poor aqueous solubility and variable bioavailability, necessitating techniques to enhance its solubility and dissolution for improved therapeutic efficacy. This study reviewed methods to enhance EFV solubility using data from research published between 2019 and 2023. Various approaches, including Nano Micelles, Wet Milling, Co-crystals, Physical Mixtures, Nanocrystals, Dry Milling, and Liquisolid techniques, were analysed. The results demonstrated significant solubility enhancements. For instance, Fuentes (2024) achieved a 50% dissolution efficiency using Nano Micelles, while wet milling by Prado (2024) increased dissolution from 83.48% to 99.10% over 150 minutes. Co-crystals, such as those studied by Gowda (2022), improved solubility from 94.16 µg/mL (pure EFV) to 197.32 µg/mL (EFV-DL-Alanine). Sartori's (2022) Nanocrystals technique demonstrated a dissolution efficiency of 98.41%. Furthermore, physical mixtures like Nel's (2022) combination of EFV with pea protein isolate achieved a solubility increase from 1.00 mg/mL to 2.30 mg/mL. These methods highlight advancements in solubility enhancement techniques that improve EFV’s pharmacokinetic profile. These findings can guide the development of more effective pharmaceutical formulations, improving treatment outcomes for individuals living with HIV/AIDS.
Pengembangan Gel Antiseptik Tangan Mengandung Minyak Atsiri Jeruk Lemon Menggunakan Metode Mikroemulsi Gel Husni, Patihul; Cahya Lestari, Riska; Hartono, Kusdi
JURNAL FARMASI GALENIKA Vol 11 No 2 (2024): Jurnal Farmasi Galenika Vol 11 No 2
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i2.342

Abstract

Hand antiseptic gel preparation is a product that is widely used to protect the body from the entry of bacteria through the hands because of its practical use. Lemon peel (Citrus limon (L) Burm. F) contains essential oils that can inhibit the growth of bacteria so it can be used as a natural antiseptic. This research is aimed at obtaining the best formula preparation of hand antiseptic gel containing lemon essential oil (Citrus lemon (L) Burm. F). The microemulsion formula of lemon essential oil is optimized by making variations in the concentration of surfactant (Tween 80) and cosurfactant (propyleneglycol dan glycerin) which is then formulated into gel dosage form by using a variation in the concentration of the gelling agent. The preparation of the gel carried out a physical stability test that included organoleptic testing, homogeneity, pH, and viscosity. The optimization result of the best microemulsion formula is a formula with a Tween 80 as a surfactant and propylene glycol as a cosurfactant. Hand antiseptic gel preparation containing lemon essential oil (Citrus limon (L) Burm. F) with formula F2 is the best preparation because it is more stable according to the physical stability test of the preparation.
Formulasi Dan Evaluasi Sediaan Gummy Candies Mengandung Infusa Daun Jambu Biji (Psidium guajava L.) Dengan Variasi Konsentrasi Sukrosa Christiningtyas Eryani, Mikhania; Judy Handojo, Kukuh; Safitri, Manzil; Husni, Patihul
JURNAL FARMASI GALENIKA Vol 11 No 3 (2024): Jurnal Farmasi Galenika Vol 11 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i3.347

Abstract

Guava leaves (Psidium guajava L.) are a traditional medicine used to treat diarrhea. The subtance contained in guava leaves that can have antidhiarrheal properties is tannin. Gummy candies are sweet product made from the main gel- forming ingredients such as gelatin, carrageenan, jelly, as well as sweetening ingredients such as sucrose, lactose, glukose, and others. This research aims to formulate and evaluate guava leave infused gummy candies with varying sucrose concentrations of 15 (F1)%, 20% (F2), and 25% (F3). Test data for the organoleptic physical properties of F1, F2, and F3 are chewy texture, weak melon aroma, green color, and sweet taste. In the weight uniformity test there was no difference between F1, F2, and F3. The average pH test results where F1 is 5.81, F2 is 6.16 and, F3 is 6.63. Testing the water content of gummy candies resulted in average of F1 is 12.4%, F2 is 27.5, and F3 is 43,29%. The conclusion is variation concentration of sucrose affect pH and water content but its not affect organoleptic and weight uniformity of gummy candies.
Pengembangan Bahan Farmasi: Pengaruh Variasi Suhu Pengeringan Terhadap Sifat Fisik Serbuk Kering Labu Siam Husni, Patihul; Tryani Sutisna Putri, Sussy; Erika Herawati, Irma; Christiningtyas Eryani, Mikhania
JURNAL FARMASI GALENIKA Vol 11 No 3 (2024): Jurnal Farmasi Galenika Vol 11 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i3.357

Abstract

Chayote (Sechium edule (Jacq). Swartz) is potential to be a pharmaceutical material.  Therefore, this study aimed to determine the effect of drying temperature variations on the physical properties of dry chayote powder. The temperatures used in the drying process are 100 ºC, 80 ºC, and 60 ºC. Evaluation of dry chayote powder includes organoleptic test, water content, flow time, angle of repose, compressibility index, and particle size distribution. The results showed brown powder in color with a distinctive aromatic odor and sweet taste, 2.50-2.80% of water content, 5-6 second in flow time showing good flow properties, 32.21-33.42 º in angle of repose showing powder easy to flow, and compressibility index of 10% -18%. The particle size distribution of dry chayote powder was fine powder with particle size around 0.5-0.7 mm. Statistical analysis results showed there were no significant effect of the drying temperature variations on the physical properties of dry chayote powder. The conclusion of this study is drying temperature variations (100 ºC, 80 ºC, dan 60 ºC) does not affect the physical properties of dry chayote powder.
Pemanfaatan Ekstrak Kulit Buah Naga (Hylocereus polyrhizus) Sebagai Bahan Aktif Pembuatan Sabun Cair Alami Januarti, Melinda; Husni, Patihul; Christiningtyas Eryani, Mikhania
JURNAL FARMASI GALENIKA Vol 11 No 3 (2024): Jurnal Farmasi Galenika Vol 11 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i3.358

Abstract

Nowadays, many people are paying attention to the benefits of natural soap because it is believed to be gentler on the skin and environmentally friendly. This research aims to determine the formulation of natural liquid soap with the addition of dragon fruit peel extract that is effective and meets the requirements. The method used is an experimental method by formulating a natural liquid soap containing 0.5% dragon fruit peel extract as the active ingredient and adding cocamid-DEA as a foam stabilizer in variations of 1%, 3%, and 5%. The tests conducted include organoleptic tests, pH tests, foam height tests, viscosity tests, and skin condition tests. Research shows that the natural liquid soap produced has characteristics of a reddish-purple color, a distinctive scent, and varying consistency depending on the concentration of cocamid-DEA added, where F3 has the highest viscosity at 528.9 mPa, F2 at 525.7 mPa, and F1 at 428.9 mPa. From the pH testing results, F1 has a pH of 8, while F2 and F3 have a pH of 9. In the foam height test, all formulas met the soap foam height requirement of 1.3-22 cm. The first formulation of natural liquid soap with the addition of dragon fruit peel extract as an active ingredient, based on organoleptic tests, pH tests, viscosity, and foam height tests, produced the best results and met the requirements.
Formulasi Dan Evaluasi Sifat Fisik Blush On Powder Ekstrak Buah Tomat (Solanum lycopersicum L.) Sebagai Pewarna Alami Eryani, Mikhania Christiningtyas; Syuhuriah, Ainin; Azizah, Siti Nur; Husni, Patihul
Journal of Agropharmacy Vol. 2 No. 1 (2025)
Publisher : Faculty of Pharmacy, University of Jember

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Abstract

Blush on is a cosmetic product that is used to provide color or add aesthetics to facial makeup. Tomato fruit (Solanum lycopersicum L.) contains red carotenoid pigments which can be used as natural dyes. This research aims to formulate and evaluate the physical properties of blush on tomato fruit extract with concentrations of 3% (F1),5% (F2) and 7% (F3). The results of organoleptic research showed that F1 was light orange, F2 was bright orange and F3 was bright orange. The entire formula smells of rosae, has a smooth and homogeneous texture. The pH value of the entire formula is 6.0. Evaluation of spreadability shows that the entire formula adheres after 5 applications. The conclusion of this research is that tomato fruit extract has an effect on the physical properties of blush on powder, namely organoleptic odor and color. However, it has no effect on organoleptic texture, pH, homogeneity and spreadability
Peran Badan Pengawas Obat dan Makanan (BPOM) dalam Pengendalian Resistensi Antimikroba di Indonesia Muthia Izati; Patihul Husni; Yosita Aulia Mustofa
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.571

Abstract

Antimicrobial resistance when microbes such as bacteria, viruses, fungi, and parasites bo longer respond to antimicrobial medicines. Antimicrobial resistance is one of the 10 health threats faced by the global community. Controlling antimicrobial resistance involves various governmental agencies, including the Indonesia Food and Drug Authority (BPOM), which has responsibilities in the field of drug and food surveillance in Indonesia. The article is prepared to examine the role of BPOM in the Control of Antimicrobial Resistance in Indonesia. The article is prepared using a normative approach, which is a study of articles referring to normative laws found in legislation. The role of BPOM role in antimicrobial resistance control in Indonesia includes the drafting, strengthening, and implementation of policies surveillance of antimicrobial lifecycle, public education, and conducting joint inspection inspection with relevated institutions. The results of this article show that controlling antimicrobial resistance in Indonesia requires coordination and cooperation from all relevant institutions.
Co-Authors Adi Prayitno Agita, Kiva Agnis Pondineka Ria Aditama Agustin, Eka Yulia Ahmad Muhtadi Alicia Ima Dara Ami Tjitraresmi, Ami Anis Yohana Chaerunisaa, Anis Yohana ANUGRAHANI YUNIAR EKAWATI Apriyani, Mila Ardian Baitariza, Ardian Aryani, Annisa Fitri Asa Falahi Astri Sherly Inggriani Astri Sherly Inggriani Ayuning Trias, Diah Aziz, Calista Sasikirana Finola Billa Nidia Hikmatiana Budianto, Muhamad Oke Cahya Lestari, Riska Carolina, Theresia Denok Risky Ayu Paramita Devani Olivia Winardi Dolih Gozali Dwi Puji Astuti Een herliani Erika Herawati, Irma Eryani, Mikhania Christiningtyas Fakhirah, Maitsa Alya Fakhri Rabbani FARIANTI EKO NUR KHASANAH Fauziah, Neneng Alifia Nur Firmansyah Firmansyah Hazrina, Aghnia Henny Lucida Hery Diar Febryanto Ida Musfiroh -, Ida Musfiroh IRMA RAHAYU LATARISSA Januarti, Melinda Judy Handojo, Kukuh Junaedi Junaedi Khanifah Hidayati Puspa Negara Khoirunnisa, Arina Kurniati, Bunga Dian Kusdi Hartono Kusdi Hartono, Kusdi Layyareza, Rania Talinta Luthfiah, Annisa Mayang K. Dewi MAYANG KUSUMA DEWI, MAYANG KUSUMA MEGA HIJRIAWATI Mikhania Christiningtyas Eryani Muhaimin Muhaimin Mulyani, Tuti Sri Muthia Izati NADYA INDAH DEWANTI, NADYA INDAH Nafisa Nurfatia Hidayat Norisca A. Putriana NORISCA ALIZA PUTRIANA Norisca Aliza Putriana, Norisca Aliza NUR DIANA HADAD Nuryani, Tri Winarsih Permatasari, Lina Putri Perwira, Anggun Putri Puspitaningrum, Kartika Putri, Refitha Nurul Rashati, Dewi Ratnawati, Aini RESTIKA ERIA PUTRI Rini Hendriani Safitri, Manzil Salsabila, Annisa Siti Sigalingging, Asima Rohana Silvia, Nurfianti Silviya, Rini Siti Nur Azizah, Siti Nur Sitinjak, Bernap Dwi Putra Soewahju, Renata Bella SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN Sri Agung Fitri Kusuma, Sri Agung SWM, Alyanis Mufid Syuhuriah, Ainin Taofik Rusdiana Tryani Sutisna Putri, Sussy Uswatul Hasanah, Uswatul Vinny Hosiana Widayanti Supraba Yoga Windhu Wardhana Yoshihito Shiono Yosita Aulia Mustofa Yuli Agung Prasetyo YUNIKE KARUNIA PUTRI Yusuf, Marsha Afifah