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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia IDJP (Indonesian Journal of Pharmaceutics) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) JURNAL FARMASI GALENIKA Majalah Farmasetika ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi MAHESA : Malahayati Health Student Journal Indonesian Journal of Biological Pharmacy Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Praba: Jurnal Rumpun Kesehatan Umum Journal of Agropharmacy Jurnal Farmasi Galenika
Patihul Husni
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Evaluasi Kepatuan Penyimpanan Narkotika, Psikotropika, Dan Prekursor (NPP) Di Gudang Penyimpanan Pedangan Besar Farmasi (PBF) Di Kota Cirebon Apriyani, Mila; Husni, Patihul
Farmaka Vol 23, No 2 (2025): Farmaka (Juli) (In Press)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v23i2.65473

Abstract

Narkotika, Psikotropika, dan Prekursor (NPP) merupakan bahan yang memiliki potensi penyalahgunaan tinggi dan efek farmakologis yang signifikan. Oleh karena itu, penyimpanan dan distribusinya harus memenuhi standar regulasi yang ketat, termasuk pedoman Cara Distribusi Obat yang Baik (CDOB) sebagaimana tercantum dalam Peraturan BPOM No. 9 Tahun 2024 dan No. 12 Tahun 2025. Penelitian ini bertujuan mengevaluasi tingkat kepatuhan tempat penyimpanan NPP pada gudang Pedagang Besar Farmasi (PBF) di Kota Cirebon terhadap standar CDOB. Penelitian menggunakan pendekatan observasional-deskriptif dengan metode evaluatif. Data dikumpulkan melalui observasi langsung, wawancara dengan personel kunci, serta checklist berbasis prinsip CDOB. Hasil penelitian menunjukkan bahwa tingkat kepatuhan penyimpanan NPP mencapai 100% dengan seluruh 25 indikator CDOB terpenuhi, meliputi aspek infrastruktur, keamanan, penyimpanan produk khusus, manajemen stok, pencatatan, dan kebersihan. Capaian ini berbeda dengan beberapa penelitian lain yang melaporkan adanya ketidakpatuhan di sejumlah PBF, namun sejalan dengan temuan di wilayah Bandung yang menunjukkan kepatuhan penuh. Penelitian ini menyimpulkan bahwa penerapan standar penyimpanan NPP di PBF Kota Cirebon telah optimal, meskipun masih diperlukan peningkatan berkelanjutan melalui pelatihan rutin, audit internal, dan pemanfaatan teknologi digital untuk mendukung efisiensi serta transparansi sistem distribusi.
Tata Cara Sertifikasi Pemenuhan Aspek Obat Cara Pembuatan Obat Tradisional yang Baik (CPOTB) secara Bertahap dalam Rangka Menjamin Mutu dan Keamanan Obat Bahan Alam di Jawa Barat Soewahju, Renata Bella; Husni, Patihul; Firmansyah, Firmansyah
Farmaka Vol 23, No 3 (2025): Farmaka (November) (In Press)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v23i3.69009

Abstract

Undang-Undang No. 17 Tahun 2023 tentang Kesehatan menjelaskan bahwasanya obat bahan alam hanya dapat diedarkan setelah memperoleh izin edar. Penerapan Cara Pembuatan Obat Tradisional yang Baik (CPOTB) menjadi standar penting guna memberikan jaminan mutu dan keamanan produk. Namun, keterbatasan sumber daya pada Usaha Kecil Obat Tradisional (UKOT) maupun Usaha Mikro Obat Tradisional (UMOT) kerap menjadi hambatan dalam pemenuhan CPOTB secara menyeluruh. Untuk mendukung kesiapan pelaku usaha, BPOM menerapkan Sertifikasi Pemenuhan Aspek (SPA) CPOTB secara Bertahap. Artikel ini bertujuan memberikan gambaran mengenai persyaratan dan tahapan pengajuan SPA CPOTB secara Bertahap serta implementasinya di wilayah Jawa Barat melalui peran BBPOM Bandung. Metode penulisan menggunakan studi literatur dan penelusuran regulasi terkait sertifikasi. Permohonan diajukan melalui sistem OSS-RBA yang telah tersambung dengan e-sertifikasi BPOM dengan estimasi waktu proses sekitar 40 hari kerja. Sertifikat memiliki jangka waktu berlaku tiga tahun dengan opsi perpanjangan maksimal dua kali. Dengan pemahaman prosedur dan persyaratan yang tepat, UKOT dan UMOT diharapkan dapat melakukan proses sertifikasi lebih efektif dan efisien.
Pseudomonas Aeruginosa Sebagai Indikator Kontaminasi Produk Kosmetika : Tinjauan Literatur Nafisa Nurfatia Hidayat; Patihul Husni
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 3 No. 1 (2026): Januari: Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v3i1.2681

Abstract

Pseudomonas aeruginosa is a Gram-negative bacterium commonly found in the environment and serves as an important indicator of microbiological contamination in cosmetic products. Its ability to survive in low nutrient conditions and its resistance to various preservatives make it a microorganism frequently found in water-based products. Contamination can occur during production, storage, and use, and has the potential to cause irritation or infection, especially in individuals with low immunity. This literature review was compiled based on data searches on PubMed, Elsevier, Google Scholar, and Scopus with inclusion criteria of original studies from 2015 to 2025 that reported the detection of P. aeruginosa in cosmetic products. The results of the review show that P. aeruginosa is not only found in new products but also in used products, mainly due to unhygienic usage practices. Although some products are declared free from contamination, monitoring of the production process and consumer education on how to use and store cosmetics are still necessary. Thus, the detection and control of P. aeruginosa are important aspects in ensuring the safety of cosmetic products on the market.
Formulasi Dan Evaluasi Fisik Lipstik Dari Ekstrak Kulit Umbi Bit (Beta vulgaris L.) Eryani, Mikhania Christiningtyas; Aditama, Agnis Pondineka Ria; Husni, Patihul; Permatasari, Lina Putri
JURNAL FARMASI GALENIKA Vol 12 No 3 (2025): Jurnal Farmasi Galenika Volume 12 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i3.417

Abstract

Lipstick is a cosmetic used to add color to the lips. Natural dyes that can be used as a lipstick component are beet (Beta vulgaris L.) skin extract. The skin of beet contains betacyanin which can give color to the lips. This study aims to determine the effect of varying concentrations of beet skin extract on the physical properties of lipstick. There are 3 lipstick formulas used with a 1% (F1), 2% (F2), and 3% (F3) concentration of beet skin extract. The research results show that F1 is pink, F2 is red, and F3 is dark red. The entire formula has even spreadability. The pH values of F1, F2, and F3 are 4.9±0.173, 5±0.3, and 5.3±0, respectively. The melting points of F1, F2, and F3 are 50.66±1.15°C, 52.66±1.15°C, and 53.66±0.58°C, respectively. The conclusion of this study is that variations in the concentration of beet extract affect the color, pH, and melting point of lipstick but do not affect the spreadability of lipstick.
Pengembangan Sediaan Losio Ekstrak Buah Naga Putih Husni, Patihul; Budianto, Muhamad Oke; Baitariza, Ardian; Eryani, Mikhania Christiningtyas; Febryanto, Hery Diar; Januarti, Melinda
JURNAL FARMASI GALENIKA Vol 12 No 3 (2025): Jurnal Farmasi Galenika Volume 12 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i3.419

Abstract

White dragon fruit (Hylocereus undatus) is a tropical fruit from a type of cactus plant that contains various powerful antioxidants. The purpose of this study was to obtain the best lotion formula containing extract of white dragon fruit based on physical evaluation. Three lotion formulas (F1, F2, F3) containing 7,5% white dragon fruit extract were prepared in this study. Physical assessment of the lotion preparation included organoleptic tests, homogeneity, pH determination, and viscosity evaluation. The results showed that the preparation was in the form of a liquid and homogeneous lotion with a white color and a rose odor. The pH of the preparation was around 5.2-6.5 with a viscosity between 1200-1800 cps. F3 is the best lotion formula based on physical evaluation during four weeks of storage with a composition of 7.5% white dragon fruit extract, 1% glycerin, 0.05% triethanolamine, 3% liquid paraffin, 0,3% methyl paraben, 2% dimethicone, 2% stearyl alcohol, 1.5% glycerol monostearate, 3% virgin coconut oil, 0.1% disodium edetate, 3% cetyl alcohol, 0.2% titanium dioxide, parfum qs, and aquadest ad 100%.
Strategi Komunikasi dan Peran BPOM dalam Menghadapi Produk Bahan Alam Ilegal Yusuf, Marsha Afifah; Husni, Patihul; Ratnawati, Aini
Indonesian Journal of Biological Pharmacy Vol 5, No 3 (2025): IJBP (Desember)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v5i3.68556

Abstract

Peredaran produk bahan alam ilegal, terutama Obat Tradisional (OT) yang mengandung Bahan Kimia Obat (BKO) terus meningkat di Indonesia, dari 31 kasus pada tahun 2020 menjadi 61 kasus pada tahun 2022. Fenomena ini merupakan tanggung jawab Badan Pengawas Obat dan Makanan (BPOM). Artikel ulasan ini bertujuan untuk menganalisis strategi komunikasi dan peran BPOM dalam menghadapi isu produk bahan alam ilegal. Penelitian ini menggunakan metode tinjauan pustaka (literature review) dengan mengidentifikasi, mengevalusi, dan mensintesis studi dan publikasi resmi BPOM/pemerintah dalam rentang waktu 2015-2025. Hasil analisis menunjukan bahwa peran BPOM sudah komprehensif, mencakup regulasi, pengawasan, dan penindakan. Namun, peningkatan tren kasus produk ilegal yang berulang mengindikasikan bahwa regulasi yang ketat dan upaya penindakan seperti penarikan produk yang rutin dilakukan BPOM pada Juli, Agustus, dan September 2025 belum sepenuhnya efektif. Keberhasilan pengawasan juga bergantung pada kerjasama antar lembaga dan penagak hukum untuk meningkatkan efek jera. Strategi komunikasi BPOM dan BBPOM berfokus pada Komunikasi, Informasi, dan Edukasi (KIE) melalui media daring dan luring. Diperlukan optimalisasi platform regional BBPOM agar informasi resmi dapat bersaing dengan berita palsu. 
Encapsulation Natural Oils Plant Based Using Freeze-Drying SWM, Alyanis Mufid; Mita, Soraya Ratnawulan; Husni, Patihul
MAHESA : Malahayati Health Student Journal Vol 6, No 3 (2026): Volume 6 Nomor 3 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i3.21306

Abstract

ABSTRACT Natural oils, such as essential oils and oils with high unsaturated fatty acids, can be derived and extracted from plant sources. Essential oils contain aromatic compounds commonly used in the food industry, while oils rich in unsaturated fatty acids, such as omega-3, -6, and -9, along with vitamin E, are highly beneficial in industrial sectors. Furthermore, natural oils possess antimicrobial and antioxidant properties that are valuable in daily life. However, degradation of natural oils is inevitable due to various external factors such as temperature, humidity, and light. Therefore, an effective technique is required to enhance the stability of natural oils, with one of the methods being freeze drying, using wall materials made from various polymers depending on the intended application. This review aims to summarize the development of natural oils encapsulated by freeze dryingThe literature search in this review was conducted using the search engines Google Scholar and ScienceDirect. The selected papers used for this review consist of original research articles published between 2021 and 2025, focusing on natural oils unsaturated fatty acids or essential oils as the primary subject of study. Stability can be improved by examining thermal analysis parameters in various natural oils, such as walnut, sacha inchi, rose damascena, mandarin, and boswellia sacra. Storage at low temperatures helps enhance the chemical stability of natural oils. In natural oils, both essential oils and oils with high unsaturated fatty acids, stability improvement can be achieved through freeze drying using polymers as wall materials such as polysaccharides, proteins, gums, lignin, or other polymers. The use of proper machine freeze drying parameter settings is also necessary to obtain the best results with high encapsulation efficiency Keywords: Encapsulation, Essential Oils, Freeze Drying, Natural Product, Unsaturated fatty Acids.
Pengembangan Lotion Anti Nyamuk Ekstrak Daun Kenikir (Tagetes erecta L.) Dengan Variasi Konsentrasi Setil Alkohol Eryani, Mikhania Christiningtyas; Rashati, Dewi; Falahi, Asa; Husni, Patihul; Agustin, Eka Yulia
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.423

Abstract

The use of chemical-based mosquito repellents has excellent repellent power, but their use can cause hypersensitivity and irritation. In Indonesia, there are several plants that contain essential oils and have mosquito repellent effects. One of them is cosmos (Tagetes erecta L). Cosmos leaf extract is formulated into a lotion preparation so that it can adhere to the skin for a longer time, thus providing longer-lasting mosquito repellent properties. This research aims to determine the effect of varying cetyl alcohol concentrations on the physical properties of lotion. There are 3 lotion formulas used with cetyl alcohol concentrations of 2% (F1), 2.5% (F2), and 3% (F3). The research results show that F1 has a thick texture and brownish-yellow color, F2 has a thick texture and green color, and F3 has a very thick texture and green color. All formulas are homogeneous. F1, F2, and F3 had pH values of 7.5±0, 7.5±0, and 7.9±0, respectively. F1, F2, and F3 have respective viscosities of 20±0 dPas, 30±0 dPas, and 35±0 dPas. F1, F2, and F3 had spreadability values of 8.48±0.51 cm, 7.81±0.05 cm, and 7.10±0.37 cm, respectively. The conclusion of this study is that variations in cetyl alcohol concentration affect the texture, color, pH, viscosity, and spreadability of the lotion.
Pengaruh Variasi Konsentrasi Cocamidopropyl Betaine Pada Karakteristik Fisik Sampo Ekstrak Kering Teh Hijau Husni, Patihul; Silviya, Rini; Hasanah, Uswatul; Eryani, Mikhania Christiningtyas; Dewi, Mayang Kusuma; Putriana, Norisca Aliza; Januarti, Melinda
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.435

Abstract

Hair growth–promoting preparations are used to prevent hair damage problems. Compounds contained in green tea extract have activity as hair growth promoters. This study aimed to obtain data on the effect of variations in cocamidopropyl betaine concentration on the physical characteristics of shampoo containing dry green tea extract. The formulations were prepared in three formulas (F1, F2, and F3) containing different concentrations of cocamidopropyl betaine (8.25%, 8.5%, and 8.75%). The research stages included formulation followed by physical evaluation, including organoleptic properties, homogeneity, pH, viscosity, and foam stability. The results showed that the shampoo preparations were viscous liquids, brown in color, with a characteristic odor, pH of 7–8, viscosity of 250–300 cPs, and foam stability of 15–20 cm. The conclusion of this study is that variations in cocamidopropyl betaine concentration affect the physical characteristics of shampoo containing dry green tea extract. The concentration of cocamidopropyl betaine greatly influences the physical stability of the shampoo, with F3 as the best formula based on physical evaluation, which contains 8.75% cocamidopropyl betaine.
Dampak Minor Stoppage terhadap Overall Equipment Effectiveness pada Lini Produksi Sediaan Steril : Tinjauan Literatur Aziz, Calista Sasikirana Finola; Husni, Patihul; Sigalingging, Asima Rohana
Majalah Farmasetika Vol 11, No 3 (2026)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v11i3.70346

Abstract

Industri farmasi, khususnya pada lini produksi sediaan steril, menuntut tingkat mutu dan efisiensi yang tinggi untuk menjamin keselamatan pasien serta memenuhi persyaratan regulasi. Salah satu faktor yang memengaruhi efektivitas produksi adalah penghentian singkat (minor stoppage), yaitu gangguan singkat pada mesin atau lini produksi yang cenderung dapat diatasi dengan intervensi ringan operator. Tinjauan literatur ini bertujuan untuk mengkaji dampak penghentian singkat (minor stoppage) terhadap Efektivitas Keseluruhan Peralatan (Overall Equipment Effectiveness / OEE) pada lini produksi sediaan farmasi steril. Metode yang digunakan adalah tinjauan literatur melalui database Google Scholar, PubMed, dan ScienceDirect. Hasil menunjukkan bahwa minor stoppage termasuk kategori kerugian akibat penurunan kecepatan (speed losses) yang dominan menurunkan komponen kinerja (performance) pada OEE. Meskipun berdurasi singkat, frekuensi kejadian minor stoppage yang tinggi menyebabkan akumulasi kehilangan waktu operasional yang signifikan. Dampak tersebut semakin kompleks pada produksi sediaan farmasi steril karena keterbatasan intervensi operator dan persyaratan lingkungan aseptik. Faktor penyebab minor stoppage dapat berasal dari mesin, manusia, material, dan lingkungan. Pengendalian melalui Pemeliharaan Produktif Total (Total Productive Maintenance / TPM) terbukti efektif menekan gangguan dan meningkatkan OEE. Kesimpulannya, minor stoppage merupakan salah satu penyebab utama penurunan OEE sehingga perlu dikendalikan secara sistematis. 
Co-Authors Adi Prayitno Agita, Kiva Agnis Pondineka Ria Aditama Agustin, Eka Yulia Ahmad Muhtadi Alicia Ima Dara Ami Tjitraresmi, Ami Anis Yohana Chaerunisaa, Anis Yohana ANUGRAHANI YUNIAR EKAWATI Apriyani, Mila Ardian Baitariza, Ardian Aryani, Annisa Fitri Asa Falahi Astri Sherly Inggriani Astri Sherly Inggriani Ayuning Trias, Diah Aziz, Calista Sasikirana Finola Billa Nidia Hikmatiana Budianto, Muhamad Oke Cahya Lestari, Riska Carolina, Theresia Denok Risky Ayu Paramita Devani Olivia Winardi Dolih Gozali Dwi Puji Astuti Een herliani Erika Herawati, Irma Eryani, Mikhania Christiningtyas Fakhirah, Maitsa Alya Fakhri Rabbani FARIANTI EKO NUR KHASANAH Fauziah, Neneng Alifia Nur Firmansyah Firmansyah Hazrina, Aghnia Henny Lucida Hery Diar Febryanto Ida Musfiroh -, Ida Musfiroh IRMA RAHAYU LATARISSA Januarti, Melinda Judy Handojo, Kukuh Junaedi Junaedi Khanifah Hidayati Puspa Negara Khoirunnisa, Arina Kurniati, Bunga Dian Kusdi Hartono Kusdi Hartono, Kusdi Layyareza, Rania Talinta Luthfiah, Annisa Mayang K. Dewi MAYANG KUSUMA DEWI, MAYANG KUSUMA MEGA HIJRIAWATI Mikhania Christiningtyas Eryani Muhaimin Muhaimin Mulyani, Tuti Sri Muthia Izati NADYA INDAH DEWANTI, NADYA INDAH Nafisa Nurfatia Hidayat Norisca A. Putriana NORISCA ALIZA PUTRIANA Norisca Aliza Putriana, Norisca Aliza NUR DIANA HADAD Nuryani, Tri Winarsih Permatasari, Lina Putri Perwira, Anggun Putri Puspitaningrum, Kartika Putri, Refitha Nurul Rashati, Dewi Ratnawati, Aini RESTIKA ERIA PUTRI Rini Hendriani Safitri, Manzil Salsabila, Annisa Siti Sigalingging, Asima Rohana Silvia, Nurfianti Silviya, Rini Siti Nur Azizah, Siti Nur Sitinjak, Bernap Dwi Putra Soewahju, Renata Bella SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN Sri Agung Fitri Kusuma, Sri Agung SWM, Alyanis Mufid Syuhuriah, Ainin Taofik Rusdiana Tryani Sutisna Putri, Sussy Uswatul Hasanah, Uswatul Vinny Hosiana Widayanti Supraba Yoga Windhu Wardhana Yoshihito Shiono Yosita Aulia Mustofa Yuli Agung Prasetyo YUNIKE KARUNIA PUTRI Yusuf, Marsha Afifah