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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia IDJP (Indonesian Journal of Pharmaceutics) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) JURNAL FARMASI GALENIKA Majalah Farmasetika ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi MAHESA : Malahayati Health Student Journal Indonesian Journal of Biological Pharmacy Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Praba: Jurnal Rumpun Kesehatan Umum Journal of Agropharmacy Jurnal Farmasi Galenika
Patihul Husni
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Tata Cara Pengajuan Notifikasi Produk Kosmetika Dalam Rangka Peningkatan Produk Kosmetik Yang Aman dan Bermutu di Bandung Jawa Barat Luthfiah, Annisa; Husni, Patihul
Farmaka Vol 22, No 1 (2024): Farmaka (Maret)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i1.51263

Abstract

Dalam peraturan badan pengawas obat dan makanan nomor 17 tahun 2023 tentang pedoman dokumen informasi produk kosmetik menyatakan bahwa setiap kosmetik yang diedarkan di wilayah Indonesia wajib telah memiliki izin edar berupa notifikasi. Berdasarkan Laporan Tahunan BBPOM di Bandung tahun 2022 dari hasil pemetaan rawan kasus di Jawa Barat ada sebanyak 7 data kasus kosmetik di wilayah Balai Besar POM di Bandung, yakni 7 data tersebut tanpa izin edar. Kemudian dalam data kerawanan kejahatan obat dan makanan di Kota Bandung terdapat 16 produk kosmetik yang ditemukan mengedarkan kosmetika tanpa izin edar secara online. Berdasarkan hasil data tersebut hal ini dapat disebabkan oleh kurangnya kesadaran dan pengetahuan pelaku usaha mengenai registrasi produk kosmetik. Tujuan artikel ini yaitu untuk menjelaskan tata cara pengajuan notifikasi dalam upaya meningkatkan tersebar luasnya produk kosmetik yang aman dan bermutu dengan memiliki notifikasi kosmetika. Penyusunan artikel ini mengacu pada studi literatur dari berbagai sumber referensi dan Peraturan BPOM yang mengacu terkait notifikasi kosmetik. Dengan adanya notifikasi, masyarakat dapat yakin bahwa produk kosmetik yang akan digunakan terjamin mutunya dan keamanannya serta tidak menimbulkan kerusakan kulit yang berbahaya bagi konsumen di kemudian hari. Adapun pengajuan notifikasi ini dimulai melalui laman OSS, yang kemudian akan terintegrasi dengan sistem dari Badan POM yaitu notifkos dimana pada sistem ini akan memproses persyaratan, pembayaran, verifikasi, evaluasi hingga mendapatkan notifikasi persetujuam atau penolakan.Kata kunci: notifikasi, kosmetik, BPOM, OSS.
STUDI PENGGUNAAN KAPPA KARAGENAN SEBAGAI PENGIKAT TABLET HISAP EKSTRAK KERING DAUN SIRIH HIJAU (Piper betle L.) Husni, Patihul; Mulyani, Tuti Sri; Hartono, Kusdi
Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi Vol 11, No 2 (2023): SABDARIFFARMA
Publisher : Prodi Farmasi - Universitas Al Ghifari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53675/jsfar.v11i2.1182

Abstract

Daun sirih hijau (Piper betle L.) dengan sifat antiseptiknya digunakan untuk menyembuhkan kaki yang luka, menyegarkan dan mengurangi bau mulut. Tujuan penelitian ini untuk mengetahui pengaruh konsentrasi kappa karagenan sebagai bahan pengikat terhadap sifat fisik granul dan tablet hisap ekstrak daun sirih (Piper betle L.) yang dihasilkan. Tablet hisap dibuat sebanyak tiga formula (F1, F2, F3) dengan variasi konsentrasi pengikat kappa karagenan dibuat menggunakan cara granulasi basah (wet granulation). Data hasil pengujian dianalisis dengan menggunakan analisis data one-way anova (p 0,05). Evaluasi sediaan tablet meliputi pemeriksaan sifat fisik granul dan uji stabilitas fisik tablet. Hasil penelitian pemeriksaan sifat fisik granul menunjukan bahwa sediaan mempunyai sifat alir kurang dari 10 g/detik, sudut diam 26,56-34,99⁰, kompresibilitas 11,5-14% dan kandungan lembab 1%. Sementara itu, stabilitas fisik tablet menunjukan bahwa tablet mempunyai keseragaman bobot yang baik (tidak ada tablet yang menyimpang dari 5%), keseragaman ukuran yang baik, kerapuhan kurang dari 1%, kekerasan 4-6,5 kp dan waktu larut 4-8 menit sehingga tablet memenuhi persyaratan tablet yang baik. Sebagai kesimpulan, F2 yang mengandung ekstrak daun sirih 100 mg, laktosa 77,5%, mucilago kappa karagenan 55 mg, asam sitrat 1,5%, manitol 1,3%, talk 2%, mg stearat 1%, dan aerosil 0,5% merupakan formula terbaik berdasarkan uji stabilitas fisik.
POTENSI KITOSAN DARI CANGKANG RAJUNGAN (Portunus pelagicus) SEBAGAI ZAT ANTIBAKTERI Husni, Patihul; Junaedi, Junaedi; Gozali, Dolih
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 1 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i1.14588

Abstract

Plak gigi merupakan suatu lapisan biofilm yang tersusun atas sel-sel dari koloni mikroorganisme pada permukaan gigi yang berperan sangat dominan dalam pembentukan karies gigi. Salah satu penyebab timbulnya plak adalah bakteri Staphylococcus aureus. Kitosan dari cangkang rajungan (Portunus pelagicus) diketahui memiliki aktivitas antibakteri. Tujuan penelitian ini adalah menguji potensi kitosan dari cangkang rajungan yang diperoleh dari pantai Pasir Putih, Cilamaya, Karawang sebagai zat antibakteri. Uji aktivitas antibakteri kitosan dilakukan terhadap bakteri S. aureus dengan nilai konsentrasi hambat tumbuh minimum (KHTM) pada konsentrasi 0,05–0,1% dan konsentrasi bunuh minimum (KBM) pada konsentrasi 0,1%. Hasil penelitian menunjukkan bahwa aktivitas antibakteri terhadap S. aureus terjadi pada konsentrasi 0,4% dan 0,8% berdasarkan zona hambat. Kesimpulan studi ini adalah kitosan dari cangkang rajungan menunjukkan potensinya sebagai agen antibakteri.
Study of Formulation, Characteristics, and Evaluation of Self Nanoemulsifying Drug Delivery System (SNEDDS) for Atorvastatin Calcium Silvia, Nurfianti; Rusdiana, Taofik; Gozali, Dolih; Husni, Patihul
Indonesian Journal of Pharmaceutics Vol 5, Issue 2, May - August 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.50996

Abstract

A Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a formulation approach used in the pharmaceutical and biotechnology industries to improve the solubility and bioavailability of poorly water-soluble drugs. Atorvastatin calcium has limited water solubility, which can affect its bioavailability when administered orally. Its solubility can be enhanced by various formulation techniques, such as the use of self-nanoemulsifying drug delivery systems (SNEDDS). The purpose of this study is to determine the formulation and characterization of SNEDDS and determine how it affects the bioavailability of atorvastatin calcium. The data were collected from published journals. The carrier components required in the formulation of atorvastatin calcium with SNEDDS formulation include oils (oleic acid, peceol, capyrol 90, and capmul CMC), surfactants (tween 80, tween 20, labrasol, cremophor RH 40) and co-surfactants (brij 30, propylene glycol, transcutol-P, PEG 400, transcutol HP). Characterization of atorvastatin calcium with SNEDDS formulation showed droplet size 21.6-162.2 nm; zeta potential -1.32 - 24.6±6.47 mV; and polydensity index 0.164 - 0.297. SNEDDS formulation increased the percentage of drug release and increased the bioavailability of atorvastatin calcium. Keywords: self-nanoemulsifying drug delivery system, SNEDDS, atorvastatin                      calcium, formulation, characteristics, dissolution, bioavailability
Topical Formulation of Herbal Nanocosmetics for Anti-Aging Husni, Patihul; Eryani, Mikhania Christiningtyas
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.56857

Abstract

Skin aging is a biological process that involves a decline in skin function. Regarding prevention and inhibition of skin aging, use of cosmetic products is an option to avoid skin aging because it can improve texture and function of skin. Recently, development of a topical formulation of herbal nanocosmetics for anti-aging has grown increasingly popular. This review is aimed to summarize and describe topical formulation of herbal nanocosmetics for anti-aging application. In addition, this review also shows several studies performed by researchers in development of topical formulation of herbal nanocosmetics for anti-aging. The data were collected from published journals in the range of 2011-2023. Study result showed that nanoemulsion, nanostructured lipid carriers (NLC), solid lipid nanoparticles (SLN), niosomes, liposomes, ethosomes, and transfersomes are nanotechnology methods used to prepare herbal nanocosmetics for anti-aging in the cream or gel dosage form. In conclusion, herbal nanocosmetics combine the benefits of herbal extracts with nanotechnology which can be used to enhance the effectiveness of natural ingredients for anti-aging effect. Keywords: topical, herbal, nanocosmetics, anti-aging
Lip Balm Formulation and Physical Properties Evaluation Of Yellow Pumpkin Fruit (Cucurbita Moschata Duchesne) Ethanol Extract with Cera Alba Variation Concentration Christiningtyas Eryani, Mikhania; Risky Ayu Paramita, Denok; Ayuning Trias, Diah; Husni, Patihul
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.60617

Abstract

Lip balm is a cosmetic product generally used to care for, moisturize, decorate, and protect lips from environmental influences. This study aims to determine the effect of variations inconcentration of cera alba as base on the lip balm physical properties of yellow pumpkin fruit (Cucurbita moschata Duchesne)ethanol extract. The experimental design used was a pre-experimental one-shot case study. This study employed three formulas with varying concentrations of Cera alba, namely 10% (F1), 15% (F2), and 20% (F3). The physical properties of the lip balm under investigation included homogeneity, pH, adhesion, and hardness. The results showed that the variation concentration of cera alba had affect on adhesion and hardness, while not affect the homogeneity of physical properties and pH. Keywords : Yellow pumpkin, cera alba, lip balm
Formulation of Serum Sunflower (Helianthus annuus L.) Seed Oil as Antiacne Preparation Mita, Soraya Ratnawulan Mita; Sri Agung Fitri Kusuma; Devani Olivia Winardi; Patihul Husni; Yoshihito Shiono
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.197-207.2024

Abstract

Acne is caused by a microbial imbalance due to the overgrowth of Propionibacterium acnes in the skin microbiome. Sunflower seed oil (Helianthus annuus L.), which contains linoleic acid and terpenoids, has an antibacterial activity against P. acnes. This study aimed to increase the availability of anti-acne compounds from natural resources by formulating an anti-acne serum containing sunflower seed oil. The research methods included antibacterial activity testing of sunflower seed oil, serum formulation, product evaluation, and serum effectiveness testing. The results of the antibacterial activity test of sunflower seed oil against P. acnes ATCC 6919 showed a minimum inhibitory concentration (MIC) of 100 mg/mL and a minimum bactericidal concentration (MBC) of 200 mg/mL. The result of serum evaluation and stability testing during the freeze-thaw cycling test depicted stable formulation for all formulas based on organoleptic parameters, homogeneity, pH, viscosity, and spreadability. The effectiveness test results of the serum preparation showed that formula 3, containing 200 mg/L of sunflower seed oil, was the best formula with an inhibition zone diameter of 12.76 ± 0.03 mm. In conclusion, sunflower seed oil demonstrates the ability to prevent and treat acne-prone skin, making it a suitable alternative anti-acne compound.
Peran Badan Pengawas Obat dan Makanan (BPOM) dalam Strategi Nasional Pengendalian Antimikroba Tahun 2025-2029 Billa Nidia Hikmatiana; Patihul Husni
Jurnal Praba : Jurnal Rumpun Kesehatan Umum Vol. 3 No. 2 (2025): Juni : Jurnal Praba : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/praba.v3i2.365

Abstract

Antimicrobial resistance (AMR) is a major global threat, contributing to high mortality and infectious complications worldwide. In response, Indonesia has developed the National Strategy for the Control of Antimicrobial Resistance in the Health Sector for 2025–2029. Within this framework, the National Agency of Drug and Food Control (BPOM) plays a strategic role both as a lead organizer and partner in implementing cross-sectoral interventions. BPOM is involved in drafting regulations, supervising the distribution and use of antimicrobials, and conducting public education programs. Its role aligns with the people-centred and One Health approaches, emphasizing multi-sectoral collaboration and community engagement in AMR control. This study applies a normative legal approach based on literature and regulatory analysis to evaluate BPOM’s role in the national strategy.
Pengembangan Sediaan Gel Ekstrak Bonggol Pisang Ambon Husni, Patihul; Prayitno, Adi; Baitariza, Ardian; Christiningtyas Eryani, Mikhania; Januarti, Melinda
JURNAL FARMASI GALENIKA Vol 12 No 1 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i1.382

Abstract

Ambonese banana (Musa paradisiaca var. Sapientum (L.)) has a tuber with several benefits including for wound-healing. The Ambonese banana tuber contains protein, fat, vitamins A and C. In addition, the tannins, flavonoids, and saponins contained in the sap of the Ambonese banana tuber are beneficial in wound healing. The purpose of this study was to obtain the best gel formula containing extract of Ambonese banana tuber based on physical evaluation. The study was conducted by making three different gel formulations (F1, F2, F3) containing 5% Ambonese banana tuber extract. Physical assessment of the gel preparation included organoleptic tests, pH determination, homogeneity, viscosity, and spreadability evaluation. The results showed that the preparation was in the form of a homogeneous gel with a reddish-brown color and a distinctive odor. The pH of the preparation was around 5-8 with a viscosity between 500-3500 cps and a spreadability of 5-8 cm. F2 is the best gel formula based on physical evaluation during four weeks of storage with a composition of 5% HPMC, 15% propylene glycol, 0.2% methylparaben, 5% Ambonese banana tuber extract, and 100% aquadest.
Beyond The Skin Barrier: How Transfersomes and Transethosomes are Revolutionizing Topical Therapies Widayanti Supraba; Husni, Patihul; Chaerunisaa, Anis Yohana
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57146

Abstract

Introduction: The fundamental challenge of effective skin permeation has long limited the therapeutic potential of topical drug delivery systems. Conventional formulations frequently fail to achieve adequate penetration through the skin barrier, necessitating innovative approaches to enhance drug bioavailability while maintaining targeted delivery to specific skin layers.  Aims: This review evaluates the transformative impact of transfersomes and transethosomes as advanced nanovesicular systems designed to overcome traditional limitations in topical drug delivery. Methods: The review examines ultra-deformable nanovesicle technologies through comprehensive analysis of their operational mechanisms, including osmotic gradient exploitation in transfersomes and ethanol-facilitated lipid fluidization in transethosomes. Performance comparisons with conventional formulations across various therapeutic applications were conducted to assess clinical efficacy and delivery capabilities. Result: These nanovesicular systems demonstrate superior performance in delivering diverse therapeutic agents to targeted skin layers while effectively minimizing systemic absorption. The analysis reveals significant advantages over traditional formulations, with enhanced penetration capabilities that extend to macromolecular therapeutics and biologics when integrated with complementary technologies such as microneedle arrays and iontophoresis. Current research developments focus on addressing existing limitations through lyophilization techniques, hybrid polymer systems, and advanced manufacturing processes. Conclusion: Transfersomes and transethosomes represent a significant advancement in topical drug delivery technology, offering promising solutions to longstanding permeation challenges. The future trajectory toward personalized formulations and sustainable production methods using plant-derived components indicates their potential to fundamentally redefine treatment approaches in dermatology, oncology, and pain management, establishing minimally invasive yet highly effective therapeutic options as the standard in patient care.
Co-Authors Adi Prayitno Agita, Kiva Agnis Pondineka Ria Aditama Agustin, Eka Yulia Ahmad Muhtadi Alicia Ima Dara Ami Tjitraresmi, Ami Anis Yohana Chaerunisaa, Anis Yohana ANUGRAHANI YUNIAR EKAWATI Apriyani, Mila Ardian Baitariza, Ardian Aryani, Annisa Fitri Asa Falahi Astri Sherly Inggriani Astri Sherly Inggriani Ayuning Trias, Diah Aziz, Calista Sasikirana Finola Billa Nidia Hikmatiana Budianto, Muhamad Oke Cahya Lestari, Riska Carolina, Theresia Denok Risky Ayu Paramita Devani Olivia Winardi Dolih Gozali Dwi Puji Astuti Een herliani Erika Herawati, Irma Eryani, Mikhania Christiningtyas Fakhirah, Maitsa Alya Fakhri Rabbani FARIANTI EKO NUR KHASANAH Fauziah, Neneng Alifia Nur Firmansyah Firmansyah Hazrina, Aghnia Henny Lucida Hery Diar Febryanto Ida Musfiroh -, Ida Musfiroh IRMA RAHAYU LATARISSA Januarti, Melinda Judy Handojo, Kukuh Junaedi Junaedi Khanifah Hidayati Puspa Negara Khoirunnisa, Arina Kurniati, Bunga Dian Kusdi Hartono Kusdi Hartono, Kusdi Layyareza, Rania Talinta Luthfiah, Annisa Mayang K. Dewi MAYANG KUSUMA DEWI, MAYANG KUSUMA MEGA HIJRIAWATI Mikhania Christiningtyas Eryani Muhaimin Muhaimin Mulyani, Tuti Sri Muthia Izati NADYA INDAH DEWANTI, NADYA INDAH Nafisa Nurfatia Hidayat Norisca A. Putriana NORISCA ALIZA PUTRIANA Norisca Aliza Putriana, Norisca Aliza NUR DIANA HADAD Nuryani, Tri Winarsih Permatasari, Lina Putri Perwira, Anggun Putri Puspitaningrum, Kartika Putri, Refitha Nurul Rashati, Dewi Ratnawati, Aini RESTIKA ERIA PUTRI Rini Hendriani Safitri, Manzil Salsabila, Annisa Siti Sigalingging, Asima Rohana Silvia, Nurfianti Silviya, Rini Siti Nur Azizah, Siti Nur Sitinjak, Bernap Dwi Putra Soewahju, Renata Bella SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN Sri Agung Fitri Kusuma, Sri Agung SWM, Alyanis Mufid Syuhuriah, Ainin Taofik Rusdiana Tryani Sutisna Putri, Sussy Uswatul Hasanah, Uswatul Vinny Hosiana Widayanti Supraba Yoga Windhu Wardhana Yoshihito Shiono Yosita Aulia Mustofa Yuli Agung Prasetyo YUNIKE KARUNIA PUTRI Yusuf, Marsha Afifah