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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia IDJP (Indonesian Journal of Pharmaceutics) Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research Pharmaceutical Journal of Indonesia JURNAL FARMASI GALENIKA Majalah Farmasetika ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Indonesian Journal of Biological Pharmacy Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Journal of Agropharmacy Jurnal Farmasi Galenika
Patihul Husni
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Tata Cara Pengajuan Notifikasi Produk Kosmetika Dalam Rangka Peningkatan Produk Kosmetik Yang Aman dan Bermutu di Bandung Jawa Barat Luthfiah, Annisa; Husni, Patihul
Farmaka Vol 22, No 1 (2024): Farmaka (Maret)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i1.51263

Abstract

Dalam peraturan badan pengawas obat dan makanan nomor 17 tahun 2023 tentang pedoman dokumen informasi produk kosmetik menyatakan bahwa setiap kosmetik yang diedarkan di wilayah Indonesia wajib telah memiliki izin edar berupa notifikasi. Berdasarkan Laporan Tahunan BBPOM di Bandung tahun 2022 dari hasil pemetaan rawan kasus di Jawa Barat ada sebanyak 7 data kasus kosmetik di wilayah Balai Besar POM di Bandung, yakni 7 data tersebut tanpa izin edar. Kemudian dalam data kerawanan kejahatan obat dan makanan di Kota Bandung terdapat 16 produk kosmetik yang ditemukan mengedarkan kosmetika tanpa izin edar secara online. Berdasarkan hasil data tersebut hal ini dapat disebabkan oleh kurangnya kesadaran dan pengetahuan pelaku usaha mengenai registrasi produk kosmetik. Tujuan artikel ini yaitu untuk menjelaskan tata cara pengajuan notifikasi dalam upaya meningkatkan tersebar luasnya produk kosmetik yang aman dan bermutu dengan memiliki notifikasi kosmetika. Penyusunan artikel ini mengacu pada studi literatur dari berbagai sumber referensi dan Peraturan BPOM yang mengacu terkait notifikasi kosmetik. Dengan adanya notifikasi, masyarakat dapat yakin bahwa produk kosmetik yang akan digunakan terjamin mutunya dan keamanannya serta tidak menimbulkan kerusakan kulit yang berbahaya bagi konsumen di kemudian hari. Adapun pengajuan notifikasi ini dimulai melalui laman OSS, yang kemudian akan terintegrasi dengan sistem dari Badan POM yaitu notifkos dimana pada sistem ini akan memproses persyaratan, pembayaran, verifikasi, evaluasi hingga mendapatkan notifikasi persetujuam atau penolakan.Kata kunci: notifikasi, kosmetik, BPOM, OSS.
STUDI PENGGUNAAN KAPPA KARAGENAN SEBAGAI PENGIKAT TABLET HISAP EKSTRAK KERING DAUN SIRIH HIJAU (Piper betle L.) Husni, Patihul; Mulyani, Tuti Sri; Hartono, Kusdi
Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi Vol 11, No 2 (2023): SABDARIFFARMA
Publisher : Prodi Farmasi - Universitas Al Ghifari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53675/jsfar.v11i2.1182

Abstract

Daun sirih hijau (Piper betle L.) dengan sifat antiseptiknya digunakan untuk menyembuhkan kaki yang luka, menyegarkan dan mengurangi bau mulut. Tujuan penelitian ini untuk mengetahui pengaruh konsentrasi kappa karagenan sebagai bahan pengikat terhadap sifat fisik granul dan tablet hisap ekstrak daun sirih (Piper betle L.) yang dihasilkan. Tablet hisap dibuat sebanyak tiga formula (F1, F2, F3) dengan variasi konsentrasi pengikat kappa karagenan dibuat menggunakan cara granulasi basah (wet granulation). Data hasil pengujian dianalisis dengan menggunakan analisis data one-way anova (p 0,05). Evaluasi sediaan tablet meliputi pemeriksaan sifat fisik granul dan uji stabilitas fisik tablet. Hasil penelitian pemeriksaan sifat fisik granul menunjukan bahwa sediaan mempunyai sifat alir kurang dari 10 g/detik, sudut diam 26,56-34,99⁰, kompresibilitas 11,5-14% dan kandungan lembab 1%. Sementara itu, stabilitas fisik tablet menunjukan bahwa tablet mempunyai keseragaman bobot yang baik (tidak ada tablet yang menyimpang dari 5%), keseragaman ukuran yang baik, kerapuhan kurang dari 1%, kekerasan 4-6,5 kp dan waktu larut 4-8 menit sehingga tablet memenuhi persyaratan tablet yang baik. Sebagai kesimpulan, F2 yang mengandung ekstrak daun sirih 100 mg, laktosa 77,5%, mucilago kappa karagenan 55 mg, asam sitrat 1,5%, manitol 1,3%, talk 2%, mg stearat 1%, dan aerosil 0,5% merupakan formula terbaik berdasarkan uji stabilitas fisik.
Study of Formulation, Characteristics, and Evaluation of Self Nanoemulsifying Drug Delivery System (SNEDDS) for Atorvastatin Calcium Silvia, Nurfianti; Rusdiana, Taofik; Gozali, Dolih; Husni, Patihul
Indonesian Journal of Pharmaceutics Vol 5, Issue 2, May - August 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.50996

Abstract

A Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a formulation approach used in the pharmaceutical and biotechnology industries to improve the solubility and bioavailability of poorly water-soluble drugs. Atorvastatin calcium has limited water solubility, which can affect its bioavailability when administered orally. Its solubility can be enhanced by various formulation techniques, such as the use of self-nanoemulsifying drug delivery systems (SNEDDS). The purpose of this study is to determine the formulation and characterization of SNEDDS and determine how it affects the bioavailability of atorvastatin calcium. The data were collected from published journals. The carrier components required in the formulation of atorvastatin calcium with SNEDDS formulation include oils (oleic acid, peceol, capyrol 90, and capmul CMC), surfactants (tween 80, tween 20, labrasol, cremophor RH 40) and co-surfactants (brij 30, propylene glycol, transcutol-P, PEG 400, transcutol HP). Characterization of atorvastatin calcium with SNEDDS formulation showed droplet size 21.6-162.2 nm; zeta potential -1.32 - 24.6±6.47 mV; and polydensity index 0.164 - 0.297. SNEDDS formulation increased the percentage of drug release and increased the bioavailability of atorvastatin calcium. Keywords: self-nanoemulsifying drug delivery system, SNEDDS, atorvastatin                      calcium, formulation, characteristics, dissolution, bioavailability
Topical Formulation of Herbal Nanocosmetics for Anti-Aging Husni, Patihul; Eryani, Mikhania Christiningtyas
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.56857

Abstract

Skin aging is a biological process that involves a decline in skin function. Regarding prevention and inhibition of skin aging, use of cosmetic products is an option to avoid skin aging because it can improve texture and function of skin. Recently, development of a topical formulation of herbal nanocosmetics for anti-aging has grown increasingly popular. This review is aimed to summarize and describe topical formulation of herbal nanocosmetics for anti-aging application. In addition, this review also shows several studies performed by researchers in development of topical formulation of herbal nanocosmetics for anti-aging. The data were collected from published journals in the range of 2011-2023. Study result showed that nanoemulsion, nanostructured lipid carriers (NLC), solid lipid nanoparticles (SLN), niosomes, liposomes, ethosomes, and transfersomes are nanotechnology methods used to prepare herbal nanocosmetics for anti-aging in the cream or gel dosage form. In conclusion, herbal nanocosmetics combine the benefits of herbal extracts with nanotechnology which can be used to enhance the effectiveness of natural ingredients for anti-aging effect. Keywords: topical, herbal, nanocosmetics, anti-aging
Lip Balm Formulation and Physical Properties Evaluation Of Yellow Pumpkin Fruit (Cucurbita Moschata Duchesne) Ethanol Extract with Cera Alba Variation Concentration Christiningtyas Eryani, Mikhania; Risky Ayu Paramita, Denok; Ayuning Trias, Diah; Husni, Patihul
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.60617

Abstract

Lip balm is a cosmetic product generally used to care for, moisturize, decorate, and protect lips from environmental influences. This study aims to determine the effect of variations inconcentration of cera alba as base on the lip balm physical properties of yellow pumpkin fruit (Cucurbita moschata Duchesne)ethanol extract. The experimental design used was a pre-experimental one-shot case study. This study employed three formulas with varying concentrations of Cera alba, namely 10% (F1), 15% (F2), and 20% (F3). The physical properties of the lip balm under investigation included homogeneity, pH, adhesion, and hardness. The results showed that the variation concentration of cera alba had affect on adhesion and hardness, while not affect the homogeneity of physical properties and pH. Keywords : Yellow pumpkin, cera alba, lip balm
Pengembangan Sediaan Gel Ekstrak Bonggol Pisang Ambon Husni, Patihul; Prayitno, Adi; Baitariza, Ardian; Christiningtyas Eryani, Mikhania; Januarti, Melinda
JURNAL FARMASI GALENIKA Vol 12 No 1 (2025): Jurnal Farmasi Galenika
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i1.382

Abstract

Ambonese banana (Musa paradisiaca var. Sapientum (L.)) has a tuber with several benefits including for wound-healing. The Ambonese banana tuber contains protein, fat, vitamins A and C. In addition, the tannins, flavonoids, and saponins contained in the sap of the Ambonese banana tuber are beneficial in wound healing. The purpose of this study was to obtain the best gel formula containing extract of Ambonese banana tuber based on physical evaluation. The study was conducted by making three different gel formulations (F1, F2, F3) containing 5% Ambonese banana tuber extract. Physical assessment of the gel preparation included organoleptic tests, pH determination, homogeneity, viscosity, and spreadability evaluation. The results showed that the preparation was in the form of a homogeneous gel with a reddish-brown color and a distinctive odor. The pH of the preparation was around 5-8 with a viscosity between 500-3500 cps and a spreadability of 5-8 cm. F2 is the best gel formula based on physical evaluation during four weeks of storage with a composition of 5% HPMC, 15% propylene glycol, 0.2% methylparaben, 5% Ambonese banana tuber extract, and 100% aquadest.
Beyond The Skin Barrier: How Transfersomes and Transethosomes are Revolutionizing Topical Therapies Widayanti Supraba; Husni, Patihul; Chaerunisaa, Anis Yohana
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57146

Abstract

Introduction: The fundamental challenge of effective skin permeation has long limited the therapeutic potential of topical drug delivery systems. Conventional formulations frequently fail to achieve adequate penetration through the skin barrier, necessitating innovative approaches to enhance drug bioavailability while maintaining targeted delivery to specific skin layers.  Aims: This review evaluates the transformative impact of transfersomes and transethosomes as advanced nanovesicular systems designed to overcome traditional limitations in topical drug delivery. Methods: The review examines ultra-deformable nanovesicle technologies through comprehensive analysis of their operational mechanisms, including osmotic gradient exploitation in transfersomes and ethanol-facilitated lipid fluidization in transethosomes. Performance comparisons with conventional formulations across various therapeutic applications were conducted to assess clinical efficacy and delivery capabilities. Result: These nanovesicular systems demonstrate superior performance in delivering diverse therapeutic agents to targeted skin layers while effectively minimizing systemic absorption. The analysis reveals significant advantages over traditional formulations, with enhanced penetration capabilities that extend to macromolecular therapeutics and biologics when integrated with complementary technologies such as microneedle arrays and iontophoresis. Current research developments focus on addressing existing limitations through lyophilization techniques, hybrid polymer systems, and advanced manufacturing processes. Conclusion: Transfersomes and transethosomes represent a significant advancement in topical drug delivery technology, offering promising solutions to longstanding permeation challenges. The future trajectory toward personalized formulations and sustainable production methods using plant-derived components indicates their potential to fundamentally redefine treatment approaches in dermatology, oncology, and pain management, establishing minimally invasive yet highly effective therapeutic options as the standard in patient care.
A Review of the Impact of Stevia Leaf (Stevia rebaudiana Bert.) as a Sweetener in Blood Glucose in Alloxan-Induced Rats Putri, Refitha Nurul; Husni, Patihul
Indonesian Journal of Biological Pharmacy Vol 4, No 2 (2024): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus (DM) is a chronic condition characterized by elevated blood glucose levels due to insulin-related deficiencies and is often referred to as “The Silent Killer”. Medicinal plants have been widely explored as alternative therapies for managing DM. Among these, Stevia rebaudiana Bert. has garnered significant attention for its potent antidiabetic properties. Known as a natural sweetener 200–300 times sweeter than sucrose, Stevia boasts a zero glycemic index, making it particularly suitable for individuals with diabetes. This review aims to evaluate the antihyperglycemic potential of Stevia rebaudiana Bert. as an alternative to conventional therapies. A systematic review was conducted by acquiring data from scientific databases such as Semantic Scholar, PubMed, Scopus, OpenAlex, Crossref, and ScienceDirect, focusing on literature published between 2020–2024. Studies on diabetic rat models induced with alloxan were analyzed, with doses ranging from 20–1000 mg/kgBW and optimal doses identified between 120–150 mg/kgBW. The results demonstrated that Stevia significantly reduced blood glucose levels in diabetic rats and sustained hyperglycemia, effectively modeling type 1 diabetes. The bioactive constituents, including phenolics, alkaloids, glycosides, steviosides, flavonoids, and tannins, were identified as key contributors to its antihyperglycemic activity. In conclusion, Stevia rebaudiana Bert. exhibits promising efficacy as a natural antidiabetic agent. Its ability to reduce blood glucose levels and its zero glycemic index position it as a viable alternative to conventional antihyperglycemic therapies, especially for managing type 1 DM.
ARTIKEL REVIEW: PERSPEKTIF FARMAKOLOGI DAN PERAN APOTEKER TERHADAP PENGEMBANGAN SERTA PENGGUNAAN NUTRASEUTIKAL Sitinjak, Bernap Dwi Putra; Husni, Patihul
Farmaka Vol 22, No 3 (2024): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i3.54336

Abstract

Peningkatan derajat kesehatan dapat dilakukan dalam promotif, pencegahan (preventif), penyembuhan (kuratif), dan pemulihan (rehabilitatif). Makanan bernutrisi menjadi salah satu upaya preventif terhadap kejadian penyakit. Nutraseutikal merupakan nutrisi pada pangan yang memiliki manfaat secara farmakologi ketika dijadikan konsumsi. Oleh sebab itu artikel ini akan membahas aspek farmakologi pada kesehatan pada nutraseutikal serta peran apoteker pada penggunaannya. Review dilakukan pada artikel yang terdapat pada database Google scholar yang muncul dari hasil pencarian terkait nutraseutikal kemudian dilakukan screening dan dipilah berdasarkan judul dan abstrak lalu hasil review disajikan dalam bentuk narasi. Secara garis besar nutraseutikal dibedakan menjadi dua jenis yakni nutraseutikal tradisional dan non-tradisional. nutraseutikal tradisional bersumber dari organisme probiotik, enzim, dan senyawa kimia berupa nutrien dan metabolit hewan tumbuhan. Sementara senyawa non tradisional dapat bersumber dari pangan fortifikasi maupun pangan rekombinan. Berdasarkan hasil penelusuran menunjukkan banyaknya aktivitas antioksidan yang berpotensi mencegah stres oksidatif. Selain itu, berdasarkan hasil review tanaman hasil rekayasa genetik dapat meningkatkan konsentrasi nutraseutikal. Sehingga tidak menutup kemungkinan bahwa peran apoteker akan semakin dibutuhkan dalam penggunaan nutraseutikal khususnya pada pengembangan dan penjaminan mutu produk, pemberi KIE agar obat dapat digunakan dengan tepat oleh konsumen, serta merancang regulasi. Kata kunci: Nutraseutikal, Nutrien, Farmakologi, dan Apoteker.
Increased Toxicity Risk from Nanoparticulate System in Food and Drug Applications Hazrina, Aghnia; Muhaimin, Muhaimin; Chaerunisaa, Anis Yohana; Husni, Patihul; Wardhana, Yoga Windhu
Indonesian Food Science and Technology Journal Vol. 8 No. 2 (2025): Volume 8 Number 2, July 2025 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v8i2.40494

Abstract

Abstract— Nanotechnology involves manipulating matter at the atomic and molecular levels, leading to the creation of new materials for food and drug application with properties that are not always easily anticipated based on existing knowledge. Among the nearly infinite variety of these substances, some are toxic to biological systems, others are generally harmless, and yet others confer health advantages. The biocompatibility and distribution of these materials must be assessed prior to their use in biological and environmental. Consequently, it is essential to comprehend the toxicity of nanomaterials. Mechanisms of cellular uptake and nanoparticles dispersion in biological settings depend on their physicochemical properties. The pathways in which exposure to nanoparticles is harmful to health are through oxidative stress and inflammation. Recent research have indicated that nanoparticles may cause major health impacts when ingested, inhaled, or applied to the skin without precaution. The main sources of toxicity in nanomaterials include their size, shape, concentration, aspect ratio, crystallinity, surface charge, dissolution, and agglomeration. This review article aims to comprehensively summarize the toxicity aspects of nanoparticles for food and drug application, including physiochemical properties, mechanisms of nanoparticle toxicity, and the health risks, so as to provide an overview for future researchers to develop nanoparticulate in a safer way.
Co-Authors Adi Prayitno Aditama, Agnis Agita, Kiva Agnis Pondineka Ria Aditama Ahmad Muhtadi Alicia Ima Dara Ami Tjitraresmi, Ami Anis Yohana Chaerunisaa, Anis Yohana ANUGRAHANI YUNIAR EKAWATI Apriyani, Mila Ardian Baitariza, Ardian Aryani, Annisa Fitri Astri Sherly Inggriani Astri Sherly Inggriani Ayuning Trias, Diah Aziz, Calista Sasikirana Finola Billa Nidia Hikmatiana Budianto, Muhamad Oke Cahya Lestari, Riska Carolina, Theresia Denok Risky Ayu Paramita Dolih Gozali Dwi Puji Astuti Een herliani Erika Herawati, Irma ERYANI, MIKHANIA Eryani, Mikhania Christiningtyas Fakhirah, Maitsa Alya Fakhri Rabbani FARIANTI EKO NUR KHASANAH Fauziah, Neneng Alifia Nur Firmansyah Firmansyah Hazrina, Aghnia Henny Lucida Hery Diar Febryanto Ida Musfiroh -, Ida Musfiroh IRMA RAHAYU LATARISSA Januarti, Melinda Judy Handojo, Kukuh Khanifah Hidayati Puspa Negara Khoirunnisa, Arina Kurniati, Bunga Dian Kusdi Hartono Kusdi Hartono, Kusdi Layyareza, Rania Talinta Luthfiah, Annisa Mayang K. Dewi MEGA HIJRIAWATI Mikhania Christiningtyas Eryani Muhaimin Muhaimin Mulyani, Tuti Sri Muthia Izati NADYA INDAH DEWANTI, NADYA INDAH Nafisa Nurfatia Hidayat Nina Wijiani Norisca A. Putriana NORISCA ALIZA PUTRIANA NUR DIANA HADAD Nuryani, Tri Winarsih Permatasari, Lina Putri Perwira, Anggun Putri perwita, tista Puspitaningrum, Kartika Putri, Refitha Nurul Rashati, Dewi Ratnawati, Aini RESTIKA ERIA PUTRI Rini Hendriani Safitri, Manzil Salsabila, Annisa Siti Sigalingging, Asima Rohana Silvia, Nurfianti Siti Nur Azizah, Siti Nur Sitinjak, Bernap Dwi Putra Soewahju, Renata Bella SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN Syuhuriah, Ainin Taofik Rusdiana Tryani Sutisna Putri, Sussy Vinny Hosiana Widayanti Supraba Yoga Windhu Wardhana Yosita Aulia Mustofa Yuli Agung Prasetyo YUNIKE KARUNIA PUTRI Yusuf, Marsha Afifah