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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Hilirisasi IPTEKS (JHI) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea Majalah Farmasetika JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Pharmaceutical And Biomedical Sciences Journal (PBSJ) Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Erizal Zaini
Departemen Farmasetik, Fakultas Farmasi, Universitas Andalas, Padang 25163
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Pembentukan Kokristal Katekin dengan Nikotinamida Bakhtiar, Amri; Gaesari, Sherly Rahmah; Zaini, Erizal
Jurnal Farmasi Sains dan Terapan Vol 2, No 2 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1366.084 KB) | DOI: 10.33508/jfst.v2i2.720

Abstract

Telah dilakukan pembuatan kokristal katekin-nikotinamida dan evaluasi kelarutannya dalam pelarut air. Kokristal dibuat dengan dua metode, yaitu rekristalisasi dengan penguapan pelarut etanol 96% menggunakan rotary evaporator (metode I) dan penguapan pelarut pada suhu ruang (metode II). Karakterisasi kokristal katekin-nikotinamida dilakukan dengan difraksi sinar-X, analisis termal DTA (Differential Thermal Analysis), FT IR (Fourier Transform Infra Red), dan SEM (Scanning Electron Microscopy), serta uji kelarutan dalam pelarut air menggunakan orbital shaker selama 24 jam. Penetapan kadar katekin dilakukan dengan metode KCKT (Kromatografi Cair Kinerja Tinggi) menggunakan fase gerak air-asetonitril-metanol-etil asetat-asam asetat glasial (89:6:1:3:1). Hasil difraktogram sinar-X pada kokristal metode I menunjukkan terbentuknya padatan amorf, sedangkan pada metode II menunjukkan terbentuknya fase kristalin baru (kokristal). Pada analisis termal menggunakan DTA terjadi perubahan titik lebur pada kokristal metode I maupun metode II yang berbeda dengan titik lebur katekin dan nikotinamida yang menunjukkan terbentuknya campuran eutektik. Pada analisis FT IR, baik kokristal metode I maupun metode II terjadi pergeseran bilangan gelombang dari spektrum katekin dan nikotinamida yang menunjukkan terbentuknya ikatan hidrogen antara gugus hidroksi fenol dari katekin dengan gugus amida dari nikotinamida. Dari hasil SEM, terlihat habit kristal dari kokristal metode I maupun metode II berbeda dibandingkan dengan habit kristal katekin maupun nikotinamida yang menunjukkan terbentuknya kokristal. Namun kelarutan kokristal katekin-nikotinamida metode I (132,17 mg/100 mL) maupun metode II (131,09 mg/100 mL) tidak berbeda nyata dengan kelarutan katekin (124,58 mg/100 mL). Kata kunci: kokristal, katekin, nikotinamida, kelarutan, KCKT.
MANUFACTURE OF PLASTICS FILM CONTAINING OF POLYSTIRENE, POLYCAPROLACTONE, POLY(3-HIDROKSIBUTYRATE-CO-3- HIDROXYVALERATE) AND BIODEGRADATION STUDY IN OCEAN WATER Dewi, Asiska Permata; Zaini, Erizal; Djamaan, Akmal
Jurnal Riset Kimia Vol 7, No 2 (2014): March
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v7i2.167

Abstract

 ABSTRACTThe manufacture of a biodegradable plastics film containing of polymer synthetic polystyrene(PS) and biopolymer of polycaprolactone (PCL), poly(3-hydroxybutyrate-co-3-hydroxyvalerate)[P(3HB-ko-3HV)] and biodegradation study in ocean water has been carried out. Plastics filmcontaining of PS/PCL/P(3HB-ko-3HV) produced by blending techniques followed by solventcasting with ratios were of 100/0/0, 95/5/0, 95/0/5, 90/5/5, 85/10/5, 85/5/10. This testing wasconducted based on immersion test method recommend by American Society for Testing andMaterials. Poly blend plastics film PS/PCL/P(3HB-ko-3HV) were characterized by tensilestrength, thermal properties and SEM analysis. The profiles of the rate biodegradation view byweight reduction of the tested plastic film for 1-7 weeks period. Tensile strength analysisshowed the decreasing of tensile strength with the addition of P(3HB-ko-3HV). Thermalanalysis showed a decreasing in the melting point with the addition of PCL and P(3HB-co-3HV). SEM micrograph showed the destruction occurred and erosion at surface of plastic filmduring observation time. The rate of biodegradation showed that increasing of PCL and P (3HBco-3HV) in a mixture of plastic film, so biodegradation increased.Keywords: polystyrene, polycaprolactone, poly(3-hidroxybutyrate-co-3-hydroxyvalerate),biodegradation, film plastic.
PENINGKATAN LAJU PELARUTAN TRIMETOPRIM MELALUI METODE KO-KRISTALISASI DENGAN NIKOTINAMIDA Zaini, Erizal; Halim, Auzal; Soewandhi, Sundani N.; Setyawan, Dwi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 4 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Co-crystallization of trimethoprim with nicotinamide had been done using solvent (methanol as a solvent) and melted technique. Kofler’s hot contact methode was used to identify the solid state interaction between these two components. The solid phase was characterized by microscopic, powder X-ray diffraction, thermal DTA and FT-IR spectroscopy analysis. Dissolution rate profile was performed by  paddle methode (Type II USP), distilled water as a medium. Solid state interaction between trimethoprim and nicotinamide show a formation of  conglomerate (simple eutectic) at eutectical point 125 0C. Dissolution rate of co-crystallization product of trimethoprim and nicotinamide increase  significantly compare to physical mixture and intact trimethoprim. ABSTRAK Telah dilakukan ko-kristalisasi trimetoprim dengan bahan tambahan nikotinamida dengan metode pelarutan (menggunakan pelarut metanol) dan peleburan. Metode kontak panas Kofler digunakan untuk identifikasi awal pembentukan interaksi antar kedua komponen. Padatan hasil ko-kristalisasi dikarakterisasi  dengan analisis mikroskopik, difraksi sinar-X, termal DTA dan spektrofotometer FT-IR. Uji laju pelarutan dilakukan dengan metode dayung (tipe II USP) dengan medium air. Hasil interaksi menunjukkan pembentukan konglomerat (eutektikal) antara kedua fase kristalin dalam keadaan padat, dengan titik eutektik pada temperatur 125 0C. Laju pelarutan trimetoprim hasil ko-kristalisasi meningkat secara signifikan dibandingkan dengan campuran fisika dan senyawa tunggal trimetprim.
Kajian Biodegradasi Filem Plastik Campuran Polimer Sintetik dengan Biopolimer dalam Larutan Air Octaviani, Melzi; Zaini, Erizal; Djamaan, Akmal
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 2 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1542.725 KB)

Abstract

The degradation of a plastic film containing polymer syntheticpolystyrene (PS) and biopolymer poly(3-hydroxybutyrate)[P(3HB)] and poly (3-hydroxybutyrate-co-3-hydroxy valerat)[P(3HB-co-3HV)] in various composition in aquous solution by in-vitro and in-vivo has been carried out. The testing was conducted based on immersion test in aquadest, river water, pH 4 solution, 6,8 and 10. Rate degradation measured use linear regression equality and parameter is time degradation 50% (t 50%), time degradation 95% (t 95%) and indicated by the slope (k). The result showed that, degradation of a plastic film containing PS and P(3HB) in pH 6 solution occurred faster, followed by ratio PS/P(3HB) 95:5, PS/P(3HB) 90:10, PS/P(3HB) 85:15 and PS/P (3HB) 80:20, in contrast degradation of pure PS (100:0) not occured. It is also observed that the biodegradation plastic film containing PS/P(3HB-co-3HV) in river water ratio PS/P(3HB-co-3HV) 95:5, PS/P (3HB-co-3HV) 90:10 and PS/P (3HB-co-3HV) 85:15, in contrast degradation of pure PS (100:0) not occurred.Keywords : biodegradation, polystyrene, poly(3-hydroxybutyrate), poly (3-hydroxybutyrate-co-3-hydroxyvalerat), plastic film.
Karakterisasi Kompleks Inklusi Simvastatin – β-Siklodekstrin yang Dibuat dengan Metoda Kneading Octavia, Maria Dona; Zaini, Erizal; Halim, Auzal
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
Publisher : Indonesian Research Gateway

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Abstract

ABSTRACT : Characterization of Inclusion Complex Simvastatin - β - cyclodextrin prepared by Kneading Method" has been done . This study aims to improve the dissolution rate and characterize inclusion complexes simvastatin - β - cyclodextrin developed into 3 formula , the ratio between the simvastatin and β - cyclodextrin following formula I ( 1 : 1 ), the formula II ( 1 : 2 ), and the formula III ( 2 : 1 ). Inclusion complex prepared by adding water solvent to form a paste and then dried at room temperature. The results of the inclusion complexes were characterized by analysis Differential Thermal Analysis ( DTA ), X-ray diffraction, IR spectrophotometry, Scanning Electron Microscopy ( SEM ), and dissolution rate . The results of this analysis indicate that the inclusion complex formed, characterization and dissolution profiles better than the pure simvastatin and mixed physics simvastatin and β - cyclodextrin.   Key words : Inclusion complex, Simvastatin, β-Cyclodextrin, Kneading Methods   ABSTRAK : Telah dilakukan penelitian dengan judul "Karakterisasi Kompleks Inklusi Simvastatin - β-Siklodekstrin yang dibuat dengan Metoda Kneading". Penelitian ini bertujuan untuk meningkatkan laju disolusi serta mengkarakterisasi kompleks inklusi Simvastatin - β-Siklodekstrin yang dikembangkan menjadi 3 formula, dengan perbandingan antara simvastatin dan β - siklodekstrin sebagai berikut formula I (1 : 1), formula II (1 : 2), dan formula III (2 : 1). Komplek inklusi dibuat dengan cara menambahkan pelarut air hingga terbentuk masa seperti pasta dan kemudian dikeringkan pada suhu kamar. Hasil komplek inklusi ini dikarakterisasi dengan analisa Differensial Thermal Analysis (DTA), Difraksi Sinar X, Spektrofotometri Infra Red, Scanning Electron Microscopy (SEM), dan disolusi. Hasil analisa tersebut menunjukkan bahwa kompleks inklusi yang terbentuk memberikan karakterisasi dan profil disolusi yang lebih baik dibandingkan dengan simvastatin murni dan campuran fisika simvastatin dan β-siklodekstrin yang dibuat dengan penggerusan biasa. Kata Kunci : Kompleks inklusi, Simvastatin, β-Siklodekstrin, Metoda Kneading
Identifikasi Interaksi Padat Campuran Parasetamol dan Ibuprofen dengan Metode Thermal Noviza, Deni; Zaini, Erizal
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Solid-state interaction between parasetamol and ibuprofen was studied using thermal and spectroscopic techniques. Parasetamol-Ibuprofen binary mixtures were prepared by rotary ball mill grinding method. Differential scanning calorimetry was used to investigate the stoichiometry and thermal properties of the complex between parasetamol and ibuprofen. Powder X-ray diffraction were used to investigate the type of interaction between the two components. Two endothermic peaks in a binary mixture of paracetamol and ibuprofen was observed in DSC thermograph. X-ray powder diffractogram do not shows shift and formation of new peaks and the position of each peak is a super-imposition of each component without dominates. It can be concluded that the solid interaction between paracetamol and ibuprofen for grinding effect is the formation of mixed crystal system.
Kajian Biodegradasi Filem Plastik Campuran Polimer Sintetik dengan Biopolimer dalam Larutan Air Octaviani, Melzi; Zaini, Erizal; Djamaan, Akmal
Jurnal Farmasi Indonesia Vol 6, No 2 (2012)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1542.725 KB) | DOI: 10.35617/jfi.v6i2.131

Abstract

The degradation of a plastic film containing polymer syntheticpolystyrene (PS) and biopolymer poly(3-hydroxybutyrate)[P(3HB)] and poly (3-hydroxybutyrate-co-3-hydroxy valerat)[P(3HB-co-3HV)] in various composition in aquous solution by in-vitro and in-vivo has been carried out. The testing was conducted based on immersion test in aquadest, river water, pH 4 solution, 6,8 and 10. Rate degradation measured use linear regression equality and parameter is time degradation 50% (t 50%), time degradation 95% (t 95%) and indicated by the slope (k). The result showed that, degradation of a plastic film containing PS and P(3HB) in pH 6 solution occurred faster, followed by ratio PS/P(3HB) 95:5, PS/P(3HB) 90:10, PS/P(3HB) 85:15 and PS/P (3HB) 80:20, in contrast degradation of pure PS (100:0) not occured. It is also observed that the biodegradation plastic film containing PS/P(3HB-co-3HV) in river water ratio PS/P(3HB-co-3HV) 95:5, PS/P (3HB-co-3HV) 90:10 and PS/P (3HB-co-3HV) 85:15, in contrast degradation of pure PS (100:0) not occurred.Keywords : biodegradation, polystyrene, poly(3-hydroxybutyrate), poly (3-hydroxybutyrate-co-3-hydroxyvalerat), plastic film.
PENINGKATAN LAJU PELARUTAN TRIMETOPRIM MELALUI METODE KO-KRISTALISASI DENGAN NIKOTINAMIDA Zaini, Erizal; Halim, Auzal; Soewandhi, Sundani N.; Setyawan, Dwi
Jurnal Farmasi Indonesia Vol 5, No 4 (2011)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i4.57

Abstract

Co-crystallization of trimethoprim with nicotinamide had been done using solvent (methanol as a solvent) and melted technique. Koflerâ??s hot contact methode was used to identify the solid state interaction between these two components. The solid phase was characterized by microscopic, powder X-ray diffraction, thermal DTA and FT-IR spectroscopy analysis. Dissolution rate profile was performed by  paddle methode (Type II USP), distilled water as a medium. Solid state interaction between trimethoprim and nicotinamide show a formation of  conglomerate (simple eutectic) at eutectical point 125 0C. Dissolution rate of co-crystallization product of trimethoprim and nicotinamide increase  significantly compare to physical mixture and intact trimethoprim. ABSTRAK Telah dilakukan ko-kristalisasi trimetoprim dengan bahan tambahan nikotinamida dengan metode pelarutan (menggunakan pelarut metanol) dan peleburan. Metode kontak panas Kofler digunakan untuk identifikasi awal pembentukan interaksi antar kedua komponen. Padatan hasil ko-kristalisasi dikarakterisasi  dengan analisis mikroskopik, difraksi sinar-X, termal DTA dan spektrofotometer FT-IR. Uji laju pelarutan dilakukan dengan metode dayung (tipe II USP) dengan medium air. Hasil interaksi menunjukkan pembentukan konglomerat (eutektikal) antara kedua fase kristalin dalam keadaan padat, dengan titik eutektik pada temperatur 125 0C. Laju pelarutan trimetoprim hasil ko-kristalisasi meningkat secara signifikan dibandingkan dengan campuran fisika dan senyawa tunggal trimetprim.
Identifikasi Interaksi Padat Campuran Parasetamol dan Ibuprofen dengan Metode Thermal Noviza, Deni; Zaini, Erizal
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.432 KB) | DOI: 10.35617/jfi.v7i3.190

Abstract

Solid-state interaction between parasetamol and ibuprofen was studied using thermal and spectroscopic techniques. Parasetamol-Ibuprofen binary mixtures were prepared by rotary ball mill grinding method. Differential scanning calorimetry was used to investigate the stoichiometry and thermal properties of the complex between parasetamol and ibuprofen. Powder X-ray diffraction were used to investigate the type of interaction between the two components. Two endothermic peaks in a binary mixture of paracetamol and ibuprofen was observed in DSC thermograph. X-ray powder diffractogram do not shows shift and formation of new peaks and the position of each peak is a super-imposition of each component without dominates. It can be concluded that the solid interaction between paracetamol and ibuprofen for grinding effect is the formation of mixed crystal system.
Karakterisasi Kompleks Inklusi Simvastatin – β-Siklodekstrin yang Dibuat dengan Metoda Kneading Octavia, Maria Dona; Zaini, Erizal; Halim, Auzal
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.425 KB) | DOI: 10.35617/jfi.v7i3.179

Abstract

ABSTRACT : Characterization of Inclusion Complex Simvastatin - β - cyclodextrin prepared by Kneading Method" has been done . This study aims to improve the dissolution rate and characterize inclusion complexes simvastatin - β - cyclodextrin developed into 3 formula , the ratio between the simvastatin and β - cyclodextrin following formula I ( 1 : 1 ), the formula II ( 1 : 2 ), and the formula III ( 2 : 1 ). Inclusion complex prepared by adding water solvent to form a paste and then dried at room temperature. The results of the inclusion complexes were characterized by analysis Differential Thermal Analysis ( DTA ), X-ray diffraction, IR spectrophotometry, Scanning Electron Microscopy ( SEM ), and dissolution rate . The results of this analysis indicate that the inclusion complex formed, characterization and dissolution profiles better than the pure simvastatin and mixed physics simvastatin and β - cyclodextrin.   Key words : Inclusion complex, Simvastatin, β-Cyclodextrin, Kneading Methods   ABSTRAK : Telah dilakukan penelitian dengan judul "Karakterisasi Kompleks Inklusi Simvastatin - β-Siklodekstrin yang dibuat dengan Metoda Kneading". Penelitian ini bertujuan untuk meningkatkan laju disolusi serta mengkarakterisasi kompleks inklusi Simvastatin - β-Siklodekstrin yang dikembangkan menjadi 3 formula, dengan perbandingan antara simvastatin dan β - siklodekstrin sebagai berikut formula I (1 : 1), formula II (1 : 2), dan formula III (2 : 1). Komplek inklusi dibuat dengan cara menambahkan pelarut air hingga terbentuk masa seperti pasta dan kemudian dikeringkan pada suhu kamar. Hasil komplek inklusi ini dikarakterisasi dengan analisa Differensial Thermal Analysis (DTA), Difraksi Sinar X, Spektrofotometri Infra Red, Scanning Electron Microscopy (SEM), dan disolusi. Hasil analisa tersebut menunjukkan bahwa kompleks inklusi yang terbentuk memberikan karakterisasi dan profil disolusi yang lebih baik dibandingkan dengan simvastatin murni dan campuran fisika simvastatin dan β-siklodekstrin yang dibuat dengan penggerusan biasa. Kata Kunci : Kompleks inklusi, Simvastatin, β-Siklodekstrin, Metoda Kneading
Co-Authors -, Salman AA Sudharmawan, AA Adhitya Jessica Agusri Boestari Agustina, Annisa Akmal Djamaan Amri Bakhtiar Annisa Agustina Aprilianti, Hizra Dwi Arif, Zhafira Asiska Permata Dewi Asiska Permata Dewi Asiska Permatadewi Auzal Halim Auzal Halim Azhoma Gumala Azzahra, Cindy Maynia Ben, Elfi Sahlan Dachriyanus Deni Anggraini Deni Noviza Dhea Sultana Lutfiyah Dini Hanifa Dwi Setyawan Ellyza Nasrul Elpa Giovana Zola Elsa Badriyya Elvi Rahma Yulisman Elvita Sari Fadhila, Muthia Fajriani, Aisyah Fatma Sri Wahyuni Fauzi Saputra Fauziah, Gusrina Fifi Harmely Firdaus Thantawi Firdaus, Wahyu Alfath Friardi Ismed Gaesari, Sherly Rahmah Gaesari, Sherly Rahmah Ghiffari, Habibie Deswilyaz Hansen Nasif Haq AH, Ahdi Dinil Hasmiwati Helen Sonita Henny Lucida Hulwa Salsabila Ihsan, Ikhwanul Ima Kurniati Indah Syahrani Irna Kurniati Jessica, Adhitya Kiki Rizky Wirza Kurniati, Irna Lili Fitriani Mai Efdi Maria Dona Octavia Melanny Ika Sulistyowaty Melisa Melisa Melzi Octaviani Mohd Amin, Mohd Cairul Iqbal Muhammad Taher Muthia Fadhila Najmi Hilaliyati Netty Novitasari Nova Syafni Novica Sari Prameswari, Putu Pradnya Mimba Purnawan Pontana Putra Raden Joko Kuncoroningrat Susilo Rahmadasmi, Nola Rahmadevi Rahmi Nofita Rahmi Yosmar Rahmi Yosmar Resva Meinisasti Revila, Gusti Reza Safitri Rifka Naura Rini Agustin Rini Agustin Rizky, Fattihatul Rosaini, Henni Rose Intan Perma Sari Rustini Rustini Rustini Rustini S, Agnes Saafrida Saafrida Saafrida Saafrida Saafrida Salman - Salman Salman Salman Umar Sari, Elvita Sayyidina, Fasqina Simbolon, Clara Alverina Sundani N. Soewandhi Sundani N. Soewandhi, Sundani N. Syofyan Syofyan SYUKRAN HAMDENI Syukriati Chaira Tahta Amrillah Trisfa Augia Try Andy Sahputra Try Andy Sahputra Usman, Hendrizal Uswatul Hasanah Uswatul Hasanah, Uswatul Verlia Nisrina Putri Vike Zulia Putri Vina Oktavia Yelly Oktavia Sari Yeni Novita Sari Yeyet C. Sumirtapura Yufri Aldi Yuliza, Sukma Yuska Noviyanty Zahara Gayo Zidan, Sabry A. H. Zulhadjri Zulhadjri