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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea Majalah Farmasetika JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Pharmaceutical And Biomedical Sciences Journal (PBSJ) Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Erizal Zaini
Departemen Farmasetik, Fakultas Farmasi, Universitas Andalas, Padang 25163
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Enhancing Gambir's Economic Value from Processing to Bath Soap Raw Materials: Community Service Program Uswatul Hasanah; Nova Syafni; Adhitya Jessica; Erizal Zaini; Rini Agustin
Warta Pengabdian Andalas Vol 31 No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.2.277-284.2024

Abstract

Gambir, an extract derived from the leaves and branches of the gambir plant, holds significant potential for enhancing the local economy and its benefits as a cosmetics product. Jorong Balai Tampuak Pinang, Nagari Simpang Kapuak, Kecamatan Mungka, was one of the areas producing traditional gambir in Lima Puluh Kota district, West Sumatra, Indonesia. This community service initiative aimed to augment the economic value of gambir from its processing to raw materials of bath soap. The initiative began with an educational session for training participants, outlining the advantages of gambir in skincare and how to incorporate it into bath soap formulations. Following the learning session, participants actively produced gambir-contained bath soap utilizing the provided formula. The activity received favorable feedback from participants who appreciated enhancing knowledge and skills. The outcomes of this endeavor underscore the substantial potential of developing body care products utilizing gambir as a primary ingredient. Participant testimonials underscore the need to conduct similar community engagement activities to harness Gambir's further utilization of other personal care products. The collaboration between the pharmacy study program and the local community has opened new avenues for local economic development and sustainable growth, significantly impacting the local population's well-being in the region.
Body Mist-Making Training and Socialization of Cosmetic Product Registration and Marketing Authorization to Youth Organisations in Kerinci Nova Syafni; Try Andy Sahputra; Saafrida Saafrida; Uswatul Hasanah; Rini Agustin; Rahmi Yosmar; Friardi Ismed; Erizal Zaini
Warta Pengabdian Andalas Vol 31 No 2 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.2.336-342.2024

Abstract

Indonesia is an important country that produces essential oils that are widely used in fragrance cosmetic products. The use of local essential oils for cosmetics needs to be introduced to the youth generation with the aim that they do not just become consumers. Youth organisations in Kerinci have many activities to improve their skills and abilities for a better future. Collaboration between the university and the youth organisation was achieved by providing training on doing cosmetic product training on making cosmetic products. The product uses essential oils called body mist. Nowadays, the youth still know very little about the manufacturing process of cosmetics products. To provide further benefits, this community service activity collaborated with BBPOM in Padang, West Sumatra, to explain cosmetic safety and the registration process of cosmetic products. With this series topic in this training and outreach-related cosmetics, it is hoped that it can increase business ideas for young people who are members of the Sakti Alam Kerinci Organisation.
PREPARATION AND CHARACTERIZATION PHISICOCHEMICAL PROPERTIES OF MULTI COMPONENT KETOPROFEN WITH CO-FORMER GLUTAMINE Helen Sonita; Erizal Zaini; Salman Umar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.799

Abstract

Ketoprofen is a non-steroidal anti-inflammatory compound (NSAID) which has low solubility in water. This study aimed to increase the dissolution rate of ketoprofen by forming multicomponent ketoprofen-glutamine in ratios of 1:1, 1:2, and 2:1 using the solid-state grinding method. The samples were characterized using Powder X-Ray Diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) Spectroscopy, Scanning Electron Microscope (SEM), solubility, dissolution rate, and stability tests. These results indicated the formation of a eutectic mixture of ketoprofen-glutamine. From the study of the ketoprofen–glutamine eutectic mixture, the eutectic point at a ratio of 1:1 was obtained at 95.51°C. The PXRD spectra did not show new crystal habits; the solubility test of the eutectic mixture of ketoprofen-glutamine showed increases of 2.450, 2.518, and 2.374 times, respectively. The eutectic mixture of ketoprofen–glutamine had rod-like crystal particles that formed and aggregated. The samples showed an increased dissolution rate of ketoprofen. The stability test showed that ketoprofen-glutamine was stable during storage at 75% relative humidity (RH) and 40 °C for 6 months; there was only a decrease in intensity, as seen from the PXRD spectrum. Keywords: eutectic mixture, ketoprofen, glutamine, solubility, dissolution rate, stability
Review Pembuatan Kokristal Farmasi dengan Metode Mekanokimia Yenti, Revi; Zulhadjri, Zulhadjri; Efdi, Mai; Zaini, Erizal
Majalah Farmasetika Vol 9, No 1 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v9i1.48094

Abstract

Pengembangan bahan aktif farmasi saat ini cukup pesat, salah satunya adalah pengembangan kokristal. Kokristal dibuat dengan menggabungkan antara bahan aktif farmasi dan koformernya dengan berbagai metode misalnya pelarutan dan penggilingan. Mekanokimia adalah metode yang efektif untuk persiapan sistem kristal multikomponen. Mekanokimia dianggap sebagai alternatif pendekatan ramah lingkungan karena dilakukan dalam kondisi bebas pelarut atau dengan adanya pelarut dalam jumlah minimal. Artikel review ini dibuat dengan metode instrumen pencarian online terbitan internasional yang akan membahas definisi dan sejarah kokristal farmasi, teknik pembuatan kokristal, sejarah dan definisi mekanokimia, metode mekanokimia pada pembuatan kokristal farmasi, mekanisme metode mekanokimia, serta keuntungan dan kerugian metode mekanokimia. Oleh karena itu pada ulasan ini dijelaskan dan dibahas relevansi prosedur mekanokimia dalam pembentukan kristal multikomponen yang fokus pada kokristal farmasi. Selain itu pada akhir tinjauan ini juga dilaporkan ringkasan makalah ilmiah tentang sintesis mekanokimia kokristal farmasi.
Literature Review: Application Lyotropic Liquid Crystals in Topical and Transdermal Drug Delivery Systems Rahmadasmi, Nola; Zaini, Erizal; Agustin, Rini
JURNAL PROTEKSI KESEHATAN Vol 12 No 2 (2023): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v12i2.681

Abstract

This review article discusses the composition, formula, characterization, lyotropic liquid crystals which are formulated in topical and transdermal preparations with different liquid crystal phase carriers. Lyotropic liquid crystals have considerable potential in drug delivery systems. Lyotropic liquid crystals can be characterized by polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), atomic force microscopy (AFM), thermogram electron microscopy (TEM), particle size, viscosity, drug release studies, drug permeation studies. . The formation of liquid crystals can be ascertained by observing birefringence using PLM or SAXS. This review also focuses on the structural classification of lyotropic liquid crystals into cubic, lamellar, and hexagonal phases. The structure of these phases is affected by the addition of surfactants, which include a variety of non-toxic, biodegradable lipids and also enhance drug solubility, drug permeation, bioavailability, and drug efficacy.
Literature Review: Multicomponent Crystal of Active Pharmaceutical Ingredients to Improve the Solubility Haq AH, Ahdi Dinil; Umar, Salman; Zaini, Erizal
JURNAL PROTEKSI KESEHATAN Vol 12 No 2 (2023): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v12i2.683

Abstract

The purpose of this review was to discuss abouts active pharmaceutical ingredients (API), formulations of drugs that are poorly soluble in water using various coformers and various methods of forming multicomponent crystals to increase the solubility of API. The formula used is equivalent in molecular weight between the active pharmaceutical ingredients (API) and coformers, using solvent evaporation and solvent drop grinding methods. A series of characterizations using X-ray Diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) and Scanning electron microscopy (SEM) to confirm the formation of multicomponent crystals. The analysis from the results of the research show an increase in the solubility of API in water, that is 1.3 up to 115 times compared to intactsubstances.
Improvement of Solubility Usnic Acid Loaded on Mesoporous Silica SBA-15 and Physicochemical Characterization Fitriani, Lili; Azzahra, Cindy Maynia; Jessica, Adhitya; Hasanah, Uswatul; Zaini, Erizal
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.251-259

Abstract

Usnic acid, a secondary metabolite of lichen Usnea sp., has several pharmacological activities, but it is poorly soluble in water. This study aimed to improve the solubility and dissolution rate of usnic acid loaded in mesoporous silica SBA-15 at a mass ratio of 1:1. and evaluate its physical stability. Physicochemical characterization was carried out via the nitrogen adsorption desorption isotherm, differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, and powder X-ray diffraction (PXRD). Usnic acid-loaded SBA-15 was stored at 40 °C with various relative humidities (RH) and then analyzed by PXRD for the physical stability. Usnic acid adsorbed well in the pores of SBA-15, as shown by a decrease in the volume pore and surface area of SBA-15 according to the nitrogen adsorption. Moreover, usnic acid-SBA-15 showed a decrease in the degree of crystallinity according to PXRD analysis and no melting point based on DSC analysis. The FTIR spectrum of usnic acid–SBA-15 corresponds to the spectra of each raw material. The solubility of usnic acid increased 5.15 times after adsorbed on SBA-15. The dissolution rate also showed a significant increase (p < 0.05) from 19.51% to 84.27%. Usnic acid–SBA-15 was relatively stable at RH 75%. Thus, the adsorption of usnic acid on SBA-15 can increase its solubility, dissolution rate, and physical stability.
A Comparison Study between Green Synthesis of Microwave Irradiation and Solvent Evaporation Methods in The Formation of p-Methoxycinnamic Acid-Succinic Acid Cocrystals Sulistyowaty, Melanny Ika; Setyawan, Dwi; Prameswari, Putu Pradnya Mimba; Susilo, Raden Joko Kuncoroningrat; Amrillah, Tahta; Zaini, Erizal; Zidan, Sabry A. H.
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.629-636

Abstract

Cocrystal of p-Methoxycinnamate acid-succinic acid has been produced by microwave irradiation and solvent evaporation methods. Cocrystals are formed using succinic acid as the coformer at a molar ratio of 1:1. The formation of cocrystal can be done by solvent evaporation method and microwave radiation method. Physicochemical properties have been studied by FT-IR, DSC, PXRD, and SEM analysis. The solubility test was carried out with pH 6.8 phosphate buffer at a temperature of 25±0.5°C for 5 hours and the dissolution test was carried out with 900 mL pH 6.8 phosphate buffer at a temperature of 37±0.5°C with the speed of 75 rpm using a paddle-type dissolution test apparatus. The solubility of PMCA has increased its solubility in cocrystals by the solvent evaporation method by 1.19 times and by the microwave radiation method by 1.16 times compared to PMCA. The dissolution rate of the cocrystals of the solvent evaporation method increased by 3.50 times and the cocrystals of the microwave radiation method increased by 2.29 times compared to PMCA.
Ketoprofen-Tromethamine: Binary Phase Diagram of Multicomponent Crystal, Dissolution Rate, and Analgesic Activity Evaluation Hasanah, Uswatul; Badriyya, Elsa; Safitri, Reza; Yuliza, Sukma; Ihsan, Ikhwanul; Saafrida; Rosaini, Henni; Jessica, Adhitya; Zaini, Erizal
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.726-734

Abstract

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose formulation options are limited due to its low dissolution rate in aqueous media. This research aimed to enhance the solubility of ketoprofen in distilled water and to compare the anti-inflammatory and analgesic effects of its resulting multicomponent crystal with tromethamine. The binary phase diagram of ketoprofen-tromethamine was created across molar ratios ranging from 1:9 to 9:1. The multicomponent crystal comprising ketoprofen and tromethamine in the selected ratio was synthesized using a solvent drop grinding method and subjected to further characterization for thermal properties, crystallinity, chemical groups, and morphology. The dissolution rate assessments were evaluated in CO2-free distilled water. Pharmacological analyses examined the anti-inflammatory and analgesic effects of the multicomponent crystal. The binary phase analysis identified the 5:5 (1:1) molar ratio as optimal in forming a multicomponent crystal. Thermograms and diffractograms revealed crystalline alterations attributed to a new crystalline phase. The new multicomponent crystal exhibited approximately 2.7 times higher dissolution rate after 30 minutes, outperforming pure ketoprofen. Pharmacological assessments demonstrated superior analgesic effects of the multicomponent crystal. In summary, the ketoprofen-tromethamine cocrystal in 1:1 molar ratio offers enhanced dissolution rate and provides better analgesic activity than ketoprofen alone.
PENGARUH PENYIAPAN DISPERSI PADAT ATORVASTATIN CALCIUM-POLIVINILPIROLIDON K-30 (PVP K30) TERHADAP KARAKTERISTIK, KELARUTAN DAN DISOLUSI Aprilianti, Hizra Dwi; Umar, Salman; Zaini, Erizal
Jurnal Farmasi Higea Vol 16, No 1 (2024)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v16i1.609

Abstract

Tujuan dari penelitian ini adalah untuk meningkatkan kelarutan dari atorvastatin kalsium yang memiliki kelarutan rendah didalam air dengan menggunakan metode dispersi padat. Metode dispersi padat yang digunakan adalah penguapan pelarut (solvent evaporation). Dispersi padat atorvastatin kalsium dan polivinilpirolidon K-30 sebagai polimer dibuat dengan perbandingan 1:9, 3:7, 5:5, 7:3, dan 9:1. Hasil uji kelarutan dan disolusi dispersi padat yang terbaik dilakukan karakterisasi dengan analisis powder X-ray diffraction (PXRD), fourier transform infrared (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM). Hasil uji kelarutan menunjukkan kelarutan dispersi padat 1:9 memiliki kelarutan yang paling tinggi dengan peningkatan kelarutan 9,986 kali. Hasil persen terdisolusi menit ke-30 yang terbaik pada dispersi padat 1:9 dalam dapar fosfat pH 6,8 adalah 86,136%. Berdasarkan hasil karakterisasi menunjukan bahwa terbentuknya dispersi padat atorvastatin kalsium dan polivinilpirolidon K-30 (PVP K-30) yang bersifat amorf. Kesimpulannya dispersi padat atorvastatin kalsium dan polivinilpirolidon K-30 menggunakan metode penguapan pelarut dapat meningkatkan kelarutan dari atorvastatin kalsium.
Co-Authors -, Salman Adhitya Jessica Agusri Boestari Agustina, Annisa Akmal Djamaan Amri Bakhtiar Andarifera, Alya Zahira Annisa Agustina Aprilianti, Hizra Dwi Arif, Zhafira Asiska Permata Dewi Asiska Permata Dewi Asiska Permatadewi Auzal Halim Auzal Halim Azzahra, Cindy Maynia Ben, Elfi Sahlan Deni Anggraini Deni Noviza Dhea Sultana Lutfiyah DINI HANIFA, DINI Dwi Setyawan Ellyza Nasrul Elpa Giovana Zola Elsa Badriyya Elvi Rahma Yulisman Elvita Sari Fadhila, Muthia Fauzi Saputra Fifi Harmely Friardi Ismed Gaesari, Sherly Rahmah Gaesari, Sherly Rahmah Gumala, Azhoma Habibie Deswilyaz Ghiffari Hansen Nasif Haq AH, Ahdi Dinil Hasmiwati Helen Sonita Henny Lucida Hulwa Salsabila Ihsan, Ikhwanul Ima Kurniati Irna Kurniati Jessica, Adhitya Kiki Rizky Wirza Kurniati, Irna Lili Fitriani Mai Efdi Maria Dona Octavia Melanny Ika Sulistyowaty Melisa Melisa Melzi Octaviani Mohd Amin, Mohd Cairul Iqbal Muhammad Taher Muthia Fadhila Mutiara Zulkarnaini Najmi Hilaliyati Netty Novitasari Nova Syafni Novica Sari Prameswari, Putu Pradnya Mimba Raden Joko Kuncoroningrat Susilo Rahmadasmi, Nola Rahmadevi Rahmi Nofita Rahmi Yosmar Rahmi Yosmar Resva Meinisasti Revila, Gusti Reza Safitri Rifka Naura Rini Agustin Rini Agustin Rizky, Fattihatul Rosaini, Henni Rose Intan Perma Sari Rustini Rustini Rustini Rustini S, Agnes Saafrida Saafrida Saafrida Saafrida Saafrida Salman - Salman - Salman Salman Salman Umar Sari, Elvita Sayyidina, Fasqina Simbolon, Clara Alverina Sundani N. Soewandhi Sundani N. Soewandhi, Sundani N. Syofyan Syofyan SYUKRAN HAMDENI Syukriati Chaira Tahta Amrillah Trisfa Augia Try Andy Sahputra Try Andy Sahputra Usman, Hendrizal Uswatul Hasanah Uswatul Hasanah, Uswatul Verlia Nisrina Putri Vike Zulia Putri Vina Oktavia Yeni Novita Sari Yeyet C. Sumirtapura Yufri Aldi Yuliza, Sukma Yuska Noviyanty Zahara Gayo Zidan, Sabry A. H. Zulhadjri Zulhadjri