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All Journal HAYATI Journal of Biosciences Jurnal Pengolahan Hasil Perikanan Indonesia Atom Indonesia Journal Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY The Indonesian Biomedical Journal JOIV : International Journal on Informatics Visualization JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Ilmu Kefarmasian Indonesia Majalah Patologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Narra J Indonesian Journal of Cancer Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Indonesian Journal of Medical Chemistry and Bioinformatics Jurnal Kefarmasian Indonesia Biodiversitas Journal of Biological Diversity
Kusmardi
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : indonesian journal of pharmacy

 1 
Potential Deleterious Effects of L-Citrulline Supplementation in Isoproterenol-Induced Myocardial Infarction: Focus on Nitrosative Stress Gregorius Bhaskara Wikanendra; Wawaimuli Arozal; Kusmardi Kusmardi; Vetnizah Juniantito; Andrea Laurentius
Indonesian Journal of Pharmacy Vol 30 No 4, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm30iss4pp269

Abstract

L-Citrulline shows potential activity as a supplement to prevent myocardial infarction through vasodilative and possible antioxidative effects but may be deleterious by causing nitrosative stress. This study determined the potentially deleterious effects of L-citrulline supplementation in isoproterenol-induced myocardial infarction with a focus on nitrosative stress. L-Citrulline supplementation was given orally at dosages of 300 or 600mg/kg body weight daily for 6 days. Myocardial infarction was induced in Wistar rats via subcutaneous injection of isoproterenol (85 mg/kg body weight (BW)) on day 4 and 5. Blood pressure was measured at the end of the study (day 6) and rats were sacrificed to collect heart tissue samples for a histopathological evaluation. The histopathological evaluation was done using hematoxylin and eosin staining for the myocardial damage evaluation and immunohistochemical (IHC) staining of arginase-2, inducible nitric oxide synthase (iNOS), and 3-nitrotyrosine to evaluate nitrosative stress. L-Citrulline supplementation failed to show a significant protective effect on blood pressure and exacerbated the decrease of diastolic blood pressure. Both low and high dose L-citrulline supplementation had a significant protective effect on myocardial damage compared to the isoproterenol group (p<0.01). L-Citrulline also caused increased nitrosative stress as shown by increased expression of arginase-2 and 3-nitrotyrosine on IHC staining but tended to show an ameliorative effect on iNOS expression. A significant increase in arginase-2 expression was detected between the high dose group and the other groups (p<0.01 vs. normal and isoproterenol groups; p<0.05 vs. low dose group). L-Citrulline supplementation increased 3-nitrotyrosine expression in a dose-dependent manner, which was significantly different compared to the normal group (low dose: p<0.013; high dose: p<0.003). L-Citrulline increased the production of nitrosative stress but resulted in less myocardial damage through its other effects.
Co-Authors . Hayun . Syamsudin Adisti Dwijayanti Adriana Viola Miranda Afif Rasyad Agnes Stephanie Harahap Alfred Pakpahan Andrea Laurentius Aniati Murni Anwar S. Ibrahim Anwar S. Ibrahim Aprilliyani, Ifana Ari Estuningtyas Ariadi Humardhani Ariffandi, Bagas Arleni Bustami Aryo Tedjo Atmaja, Fredy Wirya Ayu Werawati Azizah, Norma N. Bambang Ponco Priosoeryanto Berna Elya Budiana Tanurahardja Budiana Tanurahardja D. P. Perkasa Dayanto Indro Utomo Dewi Sukmawati Diah Rini Handjari Dian Ratih Laksmitawati Dimas Ramadhian N Ditha Diana Ditha Diana Diyah Kristianty Dwitia Wulandari Endang SR Hardjolukito Endang SR. Hardjolukito Endang Sri Roostini Hardjolukito Enif Esti Triana Ening Krisnuhoni Erlina, Linda Erwina Muhadi Esti Mumpuni Fadhillah, Muhamad Rizqy Fajriati, Annisa Gregorius Bhaskara Wikanendra Ham, Maria Francisca Hamdani Zain Hanum, Sitti Fatimah Hardjolukito, Endang SR Hashim, Najihah M. Hellyanti, Tantri Hendig Winarno Hendig Winarno Heri Wibowo Heru Suhartanto Hikariastri, Pangartika Imelda Setiana Silitonga Irandi Putra Pratomo Ismalasari, Wahyu Jasni Mohammad Zain Juliana Irem Adriana Purukan Karina Rahmaningrum Khatimah, Nurul Gusti Kristanty, Diyah Ladeska, Vera Landyyun Rahmawan Sjahid Landyyun Rahmawan Sjahid Lestari, Tri Wahyuni Lili Indrawati Linggodigdo, Michelle Lisnawati Lisnawati Liviandari, Regina Lubis, Nadar Sukri M. Syaifudin Maris, Stephanie Megawati, Ajeng Mieke Marindawati Muhammad Hanafi Murtiani, Farida Nina Yolanda Putri Noor, Dimas Ramadhian Novi Fajar Utami Nurdin, Wildawati Nurhuda Sahar Pangartika Hikariastri Peni Kistijani Samsuria Ponco Birowo Putri Reno Intan Ramadhian N, Dimas Rani Wardani Hakim Regina Liviandari Rino Patiatta Rizky Clarinta Putri Rohmat, Siti Saudah Shirly Kumala Silitonga, Imelda Setiana Sri S. Ningsih, Sri S. Sri Suryo Adiyanti, Sri Suryo Stephanie Maris Surya Dwira Syamsu Nur, Syamsu Syamsudin Abdillah Syofyan, Stephen Dario Toto Haryanto Triana, Novi Utomo, Dayanto Indro Vetnizah Juniantito Virhan Novianry Vivi Setiawaty Vivitri Prasasty W. Arozal Wahyu Hidayati Wahyu Hidayati Wahyu Ismalasari Wangi, Surya Buana Wawaimuli Arozal Welly Hartono Ruslim Widiantari, Aninda Dinar Wildawati Nurdin Wiwiek Ernajanti Wiyanto, Marwito Yulhasri Yulhasri Yusoff, Marina Yusra Yusra