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Disfungsi Seksual Pada Wanita Dengan Polikistik Ovarium Sindrom: Systematic Review Aprida Putri; Safari Wahyu Jatmiko; Nining Lestari; Dodik Nursanto
Prosiding University Research Colloquium Proceeding of The 13th University Research Colloquium 2021: Kesehatan dan MIPA
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Latar belakang: Polikistik ovarium sindrom (PCOS) adalah kelainan endokrin yang paling umum terjadi pada wanita usia reproduksi. Ini memengaruhi hampir 20% dari mereka, namun persentase ini bervariasi sesuai dengan kriteria diagnostik yang diadopsi. Sindrom ini ditandai dengan oligo-amenore, dengan atau tanpa hiperandrogenisme/hiperandrogenemia atau morfologi ovarium polikistik, dan obesitas juga sangat sering dikaitkan dengannya. Ciri PCOS tersebut jadi faktor terbentuknya morbiditas psikologis penderita, sebab penderita merasa kurang feminin serta memelihara perasaan yang lebih depresi. Mereka bisa jadi pula secara negatif mempengaruhi citra diri mereka yang berakibat pada seksualitas. Fungsi seksual tergantung pada integrasi aspek fisik, sosioemosional, serta intelektual. Pengetahuan yang lebih baik tentang kejadian, penyebab dan faktor risiko disfungsi seksual pada wanita dengan PCOS akan membantu dalam pencegahan, pengobatan dan prognosis pasien. Tujuan: Peneliti ingin mengetahui adakah pengaruh PCOS terhadap disfungsi seksual pada wanita dengan polikistik ovarium sindrom? Metode: Penelitian ini adalah studi systematic review. Data yang diperoleh adalah data sekunder yaitu hasil penelitian yang sudah dilakukan oleh peneliti terdahulu. Sumber data sekunder yang diperoleh berupa artikel jurnal internasional. Pencarian literature dalam systematic review ini menggunakan dua database yaitu Pubmed, Science Direct. Hasil: Didapatkan hasil data gabungan dari 2 database sebanyak 1764 artikel, 29 terduplikat, sisa hasil didapatkan 1735 artikel, dieliminasi kembali sesuai tittle, abstrack dan fulltext didapatkan 1491 data exclude, hasil sisa 244 artikel diantara nya data full text excluded 232 dan sebanyak 12 data yang sudah dilakukan analisa kritis. Kesimpulan: Berdasarkan hasil penelitian atau tinjaun sistematis dari 12 artikel dapat disimpulkan bahwa tidak ada perbedaan signifikan antara kejadian disfungsi seksual pada wanita dengan PCOS dibanding kontrol dalam skor FSFI, tetapi terdapat efek kecil yang signifikan ditemukan pada subskala fungsi seksual (gairah: P = 0,019; lubrikasi: P = 0,023; kepuasan: P = 0,015; orgasme: P = 0,028), hal ini menunjukkan gangguan fungsi seksual pada wanita dengan PCOS.
Toll-Like Receptor Activation and B Cell Maturation Via MyD88-Dependent Pathway Under Hyperglycemia Condition Riandini Aisyah; Safari Wahyu Jatmiko
Bioeksperimen: Jurnal Penelitian Biologi Vol 10, No 1: March 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v10i1.23328

Abstract

hyperglycemia causes a degenerative syndrome that involves an inflammatory process with an increase in certain proinflammatory cytokines and chemokines which in the process will activate B cells to produce immunoglobulins through several mechanisms. One of the interesting mechanisms is the mechanism via the MyD88 pathway. Objectives: to explore the role of MyD88 adapter protein in Toll-like receptor activation and B cell maturation under hyperglycemia conditions. Methods: a literature review was done to answer the study objectives. Results: Class switching process under hyperglycemia conditions involves activation of NFkB through the inflammatory MyD88-dependent pathway to trigger the expression of TLR and B cell maturation and proliferation as well as antibody production. The MyD88 adapter protein is a protein formed by stimulation of pro-inflammatory cytokines IL-6 and plays a role in the continuation of signals from the TLR and IL-1 pathways. Mature B cell stimulation induces 2 genetic changes in the Ig gene locus, called somatic hypermutation (SHM) and class switch recombination (CSR) to produce antibodies. Changes in immunoglobulin genes occur related to changes in certain DNA segments at the locus of genes where CSR occurs, this gene change requires the role of AID (activated-induced cytidine deaminase) in DNA cleavage. AID in mature B cells is activated by proinflammatory cytokines via induction of NfKB activation via the inflammatory MyD88-dependent pathway. Conclusion: Toll-like receptor activation plays a crucial role in B cell maturation activated by pro-inflammatory cytokine via MyD88 dependent-NFkB activation. 
Expression and Activation of Toll-Like Receptor 9 in Dengue Virus Infection: A Scoping Review Safari Wahyu Jatmiko; Riandini Aisyah
Bioeksperimen: Jurnal Penelitian Biologi Vol 9, No 2: September 2023
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v9i2.23052

Abstract

Toll-like receptors (TLR) are essential to pathogen recognition to activate innate immunity. TLR2, 3, 4, 6, 7, 8, and 9 are involved in immunity to dengue virus. The involvement of TLR9, known to recognize CpG DNA, in dengue virus (DVI) infection, an RNA virus, is unusual. We hypothesize that there is an elevated expression and activation of TLR9 through specific mechanisms in DVI. A scoping review was carried out to collect articles that have been written regarding this topic. Article searches were carried out on the PubMed (Medline), Proquest, EBSCO, and Google Scholar databases with inclusion criteria: articles in the form of research results using human subjects or human cells, conducted from 2013 to 2023, in English, and can be accessed in full -text. Gray articles, books, and review articles were excluded from the study. The literature search results found 821 articles, with eight articles meeting the criteria. Based on mapping, synthesis, and analysis of the articles obtained, it was found that there was increased expression and activation of TLR9 in the DVI due to the release of mtDNA. 
Correlations between Age and Hypertension on Diabetic Foot Ulcer Marsya, Vitania; Mahmuda, Iin Novita Nurhidayati; Lestari, Nining; Jatmiko, Safari Wahyu
Indonesian Journal of Medicine Vol. 8 No. 2 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.2.622

Abstract

Background:  Diabetic foot ulcer is a wound located on the foot of a diabetic patient, which is related to peripheral neuropathy or arterial disease. Hypertension can be related to diabetic foot ulcer by its mechanism that caused peripheral artery disease. Age also can be the one of risk factors for diabetic foot ulcers, because aging occurs a reduction of insulin secretion, even insulin resistance. Insulin resistance occurs in macroangiopathy. The purpose of this study is to determine the correlation between age and hypertension with diabetic foot ulcers.Subjects and Method:  This was a cross-sectional study conducted at Arafah Islamic Hospital Rembang, Central Java. The dependent variable is diabetic ulcers. The independent variables were age and hypertension. A sample of diabetic patients using medical records from January 2022-June 2022. Data were collected using purposive sampling and analyzed using the Chi-Square test, and regression logistic test.Results:  Significant correlation was found between age (OR= 3.80; 95% CI= 1.38 to 10.57; p<0.001) and hypertension (OR= 8.12; 95% CI= 2.70 to 24.40; p<0.001) with a diabetic foot ulcer.Conclusion:  There is a significant correlation between age and hypertension with diabetic foot ulcers.Keywords:  age, hypertension, diabetes, diabetic foot ulcers.Correspondence:  Nining Lestari. Bachelor of Medicine, Muhammadiyah University of Surakarta. Jl. A. Yani, Mendungan, Pabelan, Kartasura, Sukoharjo 57162, Central Jawa, Indonesia. Email: nl209@ums.ac.id. Mobile: +62852-2939-0353Indonesian Journal of Medicine (2023), 08(02): 179-185https://doi.org/10.26911/theijmed.2023.08.02.07 
Optimalisasi Jumantik dan Pemberantasan Sarang Nyamuk dalam Mencegah Penularan Infeksi Virus Dengue pada Kader di Desa Karangbangun: Optimizing Human Resources and the Environment in Preventing the Transmission of Dengue Virus Infection to Cadres in Karangbangun Village Bestari, Rochmadina Suci; Jatmiko, Safari Wahyu; Aisyah, Riandini; Wahyuni, Sri; Mahmudah, Nur; Agustina, Tri; Salsabila, Nabila Mutia; Adha, Muhammad; Kumala, Aswa Arsa; Fauzi, Favian Arriella Shabri Ikmal
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 3 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i3.8528

Abstract

Dengue virus infection (IVD) is still a health problem in Indonesia. In Karangbangun Matesih Karanganyar Village, there were 13 cases of IVD in April 2024. The government program to eradicate IVD vectors has not been implemented optimally. Karangbangun Village has potential healthcare resources to be used as agents for eradicating IVD vectors. So far there has been no education about the function of jumantik as larva monitors and mosquito nest eradication (PSN). Therefore, it is necessary to provide education about the function of jumantik and PSN to health cadres in Karangbangun Village. The aim and benefit of this community service activity is that the health cadres of Karangbangun Matesih Karanganyar Village understand the function of jumantik and PSN. The extension activity was preceded by a pretest, and speaker presentation and ended with a posttest. The results of the education showed an increase in health cadres' knowledge after the education based on a comparison of pre-test and post-test scores (p<0.001; Effect Size (Cohen's d) = -1.993). Education about the function of jumantik and eradicating mosquito nests to health cadres in Karangbangun Village increased knowledge significantly and the average post-test score showed an increase.
PENINGKATAN PENGETAHUAN DEMAM BERDARAH DAN FAKTOR RISIKO YANG DAPAT DIMODIFIKASI PADA KADER KESEHATAN DESA KARANGBANGUN MELALUI EDUKASI Jatmiko, Safari Wahyu; Aisyah, Riandini; Wahyuni, Sri; Mahmudah, Nur; Bestari, Rochmadina Suci; Agustina, Tri; Wafiq, Muhammad Azzim; Tara , Irmanawati Audhina Nirmala
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 1, Maret 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i1.6966

Abstract

ABSTRAK Kondisi geografis desa Karangbangun, Matesih, Karanganyar secara teori relatif kurang berisiko untuk mengalami kejadian infeksi virus dengue (IVD). Akan tetapi, fakta di lapangan menunjukkan bahwa terjadi 13 kasus IVD pada bulan April 2024. Sumber daya desa Karangbangun strategis dalam mendukung pemberantasan IVD. Sumber daya manusia berupa kader gizi dan kader kesehatan yang potensial di desa Karangbangun potensial untuk ditingkatkan dalam rangka eradikasi IVD. Sumber daya tersebut perlu dilakukan edukasi untuk optimalisasi eradikasi IVD. Selama ini belum ada edukasi yang tepat mengenai hal tersebut sehingga perlu diadakan edukasi mengenai penyakit IVD beserta faktor risiko yang memperberat IVD. Tujuan dan manfaat kegiatan pengabdian masyarakat ini adalah kader kesehatan dan kader gizi desa Karangbangun, kecamatan Matesih memahami tentang IVD beserta faktor risiko yang memperberat IVD. Penyuluhan kesehatan dengan melakukan pretes dan postes pasca penyuluhan dilakukan untuk mengatasi masalah permasalahan mitra. Hasil penyuluhan adalah terjadi peningkatan pengetahuan kader kesehatan pasca penyuluhan berdasarkan perbandingan median nilai ptretes 6 (2) dan postes 7 (2) dengan nilai p=0,002 dan rB=0,59. Edukasi kesehatan terhadap kader kesehatan desa Karangbangun dengan metode ceramah berhasil meningkatkan pengetahuan kader mengenai IVD dan faktor risiko yang memperberat IVD.   ABSTRACT The geographical conditions of Karangbangun Village, Matesih, Karanganyar, are theoretically considered to have a relatively low risk of dengue virus infection (DVI). However, field data revealed 13 DVI cases in April 2024. Karangbangun Village has strategic resources to support DVI eradication, including potential health and nutrition cadres who can be further empowered. These resources require education to optimize DVI eradication efforts.  Currently, there is no adequate education on this matter, highlighting the need for awareness programs on DVI and its aggravating risk factors. The goal and benefit of this community service activity are to equip health and nutrition cadres in Karangbangun Village, Matesih District, with knowledge about DVI and its risk factors. A health education session, including pre- and post-tests, was conducted to address partner issues. The results showed an increase in cadre knowledge, with a median pre-test score of 6 (2) and a post-test score of 7 (2), yielding p=0.002 and rB=0.59. Health education through lectures successfully improved cadres' understanding of DVI and its risk factors.
Correlation of Eosinophil-basophil Count and Ratio with Length of Stay in Children Dengue Infection Yunitama, Alifa Agil Dhillu; Puspitasari, Metana; Jatmiko, Safari Wahyu; Fauziyah, Nida Faradisa
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5486

Abstract

Purpose: This study purpose is to determine the correlation between the number of absolute eosinophils, absolute basophils, and eosinophil-basophil ratio (EBR) with the length of stay of pediatric patients with dengue virus infection. Methodology: The study design used cross-sectional. The samples used in this study were taken from routine hematologic laboratory medical record data for the period January-October 2024, using consecutive non-probability sampling technique. Results: 49 samples were obtained and met the restriction criteria as subjects of this study. The results of the Spearman correlation bivariate test showed that the number of absolute eosinophil count, absolute basophil count, and EBR with length of stay had statistical data results respectively p = 0.139, p = 0.993, and p = 0.536. Applications/Originality/Value: This study provides a reference in laboratory results to determine the length of stay (LOS) in children with dengue virus infection.
Correlation of Dengue Infection Severity with Abdominal Pain, Delta Hematocrit, Platelet Count, and Delta Hematocrit-Platelet Ratio in Pediatric Patients Agustina, Dinda Dwi; Puspitasari, Metana; Jatmiko, Safari Wahyu
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5503

Abstract

Purpose: This study aimed to determine the correlation between the severity of dengue infection and abdominal pain, delta hematocrit, platelet levels, and the delta hematocrit-platelet ratio. Methodology: the study used a correlational observational design with a cross-sectional approach. Data were obtained from the medical records of dengue infection patients at PKU Muhammadiyah Sampangan Hospital from October–November 2024. A total of 39 samples were selected using a consecutive non-probability sampling technique. Data analysis was performed using JASP statistical software version 0.19.1.0. Results: The study revealed no significant relationship between the severity of dengue infection and abdominal pain (p=0.089), delta hematocrit (p=0.589), platelet levels (p=0.068), or the delta hematocrit-platelet ratio (p=0.740). Applications/Originality/Value: This study provides valuable insights into the limitations of individual clinical and laboratory parameters, emphasizing the need for a comprehensive approach to assessing dengue severity in pediatric patients.
Correlation of Mean Corpuscular Hemoglobin, Mean Corpuscular Hemoglobin Concentration and Platelet to Hemoglobin Ratio with the Degree of Dengue Virus Infection in Pediatric Patients Alim, Fika Nurul; Jatmiko, Safari Wahyu; Puspitasari, Metana
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5511

Abstract

Purpose: This study aimed to evaluate the correlation between MCH, MCHC, and PHR with the severity of DVI in pediatric patients. Methodology: A cross-sectional observational study was conducted on 47 pediatric DVI patients at PKU Muhammadiyah Sampangan Hospital, Surakarta. Medical records from January to May 2024 were analyzed. Data were statistically evaluated using Spearman’s test to determine the correlation between variables. Results: Among 47 patients, 57.45% had dengue without warning signs, while 42.55% had dengue with warning signs, with no cases of severe dengue. There was no significant correlation between MCH (p=0.383, r=0.130), MCHC (p=0.457, r=-0.111), or PHR (p=0.064, r=-0.273) and the severity of DVI. Applications/Originality/Value: This study examines the roles of MCH, MCHC, and PHR in pediatric dengue virus infection, finding no significant correlation with disease severity. It provides a basis for future research on alternative hematological markers to enhance clinical assessment. This research introduces PHR as a novel parameter in dengue studies, providing a unique perspective on its potential relevance to disease pathophysiology.
Correlation of Length of Fever before Hospital Admission, Hematocrit, Platelet Count, and Leukocytes with Length of Hospitalization Dengue Virus Infection Patients in Children Pambudi, Nasrurrofiq Risvana Bayu; Puspitasari, Metana; Jatmiko, Safari Wahyu; Aisyah, Riandini; Alfajri, Asri
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5525

Abstract

Purpose: To analyze the relationship between fever duration before admission, hematocrit, platelet count, and leukocyte count with length of hospital stay in pediatric patients with dengue infection. Methodology: This observational study with cross-sectional design was conducted at PKU Muhammadiyah Sampangan Hospital, Surakarta, using secondary data from medical records. Forty pediatric patients were selected through consecutive non-probability sampling technique. Statistical analysis was performed with Spearman correlation test using statistical applications. Results: There was a significant association between fever duration before admission and length of hospitalization (r = -0.407, p = 0.009). However, there was no significant association between hematocrit (r = 0.136, p = 0.403), platelet count (r = 0.101, p = 0.536), or leukocyte count (r = 0.111, p = 0.496) with length of hospitalization. Applications/Originality/Value: This study highlights the importance of early detection and intervention in managing pediatric dengue cases. The significant correlation found between fever duration prior to admission and length of stay underscores the need for prompt treatment to minimize hospital stay due to associated inflammation in the body. In contrast, the lack of significant associations between hematocrit, platelet count, leukocyte level and duration of hospitalization highlights the complexity of factors influencing outcomes and the need to explore other prognostic markers. This study conducted in an endemic region of Indonesia contributes to understanding the management of dengue virus infection and underscores the importance of a comprehensive multifactorial approach to improve patient care strategies.
Co-Authors Affifah, Fathiyya Noor Agus Widodo Agustina, Dinda Dwi Ahmad Alrizaldi Alfajri, Asri Alim, Fika Nurul Anam, Ilham Hafizha Maulana Anggitaratri, Zakia Novi Anika Candrasari Annas Syahirul Nugraha Annas Syahirul Nugraha, Annas Syahirul Annisa Maulidia Anton Agus Setyawan Aprida Putri Aqmarina, Nadia Wdihi Arif Pristianto Arkan Adi Widiya Arkan Adi Widiya, Arkan Adi Aryanto Asfarina, Fatin Aulia Hanif Azenta, Moch. Tabriz Azhim Rahmawati Azhim Rahmawati, Azhim Brilliantama, Fandy Akbar Budi Rahayu, Ummi Devi Usdiana Rosyidah Dewangga, Mahendra Wahyu Dewi, Asri Seftika Dewi, Listiana Masyita Dodik Nursanto Dwi Rosella Komala Sari Edi Dharmana Em Sutrisna Erika Diana Risanti Faizah, Ishmah Nur Farita Adhynda Amithya Fauzi, Favian Arriella Shabri Ikmal Fikri, Emawan Noor Fitka Romanda Fitri, Alifah Aulia Graffico Eryza Oldiara Haliza, Sheli Nur Hanif, Aulia Hasna Zahro Iftikhonsa Iin Novita Nurhidayati Mahmuda Imronudin Imronudin Kamila, Aulida Azkia Kania, Yulia Intan Komalasari, Dwi Rosella Krisna Viandara, Dewa Made Kumala, Aswa Arsa Lestari, Nining Listiana Masyita Dewi Lisyani Suromo, Lisyani Mapa, Anna Rochim Marsya, Vitania Maulida, Amira Hasna Metana Puspitasari Muhammad Adha Muhammad Alim Abdulmajid Hidayatulloh Muzakar Isa Nadia Wdihi Aqmarina Nida Faradisa Fauziyah Nining Lestari Noor Hafida Widyastuti Nur Mahmudah Nur Mahmudah Nurhaliza, Sheli Pambudi, Nasrurrofiq Risvana Bayu Pintakasari Widyaningtyas Prasetyo, Andri Sugeng Putri, Aprida Retno Sintowati Retno Siryaningsih Retno Siryaningsih, Retno Riandini Aisyah Riandini Aisyah Riandini Aisyah Rochmadina Suci Bestari Rohman, Raihan Fadzlur Salsabiela, Salwa Salsabila, Nabila Mutia Sholeh, Muhammad Dzikru Irfan Sigit Widyatmoko Sri Wahyuni Sulistiyo, Azka Hafiy Supraba, Intan Pratiwi Suryani, Latifah Syahida, Safira Tara , Irmanawati Audhina Nirmala Tri Agustina, Tri Utami, Aurelia Ratna Utami, Indari Wafiq, Muhammad Azzim Waseso, Wahyu Wibowo, Haryo Kunto Widyaningtyas, Pintakasari Yanto, AY Yuli Kusumawati Yunitama, Alifa Agil Dhillu Yusuf, Amry Irsyada Zahro Iftikhonsa, Hasna Zulfah, Khairina