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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kedokteran Brawijaya Biology, Medicine, & Natural Product Chemistry Biomedika Bioeksperimen: Jurnal Penelitian Biologi Majalah Kesehatan FKUB Jurnal Penelitian Kesehatan Suara Forikes Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Kedokteran dan Kesehatan Herb-Medicine Journal Indonesian Journal of Medicine PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Litbang Sukowati : Media Penelitian dan Pengembangan Journal La Bisecoman KESANS : International Journal of Health and Science Cermin Dunia Kedokteran Jurnal Manajemen Bisnis dan Kewirausahaan Gemakes: Jurnal Pengabdian Kepada Masyarakat Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Medika Smart Society Empowerment Journal JHeS (Journal of Health Studies) Indonesian Journal of Physiotherapy JUKEJ: Jurnal Kesehatan Jompa GEMBIRA (Pengabdian Kepada Masyarakat) Joong-Ki Proceeding Book Call for Papers Fakultas Kedokteran Universitas Muhammadiyah Surakarta Jurnal Implementa Husada (JIH)
Safari Wahyu Jatmiko
Universitas Muhammadiyah Surakarta
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Toll-Like Receptor Activation and B Cell Maturation Via MyD88-Dependent Pathway Under Hyperglycemia Condition Aisyah, Riandini; Jatmiko, Safari Wahyu
Bioeksperimen: Jurnal Penelitian Biologi Vol 10, No 1: March 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v10i1.23328

Abstract

hyperglycemia causes a degenerative syndrome that involves an inflammatory process with an increase in certain proinflammatory cytokines and chemokines which in the process will activate B cells to produce immunoglobulins through several mechanisms. One of the interesting mechanisms is the mechanism via the MyD88 pathway. Objectives: to explore the role of MyD88 adapter protein in Toll-like receptor activation and B cell maturation under hyperglycemia conditions. Methods: a literature review was done to answer the study objectives. Results: Class switching process under hyperglycemia conditions involves activation of NFkB through the inflammatory MyD88-dependent pathway to trigger the expression of TLR and B cell maturation and proliferation as well as antibody production. The MyD88 adapter protein is a protein formed by stimulation of pro-inflammatory cytokines IL-6 and plays a role in the continuation of signals from the TLR and IL-1 pathways. Mature B cell stimulation induces 2 genetic changes in the Ig gene locus, called somatic hypermutation (SHM) and class switch recombination (CSR) to produce antibodies. Changes in immunoglobulin genes occur related to changes in certain DNA segments at the locus of genes where CSR occurs, this gene change requires the role of AID (activated-induced cytidine deaminase) in DNA cleavage. AID in mature B cells is activated by proinflammatory cytokines via induction of NfKB activation via the inflammatory MyD88-dependent pathway. Conclusion: Toll-like receptor activation plays a crucial role in B cell maturation activated by pro-inflammatory cytokine via MyD88 dependent-NFkB activation. 
Expression and Activation of Toll-Like Receptor 9 in Dengue Virus Infection: A Scoping Review Jatmiko, Safari Wahyu; Aisyah, Riandini
Bioeksperimen: Jurnal Penelitian Biologi Vol 9, No 2: September 2023
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v9i2.23052

Abstract

Toll-like receptors (TLR) are essential to pathogen recognition to activate innate immunity. TLR2, 3, 4, 6, 7, 8, and 9 are involved in immunity to dengue virus. The involvement of TLR9, known to recognize CpG DNA, in dengue virus (DVI) infection, an RNA virus, is unusual. We hypothesize that there is an elevated expression and activation of TLR9 through specific mechanisms in DVI. A scoping review was carried out to collect articles that have been written regarding this topic. Article searches were carried out on the PubMed (Medline), Proquest, EBSCO, and Google Scholar databases with inclusion criteria: articles in the form of research results using human subjects or human cells, conducted from 2013 to 2023, in English, and can be accessed in full -text. Gray articles, books, and review articles were excluded from the study. The literature search results found 821 articles, with eight articles meeting the criteria. Based on mapping, synthesis, and analysis of the articles obtained, it was found that there was increased expression and activation of TLR9 in the DVI due to the release of mtDNA. 
SINYAL INTRASEL PEMICU REORGANISASI SITOSKELETON SEL MAST PADA REAKSI HIPERSENSITIVITAS TIPE I Jatmiko, Safari Wahyu
Bioeksperimen: Jurnal Penelitian Biologi Vol 2, No 1: March 2016
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/bioeksperimen.v2i1.1631

Abstract

Sel mast mempunyai peranan yang penting dalam terjadinya reaksi hipersensitivitas tipe I. Degranulasi sel mast diyakini mendasari peran sel mast dalam memunculkan reaksi tersebut. Proses degranulasi sel mast terjadi karena berpindahnya granula sel mast dari sitoplasma menuju ke membran sel dan memuntahkan isi granula ke lingkungan sekitarnya. Proses transport ini sangat ditentukan oleh reorganisasi  sitoskeleton yang terdiri atas mikrotubulus, aktin mikrofilamen, dan intermediate filament. Reorganisasi sitoskeleton diawali dengan aktifasi sel mast oleh ikatan antara alergen dengan IgE yang menempel pada FcεR. Aktfasi sel mast diperkuat dengan adanya ikatan antara c-Kit pada permukaan membran sel mast dengan c-Kit ligan. Aktifasi ini menimbulkan serangkaian proses intrasel yang memicu inisiasi reorganisasi.
Determinasi Input Sensorik dan Latihan Keseimbangan Terhadap Risiko Jatuh Lansia: Tinjauan Pustaka Sistematis Zulfah, Khairina; Komalasari, Dwi Rosella; Pristianto, Arif; Jatmiko, Safari Wahyu
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 4 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss4.1988

Abstract

In recent decades, the global elderly population has increased. As a person ages, the risk of progressive balance disorders increases, increasing the risk of falls. 30% of elderly people in Indonesia will experience falls by 2022. This increasingly requires treatment for fall risks in the elderly to improve their quality of life in old age. Currently, there is a lot of research on improving the balance of the elderly. However, there is still no further research related to the combination of floor surfaces with decreasing sensory input in the elderly, so that more sensory input is needed in the elderly. This study aims to identify the effect of floor surfaces and sensory input on balance and fall risk in the elderly. This research method uses a literature review using four main databases: PubMed, SAGE, Medline, and ScienceDirect. The journals used were published in 2020-2025. The data obtained were then analyzed using Prism Diagrams, and the journal search obtained 3,914 journals before screening. After reviewing, 5 journals were obtained and then analyzed using the PICO technique. Results: A review of five journals found that sensory input-based interventions and floor surface variations were effective in improving balance and reducing the risk of falls in older adults. Conclusion: Sensory input-based interventions and floor surface variations were effective in improving balance and reducing the risk of falls in older adults.
The The Relationship between Aerobic Exercise and Blood Sugar Levels and Blood Pressure in Patients with Type 2 Diabetes Mellitus Farita Adhynda Amithya; Dwi Rosella Komalasari; Safari Wahyu Jatmiko; Agus Widodo
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 3 (2025): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i3.506

Abstract

Introduction: Diabetes mellitus and hypertension are degenerative diseases with a high prevalence in the elderly population and commonly occur together as comorbidities, contributing to worsening metabolic and cardiovascular conditions. The coexistence of these diseases increases the risk of serious metabolic complications. Aerobic is a recommended non-pharmacological intervention because it helps control blood glucose levels, improves insulin sensitivity, and reduces blood pressure through mechanisms that enhance endothelial function and cardiorespiratory capacity. Objective: This study aims to analyze the relationship between aerobic activity levels and the status of diabetes mellitus and hypertension in elderly individuals diagnosed with type 2 diabetes mellitus in the community. Method: An analytical observational study with a cross-sectional design. Result and Discussion: The Mann-Whitney test showed a significant association between aerobic activity and diabetes mellitus status (p = 0.001), indicating that lower aerobic levels were associated with higher glucose levels. Aerobic activity was also significantly associated with hypertension status (p < 0.001), showing that lower aerobic increased the likelihood of elevated blood pressure. Conclusions: Increasing aerobic activity is an important non-pharmacological strategy to manage metabolic and cardiovascular risks in older adults with diabetes, and should be integrated into structured community health programs.
The Efektivitas Literature Review: Effectiveness of a Combination of Neuromuscular Taping and Balance Exercises on Postural Function in Patients with Peripheral Neuropathic Diabetes: Literature Review Dewi, Asri Seftika; Budi Rahayu, Ummi; Jatmiko, Safari Wahyu
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 4 (2026): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i4.537

Abstract

Introduction: Diabetic Peripheral Neuropathy is a common complication of diabetes mellitus that leads to sensory and motor impairments, reduced proprioception, and postural instability, increasing the risk of falls and functional limitations. Neuromuscular taping and balance training have been proposed as non-pharmacological interventions to improve postural function in this population. Objective: This literature review aimed to evaluate the effectiveness of the combination of neuromuscular taping and balance training on postural function in patients with diabetic peripheral neuropathy. Method: A literature review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses approach. Articles were identified from Publish or Perish and Google Scholar databases published between 2015 and 2025. Twelve eligible studies were selected based on predefined inclusion criteria and analyzed systematically. Result and Discussion: The reviewed studies demonstrated that balance training significantly improved static and dynamic balance, functional mobility, and reduced fall risk. Neuromuscular taping showed positive effects on balance, proprioception, and pain reduction. Studies combining neuromuscular taping with balance training reported more consistent and superior outcomes compared to single interventions, including improvements in postural stability and center of pressure parameters. Conclusion: The combination of neuromuscular taping and balance training is an effective and clinically applicable approach to improve postural function, reduce fall risk, and alleviate pain in patients with diabetic peripheral neuropathy.
RASIO EOSINOFIL-MONOSIT TIDAK BERKORELASI DENGAN MARKER DERAJAT PENYAKIT INFEKSI VIRUS DENGUE PADA ANAK Jatmiko, Safari Wahyu; Puspitasari, Metana; Widyastuti, Noor Hafida; Aisyah, Riandini
Majalah Kesehatan Vol. 13 No. 1 (2026): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2026.013.01.4

Abstract

Rasio Eosinofil-Monosit (REM) telah digunakan sebagai marker inflamasi yang berhubungan dengan derajat penyakit seperti stroke iskemik akut, gagal jantung, dan Grave’s disease, namun belum pernah dilakukan pada infeksi virus dengue (IVD). Eosinofil dan monosit berperan dalam patogenesis IVD dan terdapat laporan bahwa jumlah monosit berbanding terbalik dengan jumlah eosinofil pada kondisi inflamasi. Di sisi lain, platelet dan hematokrit merupakan bagian dari marker derajat penyakit pada IVD. Semakin berat derajat IVD semakin tinggi hematokrit dan semakin rendah platelet. Maka, penelitian mengenai REM dan penyusun REM yang dikaitkan dengan platelet dan hematokrit perlu dilakukan. Tujuan penelitian untuk mengetahui korelasi antara monosit dengan hematokrit, sel esoinofil dengan hematokrit dan platelet, dan REM dengan hematokrit dan platelet pada IVD anak. Metode penelitian observasional dengan desain cross-sectional. Penelitian dilakukan di RS PKU Muhammadiyah Sampangan Surakarta dari Desember 2023-2024 terhadap populasi pasien IVD di bawah 15 tahun, sesuai kriteria IVD WHO 2009, dan terkonfirmasi melalui tes antibodi anti-dengue. Pasien dengan riwayat gangguan homeostasis, komorbid, riwayat vaksinasi dengue, alergi, malignansi, kecacingan, atau sedang mengalami infeksi lainnya dikecualikan dari penelitian. Berdasarkan rumus besar sampel untuk uji korelasi Pearson  menggunakan transfor-masi Fisher’s Z didapatkan jumlah sampel sebanyak 50. Analisis monosit, eosinofil, REM, hematokrit, dan platelet dilakukan menggunakan Hematology Analyzer. Hasil penelitian ditemukan bahwa terdapat korelasi antara monosit dengan Hct (r = 0,361, p = 0,001), namun tidak ada korelasi yang signifikan secara statistik antara eosinofil dan REM dengan platelet dan hematokrit. Kesimpulan menunjukkan monosit berpotensi sebagai indikator derajat keparahan IVD, namun tidak dengan eosinofil dan REM.  
Yodium Plant (Jatropha multifida Linn.) Leaf Extract Reduces Bleeding Time Waseso, Wahyu; Mahmudah, Nur; Jatmiko, Safari Wahyu; Dewi, Listiana Masyita
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 17, No 2 (2026): February 2026
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf170214

Abstract

Bleeding is a physiological response to vascular injury; however, prolonged bleeding time may indicate impaired hemostatic function. Various medicinal plants have been traditionally used to accelerate wound healing and control bleeding. One such plant is the yodium plant (Jatropha multifida Linn.), which is widely utilized in traditional medicine due to its potential hemostatic and anti-inflammatory properties. The bioactive compounds contained in its leaves are believed to contribute to the enhancement of blood coagulation and the reduction of bleeding duration. This study aimed to determine the effect of Jatropha multifida Linn. leaf extract on bleeding time. This study employed an experimental design to evaluate the effect of Jatropha multifida Linn. leaf extract on bleeding time. The subjects were divided into control and treatment groups. The treatment group received Jatropha multifida leaf extract, while the control group did not receive the extract. Bleeding time was measured after the intervention to assess the hemostatic effect of the extract. The collected data were analyzed to compare bleeding time between the groups. The results demonstrated that the administration of Jatropha multifida Linn. leaf extract was associated with a reduction in bleeding time compared with the control group. This finding suggests that the extract possesses hemostatic potential, which may be attributed to the presence of bioactive compounds that support the blood clotting process. Jatropha multifida Linn. leaf extract has the potential to reduce bleeding time, indicating its possible role as a natural hemostatic agent.Keywords: Jatropha multifida; leaf extract; bleeding time; hemostatic effect; medicinal plants
PENDAMPINGAN IMPLEMENTASI SISTEM INFORMASI RUMAH SAKIT (SIMRS) BERBASIS OPEN SOURCE DI RSU PKU MUHAMMADIYAH PAMOTAN Dadang Nugroho; Safari Wahyu Jatmiko
Jurnal Gembira: Pengabdian Kepada Masyarakat Vol 4 No 03 (2026): JUNI 2026
Publisher : Media Inovasi Pendidikan dan Publikasi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sistem Informasi Rumah Sakit (SIMRS) merupakan kebutuhan strategis yang diwajibkan oleh Permenkes RI Nomor 82 Tahun 2013. RSU PKU Muhammadiyah Pamotan menghadapi kendala dalam implementasi SIMRS eksisting, khususnya terkait keterbatasan sinergi pengembangan layanan oleh vendor lama dan hambatan dalam proses bridging dengan sistem eksternal. Tujuan kegiatan pengabdian kepada masyarakat ini adalah meningkatkan pemahaman tenaga kesehatan RSU PKU Muhammadiyah Pamotan terhadap SIMRS Khanza yang berbasis open source sebagai alternatif solusi. Metode pelaksanaan terdiri dari tiga tahap: (1) survei dan kunjungan studi banding ke RSU Fastabiq Sehat PKU Muhammadiyah Pati, (2) pendampingan berbasis area kerja, dan (3) evaluasi menggunakan desain pre-post test. Peserta berjumlah 8 champion dari masing-masing area layanan. Hasil menunjukkan peningkatan nilai rata-rata dari 77,50 (pre-test) menjadi 86,25 (post-test), dengan peningkatan sebesar 11,29%. Hal ini mengindikasikan bahwa kegiatan pendampingan efektif dalam meningkatkan pemahaman peserta. Kegiatan pendampingan implementasi SIMRS Khanza terbukti efektif dalam meningkatkan pemahaman peserta, meskipun aspek integrasi sistem dengan aplikasi eksternal masih memerlukan penguatan kompetensi lebih lanjut.
Workshop AIK untuk Meningkatkan Profesionalisme Tenaga Kesehatan di Fasilitas Muhammadiyah Pati Luthfi Primadani Kusuma; Safari Wahyu Jatmiko
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 5 No. 4: Agustus 2026
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joong-ki.v5i4.17944

Abstract

Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman tentang nilai-nilai Al-Islam dan Kemuhammadiyahan (AIK) dan untuk menilai efektivitas lokakarya tentang profesionalisme tenaga kesehatan di fasilitas kesehatan Muhammadiyah. Kegiatan ini dilakukan melalui lokakarya pendidikan yang melibatkan 30 tenaga kesehatan dengan menggunakan desain pra-uji dan pasca-uji kuasi-eksperimental. Instrumen penelitian berupa kuesioner skala Likert yang terdiri dari tiga domain: pemahaman tentang nilai-nilai AIK, profesionalisme berbasis AIK, dan penerapan nilai-nilai AIK dalam pelayanan kesehatan. Data dianalisis menggunakan Uji Peringkat Bertanda Wilcoxon. Hasil menunjukkan peningkatan skor rata-rata di semua domain setelah lokakarya, yaitu pemahaman AIK dari 3,99 menjadi 4,71, profesionalisme dari 4,00 menjadi 4,65, dan penerapan AIK dari 3,99 menjadi 4,69, dengan p < 0,001. Temuan ini menunjukkan bahwa lokakarya tersebut meningkatkan pemahaman dan profesionalisme tenaga kesehatan berdasarkan nilai-nilai AIK. Program pendidikan berbasis nilai dapat digunakan sebagai strategi untuk memperkuat profesionalisme di fasilitas kesehatan berbasis Islam.
Co-Authors Adam Nur Rahman Affifah, Fathiyya Noor Agus Widodo Agustina, Dinda Dwi Ahmad Alrizaldi Alfajri, Asri Alim, Fika Nurul Amry Irsyada Yusuf Anam, Ilham Hafizha Maulana Anggitaratri, Zakia Novi Anika Candrasari Annas Syahirul Nugraha Annas Syahirul Nugraha, Annas Syahirul Annisa Maulidia Anton Agus Setyawan Aprida Putri Aqmarina, Nadia Wdihi Arif Pristianto Arkan Adi Widiya Arkan Adi Widiya, Arkan Adi Arsya Sakti Yudha Aryanto Asfarina, Fatin Aulia Hanif Aulida Azkia Kamila AY Yanto Azenta, Moch. Tabriz Azhim Rahmawati Azhim Rahmawati, Azhim Brilliantama, Fandy Akbar Budi Rahayu, Ummi Dadang Nugroho Dedhy Sastiyono Devi Usdiana Rosyidah Dewa Made Krisna Viandara Dewangga, Mahendra Wahyu Dewi, Asri Seftika Dewi, Listiana Masyita Dila Septianing Nugrahanifa Dodik Nursanto Dwi Kusumaningsih Dwi Rosella Komala Sari Edi Dharmana Em Sutrisna Emawan Noor Fikri Erika Diana Risanti Fadhil Emdian Nugraha Faizah, Ishmah Nur Farita Adhynda Amithya Fauzi, Favian Arriella Shabri Ikmal Favian Arriella Shabri Ikmal Fauzi Faza Ovita Balqis Fiqih Habib Marwa Fitka Romanda Fitri, Alifah Aulia Graffico Eryza Oldiara Haliza, Sheli Nur Hanif, Aulia Hasna Zahro Iftikhonsa Ichsan, Burhanuddin Iin Novita Nurhidayati Mahmuda Ilham Hafizha Maulana Anam Imronudin Imronudin Kamila, Aulida Azkia Kania, Yulia Intan Komalasari, Dwi Rosella Kumala, Aswa Arsa Lestari, Nining Listiana Masyita Dewi Lisyani Suromo, Lisyani Luthfi Primadani Kusuma Mapa, Anna Rochim Maulida, Amira Hasna Metana Puspitasari Muhammad Adha Muhammad Alim Abdulmajid Hidayatulloh Muhammad Yusuf Muzakar Isa Nadia Wdihi Aqmarina Nastiti Farasvita Putri Nida Faradisa Fauziyah Nining Lestari Nining Lestari Noor Hafida Widyastuti Nur Mahmudah Nur Mahmudah Nurhaliza, Sheli Pambudi, Nasrurrofiq Risvana Bayu Pintakasari Widyaningtyas Prasetyo, Andri Sugeng Putri, Aprida Rafif Ryandra Izdhihar Ramadhan, Variansa Sava Retno Sintowati Retno Siryaningsih Retno Siryaningsih, Retno Riandini Aisyah Rochmadina Suci Bestari Rohman, Raihan Fadzlur Sabna Ayu Sagita Berliana Salsabiela, Salwa Salsabila, Nabila Mutia Sholeh, Muhammad Dzikru Irfan Sigit Widyatmoko Sri Wahyuni Sulistiyo, Azka Hafiy Sulistyani Sulistyani Supraba, Intan Pratiwi Suryani, Latifah Syahida, Safira Tara , Irmanawati Audhina Nirmala Tri Agustina, Tri Utami, Aurelia Ratna Utami, Indari Vemas Rifki Pradana Vitania Marsya Wafiq, Muhammad Azzim Waseso, Wahyu Wibowo, Haryo Kunto Widyaningtyas, Pintakasari Yohannes Adhie Wijaya Yuli Kusumawati Yunitama, Alifa Agil Dhillu Zahro Iftikhonsa, Hasna Zakia Novi Anggitaratri Zulfah, Khairina Zulfiona Dianes